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wheelchairindia9

Travel Wheelchair Add Additional Comfort - 0 views

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    Lightweight Transport wheelchair is one of the the lightest transport chairs on the market, weighing in at only 19 lbs! With four great colors to choose from, it can be transported in style. A seat belt and swing-away removable footrests are standard and make it easy to get in and out of this chair. A fold-down back allows for easier storage and transport and padded armrests add additional comfort. It is made out of a lightweight and durable powder coated aluminum frame that is available in either red or blue. It is available in a 19" wide seat with permanent full-length arms and swing-away detachable footrests. The chair also has padded armrests and a seatbelt for safety purposes. Karma Travel Wheelchair KM TV 20.2 Karma Travel Wheelchair KM TV 20.2 - 606 T-6 aircraft-grade aluminum-alloy frame provides incredible strength. Easy-to-fold in three seconds. Karma Travel Wheelchair KM TV 20.2 Features Type: Travel Wheelchair T-6 aircraft-grade aluminum Secure brake improve safety Padded flip back armrest PU front caster & rear wheel Karma Travel Wheelchair KM TV 20.2 Measurements Weight: 8.9kg Seat width: 39.5cm Tyre: PU front casters and rear wheels Capacity: 100kg Folded size: (L/W/H): 610mm x 350mm x710mm. Ultra Lightweight Wheelchair Its compact design and feather light weight makes it suitable for people on the go. Ultra Lightweight Wheelchair Specifications Frame Style : Foldable Frame Material : Aluminium (Light weight) Rear wheel to wheel width in open position (inches) : 20" Handle to Handle : 16" Seat Width (inches): 13" Rear Wheel Size: 7" Front Wheel Size: 5" Seat to floor height (inches): 19" Seat Depth (inches): 13" Back height (inches): 16" Total height (inches): 35" Max User Weight Capacity (kgs): 80 k.g. Net Weight (kgs): 8.5 k.g. Upholstery: Cloth look like, washable Armrest: Flip up, for easy transfer to bed Legrest: Flip up footplate Wheel Quality: Tear resistant polyurethane wheels Rear Wheel Lo
wheelchairindia9

Tynor Knee Immobilizer 19 - 0 views

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    Tynor Knee Immobilizer 19 has an extra Patellar strap which is easily flexible and easy to adjust. It provides great relief to the knees after any injury and after operation. It is easily to apply and easy to remove. It properly cushioned the knee and keeps the knee immobilized as well as allows to move anywhere. It has a long shelf life because of its good quality material. Key Features Anatomically shaped back splints. Side splints with relief at knee joint. Soft and comfortable body. Additional Features Lightweight Anatomically Shaped Back Splints Side Splints with Relief at Knee Joint Soft and Comfortable Perfect Immobilization Additional Patellar Strapping
Nathan Goodyear

Branched-chain amino acids and ammonia metabolism in liver disease: Therapeutic implica... - 0 views

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    BCAA are low in patients with liver cirrhosis due to increased glutamate production from glutamine.  The addition of BCAA in these patients is not without side effects--increased NH3 production.  The addition of alpha ketoglutarate should alleviate this risk.
Nathan Goodyear

Addition of omega-3 fatty acid to maintenance medi... [Am J Psychiatry. 2002] - PubMed ... - 0 views

  • Highly significant benefits of the addition of the omega-3 fatty acid compared with placebo were found by week 3 of treatment.
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    Addition of omega-3 fatty acid to maintenance medication treatment for recurrent unipolar depressive disorder.
wheelchairindia9

Tynor Elastic Knee Support - 0 views

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    Tynor Elastic Knee Support Elastic knee Support is a versatile knee support which offers the advantage of controlled compression around the knee and a rigid lateral immobilization and support of a splint. It allows normal flexion and free movement of the knee joint. Patellar Opening. Easy application. Controlled compression. Perfect lateral splinting. Mimics movement of natural joint. Tynor Elastic Knee Support Features Strong aluminum Hinges Rigid side splinting Free flexion movement. Open patella design Release patellar pressure. Hold the patella in position Can be used for Patellofemoral diseases Wrap design Easy application and removal on swollen or asymmetric knees Easy application and removal for weak or geriatric patients. Allows customized compression Offers flexibility in sizing Patellar cushion Improves patient comfort Improves compression Improves grip of the product Large dorsal opening Ensures no buckling on bending No vaso constriction on the dorsal area Improves patient comfort and compliance.
Nathan Goodyear

Food additives and hyperactive behaviour in 3-year-old and 8/9-year-old children in the... - 0 views

  • Artificial colours or a sodium benzoate preservative (or both) in the diet result in increased hyperactivity in 3-year-old and 8/9-year-old children in the general population
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    hyperactiivty and what your children eat
Nathan Goodyear

