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Nathan Goodyear

Curcumin suppresses TGF-β signaling by inhibition of TGIF degradation in scle... - 0 views

www.sciencedirect.com/...S0006291X11012630

curcumin tumeric scleroderma autoimmune disease TGF-beta inflammation

shared by Nathan Goodyear on 22 Jan 14 - No Cached
  • Nathan Goodyear on 22 Jan 14
     
    Curcumin reduces fibrosis in scleroderma via TGF-beta inhibition.  TGF-beta plays an important role in the fibrosis in scleroderma.
Nathan Goodyear

T cells in systemic sclerosis: a reappraisal. - ResearchGate - 0 views

www.researchgate.net/...stemic_sclerosis_a_reappraisal

scleroderma IL-6 autoimmune disease cytokines

shared by Nathan Goodyear on 22 Jan 14 - No Cached
  • Nathan Goodyear on 22 Jan 14
     
    Article looks at the role of IL-6 in fibrosis in scleroderma.  The fibrosis in scleroderma appears to be a Th2 driven process.
Nathan Goodyear

http://www.anaturalhealingcenter.com/documents/Thorne/articles/scleroderma11-3.pdf - 0 views

www.anaturalhealingcenter.com/...scleroderma11-3.pdf

scleroderma vitamin E vitamin E natural therapy treatment autoimmune disease

shared by Nathan Goodyear on 22 Jan 14 - No Cached
  • Nathan Goodyear on 22 Jan 14
     
    Review of the science that support natural therapies in scleroderma.
Nathan Goodyear

Scleroderma - 8 - Fibroblasts, Systemic Sclerosis, Calcitriol - Life Extension Health C... - 0 views

www.lef.org/...scleroderma_08.htm

scleroderma natural therapy treatment

shared by Nathan Goodyear on 22 Jan 14 - No Cached
  • Nathan Goodyear on 22 Jan 14
     
    nice review of natural therapies for scleroderma.  Life extensions always does a great job of supporting natural therapies with science.
Nathan Goodyear

Treatment of linear scleroderma wit... [Pediatr Dermatol. 1999 Jan-Feb] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...10028002

scleroderma vitamin D vitamin D autoimmune disease

shared by Nathan Goodyear on 22 Jan 14 - No Cached
  • Nathan Goodyear on 22 Jan 14
     
    Very small study finds benefit, described as good to excellent, of vitamin D therapy in 5 of 7 children with linear, cutaneous scleroderma. Only the abstract is available, but one wonders if they were using sub-therapeutic therapy as most do.
Nathan Goodyear

Pediatric Scleroderma -Systemic and Localized Forms - 0 views

www.ncbi.nlm.nih.gov/...PMC3459339

autoimmune disease autoimmune disease scleroderma morpheme pediatric

shared by Nathan Goodyear on 09 Jan 14 - No Cached
  • Nathan Goodyear on 09 Jan 14
     
    pediatric scleroderma.
Nathan Goodyear

Cytokine profiles in localized scleroderma and relationship to clinical features - 0 views

www.ncbi.nlm.nih.gov/...PMC3632442

morphea autoimmune disease children scleroderma inflammation

shared by Nathan Goodyear on 22 Jan 14 - No Cached
  • Evaluation of the literature reveals a Th2 predominant cytokine profile in the biological specimens (sera, PBMCs, and tissue) of those with SSc
  • the literature available from studies in LS show that Th1, Th2, and Th17 cytokines may contribute equally to the pathogenesis of the disease
  • Classically, Th1 cells have been known to secrete IL-2, IFN-γ, and TNF-α, and are stimulated by IL-2 and IL-12
  • ...3 more annotations...
  • Th2 cells have been shown to be activated by IL-4 and produce IL-4, IL-5, IL-10 and IL-13
  • Th17 cells, a more recently identified Th cell subset that has altered the classic Th1/Th2 paradigm, produce IL-17 A/F, IL-21, and IL-22. IL-1, IL-6, IL-23, and TGF-β are now known to play important roles in the differentiation and propagation of the Th17 cell lineage
  • there is an overall notion that pro-inflammatory Th1 and Th17 associated cytokines are elevated during the early stages of scleroderma, whereas Th2 cytokines mainly correlate with disease damage and fibrosis extent
  • Nathan Goodyear on 22 Jan 14
     
    morphea
Nathan Goodyear

Effectiveness of a treatment based on mela... [Am J Ther. 2006 Jan-Feb] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...16428927

melatonin vitamin E vitamin E scleroderma autoimmune disease

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  • Nathan Goodyear on 22 Jan 14
     
    Very small study, 5 patients, found that melatonin + vitamin E provided stabilization of scleroderma at 2 months of therapy.
Nathan Goodyear

