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Nathan Goodyear

Zadaxin (Thymalfasin): Uses, Dosage, Side Effects, Interactions, Warning - 0 views

www.rxlist.com/zadaxin-drug.htm

peptide cancer TA-1 thymosin alpha-1

shared by Nathan Goodyear on 15 Aug 21 - No Cached
  • Nathan Goodyear on 15 Aug 21
     
    Not an article, but a drug review of the medication Zadaxin, which is a commercial synthetic form of TA-1; Thymosin alpha 1 improved immunological parameters increased tumor response rates, and improved survival and quality of life
Nathan Goodyear

Neural regulation of the immune system modulates hypertension-induced target-organ damage - 0 views

www.ashjournal.com/...fulltext

CVD neuroimmunology neurology immunology hypertension immune system

shared by Nathan Goodyear on 01 Oct 12 - No Cached
  • Nathan Goodyear on 01 Oct 12
     
    cool read:  the future of CVD treatment.  The link between neuroimmunology and cardiovascular disease.
Nathan Goodyear

Natural Killer Cells in Pregnancy and Recurrent Pregnancy Loss: Endocrine and Immunolog... - 0 views

edrv.endojournals.org/...44.full

natural killer cells pregnancy loss recurrent immune system miscarriage NK

shared by Nathan Goodyear on 15 Apr 12 - No Cached
  • NK cells have been the cells most extensively studied, primarily because they constitute the predominant leukocyte population present in the endometrium at the time of implantation and in early pregnancy
  • parental chromosomal abnormalities, uterine anatomic anomalies, endometrial infections, endocrine etiologies (luteal phase defect, thyroid dysfunction, uncontrolled diabetes mellitus), antiphospholipid syndrome, inherited thrombophilias, and alloimmune causes
  • estrogen
  • ...28 more annotations...
  • progesterone
  • prolactin
  • In summary, in vivo animal experiments have shown an inhibitory role of estrogen on peripheral NK cell lytic activity, which is partly due to suppression of NK cell output by the bone marrow and partly due to suppression of individual NK cell cytotoxicity. However, in vitro studies so far have failed to show conclusively a direct effect of estrogen on NK cells.
  • At the progesterone concentrations believed to be present in the uterus [up to 10−5 m at the maternal-fetal interface (35)], studies consistently show inhibition of lymphocyte proliferation (33) and inhibition of NK cytolytic activity in vitro
  • The exact role of prolactin in NK cell regulation is unknown.
  • The overall effects of estrogen on NK cells are likely multifactorial, therefore, and depend on the type of cell affected as well as the kind of ER expressed by that cell.
  • It is known that progesterone can directly affect T cell differentiation in vitro, suppressing development of the Th1 pathway and enhancing differentiation along the Th2 pathway (44)
  • Th1 cells predominantly produce interferon-γ (IFN-γ), IL-2, and TNF-β and are involved in cell-mediated immunity. Th2 cells produce IL-4, IL-5, IL-6, IL-10, and IL-13 and stimulate humoral immunity
  • Furthermore, in response to progesterone, γδ T cells produce progesterone-induced blocking factor (PIBF) (54
  • A defining characteristic of NK cells is their ability to lyse target cells without prior sensitization and without restriction by HLA antigens.
  • NK cell function is mainly regulated by IL-2 and IFN-γ
  • IL-2 causes both NK cell proliferation and enhanced cytotoxicity. IFN-γ augments NK cytolytic activity, but does not cause NK proliferation. The two cytokines act synergistically to augment NK cytotoxicity (6).
  • The largest leukocyte population in the endometrium consists of NK cells named large granulated lymphocytes
  • there is a significant increase in the number of uNK cells throughout the secretory phase, which peaks in early pregnancy when uNK cells comprise about 75% of uterine leukocytes (62)
  • Second, uNK cell phenotype changes during the normal menstrual cycle and early pregnancy (68)
  • general proinflammatory effect of estrogen, causing an influx of macrophages and neutrophils, which is antagonized by progesterone through its receptor (70, 71).
  • The mechanism of such a progesterone-induced local immunosuppression is unclear.
  • progesterone plays an important role in proliferation and differentiation of uNK cells (32).
  • Through promotion of a uterine Th2 environment, progesterone could indirectly affect uNK cell function
  • The mechanism of this increase in uNK cell numbers has been addressed in both human and mouse models, and is likely the result of: 1) recruitment of peripheral NK cells to the uterus, and 2) proliferation of existing uNK cells
  • prolactin system plays an important role in implantation and the maintenance of pregnancy
  • the exact pathways of hormonal regulation of NK cells remain to be delineated.
  • The exact function of uNK cells has not yet been unequivocally determined
  • uNK cells express a different cytokine profile, compared with resting peripheral NK cells. mRNAs for granulocyte CSF, M-CSF, GM-CSF, TNF-α, IFN-γ, TGF-β, and leukemia inhibitory factor (LIF) have been found in decidual CD56+ cells
  • Their increased numbers in early pregnancy, their hormonal dependence, and their close proximity to the infiltrating trophoblast all suggest that they play an important role in the regulation of the maternal immune response to the fetal allograft and the control of trophoblast growth and invasion during human pregnancy
  • role of uNK cell-derived cytokines on trophoblast growth and differentiation (114, 115, 116, 117).
  • Th1 immunity to trophoblast is associated with RPL, whereas Th2 immunity is associated with a successful pregnancy
  • RPL is associated with Th1 immunity, for which NK cells are partly responsible.
  • Nathan Goodyear on 15 Apr 12
     
