Skip to main content

Home/ Dr. Goodyear/ Group items tagged multiple

Rss Feed Group items tagged

Nathan Goodyear

The molecular basis of neurodegeneration in multiple sclerosis - 0 views

  • Inflammation is the most predominant feature during the early (relaping) phases of the disease and declines with aging of the patients and disease duration
  • in the process of oligodendrocyte destruction and demyelination in MS lesions iron is liberated from its intracellular ferritin bound stores into the extracellular space, where it is taken up by microglia and macrophages and again stored together with ferritin. When this happens in MS lesions in an environment, where free radicals are produced by oxidative burst, iron can be liberated from ferritin and transformed into reactive Fe++[114], which reacts with hydrogen peroxide to generate highly reactive hydroxyl radicals [36] and thus amplifies oxidative damage and associated cellular injury
  • anti-inflammatory or immunomodulatory treatments are effective in the relapsing stage, but the benefit is lost when the patients have entered the progressive phase
  • ...1 more annotation...
  • Inflammation will remain a key target, since the data suggest that microglia activation and oxidative burst is driven by inflammation throughout all stages of the disease.
  •  
    Very nice review of the neurodegenerative process in MS.  
Nathan Goodyear

Severe oxidative damage in multiple sclerosis lesions coincides with enhanced antioxida... - 0 views

  •  
    This article proposes that increased antioxidant enzymatic activity is an adaption to the increased ROS found in MS.  This increased ROS disrupts the blood-brain barrier.
Nathan Goodyear

MR spectroscopic imaging of glutathione in the white and gray matter at 7 T with an app... - 0 views

  •  
    Interesting study on glutathione.  The study looked at glutathione levels in the brain using MR.  The authors found lower glutathione levels in the Grey matter versus normal controls and lower glutathione levels in white matter lesions.
Nathan Goodyear

ERYTHROCYTE GLUTATHIONE PEROXIDASE DEFICIENCY IN MULTIPLE SCLEROSIS - Shukla - 2009 - A... - 0 views

  •  
    Reduced glutathione peroxidase in the erythrocytes of MS patients.
Nathan Goodyear

Oxidative damage in multiple sclerosis lesions - 0 views

  •  
    Lesions in MS, found to have extensive oxidative damage of oligodendrocytes and neurons.
Nathan Goodyear

Peripheral oxidative stress in relapsing-remitting multiple sclerosis - 0 views

  •  
    Relapsing remitting MS patients found to have in increased 8OHdG, reduced glutathione, reduced glutathione to oxidized glutathione ratio, super oxidized disumutase, glutathione reductase, and global oxidative stress.  In contrast, decreased total antioxidant capacity, oxidized glutathione, glutathione perioxidase, and glutathione transferase were found in relapsing remitting MS patients.
Nathan Goodyear

Vitamin D-mediated immune regulation in multipl... [J Neurol Sci. 2011] - PubMed - NCBI - 0 views

  •  
    Vitamin D's immunomodulating role is an important tool in those with MS. Particularily, it increases T reg cells.
Nathan Goodyear

Enteropathogens associated with a... [FEMS Immunol Med Microbiol. 2002] - PubMed - NCBI - 0 views

  •  
    multiple parasite infection cause of many cases of diarrhea.  A common combination of Blastocystis hominis and Endolimax nana is prevalent.
Nathan Goodyear

The conundrum of iron in multiple sclerosis - time for an individualised approach - 0 views

  •  
    Iron therapy may benefit some with MS.  
wheelchairindia9

Karma KP-80 - 0 views

  •  
    Powerchair, is more compact and has a better turning radius, making it is easier to navigate narrow doorways and tight turns. Another advantage of the powerchair wheelchair is that its armchair joystick does not require an upright posture like an electric scooter's handlebars. Most powerchair wheelchairs can also be taken apart and stowed, while scooters usually can't. Powerchair wheelchairs are also usually less. Power Wheelchairs/Electric Wheelchairs is specially designed for Disabled and Handicapped People. They are recognized as the prominent manufacturer and supplier of a wide array of Power Wheelchairs. Variety of Power Wheelchairs for handicapped and disability product like: Variety of Power Wheelchairs: Karma KP 10-2 Power Wheelchair Karma KP 10-3 Power Wheelchair Karma KP 80 Power Wheelchair GM Lite Power Wheelchair Bronco Wheelchair Angel Wheelchair Bronco Wheelchair: Bronco Reclining Power Wheelchair Description: Comfort mobility is a professional Bronco Wheelchair and power scooter manufacturer established in 1978 in Taiwan. It operates with the policy of combining high quality with innovation. With dedication to research and development, Bronco wheelchair are exported around the world and earned solid reputation for its superior quality, comfort and convenience. Bronco wheelchair - comfortable, durable, designed for easy and healthy movement with full precautions. Bronco Reclining Power Wheelchair Specifications: Anchorage points Adjustable footplates LED front lights Detachable backrest Flip-back armrests Adjustable headrest Mechanic repairs Optional handbrake Power Wheelchair Features: Battery Power Wheelchair. Seat, base & battery quickly detach for easy storage and transportation Come with captain seat. With seat platform, the captain seat can be moved forward or backward using tools which is included. Adjustable armrest width and height. Footrests can be moved forward or backward for optimum placeme
Nathan Goodyear

