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Glutathione prevents the early asthmatic reaction and airway hyperresponsiveness in gui... - 0 views

www.ncbi.nlm.nih.gov/...20228417 glutathione asthma GSH
shared by Nathan Goodyear on 07 Jul 16 - No Cached
  • Nathan Goodyear on 07 Jul 16
     
    animal model finds that glutathione depletion increases hyperactivity of bronchioles.  Early exposure to glutathione ethyl ester, a precursor to glutathione, blunted the airway hyperactivity.
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Food additives and hyperactive behaviour in 3-year-old and 8/9-year-old children in the... - 0 views

www.thelancet.com/...abstract food additives artificial ADD ADHD hyperactivity
shared by Nathan Goodyear on 17 Apr 11 - Cached
  • Artificial colours or a sodium benzoate preservative (or both) in the diet result in increased hyperactivity in 3-year-old and 8/9-year-old children in the general population
  • Nathan Goodyear on 17 Apr 11
     
    hyperactiivty and what your children eat
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Effects of Korean Red Ginseng Extract on Behavior in Children with Symptoms of Inattent... - 0 views

online.liebertpub.com/...cap.2014.0013 panax ginseng korean ginseng ADD ADHD ginseng
shared by Nathan Goodyear on 14 Apr 16 - No Cached
  • Nathan Goodyear on 14 Apr 16
     
    Panax ginseng, or korean ginseng, maybe helpful in the treatment for attention and hyperactivity.
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The effect of common genetic variati... [J Clin Endocrinol Metab. 2012] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22112815 saliva salivary hormone hormones depression 11-betaHSD1 HPA SNPs
shared by Nathan Goodyear on 10 Oct 12 - No Cached
  • Nathan Goodyear on 10 Oct 12
     
    hyperactive HPA axis associated with depression. This is becoming evident in the literature.  This study looked at SNPS in the etiology of elevated cortisol and/or androstenedione.  They followed the results with saliva and found that 3 SNPS were associated with increased 11Beta-HSD1 activity and associated increased depression.
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Effects of a restricted elimination diet on the behaviour of children with attention-de... - 0 views

www.thelancet.com/...abstract attention-deficit disorder hyperactivity ADHD
shared by Nathan Goodyear on 28 Jun 11 - No Cached
  • Nathan Goodyear on 28 Jun 11
     
    elimination diet improves ADHD symptoms based on IgG results; though relapse occurred independent of the IgG blood levels, so they discourage the use of IgG.  Makes no sense.
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metabolic correction for attention deficit/hyperactivity disorder: A biochemical-physio... - 0 views

functionalfoodscenter.net/...63028864.pdf ADHD diet children pediatrics minerals vitamins essential fatty acids amino acids
shared by Nathan Goodyear on 13 Feb 13 - No Cached
  • Nathan Goodyear on 13 Feb 13
     
    This study of 116 patients diagnosed with ADHD, found that 80% could achieve improvement or "ameliorate" ADHD symptoms with supplementation with minerals, vitamins, amino acids, and essential fatty acids. I too have seen this in my practice. Maybe ADD/ADHD is simply a gut/dietary problem manifested in the brains of our children. That we treat with powerful drugs, that simply can be treated with dietary change
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Attention-Deficit/Hyperactivity Disorder and Urinary Metabolites of Organophosphate Pes... - 0 views

pediatrics.aappublications.org/...e1270.long ADHD pediatrics children organophosphates environmental toxins pesticides
shared by Nathan Goodyear on 21 Feb 13 - No Cached
  • Nathan Goodyear on 21 Feb 13
     
    No longer a hypothesis, study shows that organophosphate exposure in children contributes to ADHD incidence.
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Effect of the herbal extract combination Panax quinquefolium and Ginkgo biloba on atten... - 0 views

www.ncbi.nlm.nih.gov/...PMC1408291 ginkgo biloba ginseng ADHD
shared by Nathan Goodyear on 14 Apr 16 - No Cached
  • Nathan Goodyear on 14 Apr 16
     
    pilot study finds low dose gingko biloba and American ginseng improved symptoms of ADHD.
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Clinical Effects of Korean Red Ginseng on Attention Deficit Hyperactivity Disorder in C... - 0 views

www.ncbi.nlm.nih.gov/...PMC3659525 panax ginseng ginseng korean ginseng ADD ADHD
shared by Nathan Goodyear on 14 Apr 16 - No Cached
  • Nathan Goodyear on 14 Apr 16
     
    Panax ginseng may be helpful in ADD and ADHD, especially for focus/attention symptoms.
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Salivary Cortisol Responsivity to an Intravenous Catheter Insertion in Children with At... - 0 views

jpepsy.oxfordjournals.org/...902.abstract salivary testing saliva cortisol ADHD pediatrics
shared by Nathan Goodyear on 27 Nov 11 - No Cached
  • Nathan Goodyear on 27 Nov 11
     
    salivary cortisol used to assess cortisol levels in ADHD
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Decreased Serum Cu/Zn SOD Associated with High Copper in Children with Attention Defici... - 0 views

www.ncbi.nlm.nih.gov/...PMC3661234 superoxide disumutase SOD ADD ADHD attention deficit disorder copper
shared by Nathan Goodyear on 07 Oct 13 - No Cached
  • Nathan Goodyear on 07 Oct 13
     
    low SOD found to be associated with ADD/ADHD
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The history of attention deficit hyperactivity disorder - 0 views

www.ncbi.nlm.nih.gov/...PMC3000907 ADD ADHD history
shared by Nathan Goodyear on 07 Oct 13 - No Cached
  • Nathan Goodyear on 07 Oct 13
     
