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Nathan Goodyear

http://circ.ahajournals.org/content/109/17/2074.full.pdf - 0 views

circ.ahajournals.org/...2074.full.pdf

Testosterone Estradiol CVD atherosclerosis carotid intima-media thickness men male hormone hormones

shared by Nathan Goodyear on 16 Jan 14 - No Cached
  • Nathan Goodyear on 16 Jan 14
     
    lower Free Testosterone and increased Estradiol through aromatase activity is associated with increased atherosclerosis.  This was monitored with Carotid intima-media thickness.  This study found an increase associated with low free Testosterone and increased free estradiol levels independent of other CVD variables.
Nathan Goodyear

Circulating estradiol is an independ... [J Clin Endocrinol Metab. 2006] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...16940451

Estradiol men male hormone hormones carotid intima-media thickness CVD atherosclerosis

shared by Nathan Goodyear on 16 Jan 14 - No Cached
  • Nathan Goodyear on 16 Jan 14
     
    increased Total and free Estradiol associated with progression of carotid intima-media thickness in men ie. increased atherosclerosis.
Nathan Goodyear

SpringerPlus | Full text | Testosterone-derived estradiol production by male endotheliu... - 0 views

www.springerplus.com/...214

aromatase activity aromatase estradiol estrogen atherosclerosis hormone hormones male ER-alpha ER alpha

shared by Nathan Goodyear on 04 Oct 13 - No Cached
  • Nathan Goodyear on 04 Oct 13
     
    Mouse study, but aromatase activity and ER alpha required for atherosclerosis in male mice.
Nathan Goodyear

Effect of androgen replacement therapy... [Clin Endocrinol (Oxf). 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25280063

atherosclerosis carotid IMT carotid intima-media thickness low T low Testosterone idiopathic hypogonadotrophic hypogonadism men male hormone hormones CVD CAD

shared by Nathan Goodyear on 06 Oct 14 - No Cached
  • Nathan Goodyear on 06 Oct 14
     
    men with idiopathic hypogonadotropic hypogonadism have increased carotid IMT--atherosclerosis.  Testosterone therapy reduced carotid IMT.  
Nathan Goodyear

A new way of targeting to treat coronary artery disease : Journal of Cardiovascular Med... - 0 views

journals.lww.com/...o_treat_coronary_artery.1.aspx

curcumin quercetin garlic cardiovascular disease atherosclerosis

shared by Nathan Goodyear on 28 Apr 11 - No Cached
  • Nathan Goodyear on 28 Apr 11
     
    Curcumin, quercetin, and garlic useful as anti-atherosclerosis treatment
Nathan Goodyear

[Low testosterone lev... [Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24654539

women female hormone low hormones total testosterone testosterone atherosclerosis IMT intima-medial thickness CVD cardiovascular disease

shared by Nathan Goodyear on 31 Mar 14 - No Cached
  • Nathan Goodyear on 31 Mar 14
     
    Testosterone, like all other hormones, appears to have a "U" shape therapeutic curve in women.  This cohort study found increased atherosclerosis, as determined by IMT and usb, in women with low serum Total Testosterone.
Nathan Goodyear

Metabolic endotoxemia: a molecular link between obesity and cardiovascular risk - 0 views

jme.endocrinology-journals.org/...R51.full

metabolic endotoxemia obesity insulin resistance cardiovascular disease LPS inflammation