    dysregulated immune system plays role in recurrent miscarriage.  Specifically, this article discusses natural killer cells (NK).
Nathan Goodyear

Theoretical causes of autism - 0 views

www.rescuepost.com/...-autism-causes-a-review1-1.pdf

autism ASD immunoexcitotoxicity immunology toxin toxic environment

shared by Nathan Goodyear on 17 Apr 12 - No Cached
  • Nathan Goodyear on 17 Apr 12
     
    This article discusses the many potential causes of the increasing autism epidemic. One listed is the toxic pregnant/infant environment and the immunoexcitotoxic impact.
Nathan Goodyear

Access : Type 2 diabetes as an inflammatory disease : Nature Reviews Immunology - 0 views

www.nature.com/...nri2925.html

inflammation diabetes type II DM

shared by Nathan Goodyear on 20 Mar 12 - No Cached
  • Nathan Goodyear on 20 Mar 12
     
    Inflammation plays critical role in the development of type II DM
Nathan Goodyear

Inflammatory Mechanisms in Obesity - Annual Review of Immunology, 29(1):415 - 0 views

www.annualreviews.org/...annurev-immunol-031210-101322

obesity inflammation overweight endoplasmic reticulum stress

shared by Nathan Goodyear on 23 Jan 12 - No Cached
  • Nathan Goodyear on 23 Jan 12
     
    good review of inflammation-obesity link.  THis article also discusses endoplasmic reticulum stress associated with inflammation and obesity.  The result is decoupling of protein synthesis.  This article also discusses some anti-inflammatory therapies.  This link is for abstract only.  Full article is not available on line.  
Nathan Goodyear

Influence of Testosterone Therapy on Clinical and Immunological Features of Autoimmune ... - 0 views

jcem.endojournals.org/...32.abstract

testosterone therapy autoimmune diseases disease men male low T inflammation inflammatory cytokines ESR RF ANA

shared by Nathan Goodyear on 12 Aug 12 - No Cached
  • Nathan Goodyear on 12 Aug 12
     
    Testosterone therapy in men with Sjogren's disease and Lupus reduces inflammation (ESR, RF, ANA).  In fact, clinical remission was noted in all patients.
Nathan Goodyear

Adipose Tissue Macrophages Are Innate to the Immunological Awareness of Adipose Tissue - 0 views

diabetes.diabetesjournals.org/...2656.extract

adipose tissue obesity inflammation inflammatory cytokines fat

shared by Nathan Goodyear on 07 Aug 13 - No Cached
  • Nathan Goodyear on 07 Aug 13
     
    adipose tissue is a biological, inflammatory producing organ.
Nathan Goodyear

Differentiation between Celiac Disease, Nonceliac Gluten Sensitivity, and Their Overlap... - 0 views

www.hindawi.com/...248482

celiac disease gluten sensitivity Crohn's

shared by Nathan Goodyear on 12 Nov 13 - No Cached
  • Nathan Goodyear on 12 Nov 13
     
    3 cases related to gluten evaluated and compared.  All 3 benefited from a gluten free diet.
Nathan Goodyear

Mucosal Immunology - Molecular signatures of a disturbed nasal barrier function in the ... - 0 views

www.nature.com/...mi20119a.html

S aureus Staphylococcus aureus autoimmune disease disease autoimmune Wegener's granulomatosis WG Wegener's vasculitis

shared by Nathan Goodyear on 15 Sep 15 - No Cached
  • Nathan Goodyear on 15 Sep 15
     
    nasal mucos colonization of S aureus found to be associated with Wegener's vasculitis as well as relapse.
Nathan Goodyear

