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fnfdoc

How Brain Tumor Affect On Health | Your Health Our Priority - 0 views

www.fnfdoc.com/...brain-tumor-affect-health

health brain tumor

shared by fnfdoc on 28 Apr 18 - No Cached
  • fnfdoc on 28 Apr 18
     
    A brain is an organ often composed of Connective tissues and nerve cells. The brain contains three important parts including breathe controlling and muscles like moving muscles and sensing like emotions breathing, memory thinking and somewhat personality.
Nathan Goodyear

Alzheimer's Disease Clinical and Research Update for Health Care Practitioners - 0 views

www.ncbi.nlm.nih.gov/...PMC3776389

Alzheimer's disease cognition memory Alzheimers brain brain health alpha-GPC phosphatidyl serine Huperzine A choline

shared by Nathan Goodyear on 26 Sep 17 - No Cached
  • Alpha GPC, phosphatidylserine, Huperzine A, and choline show promise as nutraceutical agents for enhancing cognitive performance and slowing cognitive decline
  • Alpha GPC, also known as L-Alpha Glycerylphosphorylcholine, a naturally occurring form of choline, acts as a parasympathomimetic acetylcholine precursor and has shown promise in improving cognitive symptoms related to AD, vascular dementia, and multi-infarct dementia
  • Phosphatidylserine is a widely abundant anionic phospholipid in the human body and has been shown to improve age-related cognitive changes
  • ...2 more annotations...
  • Huperzine A (a natural cholinesterase inhibitor) has been linked to improved memory performance in elderly people with benign forgetfulness, as well as patients with AD and vascular dementia
  • Cholinesterase inhibitors have been shown to have neuroprotective properties in patients with mild [37] as well as moderate-to-advanced AD
  • Nathan Goodyear on 26 Sep 17
     
    good review of treatment for Alzheimer's, both prescription and natural.
Nathan Goodyear

Frontiers | The Beneficial Effects of Physical Activity on Impaired Adult Neurogenesis ... - 0 views

www.frontiersin.org/...full

exercise neurogenesis neuroplasticity brain brain health BDNF

shared by Nathan Goodyear on 30 Nov 17 - No Cached
  • Nathan Goodyear on 30 Nov 17
     
    Neurogenesis and neuroplasticity are under epigenetic control.  Stress and aging downregulate adult neurogenesis; whereas physical activity, environment enrichment and learning/memory increase.  Check out figure 1.  Exercise increases BDNF and hence neuroplasticity.  This was a synRas mouse study.
Nathan Goodyear

Longitudinal analysis shows durable and broad immune memory after SARS-CoV-2 infection ... - 0 views

www.ncbi.nlm.nih.gov/...PMC8095229

COVID COVID19 COVID-19

shared by Nathan Goodyear on 27 Jul 21 - No Cached
  • Nathan Goodyear on 27 Jul 21
     
    Only natural immunity through infection provides the most durable B and T cells for long-term immunity. Vaccinations miss the mark.
Nathan Goodyear

Longitudinal analysis shows durable and broad immune memory after SARS-CoV-2 ... - 0 views

www.cell.com/...S2666-3791(21)00203-2

vaccination covid19 COVID-19 vaccinations COVID

shared by Nathan Goodyear on 07 Aug 21 - No Cached
  • Nathan Goodyear on 07 Aug 21
     
