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Nathan Goodyear

BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseas... - 0 views

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    BDNF should be the focus of any cognitive and neurodegenerative disease.
Nathan Goodyear

Effects of beta-hydroxybutyrate on cognition... [Neurobiol Aging. 2004] - PubMed - NCBI - 0 views

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    High ketone levels from MCT, such as cocconut oil, associated with improved memory recall in "memory-impaired adults".
Nathan Goodyear

Dietary Strategy to Repair Plasma Membrane After Brain Trauma - 0 views

  • concussive brain injury is a major cause of neuropsychological disability in spite of no obvious neuronal death
  • TBI elicits oxidative damage to plasma membrane phospholipids
  • DHA is the most abundant polyunsaturated fatty acid (PUFA) in the brain, where the DHA-containing phospholipids contribute to plasma membrane biogenesis and receptor signaling
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  • curcumin has potent anti-inflammatory and antioxidant activities that can function to reduce oxidative damage and cognitive deficits associated with neurological disorders
  • Curcumin provided in the diet before TBI can reduce oxidative damage and counteract TBI-related cognitive dysfunction
  • Our previous study indicated that n-3 fatty acids supplemented in the diet counteracted learning disability after TBI
  • curcumin contributes to enhance the effects of DHA on TBI by promoting phosphorylation of the BDNF receptor TrkB in the hippocampus
  • previous evidence indicates that curcumin10 and DHA5 counteract TBI-related learning disability by involving BDNF
  • Our findings indicate that curcumin counteracted the TBI-related reduction in n-3 DPA.
  • curcumin may promote the conversion of n-3 DPA to DHA
  • the combination of both nutrients has been reported to produce anti-inflammatory action
  • the enhanced actions of curcumin and DHA in reducing cholesterol levels could be interpreted as preservation of levels of phospholipids in the plasma membrane
  • curcumin and DHA may contribute to reduce inflammation associated with the action of cholesterol in the pathology of TBI.
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    Curcumin and DHA shown to protect against TBI through a reduction in inflammation and maintenance of brain phospholipid membranes.  BDNF is increases also.
Nathan Goodyear

French adults' cognitive performance after daily supplementation with antioxidant vitam... - 0 views

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    antioxidants improve memory in french adults followed over 6 years.
fnfdoc

Risk Factors For Alzheimer's | Health Blog - 0 views

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    Alzheimer's is a mental illness that mostly affects the elderly. It is characterized by dementia, cognitive impairment, and mood swings. The patient gradually fades into a state of perpetual darkness and lack of self-awareness. Here are some steps we can take to reduce our own risk.
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    Scientists are trying to find ways to prevent Alzheimer's before it comes knocking at your doorstep. Extensive research is taking place even as you read this. Everyone hopes to put together the answer before it becomes a global issue. Here are a few risk factors that you can and can't avoid:
KELLY147

The Role of Artificial Intelligence in the Logistics Industry - 0 views

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    The AI plays a crucial role in saving time, decreasing costs, and improving productivity with cognitive industrialization. It helps automate many time-consuming processes and assists in market forecasting. AI positively transforms warehousing operations to collect and interpret information or inventory processing.
fitspresso

https://www.thefastleanpro.us/ - 0 views

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    Fast Lean Pro™ (official) | weight lose Formula thefastleanpro.us · by Fast Lean Pro Fast Lean Pro Only $49/Bottle Limited Time Offer! Fast Lean Pro Special Deal + Special 51% Discount Save $300 + 180 Days Money Back Guarantee FastLeanPro The #1 Solution To natural metabolism booster helps you lose weight quickly without starving yourself. Fast Lean Pro is a natural powder supplement for weight loss that has recently been developed by Japanese scientists. Regular Price: $99/per bottle Only for: $49/per bottle What Is Fast Lean Pro? Fast Lean Pro is a powdered dietary powdery supplement designed to aid in weight loss. It contains a unique combination of ingredients that are believed to activate the body's "fasting switch" to optimize results. This product focuses not only on weight loss but also on promoting cellular rejuvenation, fasting, and a healthy metabolism. The concept behind Fast Lean Pro is that incorporating fasting into one's lifestyle can lead to positive outcomes irrespective of individual food choices and eating habits. To comprehend the mechanism of the Fast Lean Pro process, it is necessary to delve into its specific details. One of the few weight loss pills on the market that contains Fibersol is Fast Lean Pro. This safe, specialized fiber adds bulk to its weight when combined with water, curbing your appetite before it throws off your meal plan. If you're trying to lose weight or curb your appetite, Fast Lean Pro can help. Supporting substances such as niacin and chromium contribute to this. The body can further benefit from these nutrients, such as through improved metabolic regulation. Fast lean Pro is non-GMO, vegan friendly, and contains no artificial ingredients or stimulants. Fast Lean Pro is a weight loss product that promotes the body's natural self-feeding process. The body naturally removes old, damaged cells through a process known as autophagy to encourage cell regeneration and repair. Recent studies by a group
Nathan Goodyear

