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Study finds that massive doping of Testosterone, 600 mg weekly, results in increase muscle mass and performance with strength training.  This dosing amounts to about 100 mg daily compared to the 5-10 mg of peak daily production of a young man.

Breast cancer associated with high levels of estrone, estradiol, testosterone, and less with androstenedione and DHEAS.  Those individuals being doped by physicians (a whole lot) are increasing their risk of many health diseases, including breast cancer.

This is what amounts to science?  As if high estrogen production from overdosing Testosterone only results in gynecomastia.  This study is trying to validate doping utilizing testosterone by saying that no one listed gynecomastia as the reason for AI therapy?!?! No evaluation on PSA, TNF-alpha, CRP...was done.  This study is worthless.

Testosterone is great when needed, not doped; but Testosterone is not without risks.  Population case-control study finds increased blood clot risk in first 6 months of Testosterone therapy.  To many variables left unanswered by this study.  

Nice review of the mixed data on Testosterone and Prostate disease. It is clear that Testosterone does not precipitate prostate cancer.  The intraprostatic hormone milieu likely is different than that present in the serum.  No surprise there.  5alpha reductase decreases prostate volume, PSA, and low-grade prostate cancer, but actually increases aggressive prostate cancer. Supraphysiologic doping in young men associated with no increase in prostate disease. PSA no longer to be followed in men < 55.  Mortality rate not changed.  PSA change of 1.4 ng/ml is appropriate for additional prostate evaluation.  Testosterone therapy on average increased 0.5 ng/ml. Still, no mention of aromatase activity in this article.  Why is it that hormone sensitive disease in men is only with regards to androgens and women estrogen.

Testosterone therapy is complex in hypogonadism.  Much of the marketing-based medicine of Low T today is in fact doping.  Increasing weight is clearly associated with a declining T level in men.  Testosterone therapy should be approach individually and therapies that use the one size fits all approach never work.  This is the case whether the use of synthetics or natural hormones are employed.  Testosterone has been shown to improve dysglycemia, MetS, reduce fat and increase muscle mass.  

Study of 209 men > 65 on Testosterone therapy was stopped early due to increase cardiovascular adverse events  The likely reason was the amazingly high dosing.  The men in this study were just doped.  The dosing was 100 mg + which is in stark contrast to the 5-10 mg daily production of a young man at 22.

Low Testosterone found to disrupt restful sleep in men.  However, in contrast, Testosterone doping leads to sleep disruption as well.  I love how the authors describe it: ...in supra therapeutic doses, or in the context abuse."

This study found that increasing Testosterone, as determined by serum, is associated with increased CVD, insulin resistance, and metabolic syndrome in postmenopausal women.  I believe that this massive Testosterone doping campaign that we are seeing in men and women is following the same patter seen with premarin and provera. 

Women with metabolic syndrome have increased recurrence of breast cancer after initial therapy.  Likewise, Increasing Testosterone was associated with increasing risk of metabolic syndrome.  This is the opposite of men.  One wonders what this massive doping of Testosterone that is underway is doing to women?  Are we merely feeding disease?

Case study and review of potential side effects from the "doping" of Testosterone that is occuring today in physicians offices.

This study's conclusion is to evaluate clotting factor i.e. factor V leiden, Factor VIII, and prothrombin prior to giving Testosterone.  This small study found increased clotting in some men on Testosterone. The problem here is the dosing of Testosterone in these men was 50-160 mg.  Physiologic dosing is 5-10 mg.  The problem is doping.  One wonders if physiologic dosing was undertaken if any of the men in this study would develop clotting problems, even though they had undiagnosed hypercoagulabitliy.

Review of recent articles suggest increased risk of cardiovascular disease in men. The issue at hand is the cause is not being treated and thus the Testosterone is fuel on the metabolic fire and the doping dose that most men receive.

Study finds decreased ovarian reserve in women 20-29 with metabolic syndrome compared to controls.  They determined this via ovarian volume measurements as FSH, LH, Estradiol, and Progesterone did not differ.   One item of interest was that women with MetS, had significantly higher Testosterone levels compared to controls.  This association of MetS and elevated Testosterone in women has been shown consistently in the literature.  This should bring great questions to the doping of Testosterone in women today.

Study finds non-hormonal therapy to manage hot flashes in postmenopausal women--drug them.  The authors of this study, looked to gabapentin, also known as neurontin to treat hot flashes.  Instead of looking at the causes: hormone imbalance, stress... these authors looked to a sedating drug.  The dosing of neurontin was 900 mg.   Most can't stand at this dose.  This study points to the lunacy in the research today.  Very soon, there will be the walking dead among us.  They will be the walking doped instead of dead.

Great review by Morgentaler of Testosterone and CVD.  He highlights the significant flaws in the JAMA and the NEJM articles of Testosterone therapy risks.  Morgentaler highlights the significant evidence that points to low T and increased risk of CVD. On contention I have, is Morgantaler seems to flip aside the massive uptick of Testosterone use in the US as compared to other countries.  The evidence definitely points to Testosterone therapy as being safe in those with low T, but there is definitely a problem of significant Testosterone doping that is taking place as well.

Interesting study finds hyperandrogenism stimulates excessive inflammatory response to glucose intake.  This study was done in otherwise healthy women not in women with PCOS.  The inflammatory cytokine production was via NF-KappaB activation.  Again, this has negative implications in women being doped with Testosterone.

Very insightful study.  Study looked at hyperadrogenism and inflammation in women on the orders of PCOS.  The study subjects did not have PCOS, but hyperandrogenism via 130 mg DHEA was associated with an increase in TNF-alpha in these lean o/w healthy women.  We know this is due to hyperandrogenism as elevated Testosterone, DHEA, and androstenedione were documented with treatment. Take home:  androgens promote inflammation in women.  I believe this has serious negative implications about the massive Testosterone doping that is occurring in women today.

Study finds that transdermal testosterone effective in normal and overweight men.  The dosing involved is supra physiologic, especially those with an elevated BMI.  This was likely due to the high dosing to overcome the underlying problem i.e. high aromatase activity.  These studies all need to assess estrogens and inflammatory cytokines to better follow these results