Effects of potassium para-aminobenzoate on... [J Invest Dermatol. 1979] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...155125

scleroderma fibrosis PABA autoimmune disease

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  • Nathan Goodyear on 22 Jan 14
     
    PABA at high doses shown to reduce fibrosis in those with scleroderma.
Nathan Goodyear

Systemic sclerosis: environmental factors. [J Rheumatol. 2009] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...19797508

scleroderma environmental toxin toxins autoimmune disease

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  • Nathan Goodyear on 22 Jan 14
     
    Environmental toxins such as slice and organic solvents have been associated with the development of scleroderma.  Other exposures include bacterial, viral, pesticides, prescription drugs...
Nathan Goodyear

Epidemiology of Systemic Sclerosis - 0 views

www.medscape.com/...758480

scleroderma silica environmental toxins toxin autoimmune disease

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  • Nathan Goodyear on 22 Jan 14
     
    silica exposure plays a role in the development of scleroderma
Nathan Goodyear

[Madecassol treatment of systemic and localized scl... [Ter Arkh. 1998] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...9644746

Gotu kola scleroderma inflammation autoimmune disease Centella asiatica

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  • Nathan Goodyear on 22 Jan 14
     
    Gotu kola found to benefit the fibrosis in scleroderma both via oral and topical dosing.
Nathan Goodyear

Curcumin-induced apoptosis in scleroderma lung fibroblasts - Role of protein kinase Cep... - 0 views

eurekamag.com/...of-protein-kinase-cepsilon.php

curcumin tumeric autoimmune disease scleroderma fibrosis

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  • Nathan Goodyear on 22 Jan 14
     
    Curcumin found to cause apoptosis of fibrotic pulmonary cells versus no effect on healthy pulmonary cells.
Nathan Goodyear

Serum 25OH vitamin D concentrations are linked with various clinical aspects in patient... - 0 views

www.researchgate.net/...y_and_review_of_the_literature

vitamin d vitamin D scleroderma autoimmune disease

shared by Nathan Goodyear on 22 Jan 14 - No Cached
  • Nathan Goodyear on 22 Jan 14
     
    Vitamin D levels inversely associated with fibrosis in scleroderma.
Nathan Goodyear

http://rheumatology.oxfordjournals.org/content/49/11/2024.full.pdf - 0 views

rheumatology.oxfordjournals.org/...2024.full.pdf

EGCG epigallocatechin-3-gallate green tea NF-kappaB inflammation scleroderma autoimmune disease

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  • Nathan Goodyear on 22 Jan 14
     
    EGCG found to reduce extra cellular matrix production, fibrosis, and NF-kappaB activity in those with scleroderma.
Nathan Goodyear

Modulation of Fibrosis in Systemic Sclerosis by Nitric Oxide and Antioxidants - 0 views

www.hindawi.com/...521958

scleroderma EGCG epigallocatechin-3-gallate green tea autoimmune disease oxidative stress sclerosis inflammation antioxidants

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  • Nathan Goodyear on 22 Jan 14
     
    Animal and human study finds protection against fibrosis with EGCG in those with scleroderma.
Nathan Goodyear

20S-hydroxyvitamin D3, noncalcemic product of CYP11A1 action on vitamin D3, exhibits po... - 0 views

europepmc.org/...23295467

scleroderma vitamin D vitamin d inflammation autoimmune disease

shared by Nathan Goodyear on 22 Jan 14 - No Cached
  • Nathan Goodyear on 22 Jan 14
     
    vitamin D decreased fibrogenesis in invivo mouse model of scleroderma.
Nathan Goodyear

ANA Staining Pattern - 0 views

www.fpnotebook.com/...anstngptrn.htm

ANA staining pattern Lupus auto-immune disease Scleroderma Sjogren's syndrome mixed connective tissue CREST

shared by Nathan Goodyear on 05 Dec 11 - No Cached
  • Nathan Goodyear on 05 Dec 11
     
    ANA staining pattern
Nathan Goodyear

Interleukin-17A and interleukin-23 in morphea - 0 views

www.ncbi.nlm.nih.gov/...PMC3542501

morphea cytokines inflammation scleroderma autoimmune disease

shared by Nathan Goodyear on 22 Jan 14 - No Cached
  • Nathan Goodyear on 22 Jan 14
     
    More discussion of morphea and the cytokine presentation.
Nathan Goodyear

Egr-ly awaiting a "personalized medicine" approach to treat scleroderma - 0 views

www.ncbi.nlm.nih.gov/...PMC3368023

morphea

shared by Nathan Goodyear on 22 Jan 14 - No Cached
  • Nathan Goodyear on 22 Jan 14
     
    morphea
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