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Nathan Goodyear

Large Differences in Testosterone Excretion in Korean and Swedish Men Are Strongly Asso... - 0 views

jcem.endojournals.org/...687.full

Testosterone epi-Testosterone metabolism UGT2B17 SNP korean swedish

shared by Nathan Goodyear on 20 Feb 12 - No Cached
  • Nathan Goodyear on 20 Feb 12
     
    men with UGT2B17 found to be poor metabolizers of endogenous Testosterone.  Normally, epi-Testosterone and Testosterone exist in a relative 1:1 ratio,  However, in these individuals with this SNP, they will have slightly elevated Testosterone levels due to disrupted phase II testosterone metabolism (glucuronidation).  This is found in 60% of Asian men, 50% of black men, and 1% in white men.
Nathan Goodyear

Glucocorticoids and 11beta-hydroxysteroid... [Minerva Endocrinol. 2007] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...17912154

cortisol 11-betaHSD1 obesity metabolic syndrome

shared by Nathan Goodyear on 14 Mar 12 - No Cached
  • Nathan Goodyear on 14 Mar 12
     
    Dysregulation of 11-betaHSD1 plays significant role in metabolic syndrome.  Decreased 11-betaHSD activity is found in the liver and increased 11-betaHSD1  is found in peripheral fat.  Take home: 11-betaHSD1 activity and cortisol metabolism differs in different tissue
Nathan Goodyear

Metabolic Syndrome and Urologic Diseases - 0 views

www.ncbi.nlm.nih.gov/...PMC3020279

inflammation low T low testosterone TNF-alpha IL-1B metabolic syndrome MetS metabolic syndrome

shared by Nathan Goodyear on 29 Aug 12 - No Cached
  • Nathan Goodyear on 29 Aug 12
     
    Inflammation, TNF-alpha and IL-1B, reduces testosterone production.  Metabolic Syndrome, an inflammatory disease, shown to be associated low Testosterone.
Nathan Goodyear

metabolic endotoxemia - 1 views

dl-web.dropbox.com/...metabolic%20endotoxemia.pdf

metabolic endotoxemia inflammation insulin resistance obesity overweight LPS

shared by Nathan Goodyear on 20 Jan 12 - No Cached
  • Nathan Goodyear on 20 Jan 12
     
    great read on the current understanding on metabolic endotoxemia.
Nathan Goodyear

Study suggests nut consumption benefits for metabolic syndrome - 0 views

www.nutraingredients.com/...enefits-for-metabolic-syndrome

metabolic syndrome serotonin inflammation dietary intervention

shared by Nathan Goodyear on 14 Nov 11 - No Cached
  • Nathan Goodyear on 14 Nov 11
     
    Got metabolic syndrome: get alittle nutty, or just eat nuts.
Nathan Goodyear

Effects of testosterone supplementation on markers of the metabolic syndrome and inflam... - 0 views

onlinelibrary.wiley.com/...full

Testosterone therapy replacement low T metabolic syndrome IL-1B TNF-alpha CRP inflammation insulin leptin

shared by Nathan Goodyear on 01 Feb 12 - No Cached
  • Nathan Goodyear on 01 Feb 12
     
    Testosterone replacement found to reduce inflammation (Il-1B, TNF-alpha, and CPR) in men with metabolic syndrome.  Testosterone was also shown to reduce insulin and leptin as well.
Nathan Goodyear

Oolong Tea Increases Metabolic Rate and Fat Oxidation in Men - 0 views

jn.nutrition.org/...2848.full

Camellia sinensis green tea jade oolong weight-loss metabolism metabolic rate

shared by Nathan Goodyear on 25 Nov 11 - No Cached
  • Nathan Goodyear on 25 Nov 11
     
    Jade oolong tea shown to increase metabolism and thus aid in weight loss.  Jade oolong is a green tea leaf from Taiwan, China, and India.
Nathan Goodyear

The Dark Side of Testosterone Deficiency: I. Metabolic Syndrome and Erectile Dysfunctio... - 0 views

onlinelibrary.wiley.com/...full

low T Testosterone metabolic syndrome ED metabolic syndrome obesity men male hormone hormones

shared by Nathan Goodyear on 30 Jan 14 - No Cached
  • Nathan Goodyear on 30 Jan 14
     
