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Nathan Goodyear

Bioavailability of Vitamin D2 and D3 in Healthy Volunteers, a Randomized Placebo-Contro... - 0 views

jcem.endojournals.org/...4339.abstract

vitamin D3 D vitamin d

shared by Nathan Goodyear on 18 Nov 13 - No Cached
  • Nathan Goodyear on 18 Nov 13
     
    Vitamin D3 is better than D2.  Vitamin D3 replacement raised 25(OH)D, whereas vitamin D2 caused a decline in levels.
Nathan Goodyear

Vitamin D3 Is More Potent Than Vitamin D2 in Humans -- Heaney et al. 96 (3): E447 -- Jo... - 0 views

jcem.endojournals.org/...E447

vitamin d3 D

shared by Nathan Goodyear on 16 May 11 - No Cached
  • D3 is approximately 87% more potent in raising and maintaining serum 25(OH)D concentrations and produces 2- to 3-fold greater storage of vitamin D than does equimolar D2
  • D3 should be the preferred treatment option when correcting vitamin D deficiency
  • Nathan Goodyear on 16 May 11
     
    Vitamin D3 87% more potent than D2; D3 should be the treatment for vitamin d deficiency
Nathan Goodyear

Access : Intravenous vitamin C can improve anemia in erythropoietin-hyporesponsive hemo... - 0 views

www.nature.com/...ncpneph0281.html

IV vitamin C vitamin C vitamin C IV intravenous vitamin C anemia

shared by Nathan Goodyear on 26 Aug 14 - No Cached
  • Nathan Goodyear on 26 Aug 14
     
    IV vitamin C improves anemia.  The only possible contribution of IV vitamin C and anemia is a G6PD deficiency.
Nathan Goodyear

Vitamin C and E supplementation hampers cellular adaptation to endurance training in hu... - 0 views

jp.physoc.org/...siol.2013.267419.full.pdf+html

vitamin C vitamin E exercise training recovery mitochondria endurance vitamins vitamin

shared by Nathan Goodyear on 18 Nov 14 - No Cached
  • Nathan Goodyear on 18 Nov 14
     
    Study finds oral vitamin C and vitamin E hamper mitochondrial repair needed in exercise.  
Nathan Goodyear

Randomized trial of vitamin D supplementation to prevent seasonal influenza A in school... - 0 views

ajcn.nutrition.org/...1255.long

vitamin d influenza flu vitamin d3 asthma

shared by Nathan Goodyear on 20 Sep 17 - No Cached
  • Nathan Goodyear on 20 Sep 17
     
    Nice study from a few years ago found that a low dose vitamin D3 (1200 IU) significantly reduced the relative risk of the flu in school age children.  Also of note, a significant reduction in asthma attacks in those children with asthma were significantly reduced in the vitamin D3 treated group.  One interesting thing about this study was that they did not check prior or during the study if vitamin D deficiency was even present.  This study was conducted in Japan
Nathan Goodyear

Vitamin C preferentially kills cancer stem cells in hepatocellular carcinoma via SVCT-2... - 0 views