shared by Nathan Goodyear on 04 Aug 14 - No Cached
  • Weight gain has been associated with a higher gut permeability
  • a high-fat diet promotes LPS absorption
  • higher concentrations of fatty acids impair intestinal barrier integrity
  • ...37 more annotations...
  • The starting point for innate immunity activation is the recognition of conserved structures of bacteria, viruses, and fungal components through pattern-recognition receptors
  • TLRs are PRRs that recognize microbe-associated molecular patterns
  • TLRs are transmembrane proteins containing extracellular domains rich in leucine repeat sequences and a cytosolic domain homologous to the IL1 receptor intracellular domain
  • The major proinflammatory mediators produced by the TLR4 activation in response to endotoxin (LPS) are TNFα, IL1β and IL6, which are also elevated in obese and insulin-resistant patients
  • Obesity, high-fat diet, diabetes, and NAFLD are associated with higher gut permeability leading to metabolic endotoxemia.
  • Probiotics, prebiotics, and antibiotic treatment can reduce LPS absorption
  • LPS promotes hepatic insulin resistance, hypertriglyceridemia, hepatic triglyceride accumulation, and secretion of pro-inflammatory cytokines promoting the progression of fatty liver disease.
  • In the endothelium, LPS induces the expression of pro-inflammatory, chemotactic, and adhesion molecules, which promotes atherosclerosis development and progression.
  • In the adipose tissue, LPS induces adipogenesis, insulin resistance, macrophage infiltration, oxidative stress, and release of pro-inflammatory cytokines and chemokines.
  • the gut microbiota has been recently proposed to be an environmental factor involved in the control of body weight and energy homeostasis by modulating plasma LPS levels
  • dietary fats alone might not be sufficient to cause overweight and obesity, suggesting that a bacterially related factor might be responsible for high-fat diet-induced obesity.
  • This was accompanied in high-fat-fed mice by a change in gut microbiota composition, with reduction in Bifidobacterium and Eubacterium spp.
  • n humans, it was also shown that meals with high-fat and high-carbohydrate content (fast-food style western diet) were able to decrease bifidobacteria levels and increase intestinal permeability and LPS concentrations
  • it was demonstrated that, more than the fat amount, its composition was a critical modulator of ME (Laugerette et al. 2012). Very recently, Mani et al. (2013) demonstrated that LPS concentration was increased by a meal rich in saturated fatty acids (SFA), while decreased after a meal rich in n-3 polyunsaturated fatty acids (n-3 PUFA).
  • this effect seems to be due to the fact that some SFA (e.g., lauric and mystiric acids) are part of the lipid-A component of LPS and also to n-3 PUFA's role on reducing LPS potency when substituting SFA in lipid-A
  • these experimental results suggest a pivotal role of CD14-mediated TLR4 activation in the development of LPS-mediated nutritional changes.
  • This suggests a link between gut microbiota, western diet, and obesity and indicates that gut microbiota manipulation can beneficially affect the host's weight and adiposity.
  • endotoxemia was independently associated with energy intake but not fat intake in a multivariate analysis
  • in vitro that endotoxemia activates pro-inflammatory cytokine/chemokine production via NFκB and MAPK signaling in preadipocytes and decreased peroxisome proliferator-activated receptor γ activity and insulin responsiveness in adipocytes.
  • T2DM patients have mean values of LPS that are 76% higher than healthy controls
  • LPS-induced release of glucagon, GH and cortisol, which inhibit glucose uptake, both peripheral and hepatic
  • LPSs also seem to induce ROS-mediated apoptosis in pancreatic cells
  • Recent evidence has been linking ME with dyslipidemia, increased intrahepatic triglycerides, development, and progression of alcoholic and nonalcoholic fatty liver disease
  • The hepatocytes, rather than hepatic macrophages, are the cells responsible for its clearance, being ultimately excreted in bile
  • All the subclasses of plasma lipoproteins can bind and neutralize the toxic effects of LPS, both in vitro (Eichbaum et al. 1991) and in vivo (Harris et al. 1990), and this phenomenon seems to be dependent on the number of phospholipids in the lipoprotein surface (Levels et al. 2001). LDL seems to be involved in LPS clearance, but this antiatherogenic effect is outweighed by its proatherogenic features
  • LPS produces hypertriglyceridemia by several mechanisms, depending on LPS concentration. In animal models, low-dose LPS increases hepatic lipoprotein (such as VLDL) synthesis, whereas high-dose LPS decreases lipoprotein catabolism
  • When a dose of LPS similar to that observed in ME was infused in humans, a 2.5-fold increase in endothelial lipase was observed, with consequent reduction in total and HDL. This mechanism may explain low HDL levels in ‘ME’ and other inflammatory conditions such as obesity and metabolic syndrome
  • It is known that the high-fat diet and the ‘ME’ increase intrahepatic triglyceride accumulation, thus synergistically contributing to the development and progression of alcoholic and NAFLD, from the initial stages characterized by intrahepatic triglyceride accumulation up to chronic inflammation (nonalcoholic steatohepatitis), fibrosis, and cirrhosis
  • On the other hand, LPS activates Kupffer cells leading to an increased production of ROS and pro-inflammatory cytokines like TNFα
  • high-fat diet mice presented with ME, which positively and significantly correlated with plasminogen activator inhibitor (PAI-1), IL1, TNFα, STAMP2, NADPHox, MCP-1, and F4/80 (a specific marker of mature macrophages) mRNAs
  • prebiotic administration reduces intestinal permeability to LPS in obese mice and is associated with decreased systemic inflammation when compared with controls
  • Cani et al. also found that high-fat diet mice presented with not only ME but also higher levels of inflammatory markers, oxidative stress, and macrophage infiltration markers
  • This suggests that important links between gut microbiota, ME, inflammation, and oxidative stress are implicated in a high-fat diet situation
  • high-fat feeding is associated with adipose tissue macrophage infiltration (F4/80-positive cells) and increased levels of chemokine MCP-1, suggesting a strong link between ME, proinflammatory status, oxidative stress, and, lately, increased CV risk
  • LPS has been shown to promote atherosclerosis
  • markers of systemic inflammation such as circulating bacterial endotoxin were elevated in patients with chronic infections and were strong predictors of increased atherosclerotic risk
  • As a TLR4 ligand, LPS has been suggested to induce atherosclerosis development and progression, via a TLR4-mediated inflammatory state.
  • Nathan Goodyear on 04 Aug 14
     