Absence of chronic traumatic encephalopat... [Front Hum Neurosci. 2013] - PubMed - NCBI - 0 views

  •  
    Study finds that not all football players with a history of multiple concussions and neurologic symptoms have CTE.
Nathan Goodyear

Branched Chain Amino Acid Supplementation for Patients with Cirrhosis | Clinical Correl... - 0 views

  • low level of BCAAs in patients with cirrhosis is hypothesized to be one of multiple factors responsible for development of hepatic encephalopathy
  • supplementation of BCAAs is thought to facilitate ammonia detoxification by supporting synthesis of glutamine, one of the non-branched chain amino acids, in skeletal muscle and in the brain as well as diminishing the influx of AAAs across the blood-brain barrier
  • oral BCAA supplementation is more useful in chronic encephalopathic patients than is parenteral BCAA supplementation in patients with acute encephalopathy
  • ...35 more annotations...
  • malnutrition progressing to cachexia is another common manifestation of cirrhosis
  • Malnutrition can be mitigated with BCAA supplementation
  • Studies show that administration of amino acid formulas enriched with BCAAs can reduce protein loss, support protein synthesis, and improve nutritional status of patients with chronic liver disease
  • Leucine has been shown to be the most effective of the BCAAs because it acts via multiple pathways to stimulate protein synthesis
  • BCAAs metabolites inhibit proteolysis
  • Patients with cirrhosis have both insulin deficiency and insulin resistance
  • BCAAs (particularly leucine) help to reverse the catabolic, hyperglucagonemic state of cirrhosis both by stimulating insulin release from the pancreatic β cells and by decreasing insulin resistance allowing for better glucose utilization
  • Coadministration of BCAAs and glucose has been found to be particularly useful
  • BCAA supplementation improves protein-energy malnutrition by improving utilization of glucose, thereby diminishing the drive for proteolysis, inhibiting protein breakdown, and stimulating protein synthesis
  • Cirrhotic patients have impaired immune defense, characterized by defective phagocytic activity and impaired intracellular killing activity
  • another effect of BCAA supplementation is improvement of phagocytic function of neutrophils and possibly improvement in natural killer T (NKT) cell lymphocyte activity
  • BCAA supplementation may reduce the risk of infection in patients with advanced cirrhosis not only through improvement in protein-energy malnutrition but also by directly improving the function of the immune cells themselves
  • BCAA administration has also been shown to have a positive effect on liver regeneration
  • A proposed mechanism for improved liver regeneration is the stimulatory effect of BCAAs (particularly leucine) on the secretion of hepatocyte growth factor by hepatic stellate cells
  • BCAAs activate rapamycin signaling pathways which promotes albumin synthesis in the liver as well as protein and glycogen synthesis in muscle tissue
  • Chemical improvement with BCAA treatment is demonstrated by recovery of serum albumin and lowering of serum bilirubin levels
  • long-term oral BCAA supplementation was useful in staving off malnutrition and improving survival by preventing end-stage fatal complications of cirrhosis such as hepatic failure and gastrointestinal bleeding
  • The incidence of death by any cause, development of liver cancer, rupture of esophageal varices, or progression to hepatic failure was decreased in the group that received BCAA supplementation
  • Patients receiving BCAA supplementation also have a lower average hospital admission rate, better nutritional status, and better liver function tests
  • patients taking BCAA supplementation report improved quality of life
  • BCAAs have been shown to mitigate hepatic encephalopathy, cachexia, and infection rates, complications associated with the progression of hepatic cirrhosis
  • BCAAs make up 20-25% of the protein content of most foods
  • Highest levels are found in casein whey protein of dairy products and vegetables, such as corn and mushrooms. Other sources include egg albumin, beans, peanuts and brown rice bran
  • In addition to BCAAs from diet, oral supplements of BCAAs can be used
  • Oral supplementation tends to provide a better hepatic supply of BCAAs for patients able to tolerate PO nutrition as compared with IV supplementation, especially when treating symptoms of hepatic encephalopathy
  • Coadministration of BCAAs with carnitine and zinc has also been shown to increase ammonia metabolism further reducing the encephalopathic symptoms
  • Cirrhotic patients benefit from eating frequent, small meals that prevent long fasts which place the patient in a catabolic state
  • the best time for BCAA supplementation is at bedtime to improve the catabolic state during starvation in early morning fasting
  • A late night nutritional snack reduces symptoms of weakness and fatigability, lowers postprandial hyperglycemia, increases skeletal muscle mass,[25] improves nitrogen balance, and increases serum albumin levels.[26] Nocturnal BCAAs even improve serum albumin in cirrhotic patients who show no improvement with daytime BCAAs
  • Protein-energy malnutrition (PEM), with low serum albumin and low muscle mass, occurs in 65-90% of cases of advanced cirrhosis
  • hyperglucagonemia results in a catabolic state eventually producing anorexia and cachexia
  • BCAAs are further depleted from the circulation due to increased uptake by skeletal muscles that use the BCAAs in the synthesis of glutamine, which is produced in order to clear the ammonia that is not cleared by the failing liver
  • patients with chronic liver disease, particularly cirrhosis, routinely have decreased BCAAs and increased aromatic amino acids (AAAs) in their circulation
  • Maintaining a higher serum albumin in patients with cirrhosis is associated with decreased mortality and improved quality of life
  • the serum BCAA concentration is strongly correlated with the serum albumin level
  •  
    great review of cirrhosis and BCCA supplementation.
Nathan Goodyear