www.nature.com/...s41698-017-0044-8

cancer cancer stem cells liver cancer vitamin C IV vitamin C oncology

shared by Nathan Goodyear on 30 Jan 18 - No Cached
  • Chen et al. have revealed that ascorbate at pharmacologic concentrations (0.3–20 mM) achieved only by intravenously (i.v.) administration selectively kills a variety of cancer cell lines in vitro, but has little cytotoxic effect on normal cells.
  • Ascorbic acid (the reduced form of vitamin C) is specifically transported into cells by sodium-dependent vitamin C transporters (SVCTs)
  • SVCT-1 is predominantly expressed in epithelial tissues
  • ...41 more annotations...
  • whereas the expression of SVCT-2 is ubiquitous
  • differential sensitivity to VC may result from variations in VC flow into cells, which is dependent on SVCT-2 expression.
  • high-dose VC significantly impaired both the tumorspheres initiation (Fig. 4d, e) and the growth of established tumorspheres derived from HCC cells (Fig. 4f, g) in a time-dependent and dose-dependent manner.
  • Hepatocellular carcinoma (HCC)
  • The antioxidant, N-acetyl-L-cysteine (NAC), preventing VC-induced ROS production (a ROS scavenger), completely restored the viability and colony formation among VC-treated cells
  • DNA double-strand damage was found following VC treatment
  • DNA damage was prevented by NAC
  • Interestingly, the combination of VC and cisplatin was even more effective in reducing tumor growth and weight
  • Consistent with the in vitro results, stemness-related genes expressions in tumor xenograft were remarkably reduced after VC or VC+cisplatin treatment, whereas conventional cisplatin therapy alone led to the increase of CSCs
  • VC is one of the numerous common hepatoprotectants.
  • Interestingly, at extracellular concentrations greater than 1 mM, VC induces strong cytotoxicity to cancer cells including liver cancer cells
  • we hypothesized that intravenous VC might reduce the risk of recurrence in HCC patients after curative liver resection.
  • Intriguingly, the 5-year disease-free survival (DFS) for patients who received intravenous VC was 24%, as opposed to 15% for no intravenous VC-treated patients
  • Median DFS time for VC users was 25.2 vs. 18 months for VC non-users
  • intravenous VC use is linked to improved DFS in HCC patients.
  • In this study, based on the elevated expression of SVCT-2, which is responsible for VC uptake, in liver CSCs, we revealed that clinically achievable concentrations of VC preferentially eradicated liver CSCs in vitro and in vivo
    • Nathan Goodyear
      Nathan Goodyear on 31 Jan 18
       
      the authors here made similar mistakes to the Mayo authors i.e. under doses here in this study.  They dosed at only 2 grams IVC.  A woefully low dose of IVC.
  • Additionally, we found that intravenous VC reduced the risk of post-surgical HCC progression in a retrospective cohort study.
    • Nathan Goodyear
      Nathan Goodyear on 31 Jan 18
       
      positive results despite a low dose used.
    • Nathan Goodyear
      Nathan Goodyear on 31 Jan 18
       
      Their comfort zone was 1mM.  They should have targeted 20-40 mM.
  • Three hundred thirty-nine participants (55.3%) received 2 g intravenous VC for 4 or more days after initial hepatectomy
  • As the key protein responsible for VC uptake in the liver, SVCT-2 played crucial roles in regulating the sensitivity to ascorbate-induced cytotoxicity
  • we also observed that SVCT-2 was highly expressed in human HCC samples and preferentially elevated in liver CSCs
  • SVCT-2 might serve as a potential CSC marker and therapeutic target in HCC
  • CSCs play critical roles in regulating tumor initiation, relapse, and chemoresistance
  • we revealed that VC treatment dramatically reduced the self-renewal ability, expression levels of CSC-associated genes, and percentages of CSCs in HCC, indicating that CSCs were more susceptible to VC-induced cell death
  • as a drug for eradicating CSCs, VC may represent a promising strategy for treatment of HCC, alone or particularly in combination with chemotherapeutic drugs
  • In HCC, we found that VC-generated ROS caused genotoxic stress (DNA damage) and metabolic stress (ATP depletion), which further activated the cyclin-dependent kinase inhibitor p21, leading to G2/M phase cell cycle arrest and caspase-dependent apoptosis in HCC cells
  • we demonstrated a synergistic effect of VC and chemotherapeutic drug cisplatin on killing HCC both in vitro and in vivo
  • Intravenous VC has also been reported to reduce chemotherapy-associated toxicity of carboplatin and paclitaxel in patients,38 but the specific mechanism needs further investigation
    • Nathan Goodyear
      Nathan Goodyear on 31 Jan 18
       
      so, exclude the benefit to patients until the exact mechanism of action, which will never be fully elicited?!?!?
  • Our retrospective cohort study also showed that intravenous VC use (2 g) was related to the improved DFS in HCC patients after initial hepatectomy
    • Nathan Goodyear
      Nathan Goodyear on 31 Jan 18
       
