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Nathan Goodyear

Rethinking vitamin C and cancer: an update on nutritional oncology - 0 views

www.riordanclinic.org/...89019191.pdf

IV IV vitamin C vitamin C intravenous cancer cytotoxic

shared by Nathan Goodyear on 29 May 13 - No Cached
  • Nathan Goodyear on 29 May 13
     
    1998 article that looks at the cytotoxic effects of vitamin C on cancer cells.
Nathan Goodyear

Journal Articles | The Riordan Clinic - 0 views

www.riordanclinic.org/...journal-articles

Riordan Clinic integrative medicine research articles

shared by Nathan Goodyear on 02 Jun 13 - No Cached
  • Nathan Goodyear on 02 Jun 13
     
    Nice review of the research published out of the Riordan Clinic.  This clinic is at the forefront of integrative medicine.
Nathan Goodyear

Dehydroepiandrosterone in systemic lupus erythematosus - 0 views

www.ncbi.nlm.nih.gov/...PMC2701249

DHEA hormone hormones autoimmune disease autoimmune Lupus SLE

shared by Nathan Goodyear on 02 Jun 13 - No Cached
  • Nathan Goodyear on 02 Jun 13
     
    DHEA therapy has provided benefit in autoimmune disease.  IN this study they review the previous articles and physiology behind DHEA's proposed benefit in autoimmune disease.
Nathan Goodyear

JAMA Network | JAMA | Association of All-Cause Mortality With Overweight and Obesity Us... - 0 views

jama.jamanetwork.com/article.aspx

obese obesity overweight mortality

shared by Nathan Goodyear on 02 Jan 13 - No Cached
  • Nathan Goodyear on 02 Jan 13
     
    Don't get to excited about this article.  It is just a meta-analysis.  Second, they looked at BMI and BMI is a notoriously bad estimater of muscle mass versus fat content.  I am the perfect example, my BMI has me as obese, yet my measured fat % is 16%.   My read on this, is most of the individuals that are "overweight" are actually at a health weight with a higher muscle mass percentage not picked up with the BMI measurement.
Nathan Goodyear

Metabolic Signatures of Exercise in Human Plasma - 0 views

www.ncbi.nlm.nih.gov/...PMC3010398

metabolic exercise human

shared by Nathan Goodyear on 10 Jan 13 - No Cached
  • Nathan Goodyear on 10 Jan 13
     
    Nice article that describes the biochemical benefits of exercise.
Nathan Goodyear

The hypothalamic-pituitary-adrenal axis and sex hormones in chronic stress and obesity:... - 0 views

www.ncbi.nlm.nih.gov/...PMC3464358

obesity overweight stress HPA hormones

shared by Nathan Goodyear on 19 Feb 13 - No Cached
  • Nathan Goodyear on 19 Feb 13
     
    Very nice article on the thoughts currently involving stress, overactivity of the HPA axis and obesity.
Nathan Goodyear

Lifestyle and nutritional imbalances associated with Western diseases: causes and conse... - 0 views

www.jnutbio.com/...fulltext

lifestyle inflammation diet nutrition disease

shared by Nathan Goodyear on 24 Jun 13 - No Cached
  • Nathan Goodyear on 24 Jun 13
     
    This study finds most "western" diseases are the result of environment and only <5% genetic. Evidence is growing that the environment is the largest contributor to disease.  The greatest environment contributor is diet. This is great, because we can change diet...if one wants too. This article also shows are current understanding on how dietary inflammation results in insulin/glucose disruption.
Nathan Goodyear

The therapeutic implications of ketone bodies: the effects of ketone bodies in patholog... - 0 views

www.sciencedirect.com/...S0952327803002217

ketogenic diet ketogenic diet

shared by Nathan Goodyear on 03 Jul 13 - No Cached
  • Nathan Goodyear on 03 Jul 13
     
    need to access this article
Nathan Goodyear

Diet, Microbiota and Immune System in Type 1 Diabetes Development and Evolution - 0 views

www.ncbi.nlm.nih.gov/...PMC4663589

diabetes type I diabetes dysbiosis gut gut flora gut microbiome gut microbiota

shared by Nathan Goodyear on 17 Oct 16 - No Cached
  • Nathan Goodyear on 17 Oct 16
     
    great review article on the relationship between gut dysbiosis and type I diabetes--particularly the bacteroidetes and Veillonella species; in contrast, Prevotella and Akkermansia special protects and maintains a healthy gut epithelium.
Nathan Goodyear

