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Nathan Goodyear

Autoimmune (auto-inflammatory) syndrome induce... [Curr Med Chem. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23992328

Macrophagic myofasciitis vaccine vaccines vaccinations ASIA autoimmune syndromes induced by adjuvants autoimmune disease adjuvants

shared by Nathan Goodyear on 01 Oct 14 - No Cached
  • Nathan Goodyear on 01 Oct 14
     
    Animal proof of concept supports the thought that adjuvants in vaccines induce auto inflammatory diseases.
francois appers

Vakantie in zicht: waa op letten bij huur to? - 0 views

www.leerwiki.nl/_waar_op_letten_bi_uur_auto%3F

vakantie auto huren hoe voordelig verzekering autohuur

shared by francois appers on 10 May 11 - No Cached
  • francois appers on 10 May 11
     
    Met de zomervakantie in zicht, ligt bij de meerderheid van onze landgenoten hun vakantiebestemming ongetwijfeld al geruime tijd vast. Maar hoe is het gesteld met het huren van een auto op onze toekomstige vakantiebestemming? Welk prijskaartje hangt er aan vast, en op wat moeten we zeker letten willen we tijdens onze vakantie voor geen onoverkomenlijke hindernissen worden geplaatst?
Nathan Goodyear

LRRK2 G2019S Impairs Chaperone-Mediated Autophagy in Neurons (S13.003) -- Kuo et al. 80... - 0 views

www.neurology.org/...S13.003

Parkinsons disease neurology Lewy Bodies Chaperone-mediated autophagy

shared by Nathan Goodyear on 01 Jun 13 - No Cached
  • Nathan Goodyear on 01 Jun 13
     
    impaired auto destruction process leads to the Lewy bodies found in Parkinson's disease.
Nathan Goodyear

Arthritis Research & Therapy | Abstract | Restoration of regulatory and effector T cell... - 0 views

arthritis-research.com/...abstract

lupus SLE vitamin D D3 vitamin D Th1 Th17 inflammation autoimmune disease autoimmunity arthritis

shared by Nathan Goodyear on 28 Oct 12 - No Cached
  • Nathan Goodyear on 28 Oct 12
     
    Vitamin D supplementation in those individuals with SLE found to benefit these patients.   Vitamin D found to reduce TH1 and Th17 activity.  It also was found to decrease memory B cells and auto-antibodies.  Also of note is the level of vitamin D after therapy-only at 51.4 at 2 months and 41.5 at 6 months.
star yu

Cuando Tiempo Puedo Vivir en la Etapa 2 de la Enfermedad Renal - 0 views

www.hospitalrenal.com/...905.html

el tratamiento

shared by star yu on 06 Sep 15 - No Cached
  • star yu on 06 Sep 15
     
    Micro-Medicina China es decir hierbas medicinales chinas son tratamiento eficaz para personas con insuficiencia renal .Pueden activa la auto-curación y auto-reparación de las nefronas dañados en los riñones. A:¿Cuando tiempo puedo vivir en la etapa 2 de la enfermedad renal ?
wheelchairindia9

Large Electric Scooters LY-EW415 - 0 views

www.wheelchairindia.com/...rge-Electric-Scooters-LY-EW415

Large Electric Scooters LY-EW415 Mobility Scooters Motorized Scooter Scooter Electric Power Scooter Large Wheel Scooter 4-Wheel Electric Scooter

shared by wheelchairindia9 on 02 Mar 16 - No Cached
  • wheelchairindia9 on 02 Mar 16
     
    Large Electric Scooters LY-EW415 Large Electric Scooters LY-EW415 with CTS Suspension offers a smooth ride with performance to match. Comfort-Trac Suspension (CTS) is the next generation in mobility scooter ride comfort. Large Electric Scooters LY-EW415 first technology incorporates advanced suspension components for improved absorption over rough surfaces, and a more comfortable ride experience over various terrains. Large Electric Scooters LY-EW415 Features Comfort-Trac front and rear suspension. Feather-touch disassembly permits simple frame separation with only one hand. Delta tiller with wraparound handles. Crush Proof Front Basket. Black, non-scuffing tires. Back-lit battery gauge. Full LED lighting package that includes curb and rear lights, directional signals and courtesy light under tiller. Auto connecting front to rear harness. Easy Grip Tiller adjustment knob. Easy access tiller-mounted charger port. Storage compartment below tiller. Enhanced flush-mounted horn buttons. Large Electric Scooters LY-EW415 Specifications Large medium scooter 450W motor(Optional 550W/750W)? 50AH battery Max speed: 12 km/h Max loading: 150 kg Suspension in front and rear wheels
wheelchairindia9