      Terribly inadequate dose.  Target is 20-40 mM which other studies have found occur with 50-75 grams of IVC.
  • several clinical trials of high-dose intravenous VC have been conducted in patients with advanced cancer and have revealed improved quality of life and prolonged OS
  • high-dose VC was not toxic to immune cells and major immune cell subpopulations in vivo
  • high recurrence rate and heterogeneity
  • tumor progression, metastasis, and chemotherapy-resistance
  • SVCT-2 was highly expressed in HCC samples in comparison to peri-tumor tissues
  • high expression (grade 2+/3+) of SVCT-2 was in agreement with poorer overall survival (OS) of HCC patients (Fig. 1c) and more aggressive tumor behavior
  • SVCT-2 is enriched in liver CSCs
  • these data suggest that SVCT-2 is preferentially expressed in liver CSCs and is required for the maintenance of liver CSCs.
  • pharmacologic concentrations of plasma VC higher than 0.3 mM are achievable only from i.v. administration
  • The viabilities of HCC cells were dramatically decreased after exposure to VC in dose-dependent manner
  • VC and cisplatin combination further caused cell apoptosis in tumor xenograft
  • These results verify that VC inhibits tumor growth in HCC PDX models and SVCT-2 expression level is associated with VC response
  • qPCR and IHC analysis demonstrated that expression levels of CSC-associated genes and percentages of CSCs in PDXs dramatically declined after VC treatment, confirming the inhibitory role of VC in liver CSCs
  • Nathan Goodyear on 30 Jan 18
     
    IV vitamin C in vitro and in vivo found to "preferentially" eradicate cancer stem cells.  In addition, IV vitamin C was found to be adjunctive to chemotherapy, found to be hepatoprotectant.  This study also looked at SVCT-2, which is the transport protein important in liver C uptake.
Nathan Goodyear

The association of vitamins C and K3 kills cancer cells mainly by autoschizis, a novel ... - 0 views

vitamin cancer vitamin C autoschizis IV vitamin C vitamin K3

shared by Nathan Goodyear on 24 Jul 19 - No Cached
  • Nathan Goodyear on 24 Jul 19
     
    Nice review of the adjuvant effects of vitamin C and vitamin K3 in the process of autoschizis of cancer cells.
Nathan Goodyear

Metabolomic alterations in human cancer cells by vitamin C-induced oxidative stress - P... - 0 views

pubmed.ncbi.nlm.nih.gov/26350063

NAC vitamin C high dose vitamin C high-dose vitamin C NAD cancer IV vitamin C high-dose IV vitamin C High dose IV vitamin C

shared by Nathan Goodyear on 03 Sep 22 - No Cached
  • Nathan Goodyear on 03 Sep 22
     
    NAD and NAC counter the effects of vitamin C IN CANCER
Nathan Goodyear

European Journal of Clinical Nutrition - C-reactive protein concentration and concentra... - 0 views

www.nature.com/...1601667a.html

IV vitamin C intravenous IV vitamin C antioxidants CRP ROS vitamins

shared by Nathan Goodyear on 10 Dec 12 - No Cached
  • Nathan Goodyear on 10 Dec 12
     
    This study shows that inflammation, CRP in this study, was inversely associated with low antioxidants ie. vitamin C.  This makes since as ROS are known to stimulate inflammation.  Vitamin C should be considered as a therapeutic option in those with inflammation.
Nathan Goodyear

Vitamin D, Mitochondria, and Muscle - 0 views

jcem.endojournals.org/...961.full

vitamin vitamin d vitamins muscle phosphocreatine mitochondria

shared by Nathan Goodyear on 18 Mar 13 - No Cached
  • Nathan Goodyear on 18 Mar 13
     
    editorial discussion of the benefit of vitamin D in mitochondrial function.   Those in the vitamin D repletion arm of the study had a quicker recovery time to restored phospho-creatinine levels.  The quicker the recovery of phospho-creatinine levels, the shorter recovery phase and the likely improvement in athletic performance.
Nathan Goodyear

False Positive finger stick blood glucose readings after high-dose intravenous vitamin C - 0 views

www.riordanclinic.org/...89024578.pdf

IV vitamin C vitamin C glucose vitamin C

shared by Nathan Goodyear on 18 Jun 13 - No Cached
  • Nathan Goodyear on 18 Jun 13
     
    IV vitamin C > 15 grams falsely elevates finger sticks on glucose. Glucose and vitamin C are very similar chemically. This, however, is a false reading.
Nathan Goodyear

Intravenous administration of vitamin C in the... [Med Sci Monit. 2010] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...20424557

IV IV therapy IV vitamin C nutritional therapy vitamin C herpetic neuralgia vitamins vitamin vitamin therapy

shared by Nathan Goodyear on 23 Jan 13 - No Cached
  • Nathan Goodyear on 23 Jan 13
     
    Two case studies that show IV vitamin C aided in the resolution of herpetic neuralgia.
Nathan Goodyear