    History of ADD/ADHD
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Attention-Deficit/Hyperactivity Disorder and Urinary Metabolites of Organophosphate Pes... - 0 views

pediatrics.aappublications.org/...e1270 ADHD pesticide exposure Organophosphates
shared by Nathan Goodyear on 21 Mar 11 - No Cached
  • Nathan Goodyear on 21 Mar 11
     
    ADHD and pesticide exposure
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Do Artificial Food Colors Promote Hyperactivity in Children... : Journal of Development... - 0 views

journals.lww.com/...romote_Hyperactivity_in.7.aspx ADD ADHD chemicals artificial coloring sweetners
shared by Nathan Goodyear on 17 Apr 11 - No Cached
  • his study is consistent with accumulating evidence that neurobehavioral toxicity may characterize a variety of widely distributed chemicals.
  • Nathan Goodyear on 17 Apr 11
     
    ADD and ADHD are a product of chemicals we eat
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http://cdn.intechopen.com/pdfs-wm/27785.pdf - 0 views

cdn.intechopen.com/...27785.pdf low T low testosterone low T Testosterone men male hormone hormones LUTS BPH prostate lower urinary tract symptoms
shared by Nathan Goodyear on 04 Jan 15 - No Cached
  • Nathan Goodyear on 04 Jan 15
     
    Nice review of the literature of low T and LUTS in men.
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Growth Inhibition of Ovarian Tumor-Initiating Cells by Niclosamide | Molecular Cancer T... - 0 views

mct.aacrjournals.org/...1703.long Niclosamide Tumor-initiation cells TIC ovarian cancer cancer CSC cancer stem cells
shared by Nathan Goodyear on 16 Apr 18 - No Cached
  • Ovarian cancer is the most lethal gynecologic malignancy and the fifth-most cause of overall cancer death of women in developed countries
  • An increasingly accepted cancer stem cell hypothesis regards tumors as caricatures of normal organs, possessing a hierarchy of cell types, at various stages of aberrant differentiation, descended from precursor tumor-initiating cells (TIC) cells that are highly resistant to conventional cytotoxics
  • Significant changes of gene expression in 2,928 genes were identified after niclosamide treatment for different time periods
  • ...14 more annotations...
  • uncoupling of mitochondrial oxidative phosphorylation is believed to be its anti-helminthic mechanism of action
  • we hypothesized that niclosamides antagonistic effects on OTICs could, in part, be due to its disruption of metabolism
  • Our results showed that genes participating in protein complexes of oxidative phosphorylation were downregulated
  • niclosamide treatment resulted in a more than 20% increase in reactive oxygen species (ROS) in cultured OTICs
  • niclosamide, which has proved to be safe and effective for the past 2 decades against numerous parasites, inhibited OTIC growth both in vitro and in vivo
  • niclosamide represses metabolic enzymes responsible for bioenergetics, biosynthesis, and redox regulation specifically in OTICs, presumably leading to mitochondrial intrinsic apoptosis pathways, loss of tumor stemness, and growth inhibition
  • Niclosamide is believed to inhibit mitochondrial oxidative phosphorylation
  • Niclosamide was reported to inactivate NF-κB, causing mitochondrial damage and the generation of ROS, leading to apoptosis of leukemic stem cells
  • niclosamide were identified in a screen for mTOR-signaling inhibitors
  • mTOR was reported to maintain stemness properties of HSCs by inhibiting mitochondrial biogenesis and ROS levels (39), implying that mTOR inhibitors (such as niclosamide) may interfere with mitochondria and various metabolic pathways in TICs via disruption of antioxidant responses
  • We observed Wnt hyperactivity in OTICs, in agreement with previous hypotheses of Wnt inhibitor effectiveness as an ovarian cancer therapy
  • niclosamide has now been independently identified in screens for Wnt inhibitors
  • downregulation of the Wnt/β-catenin target oncogenes survivin and c-Myc
  • ovarian carcinogenesis, the cell-to-cell signaling pathway Notch (8), were also suppressed by niclosamide (data not shown). These results agree with another recent niclosamide study in leukemia (49), and it has been widely hypothesized that disruption of Notch signaling may represent a highly effective therapy for ovarian and other solid tumors, via its essentiality to maintaining TIC stemness
  • Nathan Goodyear on 16 Apr 18
     
    Niclosamide, common anti-parasitic medication, inhibits cellular metabolism and increases ROS; both of which provide powerful anti-proliferative, anti-cancer treatment mechanism in TICs. Powerful target therapy for cancer stem cells. Also shown to inhibit Wnt stimulated oncogenes survivin and c-Myc, disrupts Notch signaling, inactivates NF-kappaBeta, and inhibits mTOR-signaling.  This has been found in in vitro and in vivo studies.
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Artesunate Induces SKM-1 Cells Apoptosis by Inhibiting Hyperactive β-catenin ... - 0 views

www.medsci.org/v12p0524.htm Wnt artesunate cancer
shared by Nathan Goodyear on 23 Aug 19 - No Cached
  • Nathan Goodyear on 23 Aug 19
     
    ART inhibits proliferation and induce apoptosis in study.
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Artesunate attenuates the growth of human colorectal carcinoma and inhibits hyperactive... - 0 views

www.ncbi.nlm.nih.gov/...17520675 artesunate Wnt colorectal cancer
shared by Nathan Goodyear on 07 May 20 - No Cached
  • Nathan Goodyear on 07 May 20
     
    artesunate inhibits colorectal cancer cells via Wnt pathway inhibition.
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Artesunate attenuates the growth of human colorectal carcinoma and inhibits h... - 0 views

onlinelibrary.wiley.com/...ijc.22804 artesunate cancer Wnt colorectal cancer
shared by Nathan Goodyear on 07 Aug 18 - No Cached
  • Nathan Goodyear on 07 Aug 18
     
    artesunate and colorectal cancer
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