Ki-67 is a prognostic parameter in breast cancer patients: results of a large populatio... - 0 views
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A wide range of techniques is available to assess tumor cell proliferation such as calculating mitotic figures in stained tissue segments, flow cytometric analysis to determine the proportion of cells being in the S phase of the cell cycle, examination of thymidine-labeling index, proliferating cell nuclear antigen (PCNA), or cyclins E and D
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Ki-67 is a nuclear protein being associated with cellular proliferation and was originally identified by Gerdes et al.
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Ki-67 nuclear antigen is expressed in certain phases of the cell cycle namely S, G1, G2, and M phases, but is nonexisting in G0
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