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Nathan Goodyear

The effectiveness of fermented turmeric powder in subjects with elevated alanine transa... - 0 views

www.ncbi.nlm.nih.gov/...PMC3600681

turmeric curcumin curcuma longa liver enzymes liver ALT astaxantin

shared by Nathan Goodyear on 06 Jul 16 - No Cached
  • Nathan Goodyear on 06 Jul 16
     
    fermented turmeric at 3 grams daily found to lower liver enzymes.
Nathan Goodyear

Oxidative Stress and Stress-Activated Signaling Pathways: A Unifying Hypothesis of Type... - 0 views

edrv.endojournals.org/...599.long

free radicals oxidative stress damage inflammation type II DM alpha lipoic acid alpha-lipoic-acid diabetes

shared by Nathan Goodyear on 02 Aug 12 - No Cached
  • In patients with diabetes, LA levels are reduced (48, 74, 103). LA has long been used for the treatment of diabetic neuropathy in Germany
  • evidence indicates that it increases insulin sensitivity in patients with type 2 diabetes
  • LA has been shown to 1) quench free radicals, 2) prevent singlet oxygen-induced DNA damage, 3) exhibit chelating activity, 4) reduce lipid peroxidation, 5) increase intracellular glutathione levels, and 6) prevent glycation of serum albumin (73, 74). LA is able to reduce oxidative stress-mediated NF-κB activation in vitro (74, 108, 109) and in patients with type 2 diabetes
  • ...2 more annotations...
  • Activation of NF-κB can also be blocked by several other thiol-containing antioxidants including N-acetyl-l-cysteine (NAC)
  • Other clinically available antioxidants reported to have antiinflammatory, antioncogenic, and/or antiatherogenic properties that have been shown to block the activation of NF-κB include resveratrol (115, 116), (-)-epicatechin-3-gallate (117), pycnogenol (118), silymarin (119), and curcumin (120)
  • Nathan Goodyear on 02 Aug 12
     
    Great read!  If you want to see how free radicals and oxidative stress contribute to inflammation and disease (DM in this case), read this article.
Nathan Goodyear

Alpha lipoic acid is an anti-inflammatory and neuroprotective - 0 views

www.greenmedinfo.com/...rotective-treatment-alzheimers

alpha lipoic acid ALA Alzheimer's disease

shared by Nathan Goodyear on 09 Sep 13 - No Cached
  • Data from cell culture and animal models suggest that LA could be combined with nutraceuticals such as curcumin, (-)-epigallocatechin gallate (from green tea) and docosahexaenoic acid (from fish oil) to synergistically decrease oxidative stress, inflammation
  • Nathan Goodyear on 09 Sep 13
     
    Alpha lipoic acid suggested via animal studies to be possible mechanism to prevent Alzhemiers disease.
Nathan Goodyear

Effects of turmeric on Alzheimer's disease with behavioral and psychological symptoms o... - 0 views

www.ncbi.nlm.nih.gov/...PMC3665200

turmeric Alzheimer's disease alzheimer disease dementia curcumin

shared by Nathan Goodyear on 13 Aug 13 - No Cached
  • Nathan Goodyear on 13 Aug 13
     
    Small case study of 3 finds significant improvement in Alzheimer's with Turmeric.
Nathan Goodyear

Efficacy and mechanism of action of turmeric supplements in the treatment of experiment... - 0 views

onlinelibrary.wiley.com/...abstract

Curcumin Tumeric NF-KappaB inflammation arthritis

shared by Nathan Goodyear on 13 Sep 13 - No Cached
  • Nathan Goodyear on 13 Sep 13
     
    Tumeric inhibits NF-KappaB and thus inflammation in arthritis model.
Nathan Goodyear

Natural polyphenols in the management of major depression, Expert Opinion on Investigat... - 0 views

informahealthcare.com/...13543784.2013.794783

polyphenols curcumin tumeric quercetin resveratrol natural depression

shared by Nathan Goodyear on 01 Dec 13 - No Cached
  • Nathan Goodyear on 01 Dec 13
     
    Abstract only available, shows that polyphenols useful in the treatment of depression.
Nathan Goodyear

Review article: biofilm formation by Helicobacter pylori as a target for eradication of... - 0 views

onlinelibrary.wiley.com/...full

biofilms H. Pylori helicobacter pylori curcumin boswellia NAC

shared by Nathan Goodyear on 11 May 15 - No Cached
  • Nathan Goodyear on 11 May 15
     
    good discussion of biofilms and H.pylori.  This article reviews the literature behind some of the natural and traditional therapies to reduce biofilms.
Nathan Goodyear

Advances in treatment of ulcerative colitis with herbs: From bench to bedside - 0 views

www.ncbi.nlm.nih.gov/...PMC4202341

curcumin natural therapies wheat grass butyrate aloe vera aloe ulcerative colitis UC IBD inflammatory bowel disease herbs

shared by Nathan Goodyear on 25 Jan 16 - No Cached
  • Nathan Goodyear on 25 Jan 16
     
    additional reviews of natural therapies and IBD.
Nathan Goodyear

Drug Screening Identifies Niclosamide as an Inhibitor of Breast Cancer Stem-Like Cells - 0 views

journals.plos.org/...article

Niclosamide cancer cancer stem cells breast cancer

shared by Nathan Goodyear on 21 Mar 18 - No Cached
  • cancer stem cells may also contribute to tumor formation, metastasis, and treatment resistance
  • Studies have shown that some agents (such as metformin) can selectively target cancer stem cells and that dietary polyphenols, curcumin, peperine, and sulforaphane, which are derived from broccoli/broccoli sprouts, are able to target breast cancer stem cells via inhibition of the Wnt signaling, which affects mammosphere size and colony formation
  • niclosamide inhibits tumor growth and reduces tumor weight
  • ...8 more annotations...
  • Niclosamide treatment inhibited the expression of cyclin D1, Hes1, and PTCH by 33%, 57%, and 79%, respectively
  • The mechanism via which niclosamide, a protonophoric anthelmintic drug, induces stem-like-cell-specific toxicity in breast cancer is interesting. It is an old drug that has been used to treat tapeworms in animals
  • Niclosamide is known to uncouple mitochondrial oxidative phosphorylation during tapeworm killing
  • A screening of autophagy modulators revealed that niclosamide is a novel inhibitor of mTORC1 signaling
  • A recent work also demonstrated that niclosamide induces the apoptosis of myelogenous leukemic cells via the inactivation of NF-kappaB and reactive oxygen species generation
  • Niclosamide was also reported to inhibit Wnt signaling [31]–[33] in colon cancer cells
  • Our recent work demonstrated that niclosamide disrupts multiple metabolic pathways in ovarian-cancer-initiating cells
  • The present study showed that niclosamide treatment resulted in the downregulation of target genes involved in the self-renewal of cancer stem-like cells and inhibited breast SPS
  • Nathan Goodyear on 21 Mar 18
     
    Old ant-parasitic, niclosamide, found to down-regulate cancer stem cell activity.
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