Chemistry and Structural Biology of Androgen Receptor - 0 views

  • Healthy adult men typically produce approximately 3–10 mg of testosterone per day
  • circulating levels ranging from 300 to 700 ng/dL in eugonadal men
  • endogenous testosterone secretion is pulsatile and diurnal
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  • highest concentration occurring at about 8:00 a.m. and the lowest at about 8:00 p.m.
  • Average serum concentrations and diurnal variation in testosterone diminish as men age
  • 40% is sequestered with high affinity to sex hormone-binding globulin (SHBG)
  • almost 60% is bound with low affinity to albumin
  • 2% as free, unbound hormone
  • 5α-DHT has even greater binding affinity to sex hormone-binding globulin than does testosterone
  • 5α-DHT is only about 5% as abundant in the blood as testosterone and is largely derived from peripheral metabolism of testosterone
  • Both 5α-reduction and aromatization are irreversible processes
  • Approximately 90% of an oral dose of testosterone is metabolized before it reaches the systemic circulation
  • there are three modes of action of testosterone. It may directly act through AR in target tissues where 5α-reductase is not expressed, be converted to 5α-DHT (5–10%) by 5α-reductase before binding to AR, or be aromatized to estrogen (0.2%) and act through the estrogen receptor
  • 5α-DHT is a more potent AR ligand than testosterone
  • has 2–10-fold higher potency than testosterone in androgen-responsive tissues
  • estrogen plays a major role in regulating metabolic process,74,75 mood and cognition,76 cardiovascular disease,77,78 sexual function including libido,79 and bone turnover in men
  • Free testosterone is considered the most “biologically active” form
  • testosterone is the major androgen that acts in the “DHT-independent” tissues, such as skeletal muscle, where 5α-reductase is not expressed or is expressed at a very low level
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    good review of androgens and AR.
Nathan Goodyear

Testosterone Treatment Enhances Regional Brain Perfusion in Hypogonadal Men: The Journa... - 0 views

  • it is established that androgen modulates various neurotransmitters in the CNS. Testosterone decreases γ-aminobutyric acid concentration in the hypothalamus, which is blocked by flutamide, a testosterone receptor blocker (14, 15). Testosterone, probably by its conversion to estradiol, increases serotonin transporter mRNA expression in dorsal raphe nucleus (16), and it also increases the density of 5-hydroxytryptamine receptors and serotonin transporter sites in the forebrain (3, 16) of castrated male rats.
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    very interesting study of 7 men.  Increase brain perfusion found and symptom improvement as a result of Testosterone therapy in men ages 58-72.  Specific increase perfusion by SPECT scans were in the midbrain and Brodman areas 8 and 24 of the cerebral cortex.
Nathan Goodyear

Cognitive effects of estradiol after menopause - 0 views

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    No benefit to memory for post menopause women with estradiol therapy.  This study looked at early and late menopause estrogen therapy.  The study also found no harm.  Only abstract available here.  These studies would do more scientific benefit if they would follow hormone levels.  This study did not touch on dementia; other studies have shown benefit from estrogen therapy  in preventing dementia in women.
Nathan Goodyear

'Metabolic syndrome' in the brain: deficiency in omega-3 fatty acid exacerbates dysfunc... - 0 views

  • n-3 deficient diet and fructose interventions disrupted insulin receptor signalling in hippocampus as evidenced by a decrease in phosphorylation of the insulin receptor and its downstream effector Akt
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    rats fed high fructose diet and omega-3 diet found to have memory decline.  The purpose of this study was to look at the effects of Metabolic syndrome on the brain.
Nathan Goodyear

Cognitive improvement in mild to moderate Alzheime... [Clin Ther. 2003] - PubMed - NCBI - 0 views

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    alpha-GPC provides improvement in mild to moderate dementia found in Alzheimer's disease.
Nathan Goodyear

Oxytocin Increases Retention of Social Cognition in Autism - 0 views

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    oxytocin found to improve social symptoms in autism.  This is a very small study, but one that has be replicated.
Nathan Goodyear

Oxytocin Increases Retention of Social Cognition in Autism - 0 views

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    This could be a repeat post, but oxytocin shown to improve social behavior, especially recognition.
Nathan Goodyear

Dietary vitamin D deficiency in rats from middle to old age leads to elevated tyrosine ... - 0 views

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    Low dietary vitamin D intake associated with increased oxidative stress, NF-KappaB transcription and damage to brain in animal model.
Nathan Goodyear

Study Finds Estrogen Therapy Improves Depression and Anxiety in Recently Menopausal Wom... - 0 views

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    Estrogen therapy in women recently postmenopausal, found to improve symptoms of depression and anxiety.  The mean age of women in this study was 52.7.  Average age of menopause is 51, so apprx 1 year postmenopausal in this study.  Both premarin and bioidentical estradiol was used in different arms of the study.  Bioidentical progesterone was used in all 3 arms.
Nathan Goodyear

Long-term persistence of vaccine-derived alu... [J Inorg Biochem. 2009] - PubMed - NCBI - 0 views

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    Migration and long-term neurologic dysfunction as a result of aluminum hydroxide.
Nathan Goodyear

The memory enhancing effects of a ... [Psychopharmacology (Berl). 2000] - PubMed - NCBI - 0 views

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    Combination Ginkgo and Panax ginseng improves memory quality in small study of healthy middle-aged adults.
Nathan Goodyear

Effects of Thyroxine as Compared with Thyroxine plus Triiodothyronine in Patients with ... - 0 views

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    Armour Thyroid (T4 and T3 combined) provides better symptom control when compared to synthroid alone (T4)
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