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Nathan Goodyear

Glyphosate impairs male offspring reproductive ... [Arch Toxicol. 2012] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22120950

glyphosate Roundup Testosterone xenoestrogen xenoestrogens endocrine disruptor Toxins

shared by Nathan Goodyear on 04 Jul 13 - No Cached
  • Nathan Goodyear on 04 Jul 13
     
    Probably one of the more disturbing aspects of glyphosate exposure. In utero exposure, lowers Testosterone levels and effects the masculinization process of the young boy.  Very disturbing.  Our boys are being altered before they are even born.
Nathan Goodyear

JSTOR: Epidemiology, Vol. 13, No. 4 (Jul., 2002), pp. 454-458 - 0 views

www.jstor.org/...3703770

DDE environmental toxins low T testosterone men endocrine disruptors

shared by Nathan Goodyear on 21 May 12 - No Cached
  • Nathan Goodyear on 21 May 12
     
    High DDE levels in African American men associated with a 23% lower Testosteone levels
Nathan Goodyear

Bisphenol A and Metabolic Syndrome: Results from NHANES - 0 views

www.hindawi.com/...598180

metabolic syndrome MetS bisphenol A BPA EDC endocrine disruptors

shared by Nathan Goodyear on 04 Sep 13 - No Cached
  • Nathan Goodyear on 04 Sep 13
     
    Bisphenol A clearly associated with increased risk of MetS.
Nathan Goodyear

Male pubertal development: are endocrine-disrupting compounds shifting the norms? - 0 views

joe.endocrinology-journals.org/...R1.full

endocrine disruptors xenoestrogens environment environmental toxins

shared by Nathan Goodyear on 24 Jul 13 - No Cached
  • Nathan Goodyear on 24 Jul 13
     
    Study supports the mechanism behind endocrine disruption of xenoestrogens in the pubertal development of young boys.
Nathan Goodyear

Environmental/lifestyle effects on spermatogenesis - 0 views

rstb.royalsocietypublishing.org/...1697.full

sperm count xenoestrogens EDC endocrine disrupting chemicals endocrine disruptor low T Testosterone men male fertility

shared by Nathan Goodyear on 27 Jul 13 - No Cached
  • Nathan Goodyear on 27 Jul 13
     
    The environment is playing a role in reduced testicular function in men.
Nathan Goodyear

Estrogen Receptors in Colorectal Cancer: Goalkeepers, Strikers, or Bystanders? - 0 views

cancerpreventionresearch.aacrjournals.org/...897.full

estrogen colon cancer ER beta ER-beta breast

shared by Nathan Goodyear on 19 Nov 13 - No Cached
  • one can conclude that ERβ has an overall antiproliferative effect, thereby inhibiting cancer cell proliferation and antagonizing ERα function in the breast
  • HRT with estrogen alone did not increase the risk of breast cancer in the Women's Health Initiative clinical trials program
  • colorectal normal or cancer epithelium does not coexpress ERα and ERβ
  • ...7 more annotations...
  • ERβ expression resulted in the inhibition of proliferation and G1 phase cell-cycle arrest
  • ERβ expression strongly inhibited cMyc and tumor growth in a xenograft mouse model
  • induced ERβ in CRC cells has an antiproliferative, tumor-suppressive function that is independent of ERα
  • ERs also have the ability to bind many other compounds with an estrogen-like structure, including phytoestrogens and xenoestrogens (or endocrine disruptors)
  • Phytoestrogens are a diverse class of natural compounds with structural similarity to estradiol
  • Barone et al. recently found that two ERβ-selective phytoestrogens effectively counteracted CRC tumorigenesis and surprisingly increased ERβ expression in mice with mutations of the tumor-suppressor gene adenomatous polyposis coli
  • We can conclude that estrogens are important in protecting against CRC initiation and progression, and that the protective effect most likely is mediated by ERβ
  • Nathan Goodyear on 19 Nov 13
     
    ER beta is a new potential mode of therapy in colon cancer.  ER beta stimulation has been shown to inhibit colon cancer cell growth.
Nathan Goodyear

Exposure to DEHP and MEHP from hatching to adu... [Aquat Toxicol. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24292025

pthalates toxins endocrine disruptors hormones xenoestrogens

shared by Nathan Goodyear on 04 Dec 13 - No Cached
  • Nathan Goodyear on 04 Dec 13
     
    endocrine disrupting pthalates disrupt marine animal hormones.  This effect was more prevalent in males than females.
Nathan Goodyear

Cadmium - a metallohormone? - 0 views

www.ncbi.nlm.nih.gov/...PMC2709711

cadmium ER alpha ER-alpha ER estrogen receptors receptor androgen AR hormones endocrine disruptors endocrine disrupting chemicals EDC heavy

shared by Nathan Goodyear on 20 Jul 14 - No Cached
  • Nathan Goodyear on 20 Jul 14
     