The Gut Microbiota and Type 1 Diabetes - 0 views

www.ncbi.nlm.nih.gov/...PMC4761565

diabetes type I diabetes gut gut flora gut health gut microbiome gut microbiota dysbiosis

shared by Nathan Goodyear on 17 Oct 16 - No Cached
  • A study by Bosi and colleagues suggested that the increased gut permeability preceded the clinical onset of T1D
  • gut permeability may be an important player in the development of T1D but, as yet, the findings in human studies have shown association but causation will be more difficult to prove.
  • Early childhood (≤ 3 month) introduction to cereals [10, 11] and cow's milk [48] were shown to promote beta cell autoimmunity
  • ...1 more annotation...
  • These findings suggest that prebiotics and probiotics could be potential therapeutic tools to improve gut integrity in various intestinal inflammatory and autoimmune diseases including T1D
  • Nathan Goodyear on 17 Oct 16
     
    another great review article of gut dysbiosis, altered gut permeability and type I diabetes.
Nathan Goodyear

Dietary carbohydrate restriction as the first approach in diabetes management: Critical... - 0 views

www.nutritionjrnl.com/...fulltext

ketogenic diet ketones diabetes nutrition diet ketogenic carbohydrate restriction carbohydrates

shared by Nathan Goodyear on 16 Nov 16 - No Cached
  • Nathan Goodyear on 16 Nov 16
     
    Excellent article on the ketogenic diet and the treatment of diabetes.   A ketogenic diet here was defined as < 10% carbs
Nathan Goodyear

Boswellia Serrata, A Potential Antiinflammatory Agent: An Overview - 0 views

www.ncbi.nlm.nih.gov/...PMC3309643

boswellia Frankincense inflammation NF-kappaB arthritis cancer osteoarthritis rheumatoid arthritis

shared by Nathan Goodyear on 07 Jun 16 - No Cached
  • Nathan Goodyear on 07 Jun 16
     
    review article of anti-inflammatory effects of Boswellia.  Boswellia inhibits 5-LOX and resultant leukotrienes.  3-actyl-11-keto-Beta-boswellic acid is the most potent inhibitor of 5-LOX.  As it relates to disease states and symptoms, Boswellia reduces pain in OA and RA.  Boswellia also shown to inhibit NF-kappa B: a potent nuclear transcription factor for inflammation.  In prostate cancer, Boswellia inhibits prostate tumor growth.
Nathan Goodyear

Polycystic Ovary Syndrome May Be an Autoimmune Disorder - 0 views

www.ncbi.nlm.nih.gov/...PMC4871972

PCOS polycystic ovarian syndrome TPO hormones inflammation autoimmune disease autoimmune

shared by Nathan Goodyear on 14 Jun 16 - No Cached
  • Nathan Goodyear on 14 Jun 16
     
    Article proposes that PCOS may be autoimmune.  Clearly it is inflammatory.
Nathan Goodyear

Deficient Glutathione in the Pathophysiology of Mycotoxin-Related Illness - 0 views

www.ncbi.nlm.nih.gov/...PMC3942754

myctotoxins glutathione GSH mold

shared by Nathan Goodyear on 12 Jan 15 - No Cached
  • Decreased function of the enzymes of glutathione production results in a microenvironment depleted of glutathione on a chronic basis
  • In humans, deficiency of glutathione can lead to chronic conditions [97], including chronic asthma
  • Nathan Goodyear on 12 Jan 15
     
    Mycotoxins deplete glutathione production and this depletion of glutathione is a portion go the toxicity/ill effects related to mycotoxins.  This article also points to evidence that glutathione can actually be employed in the treatment of mycotoxin related conditions/illnesses.
Nathan Goodyear

The inevitability of physician burnout: Implications for interventions - 0 views

www.sciencedirect.com/...S2213058614000084

physician burnout burnout

shared by Nathan Goodyear on 09 Jul 16 - No Cached
  • Nathan Goodyear on 09 Jul 16
     
    great article on physician burnout
Nathan Goodyear

Potential Therapeutic Effects of Curcumin, the Anti-inflammatory Agent, Against Neurode... - 0 views

www.ncbi.nlm.nih.gov/...PMC2637808

curcumin inflammation disease turmeric natural cardiovascular disease CVD autoimmune disease myeloperoxidase Diabetes IBD inflammatory bowel disease

shared by Nathan Goodyear on 15 Oct 13 - No Cached
  • The starting dose was 500 mg/day and if no toxicity was noted, the dose was then escalated to another level in the order of 1,000, 2,000, 4,000, 8,000, and 12,000 mg/day. There was no treatment-related toxicity up to 8 g/day but the bulky volume of the drug was unacceptable to the patients beyond 8 g/day.
  • The serum concentration of curcumin usually peaked at 1 to 2 hours after oral intake of curcumin and gradually declined within 12 hours
  • Nathan Goodyear on 15 Oct 13
     