    Article reviews the link between obesity, low T, metabolic syndrome and ED.  ED has been shown to be predictive of CVD by 3-5 years.  
Nathan Goodyear

Hormonal Modulation in Aging Patients with Erectile Dysfunction and Metabolic Syndrome - 0 views

www.ncbi.nlm.nih.gov/...PMC3888699

low T Testosterone hypogonadism MetS metabolic syndrome men male hormone hormones

shared by Nathan Goodyear on 05 Feb 14 - No Cached
  • Hypogonadism and MetS are strongly associated [12, 13, 16], having even been demonstrated that with the increasing number of MetS parameters there is a proportional raise in the incidence of hypogonadism
  • increasing number of MetS components is inversely associated with T levels
  • the presence of MetS did not prove to be a significant determinant of hypogonadism, as it did not lead to a decline in T levels, in MetS patients with already established hypogonadism, the increasing number of MetS features was associated with further decline in T
  • ...15 more annotations...
  • In the setting of MetS, hypertriglyceridemia and increased WC have been reported as the most important determinants of hypogonadism
  • recent literature consistently associates obesity not only with higher risk of hypogonadism [4, 6, 27] but also with lower T levels
  • Visceral adiposity has been particularly related with reduction of T and SHBG levels (independent of other metabolic disorders)
  • WC was one of the MetS parameters with the greatest influence in T levels decrease, presenting itself as a strong risk factor for hypogonadism development
  • MetS-related T decline was not accompanied by an increase in pituitary LH levels, suggesting impairment in gonadotropin secretion
  • The molecules behind this smoothing compensatory effect of GnRH/LH are still unknown, but estrogens and insulin, as well as leptin, TNF-α, and other adipokines, were proposed candidates
  • fat stores undertake an increase aromatization of androgens, therefore raising estrogen levels [9, 15], which in turn decrease LH secretion
  • our data contradicts the concept that estradiol exerts a negative feedback on hypothalamic GnRH secretion
  • taking into account that high estradiol levels have already been described as the only abnormality in a subset of patients with ED, the hypothesis that the later might not only be caused by androgen deficiency is becoming increasingly evident
  • it has been reported that the chronic exposure to phosphodiesterase type 5 inhibitors (PDE5i), widely used for the treatment of ED, may influence serum estradiol levels
  • thyroid disorders (specially hyperthyroidism) have been related to ED and hypogonadism, and so must be considered in a sexual-dysfunction setting
  • It is clear from the current literature that collecting a more thorough hormonal panel might be a wise approach to further uncover hormonal relations
    • Nathan Goodyear
      Nathan Goodyear on 05 Feb 14
       
      outstanding point.  This hits to the point that Low T is the effect not the cause.
  • We concluded that in ED patients with hypogonadism and MetS, the attenuated response of HPG axis (normal or low LH levels) might not always be due to an underlying adiposity-dependent estrogen-raising effect.
  • our findings indicate that ED, aging, and estradiol might have a stronger connection than what is currently described in the literature.
  • this study underlines the importance of the collection of a full hormonal panel in ED men
  • Nathan Goodyear on 05 Feb 14
     
    low T strongly associated with metabolic syndrome in men.
Nathan Goodyear

Is administrating branched-chain amino acid-enriched nutrition achieved symptom-free in... - 0 views

www.ncbi.nlm.nih.gov/...PMC3882488

BCAA branched chain amino acids NH3 metabolism muscle glutamine glutamate glutamic acid liver cirrhosis disease nutrition

shared by Nathan Goodyear on 10 Feb 14 - No Cached
  • Nathan Goodyear on 10 Feb 14
     
    BCAA improve NH3 metabolism.  This is via muscle metabolism as reported in other studies.  This study highlighted the differences in BCAA supplementation.  One caveat is that high glutamine is the result from glutamate and this can increase hepatic encephalopathy.
Nathan Goodyear

