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Nathan Goodyear

An unusual cause of adult onset cerebellar ataxia with hypogonadism - 0 views

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    cases study of a middle age man with hypogonadotropic hypogonadism and celiac disease.
Nathan Goodyear

Amount of Testosterone on Laundered Clothing After Use of Testosterone Topical 2% Solut... - 0 views

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    first study that I have seen that looked at the issue of Testosterone transmission through laundered clothing.  Only abstract available here, but 13% was transmitted to clothing through skin application and 3% remained following laundry of the clothing.
Nathan Goodyear

Association of vitamin D status with serum androgen levels in men. - PubMed - NCBI - 0 views

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    vitamin D correlates directly with Testosterone levels, Free Androgen Index, SHBG with a seasonal patter: highest in August and lowest in March.
Nathan Goodyear

Effects of Testosterone Replacement Therapy on Lower Urinary Tract Symptoms: A Systemat... - 0 views

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    new meta-analysis finds no negative impact on LUTS with Testosterone therapy in men with low T.
Nathan Goodyear

Enhancement of dopaminergic activity and region-specific activation of Nrf2-ARE pathway... - 0 views

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    Testosterone stimulates dopaminergic activity in rat study.  
Nathan Goodyear

Testosterone may improve sexual function and mood in older men with low levels | The BMJ - 0 views

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    In men older than 65 with low Testosterone, Testosterone therapy improved sexual function and mood.
Nathan Goodyear

Long-Term Exposure to Testosterone Therapy and the Risk of High-Grade Prostate Cancer. ... - 0 views

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    Testosterone therapy is not associated with high-grade prostate cancer in men.
Nathan Goodyear

Estrogenic compounds reduce influenza A virus replication in primary human nasal epithe... - 0 views

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    this is a pdf article only and not much is available for public read: estrogen found to have antiviral activity against influenza A in women via ER-beta activation.
Nathan Goodyear

Effects of Transdermal Testosterone Gel or an Aromatase Inhibitor on Prostate Volume in... - 0 views

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    study finds both Testosterone therapy and aromatase inhibition in men > 65 both increase Testosterone levels.  Increase in prostate size was only seen in the Testosterone only group; not in the AI group.  This implicates aromatase activity in the increase in prostate volume.  
Nathan Goodyear

Effects of Testosterone Replacement on Metabolic and Inflammatory Markers in Men with O... - 0 views

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    Opiates and prescription meds are a common cause of low T in men.  In this study with men with metabolic dysfunction and opiate induced low T, Testosterone therapy did not worsen inflammatory/metabolic markers.  Of note, this study did not find improvement in the metabolic and inflammatory markers as other studies have shown.
Nathan Goodyear

International Journal of Impotence Research - Mechanisms of action of PDE5 inhibition i... - 0 views

  • Nitric oxide (NO) is produced from oxygen and L-arginine under the control of nitric oxide synthase (NOS)
  • Cyclic GMP is the intracellular trigger for penile erection
  • PDE5 is the predominant phosphodiesterase in the corpus cavernosum
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    Nice review of the mechanism of action of PDE5 inhibitors and ED.
Nathan Goodyear

Effects of testosterone on neuronal nitric oxide synthase and tyrosine hydroxylase. - P... - 0 views

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    Testosterone proposed to increase NOS
Nathan Goodyear

THERAPY OF ENDOCRINE DISEASE: Testosterone supplementation and body composition: result... - 0 views

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    new study finds Testosterone therapy in men with low T significantly reduces fat, increases lean muscle mass, and reduces fasting glucose and insulin levels.  Improvements in total cholesterol, triglycerides and HDL was also seen.  Only abstract available currently.
Nathan Goodyear

Nitric oxide mediated erectile activity is a testosterone dependent event: a rat erecti... - 0 views

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    Only abstract available here, but rat model finds Testosterone increased NO synthase activity in corpora cavernous. 
Nathan Goodyear

Androgen Deprivation Therapy and Future Alzheimer's Disease Risk - 0 views

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    new risk potential for Androgen Deprivation Therapy (ADT) for men with prostate cancer--increased Alzheimer's disease risk.
Nathan Goodyear

Serum androgens and prostate cancer risk: results from the placebo arm of the Prostate ... - 0 views

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    study finds no association between total Testosterone, free Testosterone, and 3alpha-andorstanediol glucuronide and prostate cancer.  Included: no association with SHBG and estrogen to Testosterone ratio.
Nathan Goodyear

Prospective longitudinal study of testosterone and incident depression in older men: Th... - 0 views

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    low Total Testosterone is associated with depression in oder men.
Nathan Goodyear

Effects of aromatase inhibition vs. testosterone in older men with low testosterone: ra... - 0 views

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    No surprise that Testosterone therapy improves Testosterone levels in men with low T, but aromatase inhibition (AI) did as well.  In this study, only lean mass increased compared to Testosterone therapy and placebo.  Strength increased in both Testosterone and AI.
thelori96

OnlineAskBlog - 0 views

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    Health, Fitness, Diet, Lifestyle, Workout, Skin Care, Foods, Recipes, Culture, Yoga, Bodybuilding
Nathan Goodyear

Normalization of testosterone level is associated with reduced incidence of myocardial ... - 0 views

  • In this study of men with low TT levels and without prior MI or stroke, normalization of TT levels using TRT is associated with lower all-cause mortality, fewer MIs, and ischaemic strokes.
  • retrospective study
  • significant benefit is observed only if the dose is adequate to normalize the TT levels
  • ...9 more annotations...
  • the mechanisms for these effects remain speculative
  • It can be postulated that the beneficial effect of normal T levels on adipose tissue, insulin sensitivity, and lipid profiles or by its anti-inflammatory and anticoagulant properties, as reported by other investigators, might have contributed to our findings
  • off-label use of TRT remains a concern
  • Recent FDA analyses suggest that currently only half of the men on TRT had been diagnosed with hypogonadism
  • 25% of users did not have their T concentrations tested prior to initiating therapy
  • 21% of those prescribed TRT did not have their levels tested at any time during treatment
  • two very recent meta-analyses suggested a lack of convincing evidence posed by TRT.
  • men without a history of previous MI or stroke who have low TT levels, TRT might be associated with decreased risks of MI, ischaemic stroke, and all-cause mortality in long-term follow-up
  • TRT should aim for doses resulting in normalization of TT level as this was shown to be associated with reduction in adverse CV events
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    Testosterone therapy in men with low T to restore physiologic Testosterone levels found to reduce mortality, MI, and stroke risk.
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