Pristine Flex Ostrich Mobility Wheelchair - 0 views

www.wheelchairindia.com/...ex-Ostrich-Mobility-Wheelchair

Pristine Flex Ostrich Mobility Wheelchair Ostrich Mobility Wheelchair pristine flex electric wheelchair Ostrich Wheel Chair Pristine FLEX Ostrich Pristine FLEX

shared by wheelchairindia9 on 04 Mar 16 - No Cached
  • wheelchairindia9 on 04 Mar 16
     
    Pristine Flex Ostrich Mobility Wheelchair Pristine is the most stylish powered wheelchair with revolutionary Split Frame Chassis (SFC). This indoor outdoor mobility equipment gives great comfort, stability and safety even in the toughest outdoor conditions. The body panels and the shopping basket make this equipment best suited for your kind of lifestyle. Pristine Flex Ostrich Mobility Wheelchair Features Split Frame Chassis (SFC). Call alarm, fault alarm, reverse alarm (on request). Low voltage alarm. Key pad locking. Mobility cut-off while charging. Auto shut-off after 3 minutes. Five speed selector. Length adjustable joystick control unit (can be changed from left to right and vice versa). Foldable, height adjustable and angle adjustable foot rest. Wide arm rest with height and width adjustment. Bucket seat with headrest and lap belt. Seat can be folded for transportation. Seat reclines 25 degrees in 6 steps. Removable and width adjustable calf support. Reflectors as per standards. Head lamp. Tail lamp. Pristine Flex Ostrich Mobility Wheelchair Specifications Load capacity: 110 Kg Speed: 9.5 Kmph max Speed selection: 5 speeds, Speed 1- 1.5Kmph, Speed 2-2.5 Kmph, speed 3- 4.8 Kmph, Speed 4- 7.2 Kmph, Speed 5- 9.5 Kmph Power: 320W Motor speed: 5300 rpm Gear ratio: 32:1 Brake: Electromagnetic Permissible Gradeability: 12 Degrees Drive range: 32-35 Km Ground clearance:2.5 inches Turn circle radius: 620mm Tire: Puncture free foam filled rubber tires Front- Tire diameter: 220X55 mm, Rear- Tire diameter: 320X72mm, Anti tippers-1 inch solid Battery: 24 Volt 48 Ah Sealed Maintenance Free VRLA Charger Input-230/240 Volts AC Single phase, Output-24 Volts-4 Amps DC Overall length with footrest (at 90 degree):1180mm, Overall width:640mm, Overall height: 1250mm, Overall height after folding the seat: 690mm, Overall weight: 102 Kg Seat depth: 500mm, Seat width:480mm, Backrest height: 540mm (without head rest), Backrest width: 440mm, Se
Nathan Goodyear

Oncotarget | NADH autofluorescence, a new metabolic biomarker for cancer stem cells: Id... - 0 views

www.oncotarget.com/index.php

vitamin C IV vitamin C cancer cancer stem cells milk thistle silymarin ascorbic acid bee propolis CAPE glycolytic inhibitor natural