Metabolic influences on neuroendocrine regulation of reproduction - 0 views

www.ncbi.nlm.nih.gov/...PMC3898855

metabolism metabolic regulation reproduction Leptin Ghrelin Insulin Kisspeptin GNRH

shared by Nathan Goodyear on 17 Feb 14 - No Cached
  • Energy storage occurs mainly at the level of white adipose tissue, where adipocytes secrete the anorexigenic adipokine leptin
  • humans and laboratory animals with leptin or insulin deficiency or resistance and/or increased ghrelin levels exhibit delayed or absent puberty and frequently display hypogonadotropic hypogonadism, which prevents fertility
  • Ghrelin suppresses pulsatile gonadotropin-releasing hormone (GnRH) release [14,15], thus serving as a signal to suppress reproduction in times of famine
  • ...4 more annotations...
  • Neuropeptides derived from POMC/CART neurons exert a potent anorectic action, thus decreasing food intake and body weight
  • AgRP and NPY have the opposite (orexigenic) effect, inducing food intake.
  • GnRH neurons have been shown to express insulin receptor mRNA and protein [27] and are activated by insulin
  • Kisspeptins (encoded by KISS1) have been identified in the last decade as the most potent secretagogues of GnRH release.
  • Nathan Goodyear on 17 Feb 14
     
    Good, although brief, discussion of the interaction between metabolism and hormones.  Kisspeptin is a GNRH secreatagogue "upstream".   Insulin, Leptin, and Gherlin can inhibit GNRH through resistance and low levels.  Probably a U shaped graph of optimal activity.
Nathan Goodyear

Benign prostatic hyperplasia: a new meta... [J Endocrinol Invest. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24458832

BPH benign prostatic hypertrophy Toll-like receptors TLRs hormone hormones low Testosterone T estrogen estradiol aromatase prostate metabolism

shared by Nathan Goodyear on 20 Feb 14 - No Cached
  • Nathan Goodyear on 20 Feb 14
     
    The authors of this paper describe BPH as a metabolic disease: involving inflammation with increased expression of TLRs, hormone imbalance and altered metabolism
Nathan Goodyear

Androgen Deprivation Therapy, Insulin Resistance, and Cardiovascular Mortality: An Inco... - 0 views

onlinelibrary.wiley.com/...full

androgen deprivation therapy androgen male men hormone hormones deprivation therapy prostate cancer cardiovascular disease insulin resistance diabetes metabolic syndrome mortality CVD

shared by Nathan Goodyear on 03 Mar 14 - No Cached
  • Nathan Goodyear on 03 Mar 14
     
    Androgen deprivation therapy is associated with increased diabetes, metabolic syndrome, insulin resistance, and cardiovascular mortality.  The longer the duration of therapy, the more the progression of metabolic dysfunction.  This process seems similar to chemotherapy i.e. secondary cancer due to chemotherapy.  The treatment of one disease, prostate cancer in this case, leads to an increase in the risk of the #1 killer in men--logic seems severely flawed there.
Nathan Goodyear

Metabolic syndrome, circulating RBP4, testosterone, and SHBG predict weight regain at 6... - 0 views

onlinelibrary.wiley.com/...abstract

metabolic syndrome metabolic syndrome low T Testosterone obesity overweight weight loss SHBG RBP4 men male hormones

shared by Nathan Goodyear on 13 Mar 14 - No Cached
  • Nathan Goodyear on 13 Mar 14
     
    Interesting study finds that men with low serum Total Testosterone, elevated RBP4 and low SHBG at baseline predict weight regain.  Thus Testosterone should be used as a biomarker of failure in weight loss and if low, Testosterone therapy should be employed to improved metabolic function.  Other parameters, such as leptin, adiponectin, prolactin, progesterone...were not predictive.
Nathan Goodyear

Low testosterone levels are associated with metabolic syndrome, in elderly men: the rol... - 0 views

eurheartj.oxfordjournals.org/...P4295.short

low T Testosterone metabolic syndrome metabolic syndrome MetS men male hormones hormone hs-CRP insulin HDL waist circumference inflammation

shared by Nathan Goodyear on 13 Mar 14 - No Cached
  • Nathan Goodyear on 13 Mar 14
     
    Low Serum Testosterone inversely associated metabolic syndrome in men.  This study was conducted in the Ikaria islands.  No association was found with women and Testosterone.  In men, Testosterone was inversely associated with waist circumference, hs-CRP, insulin, and HDL.
Nathan Goodyear

Fifteen years of experience with intramuscular testosterone undecanoate for substitutio... - 0 views

www.endocrine-abstracts.org/...ea0032P652.htm

Testosterone metabolic syndrome metabolic syndrome MetS men male hormones hormone PSA prostate low T

shared by Nathan Goodyear on 13 Mar 14 - No Cached
  • Nathan Goodyear on 13 Mar 14
     