Late-night salivary cortisol as a screening test f... [J Clin Endocrinol Metab. 1998] -... - 0 views

  • Late-night salivary cortisol measurement is a simple and reliable screening test for spontaneous Cushing's syndrome
  •  
    salivary cortisol validated in Cushing's Syndrome.  Multiple studies have done the same
Nathan Goodyear

Many LH peaks are needed to physiologically stimulate testosterone secretion: modulatio... - 0 views

  •  
    multiple LH peaks, 3-4 needed per day to stimulate Testosterone secretion
Nathan Goodyear

Correlation between sex hormones and magne... [Acta Neurol Scand. 1999] - PubMed - NCBI - 0 views

  •  
    Women with MS shown to have more active MS lesions with a high estradiol to progesterone ratio.
Willow O'Donnell

Refurbished Baxter Sigma Spectrum Infusion IV Pump | willowmed | Tumblr - 0 views

  •  
    The Baxter SIGMA Spectrum Infusion System is redefining smart technology with Second Generation software to help prevent pump-related medication errors. The SIGMA Spectrum Infusion System provides multiple error prevention systems along with bi-directional wireless communication and comprehensive log analysis software to create CQI reports. SIGMA Spectrum pump provides rapid, intuitive work-flow using a bright, easy to read color display and on-board digital help screens. SIGMA Spectrum pump also provides economic value by utilizing Baxter's standard IV administration sets.
Nathan Goodyear

Effect of raising endogenous testosterone levels in impotent men with secondary hypogon... - 0 views

  •  
    Small study found that 2 months of clomid therapy increased LH, FSH, total Testosterone, and free Testosterone over placebo.  Improvement in ED was minimal and most in young men.  This is consistent with other studies that have found that less effects are seen in those with multiple comorbidities.
Nathan Goodyear

http://press.endocrine.org/doi/pdf/10.1210/jc.2014-1872 - 0 views

  •  
    New study finds Testosterone therapy provides less than statistical significant improvement in constitutional/sexual symptoms, in obese men with type II diabetes with symptoms classified as mild-moderate with modest reductions in Total Testosterone.  This study highlights that low Testosterone is a biomarker of poor health and multiple comorbidities and that simply adding in Testosterone therapy will not cure all male woes.  The authors did state that ED and low T are separate issues and I will differ with them on this--they are in fact link.  This association may vary between individuals, but to flatly state they are completely separate issues is devoid of the fact that testosterone has been shown to reduce inflammatory cytokines and improve PDE5 therapy.  
Nathan Goodyear

Prevalence and Clinical Associations of 10 Defined Autoantibodies in Autoimmune Polyend... - 0 views

  •  
    multiple autoantibodies present in those with autoimmune polyendocrine syndrome type 1.
Willow O'Donnell

Refurbished Baxter Sigma Spectrum Infusion IV Pump - 0 views

  •  
    The Baxter SIGMA Spectrum Infusion System is redefining smart technology with Second Generation software to help prevent pump-related medication errors. The SIGMA Spectrum Infusion System provides multiple error prevention systems along with bi-directional wireless communication and comprehensive log analysis software to create CQI reports. SIGMA Spectrum pump provides rapid, intuitive work-flow using a bright, easy to read color display and on-board digital help screens.
« First ‹ Previous 41 - 60 of 178 Next › Last »
Showing 20 items per page