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Nathan Goodyear

Vitamin C inhibits granulocyte macrophage-colony-stimulating factor-induced signaling p... - 0 views

bloodjournal.hematologylibrary.org/...3205.full

ROS inflammation GM-CSF vitamin C vitamin C vitamins

shared by Nathan Goodyear on 10 Dec 12 - No Cached
  • Nathan Goodyear on 10 Dec 12
     
    vitamin C found to decrease inflammatory signaling.  In this study, they found a decrease in GM-CSF induction of  ROS due to vitamin C.  This was an in vitro study, but another flag in the claim that vitamin C reduces inflammation and ROS.
Nathan Goodyear

Effect of high dose intravenous ascorbic acid on the level of inflammation in patients ... - 0 views

www.riordanclinic.org/...MRI-v01n02-p26.pdf

RA rheumatoid arthritis rheumatoid arthritis IV vitamin C intravenous IV vitamin C ascorbic vitamin C inflammation autoimmune

shared by Nathan Goodyear on 10 Dec 12 - No Cached
  • Nathan Goodyear on 10 Dec 12
     
    This study, small pilot, showed that they were able to lower inflammation in those suffering from RA, through high dose vitamin C IV therapy. This study stopped at 25 gms. The vitamin C is a scavenger of ROS and ROS stimulates inflammation through NF-kappaB. This is how vitamin C can reduce inflammation.
Nathan Goodyear

Vitamin C and survival among women with breast cancer: A Meta-analysis - 0 views

www.sciencedirect.com/...S0959804914001750

vitamin C vitamin C cancer mortality women

shared by Nathan Goodyear on 13 Mar 14 - No Cached
  • Nathan Goodyear on 13 Mar 14
     
    Meta-analysis finds that for every oral daily intake of 100 mg vitamin C, the risk of total mortality was decreased by 27% and the breast cancer specific mortality was decreased by 22%.  A lot of potential variables that can play into this equation.  However, oral vitamin C is poorly bioavailable, yet according to this meta-analysis, does provide significant health benefits and even prevention.  If health and breast cancer prevention is a goal, then vitamin C needs to play a role in your daily intake.
Nathan Goodyear

Access : Intravenous vitamin C can improve anemia in erythropoietin-hyporesponsive hemo... - 0 views

www.nature.com/...ncpneph0281.html

IV vitamin C vitamin C vitamin C IV intravenous vitamin C anemia

shared by Nathan Goodyear on 26 Aug 14 - No Cached
  • Nathan Goodyear on 26 Aug 14
     
    IV vitamin C improves anemia.  The only possible contribution of IV vitamin C and anemia is a G6PD deficiency.
Nathan Goodyear

Dehydroascorbic acid, a blood-brain barrier transportable form of vitamin C, mediates p... - 0 views

www.ncbi.nlm.nih.gov/...PMC58796

vitamin C IV vitamin C dehydroascorbic acid brain stroke

shared by Nathan Goodyear on 22 Aug 17 - No Cached
  • Nathan Goodyear on 22 Aug 17
     
    vitamin C does not cross the BBB, but its oxidize form, dehydroascorbic acid does.  This experimental model looked at IV DHA. The findings was that IV DHA resulted in higher brain C levels compared to IV vitamin C.
Nathan Goodyear

Metabolomic alterations in human cancer cells by vitamin C-induced oxidative stress - P... - 0 views

pubmed.ncbi.nlm.nih.gov/26350063

NAC vitamin C high dose vitamin C high-dose vitamin C NAD cancer IV vitamin C high-dose IV vitamin C High dose IV vitamin C

shared by Nathan Goodyear on 03 Sep 22 - No Cached
  • Nathan Goodyear on 03 Sep 22
     
    NAD and NAC counter the effects of vitamin C IN CANCER
Nathan Goodyear

False Positive finger stick blood glucose readings after high-dose intravenous vitamin C - 0 views

www.riordanclinic.org/...89024578.pdf

IV vitamin C vitamin C glucose vitamin C

shared by Nathan Goodyear on 18 Jun 13 - No Cached
  • Nathan Goodyear on 18 Jun 13
     
    IV vitamin C > 15 grams falsely elevates finger sticks on glucose. Glucose and vitamin C are very similar chemically. This, however, is a false reading.
Nathan Goodyear