    Abstract presented finds that Testosterone IM undecanoate significantly reduced metabolic syndrome parameters in men.  This study looked at men with secondary hypogonadism and late onset.  The ages were from 15-72.  The full is not available as of this post.  The study only looked at serum T.  This limits the usefulness of this test.  According to this abstract, no evaluation of SHBG was performed.  Though not significant, PSA and prostate volume increased.
Nathan Goodyear

Sex hormone binding globulin, but not testosterone, is associated with the metabolic sy... - 0 views

europepmc.org/...23812344

metabolic syndrome metabolic syndrome MetS PCOS women hormone hormones Testosterone obesity obese insulin resistance SHBG

shared by Nathan Goodyear on 12 Mar 14 - No Cached
  • Nathan Goodyear on 12 Mar 14
     
    This study finds an association between low SHBG and increased metabolic syndrome in obese women with PCOS.  Testosterone was not associated.  Other studies have shown a positive association between Testosterone and MetS in women.  This follows men in that SHBG shows an association with MetS.  Only the abstract is present here, so I can't look at the data presented.
Nathan Goodyear

Cambridge Journals Online - Proceedings of the Nutrition Society - Fulltext -... - 0 views

journals.cambridge.org/...displayFulltext

11-betaHSD1 metabolism obesity energy cortisol nutrition

shared by Nathan Goodyear on 08 Oct 13 - No Cached
  • Nathan Goodyear on 08 Oct 13
     
    Peripheral 11Beta-HSD1 plays critical role in fat metabolism and energy utilization.  Good discussion on the role that extra-adrenal 11Beta-HSD1 plays in metabolism
Nathan Goodyear

Journal of Ovarian Research | Full text | Evaluation of the ovarian reserve function in... - 0 views

www.ovarianresearch.com/...63

Testosterone women metabolic syndrome metabolic syndrome hormone hormones

shared by Nathan Goodyear on 25 Jun 14 - No Cached
  • Nathan Goodyear on 25 Jun 14
     
    Study finds decreased ovarian reserve in women 20-29 with metabolic syndrome compared to controls.  They determined this via ovarian volume measurements as FSH, LH, Estradiol, and Progesterone did not differ.   One item of interest was that women with MetS, had significantly higher Testosterone levels compared to controls.  This association of MetS and elevated Testosterone in women has been shown consistently in the literature.  This should bring great questions to the doping of Testosterone in women today.
Nathan Goodyear

Testosterone Deficiency, Cardiac Health, and Older Men - 0 views

www.hindawi.com/...143763

low T Testosterone obesity type II diabetes diabetes health wellness metabolic syndrome lipids cholesterol hypogonadism TDS testicular dysgenesis syndrome men male hormone hormones prostate cancer

shared by Nathan Goodyear on 12 May 14 - No Cached
  • Studies have shown pharmacological doses of testosterone to relax coronary arteries when injected intraluminally [39] and to produce modest but consistent improvement in exercise-induced angina and reverse associated ECG changes [40]. The mechanism of action is via blockade of calcium channels with effect of similar magnitude to nifedipine
    • Nathan Goodyear
      Nathan Goodyear on 12 May 14
       
      This directly refutes the recent studies (3) that Testosterone therapy increases cardiovascular events.
    • Nathan Goodyear
      Nathan Goodyear on 13 May 14
       
      Testosterone acts as a calcium channel blocker inducing vasodilation.
  • men with chronic stable angina pectoris, the ischaemic threshold increased after 4 weeks of TRT and a recent study demonstrates improvement continuing beyond 12 months [
  • Exercise capacity in men with chronic heart failure increased after 12 weeks
  • ...36 more annotations...
  • Studies have shown an inverse relationship between serum testosterone and fasting blood glucose and insulin levels
  • Medications such as chronic analgesics, anticonvulsants, 5ARIs, and androgen ablation therapy are associated with increased risk of testosterone deficiency and insulin resistance
  • Women with T2D or metabolic syndrome characteristically have low SHBG and high free testosterone
    • Nathan Goodyear
      Nathan Goodyear on 12 May 14
       