    Good T and B cell immunity from infection recovery.
forestgood

Cheap Flights, Airline Tickets & Airfares - Find Deals on Flights at WayAway.io - 0 views

wayaway.tp.st/H2IZEX39

hotel

shared by forestgood on 15 Aug 23 - No Cached
  • forestgood on 15 Aug 23
     
    Here's some additional information about the specific hotels and brand offers available through our platform: Hotels: Our handpicked selection of hotels caters to a variety of tastes and preferences. Whether you're seeking a tranquil beachfront retreat, a vibrant city center stay, or a cozy countryside escape, we have partnered with top-notch establishments to ensure a memorable experience. Each hotel offers unique amenities, luxurious accommodations, and exceptional service, ensuring your stay is nothing short of extraordinary. Tickets: Our ticket offerings encompass a wide range of events and attractions. From sports games and concerts to theater performances and cultural exhibitions, we provide access to sought-after experiences. With our ticket deals, you can secure coveted seats, enjoy VIP access, and immerse yourself in the excitement of live entertainment. Enhance your travel itinerary with unforgettable memories. Brand Offers: We have collaborated with renowned brands to bring you exclusive offers and promotions across various industries. From fashion and beauty to technology and lifestyle, our brand partners have crafted special deals tailored to our community. Enjoy discounts, unique packages, and access to limited-edition products, elevating your everyday life with exceptional quality and value. By going straight to the product page, our platform ensures a streamlined and user-friendly experience. This allows you to explore the details, features, and pricing of each hotel, ticket, or brand offer directly, increasing the convenience and efficiency of your purchase process. Discover extraordinary accommodations, secure tickets to unforgettable events, and indulge in exclusive brand offers through our platform. Begin your journey and unlock remarkable experiences today! VISIT THIS BY CLICKING HERE: https://sharecta.com/l/40x4cx4xarc44
Nathan Goodyear

Toxicity of the spike protein of COVID-19 is a redox shift phenomenon: A novel therapeu... - 0 views

www.sciencedirect.com/...S0891584923005014

COVID19 COVID-19 cancer inflammation SARS-CoV-2 spike proteins COVID spikeopathy

shared by Nathan Goodyear on 01 Sep 23 - No Cached
  • Redox shift is due to Warburg effect and mitochondrial impairment.
  • Redox shift is due to Warburg effect and mitochondrial impairment.
  • Redox shift is due to Warburg effect and mitochondrial impairment.
  • ...88 more annotations...
  • The cytokine storm is a consequence of mitochondrial dysfunction
  • The cytokine storm is a consequence of mitochondrial dysfunction
  • The cytokine storm is a consequence of mitochondrial dysfunction
  • The cytokine storm is a consequence of mitochondrial dysfunction
  • Lipoic acid, Methylene Blue and Chlorine dioxide relieve COVID-19 spike protein toxicity
  • Lipoic acid, Methylene Blue and Chlorine dioxide relieve COVID-19 spike protein toxicity
  • Lipoic acid, Methylene Blue and Chlorine dioxide relieve COVID-19 spike protein toxicity
  • Lipoic acid, Methylene Blue and Chlorine dioxide relieve COVID-19 spike protein toxicity
  • most diseases display a form of anabolism due to mitochondrial impairment
  • most diseases display a form of anabolism due to mitochondrial impairment
  • most diseases display a form of anabolism due to mitochondrial impairment
  • infection by Covid-19 follows a similar pattern
  • chronic inflammation
  • Long-term effects include redox shift and cellular anabolism as a result of the Warburg effect and mitochondrial dysfunction
  • Long-term effects include redox shift and cellular anabolism as a result of the Warburg effect and mitochondrial dysfunction
  • Long-term effects include redox shift and cellular anabolism as a result of the Warburg effect and mitochondrial dysfunction
  • Long-term effects include redox shift and cellular anabolism as a result of the Warburg effect and mitochondrial dysfunction
  • infection by Covid-19 follows a similar pattern
  • unrelenting anabolism leads to the cytokine storm,
  • unrelenting anabolism leads to the cytokine storm,
  • unrelenting anabolism leads to the cytokine storm,
  • chronic inflammation
  • chronic inflammation
  • infection by Covid-19 follows a similar pattern
  • Lipoic acid and Methylene Blue have been shown to enhance the mitochondrial activity, relieve the Warburg effect and increase catabolism
  • Lipoic acid and Methylene Blue have been shown to enhance the mitochondrial activity, relieve the Warburg effect and increase catabolism
  • Lipoic acid and Methylene Blue have been shown to enhance the mitochondrial activity, relieve the Warburg effect and increase catabolism
  • Methylene Blue, Chlorine dioxide and Lipoic acid may help reduce long-term Covid-19 effects by stimulating the catabolism
  • Methylene Blue, Chlorine dioxide and Lipoic acid may help reduce long-term Covid-19 effects by stimulating the catabolism
  • Methylene Blue, Chlorine dioxide and Lipoic acid may help reduce long-term Covid-19 effects by stimulating the catabolism
  • direct consequence of redox iMeBalance, itself a consequence of decreased energy yield by the mitochondria
  • direct consequence of redox iMeBalance, itself a consequence of decreased energy yield by the mitochondria
  • mitochondrial dysfunction and increased levels of lactate, which are important characteristics of metabolic shift and Warburg effect in many diseases
  • mitochondrial dysfunction and increased levels of lactate, which are important characteristics of metabolic shift and Warburg effect in many diseases
  • increased lactate dehydrogenase activity (LDH) was observed in COVID-19 patients
  • increased lactate dehydrogenase activity (LDH) was observed in COVID-19 patients
  • almost every disease presents an increased anabolism
  • almost every disease presents an increased anabolism
  • cell division is the most sophisticated way to release entropy
  • cell division is the most sophisticated way to release entropy
    • Nathan Goodyear
      Nathan Goodyear on 01 Sep 23
       
