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Nathan Goodyear

Cellular and Molecular Basis of Deiodinase-Regulated Thyroid Hormone Signaling - 0 views

www.ncbi.nlm.nih.gov/...PMC2647704

thyroid hormone T3 T4 rT3 deiodinase selenium hormones

shared by Nathan Goodyear on 10 Nov 14 - No Cached
  • Nathan Goodyear on 10 Nov 14
     
    Anything and everything one would want to know regarding thyroid hormone signaling.  Doctors, especially endocrinologists, need to read this.  T4 is not or is ever inside target cells.  The enzymes, deiodinase types 1, 2, and 3, are what control the thyroid hormone at the cellular levels.  Deiodinase-2 is what generates T3 in the cytosol of the cell.  In contrast, deiodinase-3 is what generates rT3 which is inactive.  High Fat diet increases deiodinase-3.
Nathan Goodyear

Type 3 Deiodinase: Role in Cancer Growth, Stemness, and Metabolism - 0 views

www.ncbi.nlm.nih.gov/...PMC4269192

rT3 reverse T3 HIF-1alpha CSC deiodinase D3 cancer stem cells cancer

shared by Nathan Goodyear on 30 Jan 21 - No Cached
  • Nathan Goodyear on 30 Jan 21
     
    Amazing article. Increased deiodinase 3 activity in cancer increases rT3 production. What drives the increase in deiodinase 3?
Nathan Goodyear

IL-6 promotes nonthyroidal illness syndrome by blocking thyroxine activation while prom... - 0 views

europepmc.org/3083773

rT3 reverse T3 T3 thyroid deiodinase-3 inflammation IL-6 thyroid hormones T4

shared by Nathan Goodyear on 04 Feb 21 - No Cached
  • Nathan Goodyear on 04 Feb 21
     
    IL-6 decreases deiodinase type I and 2; but increases type 3. The result is an increase in rT3 and in cancer-growth.
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