      This stands in polar opposite of that with men.
  • Hypogonadism is a common feature of the metabolic syndrome
  • The precise interaction between insulin resistance, visceral adiposity, and hypogonadism is, as yet, unclear but the important mechanisms are through increased aromatase production, raised leptin levels, and increase in inflammatory kinins
  • levels of testosterone are reduced in proportion to degree of obesity
  • Men should be encouraged to combine aerobic exercise with strength training. As muscle increases, glucose will be burned more efficiently and insulin levels will fall. A minimum of 30 minutes exercise three times weekly should be advised
  • Testosterone increases levels of fast-twitch muscle fibres
  • By increasing testosterone, levels of type 2 fibres increase and glucose burning improves
  • Weight loss will increase levels of testosterone
  • studies now clearly show that low testosterone leads to visceral obesity and metabolic syndrome and is also a consequence of obesity
  • In the case of MMAS [43], a baseline total testosterone of less than 10.4 nmol/L was associated with a greater than 4-fold incidence of type 2 diabetes over the next 9 years
  • There is high level evidence that TRT improves insulin resistance
  • Low testosterone predicts increased mortality and testosterone therapy improves survival in 587 men with type 2 diabetes
  • A similar retrospective US study involved 1031 men with 372 on TRT. The cumulative mortality was 21% in the untreated group versus 10% ( ) in the treated group with the greatest effect in younger men and those with type 2 diabetes
  • the presence of ED has been shown to be an independent risk factor, particularly in hypogonadal men, increasing the risk of cardiac events by over 50%
  • A recent online publication on ischaemic heart disease mortality in men concluded optimal androgen levels are a biomarker for survival
  • inverse associations between low TT or FT (Table 2) and the severity of CAD
  • A recent 10 year study from Western Australia involving 3690 men followed up from 2001–2010 concluded that TT and FT levels in the normal range were associated with decreased all-cause and cardiovascular mortality, for the first time suggesting that both low and DHT are associated with all-cause mortality and higher levels of DHT reduced cardiovascular risk
  • TDS is associated with increased cardiovascular and all-cause mortality
  • The effect of treatment with TRT reduced the mortality rate of treated cohort (8.4%) to that of the eugonadal group whereas the mortality for the untreated remained high at 19.2%
  • hypogonadal men had slightly increased triglycerides and HDL
  • Men with angiographically proven CAD (coronary artery disease) have significantly lower testosterone levels [29] compared to controls ( ) and there was a significant inverse relationship between the degree of CAD and TT (total testosterone) levels
  • TRT has also been shown to reduce fibrinogen to levels similar to fibrates
  • men treated with long acting testosterone showed highly significant reductions in TC, LDL, and triglycerides with increase in HDL, associated with significant reduction in weight, BMI, and visceral fat
  • Low androgen levels are associated with an increase in inflammatory markers
  • A decline was noted in IL6 and TNF-alpha
  • In some studies, a decline in diastolic blood pressure has been observed, after 3–9 months [24, 26] and in systolic blood pressure
  • In the Moscow study, C-reactive protein was reduced by TRT at 30 weeks versus placebo
  • No studies to date show an increase in LUTS/BPH symptoms with higher serum testosterone levels
  • TRT has been shown to upregulate PDE5 [65] and enhance the effect of PDE5Is (now an accepted therapy for both ED and LUTS), it no longer seems logical to advice avoidance of TRT in men with mild to moderate BPH.
    • Nathan Goodyear
      Nathan Goodyear on 12 May 14
       
      What about just starting with normalization of Testosterone levels first.
  • Several meta-analyses have failed to show a link between TRT and development of prostate cancer [66] but some studies have shown a tendency for more aggressive prostate cancer in men with low testosterone
    • Nathan Goodyear
      Nathan Goodyear on 12 May 14
       
      And if one would have looked at their estrogen levels, I guarantee they would have been found to be elevated.
  • low bioavailable testosterone and high SHBG were associated with a 4.9- and 3.2-fold risk of positive biopsy
  • Current EAU, ISSAM, and BSSM guidance [1, 2] is that there is “no evidence TRT is associated with increased risk of prostate cancer or activation of subclinical cancer.”
  • Men with prostate cancer, treated with androgen deprivation, develop an increase of fat mass with an altered lipid profile
  • Erectile dysfunction is an established marker for future cardiovascular risk and the major presenting symptom leading to a diagnosis of low testosterone
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