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Nathan Goodyear

Bioavailability of Vitamin D2 and D3 in Healthy Volunteers, a Randomized Placebo-Contro... - 0 views

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    Vitamin D3 is better than D2.  Vitamin D3 replacement raised 25(OH)D, whereas vitamin D2 caused a decline in levels.
Nathan Goodyear

Vitamin D3 Is More Potent Than Vitamin D2 in Humans - 0 views

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    Vitamin D3 is more potent (87%) and just a better form than is vitamin D2.
Nathan Goodyear

Long-Term Bioavailability After a Single Oral or Intramuscular Administration of 600,00... - 0 views

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    This study is misleading.  Their conclusion is that D2 and D3 are equivalent in raising 25-OH vitamin D via po form preferentially over the IM form. However, when you look at the results, the response of D3 was statistically significant over that of D2.  That is the conclusion: vitamin D3 is the optimal form of vitamin D.
Nathan Goodyear

Vitamin D3 Is More Potent Than Vitamin D2 in Humans -- Heaney et al. 96 (3): E447 -- Jo... - 0 views

  • D3 is approximately 87% more potent in raising and maintaining serum 25(OH)D concentrations and produces 2- to 3-fold greater storage of vitamin D than does equimolar D2
  • D3 should be the preferred treatment option when correcting vitamin D deficiency
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    Vitamin D3 87% more potent than D2; D3 should be the treatment for vitamin d deficiency
Nathan Goodyear

Vitamin D2 Is Much Less Effective than Vitamin D3 in Humans - 0 views

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    Vitamin D3 is more potent and longer acting than vitamin D2
Nathan Goodyear

Brain dopamine and obesity : The Lancet - 0 views

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    low Brain dopamine D2 receptors found to be inversely associated with BMI. 
Nathan Goodyear

Vitamin D supplementation for pre... [Cochrane Database Syst Rev. 2011] - PubMed - NCBI - 0 views

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    6% relative risk reduction in mortality with vitamin D3 vs. 2% relative risk increase with vitamin D2.
Nathan Goodyear

Sign In - 0 views

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    review of study that analyzed 94,000 people on vitamin D3 and D2.
Nathan Goodyear

Vitamin D3 Is More Potent Than Vitamin D2 in Human... [J Clin Endocrinol Metab. 2010] -... - 0 views

  • Given its greater potency and lower cost, D3 should be the preferred treatment option when correcting vitamin D deficiency.
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    Vitamin D3 better absorbed than D2: and should be the preferential treatment in vitamin D deficiency
Nathan Goodyear

Vitamin D3 Is More Potent Than Vitamin D2 in Humans - 0 views

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    vitamin D3 shown to be 87% more potent than vitamn D2
Nathan Goodyear

Neuropsychopharmacology - Striatal Dopaminergic and Serotonergic Markers in Human Heroi... - 0 views

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    study points to a modest decrease in dopamine and serotonin production in heroic users.  There appears to be a decrease in dopamine production, which could be via a down regulation of tyrosine hydroxylase enzyme and thus release.  Decreased homovanillate also noted.  Other studies have pointed to a decrease/downregulation of D2/D3 receptors.
Nathan Goodyear

Cellular and Molecular Basis of Deiodinase-Regulated Thyroid Hormone Signaling - 0 views

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    Anything and everything one would want to know regarding thyroid hormone signaling.  Doctors, especially endocrinologists, need to read this.  T4 is not or is ever inside target cells.  The enzymes, deiodinase types 1, 2, and 3, are what control the thyroid hormone at the cellular levels.  Deiodinase-2 is what generates T3 in the cytosol of the cell.  In contrast, deiodinase-3 is what generates rT3 which is inactive.  High Fat diet increases deiodinase-3.
Nathan Goodyear

The Role of Thyroid Hormones in Hepatocyte Proliferation and Liver Cancer - 0 views

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    Oxidative stress/inflammation via HIF-1alpha increase D3 which increases rT3 to increase proliferation in cancer; in contrast, there is a decrease in D1 and D2 to decrease T3 and T4. The question is the systemic versus the TME.
Nathan Goodyear

Interaction Between Ascorbic Acid and Dopamine D2 Receptor in the Nucleus Accumbens She... - 0 views

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    vitamin C shown to interact with dopamine receptors and decrease food intake.
Nathan Goodyear

Arch Intern Med -- Vitamin D2 Treatment for Vitamin D Deficiency and Insufficiency for ... - 0 views

  • may be less effective than cholecalciferol (vitamin D3)
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    Long term high dose Vitamin D proven to be effective.  No toxicity.
Nathan Goodyear

Opioid-induced nausea and vomiting - Smith - Annals of Palliative Medicine - 0 views

  • Some of the “emetogenic” receptors that have been proposed are dopamine-2 (D2), histamine-1 (H1), DOR, 5-hydroxytryptamine (serotonin) (5-HT3), acetylcholine (ACh), neurokinin-1 (NK-1), and cannabinoid receptor-1 (CB1)
  • Olanzapine decreased morphine-induced nausea and vomiting in a dose-dependent manner.
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    Good review of meds for nausea.
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