    Very nice updated review on Metabolic endotoxemia
Nathan Goodyear

5-Methyltetrahydrofolate Rapidly Improves Endothelial Function and Decreases Superoxide... - 0 views

circ.ahajournals.org/...1193.long

BH4 5-methyltetrahydrofolate tetrahydrobiopterine MTHFR MTHFR A1298C eNOS NO nitric oxide atherosclerosis cardiovascular disease CVD

shared by Nathan Goodyear on 14 Sep 17 - No Cached
  • Nathan Goodyear on 14 Sep 17
     
    5-MTHF increases BH4 which increases eNOS activity and NO production providing improved endothelial function and thereby providing a mechanism to reduce atherosclerosis.  Interesting that the MTHFR A1298C decreases BH4 in contrast to the 677T.
Nathan Goodyear

Low carbohydrate diets improve atherogenic dyslipidemia even in the absence of weight loss - 0 views

www.ncbi.nlm.nih.gov/...PMC1488852

ketogenic diet low carbohydrate diet diet nutrition atherosclerosis cholesterol HDL LDL Triglycerides

shared by Nathan Goodyear on 09 Feb 18 - No Cached
mamdouh_hfz liked it
  • Nathan Goodyear on 09 Feb 18
     
    low carb diet found to benefit atherosclerosis and lipid abnormalities (Triglycerides, HDL, and LDL particle size).  Interesting enough, no significant weight loss was seen.
Nathan Goodyear

Hormone Replacement Therapy Associated with Lower Mortality - American College of Cardi... - 0 views

www.acc.org/...ssociated-with-lower-mortality

HRT hormone replacement therapy hormones menopause atherosclerosis cardiovascular disease hormone therapy

shared by Nathan Goodyear on 22 Mar 17 - No Cached
  • Nathan Goodyear on 22 Mar 17
     
    Just a press release of yet to be published study that finds women on HRT have lower atherosclerosis, calcium score, and death than younger women not on HRT.
Nathan Goodyear

Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge H... - 0 views

www.ncbi.nlm.nih.gov/...8622332

vitamins vitamin E alternative medicine safe CVD heart

shared by Nathan Goodyear on 13 Jun 16 - No Cached
  • Nathan Goodyear on 13 Jun 16
     
    vitamin E, in doses up to 800 IU daily, found to be safe and effective in reducing risk of non-fatal MI in individuals with symptomatic coronary atherosclerosis.
Nathan Goodyear

Associations of Salivary Cortisol Levels with Metabolic Syndrome and Its Components: Th... - 0 views

www.medaus.com/index.php

metabolic syndrome salivary saliva cortisol testing hormone hormones

shared by Nathan Goodyear on 08 Dec 11 - No Cached
  • Nathan Goodyear on 08 Dec 11
     
    Salivary cortisol testing used to evaluate cortisol pattern in those with metabolic syndrome.  In this study, they found no difference in cortisol pattern in people with metabolic syndrome.
Nathan Goodyear

High-dose testosterone is associated with atherosc... [Maturitas. 2007] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...16938416

Testosterone hormone hormones women female CVD cardiovascular health disease

shared by Nathan Goodyear on 20 Mar 14 - No Cached
  • Nathan Goodyear on 20 Mar 14
     
