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Nathan Goodyear

Approach To A Patient With Elevated Serum Alkaline Phosphatase - 0 views

www.ncbi.nlm.nih.gov/...PMC3341633

alkaline phosphatase bile biliary system liver

shared by Nathan Goodyear on 22 Sep 14 - No Cached
  • Nathan Goodyear on 22 Sep 14
     
    case review of patient with elevated alkaline phosphatase. This case study includes a nice review of bile formation/function.
Nathan Goodyear

Serum Leptin, Parathyroid Hormone, 1,25-Dihydroxyvitamin D, Fibroblast Growth Factor 23... - 0 views

jcem.endojournals.org/...1655.abstract

leptin PTH obesity

shared by Nathan Goodyear on 25 May 12 - No Cached
  • Nathan Goodyear on 25 May 12
     
    high leptin, high PTH, fibroblastic growth factor, and bone alkaline phosphatase associated with obesity.
Nathan Goodyear

Hepatoprotective Effect of Vitamin C (Ascorbic Acid) - 0 views

www.scirp.org/...PaperInformation.aspx

vitamin c liver liver enzymes AST ALT malondialdehyde LDH alkaline phosphatase

shared by Nathan Goodyear on 09 Mar 15 - No Cached
  • Nathan Goodyear on 09 Mar 15
     
    Vitamin C is hepatoprotective.  This review highlights the proposed methods by which vitamin C reduces ALT, AST, alkaline phosphatase, LDH, malondialdegyde...
Nathan Goodyear

Alkaline phosphatase isoenzyme activities in rheumatoid arthritis: hepatobiliary enzyme... - 0 views

www.ncbi.nlm.nih.gov/...PMC1005089

alkaline phosphatase ALP ALP fractionation

shared by Nathan Goodyear on 01 Apr 19 - No Cached
hoangkimchi liked it
  • Nathan Goodyear on 01 Apr 19
     
    ALP fractionation isoenzyme study can provide deeper understanding of disease involvement.
Nathan Goodyear

Changes in the rate of PSA progression and the level of alkaline phosphatase during hig... - 0 views

www.ffhdj.com/...634

alkaline phosphatase prostate cancer psa IV vitamin C IVC

shared by Nathan Goodyear on 12 Jun 19 - No Cached
  • Nathan Goodyear on 12 Jun 19
     
    Brief read...will re-read, but IV vitamin C (albeit relatively low doses) correlate with decline in psa and alkP.
Nathan Goodyear

Curcumin inhibits hepatic protein-tyrosine phosphatase 1B and prevents hypertriglycerid... - 0 views

www.ncbi.nlm.nih.gov/...20222050

curcumin polyphenols leptin obesity leptin resistance insulin insulin resistance fructose diet

shared by Nathan Goodyear on 05 Jun 16 - No Cached
  • Nathan Goodyear on 05 Jun 16
     
    curcumin found to reduce leptin resistance and insulin resistance in fructose-induced hypertriglyceridiemia in rat model.
Nathan Goodyear

Harriet Lane Handbook: Progesterone regulates the phosphorylation of protein phosphatas... - 0 views

www.unboundmedicine.com/...ein_phosphatases_in_the_brain_

progesterone brain hippocampus cerebellum sex hormones hormone

shared by Nathan Goodyear on 11 Mar 14 - No Cached
  • Nathan Goodyear on 11 Mar 14
     
    rat model finds that progesterone effects internal cell enzyme activity.  In this case, progesterone increased PP2A in the cerebellum and in the hyippocampus.  Interesting, that E2 priming decreased the effects on the hippocampus, but not the cerebellum.  This reveals a biochemical link between sex hormones, progesterone in this case, and the brain.  Studies have shown progesterone to be neuroprotective in TBI.  This may be one mechanism.
Nathan Goodyear

The antioxidant effects of vitamin C on liver enzymes: aspartate aminotransferase, alan... - 0 views

www.pagepressjournals.org/...1170

vitamin C liver enzymes antioxidant

shared by Nathan Goodyear on 18 Sep 13 - No Cached
  • Nathan Goodyear on 18 Sep 13
     
    Vitamin C, in oral route, prevents elevations in liver enzymes after liver insult from Paraquat.
Nathan Goodyear

Neuronal protein tyrosine phosphatase 1B deficienc... [Mol Cell Biol. 2009] - PubMed re... - 0 views

www.ncbi.nlm.nih.gov/...19528236

leptin weight loss obesity overweight

shared by Nathan Goodyear on 08 Mar 11 - No Cached
  • the mechanism by which PTP1B regulates adiposity and leptin sensitivity likely involves the coordinated regulation of AMPK in hypothalamus and peripheral tissues.
  • Nathan Goodyear on 08 Mar 11
     
    improved leptin sensitivity leads to weight loss and increased energy expenditure
Nathan Goodyear