The Addition of Beta-hydroxy-beta-methylbutyrate and Isomaltulose to Whey Protein Impro... - 0 views

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    Whey protein is beneficial as supplementation for resistance training recovery. This study found the addition of a leucine metabolite, beta-hydroxy-beta-methylbutyrate, and the carbohydrate Isomaltulose before, during, and after high intensity exercise further augmented recovery.
Nathan Goodyear

How is the Immune System Suppressed by Cancer - 1 views

  • nitric oxide (NO) released by tumor cells
  • Excellent work by Prof de Groot of Essen, indicated by adding exogenous xanthine oxidase ( XO) in hepatoma cells, hydrogen peroxide was produced to destroy the hepatoma cells
  • NO from eNOS in cancer cells can travel through membranes and over long distances in the body
  • ...43 more annotations...
  • NO also is co linked to VEGF which in turn increases the antiapoptotic gene bcl-2
  • The other important influence of NO is in its inhibition of the proapoptoic caspases cascade. This in turn protects the cells from intracellular preprogrammed death.
  • nitric oxide in immune suppression in relation to oxygen radicals is its inhibitory effect on the binding of leukocytes (PMN) at the endothelial surface
  • Inhibition of inducible Nitric Oxide Synthase (iNOS)
  • NO from the tumor cells actually suppresses the iNOS, and in addition it reduces oxygen radicals to stop the formation of peroxynitrite in these cells. But NO is not the only inhibitor of iNOS in cancer.
  • Spermine and spermidine, from the rate limiting enzyme for DNA synthases, ODC, also inhibit iNOS
  • tolerance in the immune system that decreases the immune response to antigens on the tumors
  • Freund’s adjuvant
  • increase in kinases in these cells which phosphorylate serine, and tyrosine
  • responsible for activation of many growth factors and enzymes
  • phosphorylated amino acids suppress iNOS activity
  • Hexokinase II
  • Prostaglandin E2, released from tumor cells is also an inhibitor of iNOS, as well as suppressing the immune system
  • Th-1 subset of T-cells. These cells are responsible for anti-viral and anti-cancer activities, via their cytokine production including Interleukin-2, (IL-2), and Interleukin-12 which stimulates T-killer cell replication and further activation and release of tumor fighting cytokines.
    • Nathan Goodyear
       
      Th1 cells stimulate NK and other tumor fighting macrophages via IL-2 and IL-12; In contrast, Th2, which is stimulated in allergies and parasitic infections, produce IL-4 and IL-10.  IL-4 and IL-10 inhibit TH-1 activation and the histamine released from mast cell degranulation upregulates T suppressor cells to further immune suppression.
  • Th-2 subset of lymphocytes, on the other hand are activated in allergies and parasitic infections to release Interleukin-4 and Interleukin-10
  • These have respectively inhibitory effects on iNOS and lymphocyte Th-1 activation
  • Mast cells contain histamine which when released increases the T suppressor cells, to lower the immune system and also acts directly on many tumor Histamine receptors to stimulate tumor growth
  • Tumor cells release IL-10, and this is thought to be one of the important areas of Th-1 suppression in cancer patients
  • IL-10 is also increased in cancer causing viral diseases such as HIV, HBV, HCV, and EBV
  • IL-10 is also a central regulator of cyclooxygenase-2 expression and prostaglandin production in tumor cells stimulating their angiogenesis and NO production
  • nitric oxide in tumor cells even prevents the activation of caspases responsible for apoptosis
    • Nathan Goodyear
       
      NO produced by cancer cells inhibits proapoptotic pathways such as the caspases.
  • early stages of carcinogenesis, which we call tumor promotion, one needs a strong immune system, and fewer oxygen radicals to prevent mutations but still enough to destroy the tumor cells should they develop
  • later stages of cancer development, the oxygen radicals are decreased around the tumors and in the tumor cells themselves, and the entire cancer fighting Th-1 cell replication and movement are suppressed. The results are a decrease in direct toxicity and apoptosis, which is prevented by NO, a suppression of the macrophage and leukocyte toxicity and finally, a suppression of the T-cell induced tumor toxicity
  • cGMP is increased by NO
  • NO in cancer is its ability to increase platelet-tumor cell aggregates, which enhances metastases
  • the greater the malignancies and the greater the metastatic potential of these tumors
  • The greater the NO production in many types of tumors,
  • gynecological
  • elevated lactic acid which neutralizes the toxicity and activity of Lymphocyte immune response and mobility
  • The lactic acid is also feeding fungi around tumors and that leads to elevated histamine which increases T-suppressor cells.  Histamine alone stimulates many tumor cells.
    • Nathan Goodyear
       
