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Nathan Goodyear

Relationship Between Benign Prostatic Hyperplasia/... [J Sex Med. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24612680

Testosterone men male hormone hormones BPH benign prostatic hypertrophy LUTS lower urinary tract symptoms

shared by Nathan Goodyear on 18 Mar 14 - No Cached
  • Nathan Goodyear on 18 Mar 14
     
    European study finds no correlation with Total Testosterone levels and lower urinary tract symptoms and benign prostatic hypertrophy.
Nathan Goodyear

Elderly men over 65 years of age with late-onset hypogonadism benefit as much from test... - 0 views

www.ncbi.nlm.nih.gov/...PMC4392031

low T low Testosterone Testosterone men male hormone hormones late onset hypogonadism hypogonadism

shared by Nathan Goodyear on 21 May 15 - No Cached
  • The benefits of restoring serum testosterone in men with LOH were not significantly different between men older than 65 years of age and younger men. There were no indications that side effects were more severe in elderly men. The effects on prostate and urinary function and hematocrit were within safe margins.
  • obesity, but also impaired general health, are the more common causes of low testosterone in aging men
  • Severe LOH is associated with substantially higher risks of all-cause and cardiovascular mortality,
  • ...30 more annotations...
  • advanced age, obesity, a diagnosis of metabolic syndrome, and poor general health status were predictors of LOH
  • Diabetes mellitus was correlated with hypogonadism in most studies
  • coronary heart disease, hypertension, stroke, and peripheral arterial disease did not predict hypogonadism, they did correlate with the incidence of low testosterone
  • LOH can be defined by the presence of at least three sexual symptoms associated with a total testosterone level of less than 11 nmol/L (3.2 ng/mL) and a free testosterone level of less than 220 pmol/L (64 pg/mL)
    • Nathan Goodyear
      Nathan Goodyear on 27 May 15
       
      the European Male Aging study defined low T as total < 320 ng/dl and free < 64 pg/ml.  
  • Mean weight decreased
  • Waist circumference decreased
  • Total cholesterol decreased
  • Low-density lipoprotein decreased
  • Triglycerides decreased
  • High-density lipoprotein (HDL) increased
  • ratio of total cholesterol to HDL improved
  • Prostate volume increased
  • PSA increased
  • The benefits for men older than 65 years of age were compared with those of younger men, and the improvements in body weight, metabolic factors, psychological functioning, and sexual functioning were of the same magnitude in both age groups
  • weight loss was progressive over the 6-year period, effects of testosterone on lipids and on psychological and sexual functioning reached a plateau after approximately 3 years and these effects were sustained
  • Effects of testosterone on hematopoiesis, on the prostate, and on bladder function were not more severe in older men than in younger men
  • observe a mild increase in prostate volume and serum PSA over time, which is a normal finding in aging men. Maybe somewhat surprising, postvoiding residue and the IPSS did not deteriorate with aging but showed a degree of improvement
  • the severity of the metabolic syndrome is associated with the severity of lower urinary tract symptoms
  • The symptoms of the metabolic syndrome improve upon testosterone treatment and testosterone may thus have a favorable effect on lower urinary tract symptoms
  • it seems reasonable to conclude that the risks of testosterone administration to elderly men are not disproportionately higher in elderly men than in younger men.
  • Despite evidence to the contrary, physicians still harbor a wrongful association between testosterone and the development of prostate pathology (prostate cancer and benign prostate hyperplasia)
  • Not surprisingly, the incidence of prostate cancer was higher in older men; however, it was lower than expected in both groups
  • These observations suggest that the incidence of prostate cancer in patients receiving testosterone therapy, both in the younger and in the older group, was not greater than in the general population not receiving testosterone treatment
  • The historical fear that raising testosterone levels will result in more prostate cancer has been dispelled, particularly by the work of Abraham Morgentaler
  • Higher serum testosterone levels fail to show an increased risk of prostate cancer, and supraphysiological testosterone does not increase prostate volume or PSA in healthy men
  • This apparent paradox is explained by the "saturation model,"
  • Recent studies indicate no increased risk of prostate cancer among men with serum testosterone in the therapeutic range
  • In the present observational study, no cases of major adverse cardiovascular events occurred.
  • the benefits of testosterone therapy are fully achieved only by long-term treatment
  • To achieve maximal benefits, good patient adherence is a prerequisite
  • Nathan Goodyear on 21 May 15
     