      Wow
    • Nathan Goodyear
      Nathan Goodyear on 01 Sep 23
       
      Wow
  • transition from catabolism to anabolism is driven by a redox shift
  • transition from catabolism to anabolism is driven by a redox shift
  • viral spike protein binds to ACE2 receptor of the host cell [22,23].
  • redox signaling plays an important role in regulating immune function and inflammation, and disruptions in this signaling can lead to excessive cytokine production and immune system activation
  • Aging is associated with a poor control of the redox balance
  • thiol/disulfide homeostasis
  • reduced extracellular environment in the elderly and the increased susceptibility to Covid-19 infection
  • reduced extracellular environment in the elderly and the increased susceptibility to Covid-19 infection
  • Redox signaling tightly modulates the inflammatory response and oxidative stress has been reported in acute Covid-19
  • People at high risk are the elderly, patients suffering from metabolic syndrome such as obesity, or those suffering from chronic diseases such as cancer or inflammation
  • COVID-19 patients with severe disease have higher levels of oxidative stress markers and lower antioxidant levels
  • oxidative stress can activate the NLRP3 inflammasome, which is a protein complex that plays a key role in the cytokine storm
  • inflammation leads to the formation of ROS and RNS, while redox iMeBalance results in cellular damage, which in turn triggers an inflammatory response
  • persistently elevated mtROS triggers endothelial dysfunction and inflammation, which results in a vicious loop involving ROS, inflammation, and mitochondrial dysfunction
  • Damaged mitochondria releasing ROS induce inflammation via the NLRP3 inflammasome
  • Damaged mitochondria releasing ROS induce inflammation via the NLRP3 inflammasome
  • reduced environment during the cytokine storm
  • IL-2 is highly up-regulated in Covid-19 patients [37], and IL-2 is known to significantly stimulate the generation of NO in patients
  • Nitric acid is also the key mediator of IL-2-induced hypotension and vascular leak syndrome
  • mitochondrial dysfunction has been linked to the pathogenesis of Covid-19
  • mitochondrial dysfunction triggered by SARS-CoV-2 leads to damage to the mitochondria
  • mitochondrial dysfunction triggered by SARS-CoV-2 leads to damage to the mitochondria
  • As catabolism is decreased, entropy is released through anabolism
  • Elevated levels of lactate, a characteristic of the Warburg effect, were also reported in the high-risk Covid-19
  • elevated levels of ventricular lactic acid consistent with oxidative stress
  • A decrease of ΔΨm is implicated in several inflammation-related diseases
  • decrease in ΔΨm in leucocytes from Covid-19 patients
  • vaccinated with RNA or DNA vaccines triggering the synthesis of the viral spike protein in human cells
  • viral reactivation in varicella-zoster virus [55] or hepatitis [56], coagulopathy and resulting stroke and myocarditis following both DNA-based vaccines [57] and RNA-based vaccines
  • Covid-19, mitochondrial impairment
  • characteristic of the Warburg effect is present in almost every disease and appears to be a central feature in most of the hallmarks of cancer
  • inflammation, mitochondrial dysfunction and increased lactate concentrations in the extracellular fluid
  • In Covid-19, like any inflammation, there is a metabolic rewiring where cells rely on glycolysis
  • As the mitochondria are impaired, the infected cell cannot catabolize efficiently. It will release lactic acid in the blood stream
    • Nathan Goodyear
      Nathan Goodyear on 01 Sep 23
       