Blood Pressure Effects of Vitamin C | Hypertension - 0 views

hyper.ahajournals.org/...789

blood pressure hypertension vitamin C

shared by Nathan Goodyear on 16 Jan 17 - No Cached
  • Nathan Goodyear on 16 Jan 17
     
    review article of studies on vitamin C and blood pressure finds mixed results.  I think it all comes down to dosing.  The authors highlight 2 studies to make their point. One find a significant reduction and another found a slight increase.  The dosing of the vitamin C was only 500 mg/day.  A woefully inadequate therapeutic dosing of vitamin C, especially when dealing with the significant deficiencies that can be found in disease states.
Nathan Goodyear

Vitamin B for treating peripheral... [Cochrane Database Syst Rev. 2008] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...18646107

B vitamins peripheral neuropathy neuropathy Vitamin B vitamins B

shared by Nathan Goodyear on 25 Jun 12 - No Cached
  • Nathan Goodyear on 25 Jun 12
     
    Cochrane review did show that B vitamins improve peripheral neuropathy; though less than alpha lipoic acid.  And B vitamins are well tolerated.
Nathan Goodyear

Vitamin D3 Is More Potent Than Vitamin D2 in Humans - 0 views

jcem.endojournals.org/...E447.abstract

Vitamin-D D3 D2 vitamin

shared by Nathan Goodyear on 30 Nov 11 - No Cached
  • Nathan Goodyear on 30 Nov 11
     
    Vitamin D3 is more potent (87%) and just a better form than is vitamin D2.
Nathan Goodyear

JAMA Network | Archives of Neurology | Reduced Risk of Alzheimer Disease in Users of An... - 0 views

archneur.jamanetwork.com/article.aspx

vitamin C vitamin E C E Alzheimer's disease Alzheimer's oxidative damage oxidative stress neurology antioxidant vitamin

shared by Nathan Goodyear on 13 Jun 12 - No Cached
  • Nathan Goodyear on 13 Jun 12
     
    Use of Vitamin C and Vitamin E associated with a 78% reduced prevalence of Alzheimer's disease.
Nathan Goodyear

http://onlinelibrary.wiley.com/store/10.1002/hep.21080/asset/21080_ftp.pdf;jsessionid=C... - 0 views

onlinelibrary.wiley.com/...FD1E43279D6DC7447C7FC1A.f04t01

vitamin C IV vitamin C IV intravenous cirrhosis

shared by Nathan Goodyear on 10 Feb 14 - No Cached
  • Nathan Goodyear on 10 Feb 14
     
    small study looked at patients with liver cirrhosis.  The authors used a low dose of IV vitamin C (5 grams) and found that this improved endothelial dysfunction.  Patients with cirrhosis were found to be low in vitamin C.  The IV vitamin C was well tolerated, despite a low dose.
Nathan Goodyear

Vitamin D in the healthy and inflamed central nervous system: access and function - 0 views

www.jns-journal.com/...abstract

vitamin D vitamin d CNS inflammation central nervous system MS multiple Sclerosis TBI

shared by Nathan Goodyear on 19 Mar 14 - No Cached
  • Nathan Goodyear on 19 Mar 14
     
    Vitamin D3 helpful in treatment of an inflamed CNS, such as in TBI, MS...Vitamin D protects against the development of MS and the progression of MS.
Nathan Goodyear

Long-Term Bioavailability After a Single Oral or Intramuscular Administration of 600,00... - 0 views

jcem.endojournals.org/...2709.abstract

Vitamin D D3 vitamin 25-OH D

shared by Nathan Goodyear on 22 Jul 13 - No Cached
  • Nathan Goodyear on 22 Jul 13
     
    This study is misleading.  Their conclusion is that D2 and D3 are equivalent in raising 25-OH vitamin D via po form preferentially over the IM form. However, when you look at the results, the response of D3 was statistically significant over that of D2.  That is the conclusion: vitamin D3 is the optimal form of vitamin D.
Nathan Goodyear

Altered Deoxyribonuclease Activity in Cancer Cells and its Role in Non Toxic Adjuvant C... - 0 views

ar.iiarjournals.org/...2727.full.pdf+html

autoschizis cancer IV vitamin C IV vitamin K3 vitamin C vitamin K3 vitamin C K K3

shared by Nathan Goodyear on 16 Oct 13 - No Cached
  • Nathan Goodyear on 16 Oct 13
     
    Combination of IV vitamin C and K3 in ratio of 100:1 shown to provide mechanism to induce cancer cell death through a process called autoschizis.
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