Cell Metabolism - Protein Tyrosine Phosphatase Epsilon Affects Body Weight by Downregul... - 0 views

www.cell.com/...S1550-4131(11)00139-2

leptin resistance obesity tyrosine phospatase epsilon

shared by Nathan Goodyear on 10 May 11 - No Cached
  • Nathan Goodyear on 10 May 11
     
    new insight on biochemistry of leptin resistance and obesity
Nathan Goodyear

DISTURBED MINERAL METABOLISM IN HYPERTHYROIDISM: GOOD CORRELATION WITH TRMODOTHYRONINE ... - 0 views

onlinelibrary.wiley.com/...abstract

HYPERTHYROIDISM T3 hypercalcemia phosporus alkaline phosphatase MINERAL METABOLISM

shared by Nathan Goodyear on 09 Sep 11 - No Cached
  • Nathan Goodyear on 09 Sep 11
     
    hyperthyroidism, whether medication induced or iatrogenic, results in elevated calcium, phosphorus, and alkaline phosphates.  The T3 levels show the best correlation
Nathan Goodyear

Ivermectin: enigmatic multifaceted 'wonder' drug continues to surprise and exceed expec... - 0 views

www.nature.com/ja201711

Ivermectin cancer

shared by Nathan Goodyear on 19 Mar 18 - No Cached
  • The avermectins are known to possess pronounced antitumor activity
  • Over the past few years, there have been steadily increasing reports that ivermectin may have varying uses as an anti-cancer agent, as it has been shown to exhibit both anti-cancer and anti-cancer stem cell properties
  • In human ovarian cancer and NF2 tumor cell lines, high-dose ivermectin inactivates protein kinase PAK1 and blocks PAK1-dependent growth
  • ...13 more annotations...
  • PAK1 is essential for the growth of more than 70% of all human cancers, including breast, prostate, pancreatic, colon, gastric, lung, cervical and thyroid cancers, as well as hepatoma, glioma, melanoma, multiple myeloma and for neurofibromatosis tumors
  • Ivermectin suppresses breast cancer by activating cytostatic autophagy, disrupting cellular signaling in the process, probably by reducing PAK1 expression
  • Cancer stem cells are a key factor in cancer cells developing resistance to chemotherapies and these results indicate that a combination of chemotherapy agents plus ivermectin could potentially target and kill cancer stem cells, a paramount goal in overcoming cancer
  • Triple-negative breast cancers, which lack estrogen, progesterone and HER2 receptors, account for 10–20% of breast cancers and are associated with poor prognosis
  • Ivermectin addition led to transcriptional modulation of genes associated with epithelial–mesenchymal transition and maintenance of a cancer stem cell phenotype in triple-negative breast cancers cells, resulting in impairment of clonogenic self-renewal in vitro and inhibition of tumor growth and metastasis in vivo
  • Ivermectin-induced cytostatic autophagy also leads to suppression of tumor growth in breast cancer xenografts, causing researchers to believe there is scope for using ivermectin to inhibit breast cancer cell proliferation and that the drug is a potential treatment for breast cancer
  • ivermectin synergizes with the chemotherapy agents cytarabine and daunorubicin to induce cell death in leukemia cells
  • Ivermectin inhibits proliferation and increases apoptosis of various human cancers
  • Activation of WNT-TCF signaling is implicated in multiple diseases, including cancers of the lungs and intestine,
  • A new screening system has found that ivermectin inhibits the expression of WNT-TCF targets
  • It represses the levels of C-terminal β-catenin phosphoforms and of cyclin D1 in an okadaic acid-sensitive manner, indicating its action involves protein phosphatases
  • In vivo, ivermectin selectively inhibits TCF-dependent, but not TCF-independent, xenograft growth without side effects
  • ivermectin has an exemplary safety record, it could swiftly become a useful tool as a WNT-TCF pathway response blocker to treat WNT-TCF-dependent diseases, encompassing multiple cancers.117
  • Nathan Goodyear on 19 Mar 18
     
    Ivermectin shows promise and usefullness in several cancer types.  This is a review article.
Nathan Goodyear

Mitochondria and Cancer - 0 views

www.ncbi.nlm.nih.gov/...PMC4779192

cancer mitochondria

shared by Nathan Goodyear on 05 Oct 18 - No Cached
  • aerobic glycolysis
  • aerobic glycolysis
  • the “Warburg effect” is the basis for tumor imaging by FDG-PET
  • ...1 more annotation...
  • In most cancers, oncogenic driver mutations such as activation of K-ras, c-Myc and phosphatidylinositol-3 (PI3) kinase or loss of phosphatase and tensin homolog (Pten) and p53, not mutations that inactivate mitochondrial respiration complexes, promote glycolysis
  • Nathan Goodyear on 05 Oct 18
     
    great read on mitochondria and cancer.
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