      The warburg effect in cancer cells results in the increase in local lactic acid production which suppresses lymphocyte activity and toxicity as well as stimulates histamine production with further stimulates tumor cell growth.
  • T-regulatory cells (formerly,T suppressor cells) down regulate the activity of Natural killer cells
  • last but not least, the Lactic acid from tumor cells and acidic diets shifts the lymphocyte activity to reduce its efficacy against cancer cells and pathogens in addition to altering the bacteria of the intestinal tract.
  • intestinal tract bacteria in cancer cells release sterols that suppress the immune system and down regulate anticancer activity from lymphocytes.
  • In addition to the lactic acid, adenosine is also released from tumors. Through IL-10, adenosine and other molecules secreted by regulatory T cells, the CD8+ cells can be inactivated to an anergic state
  • Adenosine up regulates the PD1 receptor in T-1 Lymphocytes and inhibits their activity
  • Adenosine is a purine nucleoside found within the interstitial fluid of solid tumors at concentrations that are able to inhibit cell-mediated immune responses to tumor cells
  • Adenosine appears to up-regulate the PD1 receptor in T-1 Lymphocytes and inhibits the immune system further
  • Mast cells with their release of histamine lower the immune system and also stimulate tumor growth and activate the metalloproteinases involved in angiogenesis and metastases
  • COX 2 inhibitors or all trans-retinoic acid
  • Cimetidine, an antihistamine has been actually shown to increase in apoptosis in MDSC via a separate mechanism than the antihistamine effect
    • Nathan Goodyear
       
      cimetidine is an H2 blocker
  • interleukin-8 (IL-8), a chemokine related to invasion and angiogenesis
  • In vitro analyses revealed a striking induction of IL-8 expression in CAFs and LFs by tumor necrosis factor-alpha (TNF-alpha)
  • these data raise the possibility that the majority of CAFs in CLM originate from resident LFs. TNF-alpha-induced up-regulation of IL-8 via nuclear factor-kappaB in CAFs is an inflammatory pathway, potentially permissive for cancer invasion that may represent a novel therapeutic target
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    Great review of the immunosuppression in cancer driven by the likes of NO.
Nathan Goodyear

Salivary estradiol, interleukin-6 product... [Eur J Appl Physiol. 2011] - PubMed - NCBI - 0 views

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    In this study, in addition to Estradiol, IL-6 was followed via salivary testing. This study found that post-exercise IL-6 elevation reduced energy availability from fat stores.  
Nathan Goodyear

Acute prooxidant effects of vitamin C in... [Free Radic Biol Med. 2005] - PubMed - NCBI - 0 views

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    This study found a pro oxidant effect of the addition of 5 grams of IV vitamin C with EDTA chelation.  As dosing of IV vitamin C goes, 5 grams is quite small.  Vitamin C has been shown to have varying effects (pro oxidant versus antioxidant) dictated by the dosage.  One wonders if higher dosing IV vitamin C provides antioxidant effects?
Nathan Goodyear

JAMA Network | Archives of Surgery | Death Rates and Causes of Death After Bariatric Su... - 0 views

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    Study reveals that death rate increased per year post-Bariatric surgery.  Up to 6.4% at 5 years.  This study did not follow up on additional procedures/surgeries.  The re-operation rate is 50%.
Nathan Goodyear

Roundup Disrupted Male Reproductive Func... [Free Radic Biol Med. 2013] - PubMed - NCBI - 0 views

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    Glyphosate, component of Roundup is well known to be an endocrine disruptor.  This rat study describes the mechanism  of disruption of the Sertoli cells resulting in male infertility.  In addition to the disruption of spermatogenesis, Glyphosate was shown to deplete glutathione levels compromising detoxification.  If that is not enough, oxidative damage marker TBARS was elevated.  
Nathan Goodyear