    Study finds new difference in Testosterone benefits and/or side effects between men < 65 with low T and men > 65 with low T.
Nathan Goodyear

Relationship between non-alcoholic fatty liver ... [World J Urol. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25189458

NAFLD BPH LUTS men male fatty liver liver metabolic syndrome

shared by Nathan Goodyear on 09 Sep 14 - No Cached
  • Nathan Goodyear on 09 Sep 14
     
    Men with NAFLD have higher incidence of lower urinary tract symptoms including BPH.
Nathan Goodyear

Lower urinary tract symptoms improve with testosterone replacement therapy in men with ... - 0 views

www.ncbi.nlm.nih.gov/...24135918

low T low Testosterone Testosterone prostate LUTS male hormone hormones men

shared by Nathan Goodyear on 27 May 15 - No Cached
  • Nathan Goodyear on 27 May 15
     
    Older men with low T found to have improved LUTS, based on prostate symptom score, with Testosterone therapy.  This flies in the face of concerns that Testosterone is a risk to the prostate.
Nathan Goodyear

Relationship between Metabolic Syndrome and Predictors for Clinical Benign Prostatic Hy... - 0 views

www.ncbi.nlm.nih.gov/...27351328

metabolic syndrome BPH LUTS lower urinary tract symptoms prostate men men's health

shared by Nathan Goodyear on 30 Jun 16 - No Cached
  • Nathan Goodyear on 30 Jun 16
     
    Metabolic syndrome in men associated with progressive BPH and increased severity of LUTS.
Nathan Goodyear

The relationship between lower urinary tract symptoms/benign prostatic hyperplasia and ... - 0 views

www.ncbi.nlm.nih.gov/...23850334

metabolic syndrome LUTS prostate BPH men male hormone hormones

shared by Nathan Goodyear on 27 May 15 - No Cached
  • Nathan Goodyear on 27 May 15
     
    Correlation found between increasing MetS components and LUTS/BPH incidence.  This points to more of a inflammatory, estrogen contribution, rather than an excess Testosterone issue as MetS is associated clearly with low T in men with MetS.
Nathan Goodyear

Testosterone Replacement Alone for Testosterone Deficiency Syndrome Improves Moderate L... - 0 views

www.ncbi.nlm.nih.gov/...PMC3640152

low T low testosterone LUTS prostate men male hormone hormones testosterone

shared by Nathan Goodyear on 27 May 15 - No Cached
  • Nathan Goodyear on 27 May 15
     
    Study finds that Testosterone therapy reduces LUTS in men with low T.  The definition of low T is a little wide in this study.  Another study that contradicts the belief that Testosterone contributes to LUTS through the prostate.
Nathan Goodyear

Effects of Testosterone Level on Lower Urinary Tract Symptoms. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...26077271

Testosterone LUTS prostate men hormones hormone

shared by Nathan Goodyear on 17 Jun 15 - No Cached
  • Nathan Goodyear on 17 Jun 15
     
    no correlation between total Testosterone with LUTS and prostate size in men.
Nathan Goodyear

http://cdn.intechopen.com/pdfs-wm/27785.pdf - 0 views

cdn.intechopen.com/...27785.pdf

low T low testosterone low T Testosterone men male hormone hormones LUTS BPH prostate lower urinary tract symptoms

shared by Nathan Goodyear on 04 Jan 15 - No Cached
  • Nathan Goodyear on 04 Jan 15
     
    Nice review of the literature of low T and LUTS in men.
Nathan Goodyear

Use of 5α-reductase inhibitors for lower urinary tract symptoms and risk of p... - 0 views

www.bmj.com/bmj.f3406

5 alpha reductase 5 alpha reductase inhibitors prostate cancer LUTS men male hormone hormones

shared by Nathan Goodyear on 09 Feb 15 - No Cached
  • Nathan Goodyear on 09 Feb 15
     
    5alpha reductase inhibitors associated with decreased risk of Gleason 2-7 prostate cancer in men with LUTS and enlarged prostate.
Nathan Goodyear

Effects of Testosterone Replacement Therapy on Lower Urinary Tract Symptoms: A Systemat... - 0 views

www.ncbi.nlm.nih.gov/...26874809

low testosterone low T Testosterone LUTS male hormones

shared by Nathan Goodyear on 16 Feb 16 - No Cached
  • Nathan Goodyear on 16 Feb 16
     
    new meta-analysis finds no negative impact on LUTS with Testosterone therapy in men with low T.
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