      Mitochondrial impairment
  • Striking similarities are seen between cancer, Alzheimer's disease and Covid-19, all related to the Warburg effect
  • Cancer, inflammation, Alzheimer's, and Parkinson's diseases share a common peculiarity, the inability of the cell to export entropy outside the body in the harmless form of heat
    • Nathan Goodyear
      Nathan Goodyear on 01 Sep 23
       
      Entropy: lack of order or predictability; gradual decline into disorder.
  • MEB relieves the Warburg effect [87], improves memory [77], is active in the treatment of depressive episodes [79,80] and reduces the importance of ischemic strokes
  • MEB relieves the Warburg effect [87], improves memory [77], is active in the treatment of depressive episodes [79,80] and reduces the importance of ischemic strokes
  • MEB has been shown to inhibit SARS-Cov-2 replication in vitro
  • MEB has been shown to inhibit SARS-Cov-2 replication in vitro
  • It has been shown that Covid-19-patients treated with MEB, have a significant reduction in hospital stay duration and mortality
  • MeB is an acceptor-donor molecule
  • MeB + can take a pair of electrons (of H atoms) and MeBH can release this pair easily, so that MeB is partially recycled like a catalyst
  • MeB acts as an electron bridge between a donor (FADH2, FMNH, NADH) and an acceptor (complex IV of ETC or oxygen itself)
  • As a coenzyme of pyruvate dehydrogenase (PDH), alpha-lipoic acid (ALA) initiates the formation of acetyl-CoA to feed the TCA cycle
  • ALA enhances the catabolism of carbon. cycle and therefore may reduce the Warburg effect and consequently, lactate production
  • Methylene Blue plays a similar role after the TCA cycle, by carrying electrons to complex IV of the electron transport chain
  • Drugs such as lipoic acid and MeB, which target the metabolism, decrease the redox shift by increasing catabolism
Nathan Goodyear

Association Between Serum 25(OH) Vitamin D and the Risk of Cognitive Decline in Older W... - 0 views

biomedgerontology.oxfordjournals.org/...1092.abstract

vitamin D cognitive decline cognitive decline memory women vitamin

shared by Nathan Goodyear on 12 Feb 13 - No Cached
  • Nathan Goodyear on 12 Feb 13
     
    Just an association, but low vitamin  D levels found to be associated with decreased cognitive function in older women.  Found in women with levels < 20.
Nathan Goodyear

Huperzine A for Alzheimer's disease. [Cochrane Database Syst Rev. 2008] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...18425924

alzheimer disease Alzheimer's disease Alzheimer's Huperzine-A memory cognition

shared by Nathan Goodyear on 03 Oct 12 - No Cached
  • Nathan Goodyear on 03 Oct 12
     
    Review of 6 trials on 454 patients found Huperzine A improved cognition and executive function with no serious adverse events in patients with Alzheimer's disease.  Yet, their conclusion is, "...inadequate evidence to make any recommendation..."   Does it improve executive cognitive function?   Yes.  Does in have serious side effects?  No.  And we are waiting on...?
wheelchairindia9

