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Nathan Goodyear

The activity of satellite cells and myonuclei following 8 weeks of ... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25294097

resistance training strength training Testosterone men male hormone hormones

shared by Nathan Goodyear on 28 Oct 14 - No Cached
  • Nathan Goodyear on 28 Oct 14
     
    Though, studies have shown that resistance training increases Testosterone production, this study finds that artificial suppression of Testosterone reduced myogenic response to 8 weeks of resistance training.
Nathan Goodyear

:: EnM :: Endocrinology and Metabolism - 0 views

e-enm.org/DOIx.php

Diabetes men low T low Testosterone low T Testosterone male hormone hormones

shared by Nathan Goodyear on 21 Oct 14 - No Cached
  • Nathan Goodyear on 21 Oct 14
     
    Study finds that hospitalized men with poorly controlled Diabetes have lower Testosterone than healthy men.  
Nathan Goodyear

http://www.eurjmedres.com/content/pdf/s40001-014-0056-6.pdf - 0 views

www.eurjmedres.com/...s40001-014-0056-6.pdf

Testosterone therapy treatment diet exercise low T low Testosterone low T Diabetes BMI weight HgbA1c hypertension blood pressure men male hormone hormones

shared by Nathan Goodyear on 27 Oct 14 - No Cached
  • Nathan Goodyear on 27 Oct 14
     
    Testosterone therapy in obese men with type II Diabetes and low T improved weight,  lipids, HgbA1c, and blood pressure.  There was more improvement with Leptin than with diet/exercise alone. What is very important is that the control group (diet, exercise, DM meds) had improvement in Testosterone levels, HgbA1c, lipids, BMI, and blood pressure; just not as strong as the treatment arm with Testosterone.
Nathan Goodyear

Reduced testosterone and adrenal C19 steroid levels in obese men. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...7723675

obesity obese men low Testosterone low Testosterone male hormones hormone adrenal cortisol

shared by Nathan Goodyear on 28 Oct 14 - No Cached
  • Nathan Goodyear on 28 Oct 14
     
    Decreased adrenal steroid production occurred in men with obesity.  Estrone positively correlated.
Nathan Goodyear

Relationship between low free testosterone levels and loss of muscle mass. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23660939

free Testosterone total Testosterone muscle Testosterone sarcopenia muscle loss men male hormone hormones

shared by Nathan Goodyear on 05 Apr 15 - No Cached
  • Nathan Goodyear on 05 Apr 15
     
    low free Testosterone associated with muscle loss in men compared to no association with total Testosterone in Japanese men.
Nathan Goodyear

In Older Men an Optimal Plasma Testosterone Is Associated With Reduced All-Cause Mortal... - 0 views

press.endocrine.org/...jc.2013-3272

Testosterone DHT dihydroTestosterone heart health disease Estradiol mortality men male hormone hormones heart disease heart health

shared by Nathan Goodyear on 02 Apr 15 - No Cached
  • Nathan Goodyear on 02 Apr 15
     
    men with Testosterone levels in the middle quintiles had the lowest risk of death compared to low and high quintile levels.  
Nathan Goodyear

Sex steroids and cardiovascular disease - 0 views

www.ncbi.nlm.nih.gov/...PMC3955333

low T Testosterone cardiovascular disease CVD men male hormone hormones

shared by Nathan Goodyear on 20 Apr 14 - No Cached
  • T circulates bound with high affinity to sex hormone binding globulin (SHBG) and with lower affinity to albumin, with a small fraction unbound or free
  • Levels of SHBG are higher in older men, therefore levels of free T decline more steeply than total T as men's age increases
  • Nathan Goodyear on 20 Apr 14
     
    Previously posted article.  The journal changed the URL
Nathan Goodyear

https://www.auanet.org/common/pdf/education/clinical-guidance/Testosterone-Deficiency-W... - 0 views

www.auanet.org/...rone-Deficiency-WhitePaper.pdf

low T low Testosterone AUA Testosterone American Urological Association men male hormone hormones

shared by Nathan Goodyear on 02 Apr 15 - No Cached
  • Nathan Goodyear on 02 Apr 15
     
    2013 AUA white paper on low Testosterone.
Nathan Goodyear

Direct Inhibitory Effect of Glucocorticoids upon Testicular Luteinizing Hormone Recepto... - 0 views

press.endocrine.org/...endo-108-6-2142

glucocorticoids cortisol Testosterone LH low T low Testosterone men male hormones hormone

shared by Nathan Goodyear on 02 Apr 15 - No Cached
  • Nathan Goodyear on 02 Apr 15
     
    glucocorticoids inhibit Testosterone production via down regulation of LH receptors at the level of the testicles.
Nathan Goodyear

Acute Suppression of Circulating Testosterone Levels by Cortisol in Men: The Journal of... - 0 views

press.endocrine.org/...jcem-57-3-671

Cortisol Testosterone stress men male hormone hormones

shared by Nathan Goodyear on 02 Apr 15 - No Cached
  • Nathan Goodyear on 02 Apr 15
     
