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Nathan Goodyear

Inflammation as a Link between Obesity and Metabolic Syndrome - 0 views

www.hindawi.com/...476380

inflammation obesity metabolic syndrome metabolic syndrome disease

shared by Nathan Goodyear on 14 Jan 13 - No Cached
  • Nathan Goodyear on 14 Jan 13
     
    inflammation shown to play a critical role in disease.  Here obesity causes inflammation, but obesity is the result of inflammation.  This then leads to metabolic syndrome, through which disease starts.
Nathan Goodyear

Low doses of LPS and minimally oxidized LDL cooperatively activate macrophages via NF-k... - 0 views

www.ncbi.nlm.nih.gov/...PMC2904601

metabolic endotoxemia atherosclerosis CVD cardiovascular disease inflammation

shared by Nathan Goodyear on 14 Jan 13 - No Cached
  • Nathan Goodyear on 14 Jan 13
     
    metabolic endotoxemia shown to play role in atherosclerosis lesion acceleration.  
Nathan Goodyear

Endotoxemia Is Associated With an Increased Risk of Incident Diabetes - 0 views

care.diabetesjournals.org/...392.short

metabolic endotoxemia diabetes inflammation

shared by Nathan Goodyear on 14 Jan 13 - No Cached
  • Nathan Goodyear on 14 Jan 13
     
    metabolic endotoxemia has been shown to play a role in the development of Diabetes.
Nathan Goodyear

Interaction between a peroxisome proliferator-activated receptor γ gene polym... - 0 views

hmg.oxfordjournals.org/...2923.long

peroxisome proliferator activated receptor gamma PPAR PPAR-gamma epigenetics obesity fat dietary diet intake gene genetics

shared by Nathan Goodyear on 21 Jan 13 - No Cached
  • uniform dietary recommendations may not be appropriate for all individuals
  • Nathan Goodyear on 21 Jan 13
     
    Peroxisome proliferator-activated receptor gamma plays an important role in obesity and fat generation.  In this study, they showed how the genetic expression of different PPAR gamma genotypes results in altered physiologic response to fat intake in humans.  The interaction between genetics and the environment.
Nathan Goodyear

Familial resemblance of 7-year changes in body mass... [Obes Res. 2002] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...12055327

epigenetics genetics BMI obesity

shared by Nathan Goodyear on 21 Jan 13 - No Cached
  • Nathan Goodyear on 21 Jan 13
     
    Genetics found to play a role in body mass, adiposity, BMI.  The only measure not shown to be associated is waist circumference.
Nathan Goodyear

An obesity-associated gut microbiome with increased capacity for energy harvest : Abstr... - 0 views

www.nature.com/...nature05414.html

gut bacteria dysbiosis microbiota balance obesity overweight metabolic endotoxemia

shared by Nathan Goodyear on 15 Jan 13 - No Cached
  • Nathan Goodyear on 15 Jan 13
     
    gut bacteria balance associated with obesity.  The balance of ones gut bacteria plays a significant role in whether a high fat,western diet leads to obesity or not.
Nathan Goodyear

Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fa... - 0 views

diabetes.diabetesjournals.org/...1470.full.pdf

dysbiosis obesity endotoxemia diabetes gut metabolic endotoxemia

shared by Nathan Goodyear on 15 Jan 13 - No Cached
  • Nathan Goodyear on 15 Jan 13
     
    This article discusses how an imbalance gut bacteria balance leads to endotoxemia and resultant obesity and diabetes. So, the balance of gut bacteria plays a role in obesity. Really changes ones view of how the body interacts and how disease develops through dysfunction.
Nathan Goodyear

Oxidative response gene polymorphisms and risk of adult brain tumors - 0 views

www.ncbi.nlm.nih.gov/...PMC2666247

brain tumor tumors CNS oxidative damage meningioma glioma

shared by Nathan Goodyear on 04 Mar 13 - No Cached
  • Nathan Goodyear on 04 Mar 13
     
    Good study shows that genetic polymorphisms play role in brain tumor risk with oxidative damage.  This study found an increased risk with SOD 2/3, and with CAT polymorphisms.  
Nathan Goodyear

Vitamin D Deficiency Modulates Graves' Hyperthyroidism Induced in BALB/c Mice by Thyrot... - 0 views

www.ncbi.nlm.nih.gov/...PMC2646531

vitamin vitamin d deficiency vitamin D deficiency low vitamin D Graves Graves disease hyperthyroid autoimmune disease autoimmune disease inflammation

shared by Nathan Goodyear on 15 May 13 - No Cached
  • Nathan Goodyear on 15 May 13
     
    Low vitamin D plays a role in immune response associated with Graves disease.  This study found small impact, but impact nonetheless.
Nathan Goodyear

Plasma concentration of gonadotrophins,... [Br J Obstet Gynaecol. 1975] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...1148139

hormone hormones estrogen progesterone hypothyroid hypothyroidism

shared by Nathan Goodyear on 03 Jun 13 - No Cached
  • Nathan Goodyear on 03 Jun 13
     
