The medical field continues to be amazed that people are different. More, that different people groups are different. This study found that black women with PCOS have an elevated risk of metabolic syndrome when compared to white women with PCOS. Body weight was a variable that was controlled for. This was a retrospective study.
Post menopause women with PCOS have high CVD. PCOS is essentially metabolic syndrome separated by age. Both PCOS and MetS in women is associated with an increase in Testosterone levels.
Weight loss is the best positive effect for women with PCOS. Higher fat and protein, with a lower carb diet benefited women with PCOS. A low Glycemic index plan benefited women with PCOS.
Though this article looked at diet and exercise on PCOS, this article gives a great review of the pathophysiology of PCOS. This study did show that diet and exercise were effective in lowering androgens and improving insulin resistance.
Statin therapy worsens insulin sensitivity and thus glucose regulation in women with PCOS. Women with PCOS are at increased risk for type II Diabetes. Statins interfere with glucose metabolism and thus will increase the effective risk for these women. This study was a randomized, prospective study.
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low grade, chronic inflammation associated with PCOS and common disease states associated with PCOS. It is known that high androgen levels in women causes inflammation.
In women with PCOS, inflammation DIRECTLY stimulates androgen production from the ovaries. Inflammation is the driving force behind the high androgen levels in women with PCOS.
The point of this post is not that the author concludes that metformin an statin therapy should be used in PCOS women on birth control with elevated cardiovascular risk; but that with struggling with PCOS should have cardiovascular risk assessment prior to starting birth control. Again, back to the individualized approach paradigm.
This study finds no association between PCOS and inflammation, when matched with age/BMI controls. However, inflammation was associated with increased BMI. Not all women with PCOS are overweight. But, the majority are and this would contribute to inflammation and thus CVD.
Study shows good predictive value, with very high correlation with free serum levels, of salivary androstenedione and salivary Testosterone levels in women with PCOS. This study suggests using salivary androstenedione:salivary testosterone be used in the diagnosis of PCOS.
This study looked at post menopause women and found that those with PCOS had an increase in CAD and worse cardiovascular event survival. PCOS is a metabolic syndrome, in part, driven by elevated androgens in women.
Study finds that increasing body fat and associated insulin resistance in women with PCOS is associated with an increase in CRP. These women with PCOS are hyperandrogenic. It makes absolutely no sense to give these women more Testosterone.
When you look at PCOS in women, it is really just the early manifestation of Metabolic Syndrome. PCOS no longer needs to be viewed through the prism of hormones and/or infertility but the means through which disease will walk.