    Great article on the benefits of curcumin in therapy for inflammation and disease.
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Nathan Goodyear

Cancer Chemopreventive Effects and Cytotoxic Activities of the Triterpene Acids from th... - 0 views

www.jstage.jst.go.jp/..._pdf

Frankincense Boswellia carteri cancer anticancer Triterpene Acid

shared by Nathan Goodyear on 11 Apr 12 - No Cached
  • Nathan Goodyear on 11 Apr 12
     
    component of Frankincese (Boswellia carter) shown to have anticancer properties. This article discusses the anticancer properties of Triterpene Acid.
Nathan Goodyear

Testosterone rates in normal adults - 0 views

www.ncbi.nlm.nih.gov/...jcinvest00287-0107.pdf

testosterone men male hormone hormones secretion rate

shared by Nathan Goodyear on 30 Apr 12 - No Cached
  • Nathan Goodyear on 30 Apr 12
     
    This article tags the normal testosterone rate in me at 4 to 11 mg daily.
Nathan Goodyear

Effects of Polyunsaturated Fatty Acids in Growth Medium on Lipid Composition and on Phy... - 0 views

www.ncbi.nlm.nih.gov/...PMC321255

PUFA poly unsaturated fatty acids GI dysbiosis bacteria microbiota

shared by Nathan Goodyear on 01 May 12 - No Cached
  • Nathan Goodyear on 01 May 12
     
    PUFA shown to effect GI bacterial balance.  Altering adhesion of lactobacillus to intestinal surface.  Also, lactobacilli species shown to alter PUFA metabolism in GI.  This article reveals the effect that diet can have on GI bacterial balance.
Nathan Goodyear

Adrenocortical dysregulation as a major player in insulin resistance and onset of obesity - 0 views

ajpendo.physiology.org/...E1465.long

cortisol insulin resistance metabolic syndrome obesity overweight

shared by Nathan Goodyear on 14 Mar 12 - No Cached
  • acute GC secretion during stress mobilizes peripheral amino acids from muscle as well as fatty acids and glycerol from peripheral fat stores to provide substrates for glucose synthesis by the liver
  • chronically elevated GC levels alter body fat distribution and increase visceral adiposity as well as metabolic abnormalities in a fashion reminiscent of metabolic syndrome
  • This local production may play an important role in the onset of obesity and insulin resistance.
  • ...9 more annotations...
  • In adipocytes, cortisol inhibits lipid mobilization in the presence of insulin, thus leading to triglyceride accumulation and retention.
  • Since the density of GC receptors is higher in intra-abdominal (visceral) fat than in other fat depots, the activity of cortisol leading to accumulation of fat is accentuated in visceral adipose tissue (24, 158), providing a mechanism by which excessive endogenous or exogenous GC lead to abdominal obesity and IR
  • obese patients generally have normal or subnormal plasma cortisol concentrations
  • This may be explained by an increased intratissular/cellular concentration of cortisol in adipose tissues
  • Intracellular GC may be produced from recycling of GC metabolites such as cortisone in adipose tissues
  • Local GC recycling metabolism is mediated by 11β-hydroxysteroid dehydrogenase enzymes (11β-HSD1 and 11β-HSD2
  • Cortisol also increases 11β-HSD1 expression in human adipocytes
  • In humans, elevated 11β-HSD1 expression in visceral adipose tissue is also associated with obesity
  • even if obese patients generally have normal or subnormal plasma cortisol concentrations (131, 158), triglyceride accumulation in visceral adipose tissue may be due, at least in part, to the local production of GC in insulin- and GC-responsive organs such as adipose tissue, liver, and skeletal muscle
  • Nathan Goodyear on 14 Mar 12
     
    another nice article on the dysregulation of cortisol and its role in insulin resistance, metabolic syndrome, and obesity.
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