    One of the rare long-term studies of Testosterone in women.  This study was a respective study of high dose Testosterone.  The authors found an increase in atherosclerosis in the aorta versus non-HRT.
Nathan Goodyear

Beneficial and Adverse Effects of Testosterone on the Cardiovascular System in Men - 0 views

jcem.endojournals.org/...4300.abstract

low T Testosterone male men hormone hormones cardiovascular aging

shared by Nathan Goodyear on 14 Nov 13 - No Cached
  • Nathan Goodyear on 14 Nov 13
     
    pubmed review of 33 years finds mix bag on low T. Low T clearly associated with increased hypertension, dyslipidemia, atherosclerosis, thrombosis, cardiac dysfunction, and CV events.  Studies on Testosterone therapy in resolution of these dysfunctions are low.  This article claims there is a lack of evidence.  That is not true.  
Nathan Goodyear

Increased oxidative stress in obesity: Implications for metabolic syndrome, diabetes, h... - 0 views

www.sciencedirect.com/...S1871403X13000434

oxidative stress obesity hypertension dyslipidemia atherosclerosis cancer metabolic syndrome

shared by Nathan Goodyear on 11 Nov 13 - No Cached
  • Nathan Goodyear on 11 Nov 13
     
    increased oxidative stress, from obesity, linked to most diseases of aging.
Nathan Goodyear

Bioenergetic and antioxidant properties of coenzym... [Mol Biotechnol. 2007] - PubMed r... - 0 views

www.ncbi.nlm.nih.gov/...17914161

CoQ10 antioxidant

shared by Nathan Goodyear on 07 Feb 11 - No Cached
  • Nathan Goodyear on 07 Feb 11
     
    CoQ10 is antioxidant and is beneficial in atherosclerosis
Nathan Goodyear

Association Between Endogenous Sex Hormones and Liver Fat in a Mult... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25592661

Testosterone Estradiol SHBG hormone hormones men women non-alcoholic fatty liver fatty liver CVD cardiovascular disease cardiovascular disease

shared by Nathan Goodyear on 02 Feb 15 - No Cached
  • Nathan Goodyear on 02 Feb 15
     
    Time that physicians start following the science.  Study using data from the Multi-ethnic Study of Atherosclerosis was used to assess hormones and fatty liver in men and women.  Increasing bioavailable Testosterone levels in women was found to be associated with increasing fatty liver in post-menopausal women.  The opposite was found to be true in men.  Higher Estradiol levels were found to be associated with increased fatty liver in both sexes.  However, the statistical significance was higher with men.  Higher SHBG was associated with lower fatty liver incidence in men.  
Nathan Goodyear

Healthy Lifestyle Change and Subclinical Atherosclerosis in Young Adults - 0 views

circ.ahajournals.org/...10

health healthy lifestyle nutrition diet CVD atherosclerosis cardiovascular disease

shared by Nathan Goodyear on 07 Jul 14 - No Cached
  • Nathan Goodyear on 07 Jul 14
     
    For so many, lifestyles are seen as unobtainable and of limited benefit.  This study proves otherwise.  This study found that lifestyle changes made in middd-life were associated with a decrease in cardiovascular disease.  Equally important, many were found to be able to implement said lifestyle changes--this flies in the face of what a lot of physicians believe.
Nathan Goodyear

Garlic and Heart Disease - 0 views

jn.nutrition.org/...jn.114.202333

aged garlic extract garlic heart disease heart disease CRP hypertension cholesterol natural therapies natural medicine alternative medicine

shared by Nathan Goodyear on 27 Jan 16 - No Cached
  • Nathan Goodyear on 27 Jan 16
     
    another positive study on Aged Garlic Extract in the treatment of hypertension, total cholesterol, and atherosclerosis.
Nathan Goodyear

Antiinflammatory and Antiatherogenic Effects of the NF-κB Inhibitor Acetyl-11... - 0 views

atvb.ahajournals.org/...272.full

inflammation arteriosclerosis boswellia NF-kappaB LPS lipopolysaccharide frankincense

shared by Nathan Goodyear on 22 Jun 17 - No Cached
  • Nathan Goodyear on 22 Jun 17
     
    animal study finds LPS, via injection in this mouse study, increases atherosclerosis via increased .  What is very interesting is that Boswellia inhibited LPS stimulate NF-kappa B
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