Telomerase at the intersection of cancer and aging - 0 views

  • The anti-aging role of telomerase has been demonstrated to be largely mediated by its canonical role in elongating telomeres, which prevents the accumulation of critically short telomeres and loss of tissue homeostasis
  • Short telomeres, and subsequent DDR activation, could occur both in cancer and aging
  • increased abundance of short telomeres correlates with higher genomic instability and decreased longevity in various organisms, including mice, zebrafish, and yeast
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  • mice deficient for telomerase or for telomere binding proteins are characterized by accelerated age-related defects
  • In humans, short telomeres are considered good indicators of an individual’s health status and correlate with both genetic and environmental factors
  • Although recent findings strongly support the idea that short telomeres drive several age-related diseases 38 we cannot exclude the possibility that in some situations short telomeres may be a consequence of the disease itself.
  • the current view is that telomerase deficiency may contribute to the early steps of cancer development by fueling chromosomal instability, while subsequent activation of telomerase may be necessary to allow tumor growth and tumor progression towards more malignant states
  • telomerase activation can be an early event in cancer, it is not necessary for cancer initiation
  • telomerase can stimulate tumor progression by ensuring maintenance of telomeres above a critically short length, thus preventing induction of cellular senescence or apoptosis
  • Almost all human cancers present activation of telomerase as a hallmark, most likely as a mechanism to allow unlimited cell proliferation of tumor cells
  • recent evidence demonstrated that short telomeres alone could lead to genomic instability and cancer
  • Getting rid of telomerase can also be problematic; the lack of telomerase could lead to increased chromosomal instability, which in turn could be at the basis for cancer initiation when tumor suppressor barriers are bypassed
  • telomerase activation is a potential therapeutic strategy for the treatment of age-related diseases
  • telomerase activation in adult or old mice by means of a gene therapy strategy was shown to be sufficient to improve metabolic fitness, neuromuscular capacity, and prevent bone loss, as well as significantly increase both median and maximum longevity, without increased cancer incidence
  • These studies suggest that telomerase expression could be considered a feasible approach to reverse tissue dysfunction and extend healthy lifespan without increasing cancer incidence
  • humans almost completely lose telomerase activity from somatic tissues in the adulthood
  • a change of paradigm seems to be occurring in telomerase biology, with a switch from viewing telomerase as fueling cancer to reversing aging
  • Telomerase expression in a background of high levels of tumor suppressors or in aged organisms seems to prevent its expected pro-cancer activity and yet it still functions as an anti-aging factor
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    Telomerase activity and longer telomere length is shown to correlated inversely with many chronic diseases of aging.  In contrast, telomerase activity is found to be involved in carcinogenesis.  Increased carcinogenic potential of telomerase activity has not borne out in studies.  In addition, increased CD8 cell activity as a result of telomerase activation will actually decrease carcinogenic potential via NK activation.
Nathan Goodyear

Role of Gut Microbiota and Short Chain Fatty Acids in Modulating Energy Harvest and Fat... - 0 views

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    gut bacteria differentiate obese versus non-obese.  Association found b/t firmicutes:bacteroidetes, increased Bacteroidetes, and Actinobacteria; in addition, acute, propionate, and butyrate (all medium chain fatty acids) were found to be associated with obesity.
Phiten Singapore

Walk & Run in Style with Phiten' s Rakuwa Anklets - 0 views

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    Mix style and comfort when you wear the newest addition to #Phiten's accessories. Get the relief your legs, feet, and ankles need with the #Rakuwa #Anklet S Slash Line. Find the #PhitenStore nearest to you: https://phitensg.com/store-locations/
Phiten Singapore

Christmas Offers on Phiten - 0 views

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    We are now running the best occasion bargains so you can give the best presents to your family and friends. #PhitenSG products are at special discount and you can even profit of additional investment funds! For more funds visit Phiten store : https://phitensg.com/store-locations/
wheelchairindia9

Tynor Knee Immobilizer 14 - 0 views

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    Tynor Knee Immobilizer 14 is a superb brace to support, immobilize and protect the operated or injured knee while it recovers. It is made according to the anatomically designed aluminum back splints that offers perfect immobilization. It provides perfect grip to the leg and enhanced the comfort. It is light in weight and ensures complete cushioning. It is made up from thecomfortable and soft body that is highly durable. This knee wrap properly fits around the knee and has non-slip properties. It offers great protection to the knee and it can easily remove it, when not required. Tynor Knee Immobilizer 14 Use & Benefit: Has extremely light weight construction Designed with anatomically shaped back splints Made up from soft and comfortable body Provides perfect immobilization Infused with additional patellar strapping Provides perfect grip to the leg Ensures no hot spots on knee protrusions Has body of PUF fused fabric Offers proper cushioning Has anti slip properties Easy to remove when not required
Nathan Goodyear

Th17: The third member of the effector T cell Trilogy - 0 views

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    Th17 is the source of IL-17 and IL-21.  This is in addition to Th1 and Th2 cells.  Th17 cells are highly inflammatory and especially in autoimmune conditions.
Nathan Goodyear

Annals of Internal Medicine | Are Organic Foods Safer or Healthier Than Conventional Al... - 0 views

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    study claims that organic foods provide no additional nutritional value above non-organic foods.  Problem is, that is not the reason to push organic.  Elimination of xenoestrogens, hormones, and other toxins is.
Nathan Goodyear

FDA says HCG weight-loss products are illegal - - CNN.com Blogs - 0 views

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    I agree with the fact that studies have not shown HCG helps with weight loss in addition to the 500 cal diet. We have many studies in diigo supporting this.  However, the FDA is stepping out of its authorized scope.  
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