shared by Nathan Goodyear on 08 Dec 17 - No Cached
  • Vitamin C was ~10 times more potent than 2-DG for the targeting of CSCs
  • Cancer stem-like cells (CSCs) are thought to be the root cause of chemotherapy-resistance and radio-resistance
  • ultimately leading to treatment failure in patients with advanced disease [1-3]. They have been directly implicated mechanistically in tumor recurrence and metastasis, resulting in poor patient survival
  • ...26 more annotations...
  • mitochondrial biogenesis may be a key driver of the CSC phenotype
  • Our results indicate that increased mitochondrial oxidative stress and high NADH levels are both key characteristics of the CSC metabolic phenotype
  • high levels of NAD(P)H auto-fluorescence are known to be a surrogate marker for mitochondrial “power”, high OXPHOS capacity and increased ATP production
  • CSCs may be strictly dependent on NAD(P)H to maintain their enhanced mitochondrial function
  • an intact NAD+ salvage pathway is strictly required for mammosphere formation, supporting our results using NAD(P)H auto-fluorescence, which enriched CSC activity by more than 5-fold.
  • Since glycolysis is especially critical for maintaining the TCA cycle, OXPHOS and overall mitochondrial function, we next assessed the effects of known glycolytic inhibitors
  • we show that two other natural products that function as effective glycolysis inhibitors, also inhibited mammosphere formation. More specifically, vitamin C (ascorbic acid), which induces oxidative stress and inhibits the activity of GAPDH (a key glycolytic enzyme) [17], also inhibited mammosphere formation, with an IC-50 of 1 mM (Figure 7B). Therefore, vitamin C was ~10 times more potent than 2-DG at targeting CSC propagation
  • silibinin (the major active constituent of silymarin, an extract of milk thistle seeds) [18], which specifically functions as an inhibitor of glucose uptake, blocked mammosphere formation, with an IC-50 between 200 and 400 µM
  • caffeic acid phenyl ester (CAPE), a key component of honey-bee propolis, has potent anti-cancer properties
  • Propolis has a strong history of medicinal use, dating back more than 2,000 years
  • Because of it aromatic ring structure (Figure 8), we speculated that CAPE might function as a potent inhibitor of oxidative mitochondrial metabolism
  • CAPE quantitatively inhibits the mitochondrial oxygen consumption rate (OCR) and, in turn, induces the onset of aerobic glycolysis (ECAR)
  • CAPE shows a clear selectivity for targeting CSCs and adherent cancer cells, relative to normal fibroblasts.
  • CAPE functions as a “natural” mitochondrial OXPHOS inhibitor, that preferentially targets the CSC sub-population. This could explain CAPE’s known anti-cancer properties
  • Our data directly shows that a small fraction of the total cell population, characterized by increased PGC1α activity, high mitochondrial ROS/H2O2 and high NADH levels, has the ability to survive and grow under anchorage-independent conditions, driving mammosphere formation
  • We highlight the utility of certain natural products, such as Silibinin, Vitamin C and CAPE, that could be used to therapeutically target CSCs. Silibinin is the major active component of silymarin, which is an extract prepared from milk thistle seeds.
  • high NADH is a property that is conserved between normal and cancerous stem cells
  • Previous studies have also shown that when non-CSCs and CSCs are both fed mitochondrial fuels (such as L-lactate or ketone bodies), that CSCs quantitatively produce more NADH in response to this stimulus
  • CSCs may be strictly dependent on NADH to maintain their enhanced mitochondrial function
  • The Noble Prize winner, Linus Pauling, was among the first to describe and clinically test the efficacy of Vitamin C, as a relatively non-toxic anti-cancer agent
  • Vitamin C has two mechanisms of action. First, it is a potent pro-oxidant, that actively depletes the reduced glutathione pool, leading to cellular oxidative stress and apoptosis in cancer cells. Moreover, it also behaves as an inhibitor of glycolysis, by targeting the activity of GAPDH, a key glycolytic enzyme.
  • Here, we show that Vitamin C can also be used to target the CSC population, as it is an inhibitor of energy metabolism that feeds into the mitochondrial TCA cycle and OXPHOS
  • Vitamin C may prove to be promising agent for new clinical trials, aimed at testing its ability to reduce CSC activity in cancer patients, as an add-on to more conventional therapies, to prevent tumor recurrence, further disease progression and metastasis
  • Interestingly, a breast cancer based clinical study has already shown that the use of Vitamin C, concurrent with or within 6 months of chemotherapy, significantly reduces both tumor recurrence and patient mortality
  • CAPE quantitatively reduces mitochondrial oxygen consumption (OCR), while inducing a reactive increase in glycolysis (ECAR). As such, it potently inhibits mammosphere formation with an IC-50 of ~2.5 µM. Similarly, it also significantly inhibits cell migration
  • we also demonstrate that 7 different inhibitors of key energetic pathways can be used to effectively block CSC propagation, including three natural products (silibinin, ascorbic acid and CAPE). Future studies will be necessary to test their potential for clinical benefit in cancer patients.
  • Nathan Goodyear on 08 Dec 17
     
    The future of cancer therapy is cancer stem cells.  Study finds that Vitamin C, silymarin, and bee propolis blocks mitochondrial energy pathways in cancer stem cells.  Vitamin C is a known glycolytic inhbitor. Vitamin C was found to inhibit glycolysis via GAPDH targeting to inhibit the energy pathways of the mitochondria in CSCs.  The authors propse that Vitamin C can be used as add on therapies for conventional therapies to specifically attack the CSCs and their contribution to recrurence, treatment resistance, and metastasis potential all in addition to the ability of vitamin C to reduce the side effects of chemotherapy.
spineneuro

Spine And Neuro Surgery Hospital India: Dr. Paresh Doshi Adding More to Life Through Ex... - 0 views

spineandneurosurgeryhospitalindia.blogspot.com/...nce-in-neurocare-in-india.html

Dr. Paresh Doshi DBS surgery specialist in India Best Deep Brain Stimulation Neurosurgeon in India Top Neurosurgeon at Jaslok Hospital Mumbai

shared by spineneuro on 13 Oct 21 - No Cached
  • spineneuro on 13 Oct 21
     
    As a neurosurgeon, Dr. Paresh Doshi has performed many lifesaving surgeries to remove brain tumors and blood clots. Recently he has performed a unique deep brain stimulation (DBS) surgical treatment using a complicated auto-sensing device (percept computer) for controlling the signs and symptoms of Parkinson's disease of a forty two-years-old patient, a scientist from Ahmedabad. For Appointment Email: dr.pareshdoshi@neurospinehospital.com Phone No.: +91-9325887033
Nathan Goodyear