Tynor Ankle Binder - 0 views

www.wheelchairindia.com/...Tynor-Ankle-Binder

Get Happy Feet With The Right Walking Boots orthopedic walking boot boot type walkers decrease pain and edema comfort to the lower leg rocking motion of the foot boots provide support to the ankle

shared by wheelchairindia9 on 23 Mar 16 - No Cached
  • wheelchairindia9 on 23 Mar 16
     
    The boot type walkers can be provided in a fixed mode or with ankle joints to provide articulation. Pneumatic support is also available. The brace has a lightweight, durable, semi rigid shell that will support the limb and provide protection. Incorporated are medial and lateral uprights, heel and rocker sole. Closure is achieved with Velcro. The strapping system provides full circumferential compression of the limb. The breathable fiber liner is washable. The articulated boot allows range of motion (ROM) usually from approximately 20 degrees dorsiflexion to 40 degrees plantar flexion. Tynor Walker Boot is designed by the Tynor to rehabilitate the person after injury or fracture. It allows easy movement as well as supports the ankle and leg. This can be a great substitute for cast and also useful during early cast removal. It can also be used during sprain in the foot and this walker gives great relief to the pain. It can easily do any mild activity. It also works for the persons with a lower leg and will give an equal level of the lower feet as well as reduces the pressure. It effectively enclosed the muscles of the leg or foot during the fracture and gives comfort without disturbing the recovery process. This walker boot is made up from the good quality material. It has Aluminum lateral bars that are corrosion free. It is light in weight and provides enhanced mobility. It gives sturdy support to feet and leg. Its Hook Loop system allows to adjust it according to the comfort. It is also infused with Foam liner and Pad set that gives soft feet and also provides great support. It is available in different sizes. Tynor Walker Boot is designed for rehabilitation after injury, fracture , sprains or surgery of foot, ankle or lower leg. The boots provide support to the ankle and leg without inhibiting mobility. They can be a substitute for cast or can be used in case of early cast removal. With a wider rocker bottom, these boots promote a natural gait, reduced
Nathan Goodyear

effects of beta-hydroxybutyrate on cognition in memory-impaired adults - 0 views

w.numedica.net/...Reger%202004.pdf

ketogenic diet ketone bodies ketosis Alzheimer's disease neurodegenerative disease MCT medium chain fatty acids

shared by Nathan Goodyear on 25 Jun 12 - No Cached
  • Nathan Goodyear on 25 Jun 12
     
    Those with Alzheimer's disease have associated dysfunction of glucose metabolism in the brain, particularly in the hippocampus. It has been reported that a ketogenic diet can improve cognitive function in these individuals. In this study, the ketone bodies were initiated through a diet high in medium chain fatty acids. The ketone bodies served as an alternative fuel source for the brain.
Nathan Goodyear

Oxidative Stress, Testosterone, and Cognition among Caucasian and Mexican-American Men ... - 0 views

iospress.metapress.com/...t1717503235m8667

Testosterone alzheimer memory disease stress oxidative oxidative stress men male hormone hormones cognition

shared by Nathan Goodyear on 03 Mar 14 - No Cached
  • Nathan Goodyear on 03 Mar 14
     
    Interesting study. This study points out the differences between individuals and groups i.e. Mexian-Americans and Caucasians in this study.  Men with low oxidative stress, Testosterone was associated with no cognitive dysfunction.  In contrast, with high oxidative stress, Testosterone therapy was associated with cognitive impairment in caucasians only.
Nathan Goodyear

MicroRNAs in the Aging Female Brain: A Putative Mechanism for Age-Specific Estrogen Eff... - 0 views

endo.endojournals.org/...2795.abstract

aging female brain estrogen HRT BHRT hormone hormones menopause neurology memory Estradiol

shared by Nathan Goodyear on 06 Aug 13 - No Cached
  • Nathan Goodyear on 06 Aug 13
     
