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Nathan Goodyear

Oxidative damage in multiple sclerosis lesions - 0 views

brain.oxfordjournals.org/...1914.short

MS multiple sclerosis oxidative damage brain oligodendrocytes

shared by Nathan Goodyear on 19 Mar 14 - No Cached
  • Nathan Goodyear on 19 Mar 14
     
    Lesions in MS, found to have extensive oxidative damage of oligodendrocytes and neurons.
Nathan Goodyear

Progesterone neuroprotection in trauma... [Front Neuroendocrinol. 2009] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...19318112

progesterone myelin BDNF traumatic brain injury TBI head trauma

shared by Nathan Goodyear on 19 Mar 14 - No Cached
  • Nathan Goodyear on 19 Mar 14
     
    Progesterone has a neuroprotective and promyelinating effects in the nervous system.  Progesterone increases BDNF.  Progesterone increases proliferation and differentiation of oligodendrocyte progenitor cells which will increase myelin production.
Nathan Goodyear

The Role of Progesterone in Traumatic Brain Injury : The Journal of Head Trauma Rehabil... - 0 views

journals.lww.com/..._Traumatic_Brain_Injury.6.aspx

progesterone TBI brain injury traumatic brain injury head trauma hormone hormones

shared by Nathan Goodyear on 17 Mar 14 - No Cached
  • Nathan Goodyear on 17 Mar 14
     
    Progesterone useful in inflammation reduction in Traumatic Brain Injuries.  This applies to both sexes.
Nathan Goodyear

The molecular basis of neurodegeneration in multiple sclerosis - 0 views

www.sciencedirect.com/...S001457931100593X

MS multiple sclerosis neurodegenerative disease CNS brain inflammation

shared by Nathan Goodyear on 19 Mar 14 - No Cached
  • Inflammation is the most predominant feature during the early (relaping) phases of the disease and declines with aging of the patients and disease duration
  • in the process of oligodendrocyte destruction and demyelination in MS lesions iron is liberated from its intracellular ferritin bound stores into the extracellular space, where it is taken up by microglia and macrophages and again stored together with ferritin. When this happens in MS lesions in an environment, where free radicals are produced by oxidative burst, iron can be liberated from ferritin and transformed into reactive Fe++[114], which reacts with hydrogen peroxide to generate highly reactive hydroxyl radicals [36] and thus amplifies oxidative damage and associated cellular injury
  • anti-inflammatory or immunomodulatory treatments are effective in the relapsing stage, but the benefit is lost when the patients have entered the progressive phase
  • ...1 more annotation...
  • Inflammation will remain a key target, since the data suggest that microglia activation and oxidative burst is driven by inflammation throughout all stages of the disease.
  • Nathan Goodyear on 19 Mar 14
     
    Very nice review of the neurodegenerative process in MS.  
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