    Great review article on the endocrine disrupting role of Cadmium.  Cadmium binds to the ER-alpha inducing an estrogen signal.  Cadmium also binds to the androgen receptor as well.  This study proposes a similar activation of ER-alpha and AR by Cadmium.
Nathan Goodyear

http://apps.who.int/iris/bitstream/10665/78102/1/WHO_HSE_PHE_IHE_2013.1_eng.pdf - 0 views

apps.who.int/...WHO_HSE_PHE_IHE_2013.1_eng.pdf

EDC endocrine disrupting chemicals endocrine disruptors hormones

shared by Nathan Goodyear on 21 Jul 14 - No Cached
  • Nathan Goodyear on 21 Jul 14
     
    2012 WHO review on EDCs
Nathan Goodyear

Prenatal Exposure to Phthalates is Associated with Reduced Masculine Behavior in Boys - 0 views

www.niehs.nih.gov/...prenatal.cfm

prenataol Phalates plastics environmental toxins endocrine hormone disruptors

shared by Nathan Goodyear on 08 Sep 11 - No Cached
  • Nathan Goodyear on 08 Sep 11
     
    phthalate exposure associated with reduced masculinity of boys
Nathan Goodyear

Disruption of adult expression of s... [Proc Natl Acad Sci U S A. 2011] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21709224

Bisphenol A hormone disruptors envornmental toxins

shared by Nathan Goodyear on 08 Sep 11 - No Cached
  • Nathan Goodyear on 08 Sep 11
     
    Female deer mice want nothing to do with Bisphenol A toxic male deer mice
Nathan Goodyear

Effects of Organochlorine Compounds on Menstrual Cycles - DERT - 0 views

www.niehs.nih.gov/...menses.cfm

DDT environmental toxins endocrine disruptors menstrual cycles

shared by Nathan Goodyear on 08 Sep 11 - No Cached
  • Nathan Goodyear on 08 Sep 11
     
    DDT effects female reproduction and development
Nathan Goodyear

Developmental exposure to endocrine disruptors and... [Reprod Toxicol. 2007 Apr-May] - ... - 0 views

www.ncbi.nlm.nih.gov/...17321108

toxins toxicity obesity

shared by Nathan Goodyear on 06 Apr 11 - No Cached
  • e review the literature that proposes an association of exposure to environmental endocrine disrupting chemicals with the development of obesity
  • Nathan Goodyear on 06 Apr 11
     
    exposure to toxins perinatally likely playing a significant role in the run-away-train obesity epidemic over last 3 decades
Nathan Goodyear

Inhibitory effects of some possible endocrine-di... [Environ Sci. 2005] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...16184081

endocrine disrupting chemicals hormone hormones cortisol cortisone endocrine disruptors EDC 11-betaHSD 11-betaHSD1 11beta-HSD2

shared by Nathan Goodyear on 05 Jun 14 - No Cached
  • Nathan Goodyear on 05 Jun 14
     
    11beta-HSD type I and type II are no equally expressed across all tissues.  Endocrine disrupting chemicals (EDC) inhibit both.
Nathan Goodyear

PLOS ONE: Persistent Organic Pollutants and Early Menopause in U.S. Women - 0 views

journals.plos.org/...article

EDC endocrine disrupting chemicals women hormone hormones female xenoestrogens endocrine disruptors menopause

shared by Nathan Goodyear on 30 Jan 15 - No Cached
  • Nathan Goodyear on 30 Jan 15
     
    study identifies 15 Endocrine Disrupting Chemicals that lead to earlier Menopause.  Maybe we should change it to Chemopause.
Nathan Goodyear

https://www.sciencedirect.com/science/article/pii/S0278691517303976 - 0 views

www.sciencedirect.com/...S0278691517303976

ER alpha ER-alpha xenoestrogen Cancer glyphosate endocrine disruptor

shared by Nathan Goodyear on 23 Apr 19 - No Cached
hoangkimchi liked it
  • Nathan Goodyear on 23 Apr 19
     
    glyphosate increases ER-alpha expression and activation though this study found no evidence that glyphosate bound to ER-alpha. This makes glyphosate a endocrine disrupter.
Nathan Goodyear

A relationship in adrenal androgen levels between mothers and their children from a dio... - 0 views

www.sciencedirect.com/...S0048969717316911

EDC endocrine disrupting chemicals hormones endocrine disruptors agent orange DHEA androstenedione

shared by Nathan Goodyear on 04 Oct 17 - No Cached
  • Nathan Goodyear on 04 Oct 17
     
    Endocrine Disrupting Chemicals from 1970 still disrupting hormones today.  Three fold increase in DHEA in 3 year old children via saliva and androstenedione in mothers compared to controls.
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