    Cortisol inhibits Testosterone production in men.
Nathan Goodyear

SHBG and testosterone are associated with inflammation in obese men - 0 views

www.endocrine-abstracts.org/...ea0032p761.htm

inflammation CRP cytokines obesity low T low Testosterone SHBG men male hormone hormones

shared by Nathan Goodyear on 07 Apr 15 - No Cached
  • Nathan Goodyear on 07 Apr 15
     
    Though, obesity is associated with increasing SHBG, inflammation (which is typically elevated in obesity) is negatively associated with SHBG.  CRP was used to evaluate inflammation in this study of obese men.  Testosterone was also negatively associated with inflammation in these men.
Nathan Goodyear

Testosterone-induced muscle hypertrophy is associated with an increase in satellite cel... - 0 views

ajpendo.physiology.org/...E197.long

Testosterone muscle muscle mass men male hormone hormones muscle satellite cells

shared by Nathan Goodyear on 14 Apr 15 - No Cached
  • Nathan Goodyear on 14 Apr 15
     
    Testosterone increases muscle satellite cells in men.
Nathan Goodyear

Urolithiasis is associated with low serum testosterone levels in men | Otunctemur | Arc... - 0 views

www.pagepressjournals.org/...4580

urolithiasis kidney stones low T low Testosterone men male hormone hormones metabolic syndrome

shared by Nathan Goodyear on 13 Apr 15 - No Cached
  • Nathan Goodyear on 13 Apr 15
     
    low Testosterone is associated with kidney stones in men through increased Metabolic Syndrome.  Better stated, low T is associated with metabolic syndrome and this metabolic dysfunction increased the findings of kidney stones in men.
Nathan Goodyear

Is serum sex hormone-binding globulin a dominant risk factor for metabolic syndrome? - ... - 0 views

www.ncbi.nlm.nih.gov/...25851658

SHBG total Testosterone free Testosterone Testosterone metabolic syndrome men male hormone hormones

shared by Nathan Goodyear on 13 Apr 15 - No Cached
  • Nathan Goodyear on 13 Apr 15
     
    Nice study of Chinese men, only abstract available, finds that serum total Testosterone and SHBG were inversely associated with metabolic syndrome in men.  SHBG association was the strongest and TT the weakest.  Free Testosterone had no association in this study.
Nathan Goodyear

Testosterone physiology in resistance exercise an... [Sports Med. 2010] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21058750

resistance exercise physiology testosterone men male hormone hormones

shared by Nathan Goodyear on 29 Jul 14 - No Cached
  • testosterone stimulates protein synthesis
  • promotion of muscle hypertrophy by testosterone
  • intracellular androgen receptor (AR)
  • ...8 more annotations...
  • In general, testosterone concentration is elevated directly following heavy resistance exercise in men
  • Findings on the testosterone response in women are equivocal with both increases and no changes observed in response to a bout of heavy resistance exercise
  • Age also significantly affects circulating testosterone concentrations.
  • Aging beyond 35-40 years is associated with a 1-3% decline per year in circulating testosterone concentration in men
  • aging results in a reduced acute testosterone response to resistance exercise in men.
  • In women, circulating testosterone concentration also gradually declines until menopause, after which a drastic reduction is found.
  • acute increases in testosterone can be induced by resistance exercise
  • testosterone is an important modulator of muscle mass in both men and women
  • Nathan Goodyear on 29 Jul 14
     
    Resistance training to increase endogenous Testosterone production: more specific, the exercise must be high rep or as the authors call it--high volume.  To do this, the weight needs to be light.
Nathan Goodyear

The Association of Obesity with Sex Hormone Binding Globulin is Str... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25777143

obesity SHBG hormone Testosterone low T low Testosterone men male hormones

shared by Nathan Goodyear on 24 Mar 15 - No Cached
  • Nathan Goodyear on 24 Mar 15
     
    Obesity is significantly associated with low SHBG.  This stands in contrast to aging association with higher SHBG.  Obesity out weighed the association compared to age.  Calculated free Testosterone did not vary between obese and non-obese men.
Nathan Goodyear

Evidence for Geographical and Racial Variation in Serum Sex Steroid Levels in Older Men - 0 views

www.ncbi.nlm.nih.gov/...PMC3050097

low T low Testosterone Testosterone men male hormone hormones

shared by Nathan Goodyear on 30 Mar 15 - No Cached
  • Asian men in Hong Kong and Japan, but not in the United States, had levels of total testosterone approximately 20% higher than in other groups
  • Nathan Goodyear on 30 Mar 15
     
    Testosterone levels vary amongst men by geography.  Testosterone levels are higher, 20% higher, in Asian men living in Hong Kong and Japan versus those that live in the US.  This is very similar to some of the date around breast cancer in Asian women.  Both suggesting diet and environment as the variable.
Nathan Goodyear