ScienceDirect - Trends in Immunology : Inflammation: the link between insulin resistanc... - 0 views

www.sciencedirect.com/science

inflammation obesity insulin resistance diabetes

shared by Nathan Goodyear on 09 Mar 11 - No Cached
  • Inflammation: the link between insulin resistance, obesity and diabetes
  • Chronic overnutrition (obesity) might thus be a proinflammatory state with oxidative stress. Secondly, the increased concentrations of TNF-α and IL-6, associated with obesity and type 2 diabetes, might interfere with insulin action by suppressing insulin signal transduction. This might interfere with the anti-inflammatory effect of insulin, which in turn might promote inflammation.
  • Nathan Goodyear on 09 Mar 11
     
    Inflammation: the link between insulin resistance, obesity and diabetes
Nathan Goodyear

Mechanism of IL-1β-Induced Increase in Intestinal Epithelial Tight Junction P... - 0 views

www.jimmunol.org/...5653.full

inflammation Gut NF-kappaB intestinal inflammatory conditions

shared by Nathan Goodyear on 22 Mar 11 - No Cached
  • The IL-1β-induced increase in intestinal epithelial tight junction (TJ) permeability has been postulated to be an important mechanism contributing to intestinal inflammation of Crohn’s disease and other inflammatory conditions of the gut
  • the role of myosin L chain kinase (MLCK)
  • IL-1β caused a progressive increase in MLCK protein expression.
  • ...1 more annotation...
  • The IL-1β-induced increase in MLCK mRNA transcription and subsequent increase in MLCK protein expression and Caco-2 TJ permeability was mediated by activation of NF-κB
  • Nathan Goodyear on 22 Mar 11
     
    How systemic inflammation comes from the gut
Nathan Goodyear

Function and Activation of NF-kappaB in the Immune System - Annual Review of Immunology... - 0 views

www.annualreviews.org/...annurev.iy.12.040194.001041

NF-KappaB Immune System

shared by Nathan Goodyear on 22 Mar 11 - No Cached
  • Nathan Goodyear on 22 Mar 11
     
    NF-KappaB and activation of the Immune System
Nathan Goodyear

IN THIS ISSUE - The Journal of Immunology - 0 views

www.jimmunol.org/...5155.short

Immune system thymus immunity

shared by Nathan Goodyear on 22 Mar 11 - No Cached
  • t has been suggested that increased permeability of intestinal epithelial tight junctions (TJ) in these diseases is mediated by proinflammatory cytokines including IL-1β,
  • Al-Sadi et al. (p. 5653 ) hypothesized that myosin light chain kinase (MLCK), which is known to be important for intestinal TJ permeability, could mediate IL-1β-induced disruption of the epithelial barrier
  • Nathan Goodyear on 22 Mar 11
     
    Heavy article on immune system activation
Nathan Goodyear

ScienceDirect - Clinical Immunology : Oral sulforaphane increases Phase II antioxidant ... - 0 views

www.sciencedirect.com/...S1521661608008620

sulforaphane detoxification

shared by Nathan Goodyear on 24 May 11 - No Cached
  • Nathan Goodyear on 24 May 11
     
    sulphoraphane increases Phase II detoxification
Nathan Goodyear

Anatomical basis of tolerance and immunity to intestinal antigens : Abstract : Nature R... - 0 views

www.nature.com/...nri1057.html

Mucosal associated lymphoid tissue MALT intestinal immune system gut

shared by Nathan Goodyear on 07 Sep 11 - No Cached
  • Nathan Goodyear on 07 Sep 11
     
    review of the physiology of the intestinal immune system
Nathan Goodyear

Complement Split Products C3a and C4a in Chronic Lyme Disease - Stricker - 2008 - Scand... - 0 views

onlinelibrary.wiley.com/...full

chronic lyme disease complement C3a C4a inflammation

shared by Nathan Goodyear on 12 Sep 11 - No Cached
  • Nathan Goodyear on 12 Sep 11
     
    complement C3a and C4a in chronic lyme disease
Nathan Goodyear

Plant sterols and sterolins: a review of thei... [Altern Med Rev. 1999] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...10383481

plant sterols sterolins immune function immunology disease

shared by Nathan Goodyear on 21 Sep 11 - No Cached
  • Nathan Goodyear on 21 Sep 11
     
    Plant sterols and sterolins shown to improve immune function
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