    Estradiol appears to have an age dependent effect on the transcription of mRNA and brain neuroplasticity.  This has a future impact on the risk of cognitive decline and dementia in elderly women.  This is only the abstract, but points to one effect of early Estradiol effect on improved brain health versus late therapy.  
Nathan Goodyear

https://endo.confex.com/endo/2014endo/webprogram/Paper14285.html - 0 views

endo.confex.com/...Paper14285.html

statin statins statin therapy brain cognition metabolic syndrome metabolic syndrome memory

shared by Nathan Goodyear on 19 Jul 14 - No Cached
  • Nathan Goodyear on 19 Jul 14
     
    Statin use found to be associated with cognitive decline.  The authors defined use as long-term, though 2 years of use was found to be associated with decline.   interestingly, metabolic syndrome was not found to be associated with cognitive decline.
Nathan Goodyear

Effect of the long-term feeding of dietary lipids on the learning ability, fatty acid c... - 0 views

www.sciencedirect.com/...S0047637497001693

DHA learning fish oil n-3 omega 3 omega-3 memory

shared by Nathan Goodyear on 01 Nov 13 - No Cached
  • Nathan Goodyear on 01 Nov 13
     
    mouse study finds high DHA diet improved learning.
Nathan Goodyear

A high-fat, refined sugar diet reduces hippocam... [Neuroscience. 2002] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...12088740

diet nutrition BDNF sugar saturated fat neurplasticity hippocampus memory

shared by Nathan Goodyear on 01 Nov 13 - No Cached
  • Nathan Goodyear on 01 Nov 13
     
    High saturated fat and sugar diet causes reduced BDNF in the hippocampus.  This is an animal model.  The effect was a reduction in spacial learning.    Dietary choice can effect the neuroplasticity and learning capacity of the hippocampus.
Nathan Goodyear

DHA dietary supplementation enhances the effects of exercise on synaptic plasticity and... - 0 views

www.ncbi.nlm.nih.gov/...PMC3208643

DHA n-3 omega 3 omega-3 fish oil cognition memory hippocampus exercise neuroplasticity BDNF brain derived neurotrophic factor lipid peroxidation

shared by Nathan Goodyear on 01 Nov 13 - No Cached
  • Nathan Goodyear on 01 Nov 13
     
    DHA enriched diet plus exercis improved cognition through a increase in brain derived neurotrophic factor (BDNF).  The result was increased neuroplasticity.  Additionally, they were shown to reduce hippocampal lipid peroxidation.
Nathan Goodyear

Brain-derived neurotrophic factor functions as a metabotrophin to mediate the effects o... - 0 views

www.ncbi.nlm.nih.gov/...PMC2805663

BDNF hippocampus memory brain MAPK

shared by Nathan Goodyear on 03 Nov 13 - No Cached
  • Nathan Goodyear on 03 Nov 13
     
    BDNF increased metabolic biomarkers, MAPK, in hippocampus.  This has implications in the treatment of learning disorders.  Exercise has consistently been shown to be the most significant mechanism to increase BDNF.
Nathan Goodyear

l-Carnitine treatment reduces severity of physical and mental fatigue and increases cog... - 0 views

ajcn.nutrition.org/...1738.short

carnitine memory fatigue brain

shared by Nathan Goodyear on 02 Nov 13 - No Cached
  • Nathan Goodyear on 02 Nov 13
     
    Carnitine improves cognition and lessens mental fatigue in centenarians.  
Nathan Goodyear

Herbal Extracts and Phytochemicals: Plant Secondary Metabolites and the Enhancement of ... - 0 views

advances.nutrition.org/...32.full

herbs brain cognition memory

shared by Nathan Goodyear on 03 Nov 13 - No Cached
  • Nathan Goodyear on 03 Nov 13
     
    Good review of the current literature on herbs and improved cognitive function
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