study of Saudi women with PCOS finds elevated LH/FSH ratio and elevated total Testosterone levels independent of age and weight; in addition, lower FSH, SHBG, and progesterone levels we found.
women with PCOS, inflammatory cytokines TNF-alpha and CRP, associated with increasing androgen levels and with abdominal fat. Women with less fat had lower levels of TNF-alpha and CRP than their higher weight counterparts, though the inflammatory cytokines were still evident.
It is well known that obesity increases CRP. However, in this meta-analysis, CRP elevation in women with PCOS was found to be independent from obesity and as they concluded: "...chronic low-grade inflammation that may underpin the pathogenesis of this disorder".
elevated insulin associated with insulin resistance causes elevated male hormones in women. Whether it is in PCOS or postmenopausal over-aggressive replacement, Testosterone also turns right around and contributes to insulin resistance. Vicious cycle.
Only abstract available. Resveratrol found to reduce total Testosterone by 23% and DHEAS by 22% in women with PCOS; a decrease in insulin by 32% and improved insulin sensitivity was also noted.
high prevalence of thyroid antibodies, TPO, in women with PCOS. This does not prove cause and effect, merely an association. Both are inflammation driven.
lean women with PCOS found to have reduced 11 beta-HSD1 and increased 5 alpha reductase activity. This, in part, is associated with the elevated cortisol and androgens in these women.
Women with PCOS have associated increased inflammation. This origin is primarily via adipose tissue and associate adipocytokines (TNF-alpha, and IL-6). CRP elevation, as found in this study, is associated with increased CVD.
green tea not shown improve weight loss in obese chinese women with PCOS. Study doesn't identify the type of green tea. There are many types and qualities of green teas.
elevated androgens (male hormones) correlated with low grade inflammation and atherogenesis in women with PCOS. This was found more in those women that were obese.
This study finds an association between low SHBG and increased metabolic syndrome in obese women with PCOS. Testosterone was not associated. Other studies have shown a positive association between Testosterone and MetS in women. This follows men in that SHBG shows an association with MetS. Only the abstract is present here, so I can't look at the data presented.
Animal model of PCOS provides insight to changes in vascular response. In this animal mode, DHT resulted in a decrease in vasorelaxation of arterial endothelium.