    Sex hormone imbalance plays a role in hypothyroidism.
Nathan Goodyear

Maternal 25-Hydroxyvitamin D and Preterm Birth in Twin Gesta... : Obstetrics & Gynecology - 0 views

journals.lww.com/...nd_Preterm_Birth_in.99784.aspx

vitamin D PTD preterm delivery pregnancy

shared by Nathan Goodyear on 07 Jun 13 - No Cached
  • Nathan Goodyear on 07 Jun 13
     
    vitamin D associated with increased Pre term delivery in twin pregnancies.  This is a cohort, so not the most reliable of study designs, but known that vitamin D inhibits inflammation and that this plays a role in labor...logic makes sense.
Nathan Goodyear

Evolving utility of sex h... [Curr Opin Endocrinol Diabetes Obes. 2012] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22531107

SHBG diabetes metabolic syndrome cardiovascular disease

shared by Nathan Goodyear on 08 Jun 13 - No Cached
  • Nathan Goodyear on 08 Jun 13
     
    SHBG plays more of a role than just sex hormone levels.  This study shows effect in metabolic syndrome, diabetes, and cardiovascular disease.
Nathan Goodyear

The role of prolactin levels in the sexual activity ... [BJU Int. 2006] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...17125484

prolactin low libido ED

shared by Nathan Goodyear on 17 Jun 13 - No Cached
  • Nathan Goodyear on 17 Jun 13
     
    Elevated Prolactin level plays role in ED and reduced sexual activity in men.
Nathan Goodyear

PLOS ONE: Birth Weight and Long-Term Overweight Risk: Systematic Review and a Meta-Anal... - 0 views

www.plosone.org/...journal.pone.0047776

obesity overweight pregnancy birth weight

shared by Nathan Goodyear on 11 Jan 13 - No Cached
  • Nathan Goodyear on 11 Jan 13
     
    An individuals obesity risk is effected prior to birth.  The health status of the mother plays a role in the obesity risk of her children.  
Nathan Goodyear

Transcriptional targets shared by estrogen receptor-related receptors (ERRs) and estrog... - 0 views

www.ncbi.nlm.nih.gov/...004270.pdf

estrogen related receptors estrogen receptor receptors estrogen related elements hormone hormones

shared by Nathan Goodyear on 09 Jan 13 - No Cached
  • Nathan Goodyear on 09 Jan 13
     
    estrogen related receptors play a role in estrogen signaling, though they don't bind estradiol. They bind estrogen related elements. Exact role is unknown. They are called "orphan" members of the nuclear family of receptors.
Nathan Goodyear

Transcriptional regulation of the GL... [Trends Endocrinol Metab. 2007] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...17317207

inflammation PPAR-gamma GLUT4 insulin resistance obesity weight gain

shared by Nathan Goodyear on 05 May 13 - No Cached
  • Nathan Goodyear on 05 May 13
     
    Inflammation causes dysregulation of GLUT4 receptor.  This leads to insulin resistance and associated weight gain.  PPAR gamma plays a role here.
Nathan Goodyear

Thyrotropin suppression by metformin in a cohort of patients with differentiated thyroi... - 0 views

www.endocrine-abstracts.org/...ea0020p141.htm

TSH thyroid metformin

shared by Nathan Goodyear on 31 Jan 13 - No Cached
  • Nathan Goodyear on 31 Jan 13
     
    Again, showing that metformin suppresses TSH secretion without change in actual thyroid hormone levels.  We know that inflammation plays a role in HPA suppression, why not with TSH?
Nathan Goodyear

SIRT3 Weighs Heavily in the Metabolic Balance: A New Role for SIRT3 in Metabolic Syndrome - 0 views

biomedgerontology.oxfordjournals.org/...105.full

SIRT3 metabolic syndrome mitochondria acetylation high fat diet diet

shared by Nathan Goodyear on 12 Feb 13 - No Cached
  • Nathan Goodyear on 12 Feb 13
     
    SIRT3 activity plays role in the development of metabolic syndrome in those fed a typical American high fat diet.
Nathan Goodyear

Is There an Association Between Meningioma and Hormone Replacement Therapy? - 0 views

jco.ascopubs.org/...279.full

meningioma hormones estrogen receptors estrogen receptor brain tumors progesterone receptors progesterone

shared by Nathan Goodyear on 05 Feb 13 - No Cached
  • Nathan Goodyear on 05 Feb 13
     
    Hormones linked to increase meningioma in women.   Clearly, the evidence shows that hormone receptors play a significant role in the growth and the potential management of these tumors.
Nathan Goodyear

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 d... - 0 views

www.ncbi.nlm.nih.gov/...PMC3018764

glucose diabetes genes genetics

shared by Nathan Goodyear on 24 Jan 13 - No Cached
  • Nathan Goodyear on 24 Jan 13
     
    genetics play role in glucose homeostasis.
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