Autoimmunity following Hepatitis B vaccine as part of the spectrum of 'Autoimmune (Auto... - 0 views

lup.sagepub.com/...146.short

ASIA autoimmune disease autoimmune adjuvants aluminum Macrophagic myofasciitis vaccine vaccines vaccinations

shared by Nathan Goodyear on 10 May 16 - No Cached
  • Nathan Goodyear on 10 May 16
     
    large case study of Autoimmune Syndrome Induced by Adjuvants; also known as ASIA.  Think of Aluminum as the perfect example and think of macrophages myofasciitis.
SEO Husain

Psoriasis information & treatment - Treat your Psoriasis with Homeopathy at Dr. Batra's - 0 views

www.drbatras.com/psoriasis

obesity hormone inflammation salivary saliva hormones disease cancer testing testosterone

shared by SEO Husain on 22 Aug 12 - No Cached
  • SEO Husain on 22 Aug 12
     
    Psoriasis is an auto-immune chronic condition that affects the growth cycle of skin cells. Treat your Psoriasis with Homeopathy at Dr. Batra's.
Nathan Goodyear

ANA Staining Pattern - 0 views

www.fpnotebook.com/...anstngptrn.htm

ANA staining pattern Lupus auto-immune disease Scleroderma Sjogren's syndrome mixed connective tissue CREST

shared by Nathan Goodyear on 05 Dec 11 - No Cached
  • Nathan Goodyear on 05 Dec 11
     
    ANA staining pattern
Nathan Goodyear

Access : Nonalcoholic fatty liver disease: Microbiota in the pathogenesis of systemic a... - 0 views

www.nature.com/...nrendo.2012.25.html

fatty liver disease NAFLD non-alcoholic fatty liver inflammation dysbiosis metabolic

shared by Nathan Goodyear on 02 Aug 12 - No Cached
  • Nathan Goodyear on 02 Aug 12
     
    Fascinating read of how inflammation as a direct result of dysbiosis in the gut contributes to the progression of NALFD.
Nathan Goodyear

Serum Folate, Homocysteine, Brain Atrophy, and Auto-CM System: The Treviso Dementia (TR... - 0 views

iospress.metapress.com/...d265g716533w7m71

Folate folic acid brain homocysteine dementia alzheimer disease

shared by Nathan Goodyear on 04 Dec 13 - No Cached
  • Nathan Goodyear on 04 Dec 13
     
    Folic acid inversely associated with brain atrophy.  Also, homocysteine is associated directly with brain atrophy in the cortical, subcortical, and hippocampus regions.
Nathan Goodyear

Mitoenergetic failure in Alzheimer disease - 0 views

ajpcell.physiology.org/...C8.abstract

neuro-toxicity Alzheimer's disease mitochondria

shared by Nathan Goodyear on 03 Mar 11 - No Cached
  • This review summarizes new insights based on the interaction of mitoenergetic failure, glutamate excitotoxicity, and amyloid toxicity in the exacerbation of AD.
  • Nathan Goodyear on 03 Mar 11
     
    discussion on mitochondria, neuro-excitotoxicity, and Alzheimer's Disease
star yu

Son Riñones Self Healing para la Enfermedad Renal Crónica - 0 views

www.hospitalrenal.com/...583.html

enfermedad renal crónica tratamiento

shared by star yu on 08 Mar 15 - No Cached
  • star yu on 08 Mar 15
     
    Sabes, algunos tejidos del cuerpo humano pueden curarse a sí mismos, por ejemplo, la fibrosis hepática y la cirrosis hepática es las manifestaciones patológicas de la regeneración hepática y reparación Sabes, algunos tejidos del cuerpo humano pueden curarse a sí mismos, por ejemplo, la fibrosis hepática y la cirrosis hepática es las manifestaciones patológicas de la regeneración hepática y reparación.Entonces, para los pacientes con enfermedad renal crónica, son los riñones auto sanación?
fnfdoc

Psoriasis: Causes, Symptoms, Types & Treatment - Health Blog - 0 views

fnfdoc.com/auses-symptoms-types-treatment

Psoriasis Psoriasis Causes Psoriasis Symptoms Psoriasis Types Psoriasis Treatment Common Causes Of Psoriasis Most Common Causes Of Psoriasis Genetics and Psoriasis Microbes And Psoriasis Key Signs And Symptoms Of Psoriasis Diagnose Psoriasis Most Popular

shared by fnfdoc on 11 Apr 20 - No Cached
  • fnfdoc on 11 Apr 20
     
    Psoriasis is a chronic skin condition that accelerates the rate at which your skin cells grow. An effective method to treat psoriasis is phototherapy or light therapy.
  • fnfdoc on 11 Apr 20
     
    Psoriasis is an auto-immune illness that affects almost three percent of the world's population. People who suffer from psoriasis experience a great deal of skin irritation and discomfort.
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