Longitudinal Effects of Aging on Serum Total and Free Testosterone Levels in Healthy Me... - 0 views

press.endocrine.org/...jcem.86.2.7219

low t low Testosterone Testosterone SHBG FAI free androgen index male hormone hormones aging obesity

shared by Nathan Goodyear on 30 Mar 15 - No Cached
  • NUMEROUS CROSS-SECTIONAL INVESTIGATIONS have demonstrated lower concentrations of circulating testosterone (T) and/or free T in older men
  • Two small-scale longitudinal investigations have observed decreases, with aging, in total T
  • T levels decline at a more or less constant rate, with age, in men, with no period of accelerated decline
  • ...15 more annotations...
  • aging in men is associated with decreases in bone mineral density (BMD) (18, 19), lean body and muscle mass
  • strength (22, 23) and aerobic capacity (24), as well as with increases in total and abdominal body fat, low-density lipoprotein cholesterol, and/or low-density lipoprotein/high-density lipoprotein cholesterol ratios (25, 26, 27, 28), all of which also occur in nonelderly hypogonadal men
  • Most (1, 5, 6, 7, 8, 9), but not all (10, 11, 12), cross-sectional studies have demonstrated a decrease, with age, in total T in men
    • Nathan Goodyear
      Nathan Goodyear on 30 Mar 15
       
      FAI: 100 x total Testosterone nmol/L/SHBG nmol/L
    • Nathan Goodyear
      Nathan Goodyear on 30 Mar 15
       
      These numbers do point to an increase in ng/dl decline in Total Testosterone with increasing age (decade group)
  • total T, but not free T index, tended to decrease with greater BMI is consistent with prior studies showing that obesity is associated with decreases in both SHBG and total T, with an unchanged T-to-SHBG ratio
  • The conventional definition for T levels is statistical (values more than 2 sd below the mean), rather than functional. Such a definition does not reflect clinical realities, such as the existence of characteristic individual set points for circulating hormone levels, below which one, but not another, individual may develop metabolic changes of hormone deficiency; nor does it address the concept of reserve capacity, the possibility that persons with hormone levels 2 sd below the population mean still may have adequate hormone concentrations to meet their metabolic needs.
    • Nathan Goodyear
      Nathan Goodyear on 30 Mar 15
       
      good explanation of problems with just using a number to define low T
  • both T and free T index (a calculated value related to free or bioavailable T) decreased progressively at a rate that did not vary significantly with age, from the third to the ninth decades.
  • contrasts with other studies showing diminished free, as well as total, T in with increasing total (48) or abdominal (49) obesity in men.
  • Our analysis of date-adjusted T and free T index levels, by decade, showed that relatively high numbers of older men in this generally healthy population had at least one hypogonadal value (defined as below the 2.5th percentile for young men)
  • The issue of how properly to define hypogonadism, or indeed any hormone deficiency, remains problematic
  • The decrease in free T index was somewhat steeper than that of total T, owing to a trend for an increase in SHBG with age
  • LH for gonadal function
  • It would clearly be better to define the lower limit of normal for a hormone as: the blood level at which metabolic and/or clinical sequelae of hormone deficiency begin to appear, or the level below which definite benefits can be demonstrated for hormone supplementation for a significant proportion of the population
  • an effect of aging to lower both total and bioavailable circulating T levels at a relatively constant rate, independent of obesity, illness, medications, cigarette smoking, or alcohol intake
  • Nathan Goodyear on 30 Mar 15
     
    Article highlights the problems with the definition of low T.  This article finds consistent decline in Total Testosterone and FAI with increasing age groups, with a significant portion of men > 60 meeting the required levels for "low T".  This study found a decrease in total T and FAI at a consistent rate independent of variables, such as BMI.    This study did find a decrease in SHBG and total T with obesity; in contrast to other studies.
Nathan Goodyear

Total testosterone may not decline with ageing in Korean men aged 40 years or older. - ... - 0 views

www.ncbi.nlm.nih.gov/...22372615

total Testosterone ageing men male hormone hormones Testosterone glucose waist circumference BMI

shared by Nathan Goodyear on 01 Apr 15 - No Cached
  • Longitudinal change of TT was approximately + 0·8% per year.
  • TT was negatively correlated with body mass index (BMI), waist circumference and glucose
  • Nathan Goodyear on 01 Apr 15
     
    In study of 220 Korean mean, there was only a small decline in total Testosterone in men followed from 2002 to 2011.  The change amounted to 0.8% annually.  The level was 18.1 nmol to 17.8 nmol.  TT was inversely associated with BMI, waist and glucose.
Nathan Goodyear

JAMA Network | JAMA | Effects of Testosterone Administration for 3 Years on S... - 0 views

jama.jamanetwork.com/article.aspx

low T low Testosterone Testosterone men male hormones atherosclerosis

shared by Nathan Goodyear on 28 Oct 15 - No Cached
  • Nathan Goodyear on 28 Oct 15
     
    new study finds Testosterone therapy does not increase atherosclerosis in older men.  Study also found little improvement in quality of life and sexual function with Testosterone therapy in men with low to low-normal Testosterone.
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