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Glyphosate, component of Roundup is well known to be an endocrine disruptor.  This rat study describes the mechanism  of disruption of the Sertoli cells resulting in male infertility.  In addition to the disruption of spermatogenesis, Glyphosate was shown to deplete glutathione levels compromising detoxification.  If that is not enough, oxidative damage marker TBARS was elevated.  

Glyphosate, component of Roundup shown to disrupt Testosterone production, aromatase activity, and the androgen receptors in this male in vivo model.

Glyphosate-based herbicides (commonly found in roundup) shown to cause damage to placenta cells.  This has major implications in infertility and pregnancy health

Glyphosate inhibits CYP 450 enzymes.  The author states it well: "glyphosate enhances the damaging effects fo other food borne chemical residues and environnmental toxins.  Additionally, Glyphosate disrupts gut bacterial function in the human gut. This dysbiosis is well known to cause systemic disease, such as obesity, diabetes...

First long-term study on GMO effects on rats. The majority of studies on GMO have been on animals with the end point at < 90 days.  This study followed the rats for 2 years.  Increased mammary tumors were found.  Is this definitive?  Of course not, but this is the first study to look at long term effects.

Scary stat--75% of samples from air and rainfall taken in delta contaminated with glyphosate and its metabolite AMPA.  These levels were not measured in 1995 so % increase is unable to be determined.  We do know that roundup use has increased dramatically over that time frame.  

Glyphosate found to lower Testosterone in rat study.  Glyphosate is a significant xenoestrogen which acts as an endocrine disruptor.

Probably one of the more disturbing aspects of glyphosate exposure. In utero exposure, lowers Testosterone levels and effects the masculinization process of the young boy.  Very disturbing.  Our boys are being altered before they are even born.