Massive Doses of Vitamin C and the Virus Diseases - 0 views

www.seanet.com/...med_surg-1951-v103-n4-p101.htm

IV therapy IV C virus viral illness nutrition nutritional therapy

shared by Nathan Goodyear on 23 Jan 13 - No Cached
  • Nathan Goodyear on 23 Jan 13
     
    High dose IV vitamin C beneficial in viral illnesses.  This is a case study article, but it discusses how viral illnesses are associated with low vitamin C levels and how high dose vitamin C therapy benefits the immune activity against viral invaders.
Nathan Goodyear

Blood Pressure Effects of Vitamin C | Hypertension - 0 views

hyper.ahajournals.org/...789

blood pressure hypertension vitamin C

shared by Nathan Goodyear on 16 Jan 17 - No Cached
  • Nathan Goodyear on 16 Jan 17
     
    review article of studies on vitamin C and blood pressure finds mixed results.  I think it all comes down to dosing.  The authors highlight 2 studies to make their point. One find a significant reduction and another found a slight increase.  The dosing of the vitamin C was only 500 mg/day.  A woefully inadequate therapeutic dosing of vitamin C, especially when dealing with the significant deficiencies that can be found in disease states.
Nathan Goodyear

Vitamin C Pharmacokinetics: Implications for Oral and Intravenous Use - 0 views

www.annals.org/...533.short

IV intravenous vitamin C therapy treatment minerals vitamins

shared by Nathan Goodyear on 22 Nov 11 - No Cached
  • Nathan Goodyear on 22 Nov 11
     
    only high dose IV vitamin C shown to produce high plasma vitamin C concentrations compared to oral vitamin c.
Nathan Goodyear

http://onlinelibrary.wiley.com/store/10.1002/hep.21080/asset/21080_ftp.pdf;jsessionid=C... - 0 views

onlinelibrary.wiley.com/...FD1E43279D6DC7447C7FC1A.f04t01

vitamin C IV vitamin C IV intravenous cirrhosis

shared by Nathan Goodyear on 10 Feb 14 - No Cached
  • Nathan Goodyear on 10 Feb 14
     
    small study looked at patients with liver cirrhosis.  The authors used a low dose of IV vitamin C (5 grams) and found that this improved endothelial dysfunction.  Patients with cirrhosis were found to be low in vitamin C.  The IV vitamin C was well tolerated, despite a low dose.
Nathan Goodyear

Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a p... - 0 views

www.ncbi.nlm.nih.gov/...PMC1224653

IV vitamin C vitamin C intravenous alternative Intravenous vitamin C vitamin C cancer H2O2 ascorbic acid

shared by Nathan Goodyear on 26 Aug 14 - No Cached
  • Nathan Goodyear on 26 Aug 14
     
    IV vitamin C and IV vitamin C only can deliver levels to tumor cells that induce formation of H2O2 that then induces cell death.
Nathan Goodyear

High Dose IV Vitamin C and Metastatic Breast Cancer: A Case Report - ISOM - 0 views

isom.ca/...atic-breast-cancer-case-report

metastasis breast cancer High dose IV vitamin C cancer IV vitamin C vitamin C high dose vitamin C

shared by Nathan Goodyear on 09 Mar 21 - No Cached
  • Nathan Goodyear on 09 Mar 21
     
    Case study of vitamin C IV up to 75 grams IV effective in stabilizing breast cancer with mets to liver.
Nathan Goodyear

Phase I study of high-dose ascorbic acid with mFOLFOX6 or FOLFIRI in patients with meta... - 0 views

bmccancer.biomedcentral.com/...s12885-019-5696-z

IV vitamin C cancer vitamin C

shared by Nathan Goodyear on 21 May 19 - No Cached
  • Nathan Goodyear on 21 May 19
     
    Phase I study of vitamin C and FOLFOX or FOLFIRI. Numerous studies have shown the extremely high safety profile of IV vitamin C in cancer. The need to show the same thing time and time again borders on the insanity. The potential adverse events listed in this study is from the FOLFOX or FOLFIRI, not the vitamin C.
Nathan Goodyear

The Effect of High Dose IV Vitamin C on Plasma Antioxidant Capacity and Level of Oxidat... - 1 views

orthomolecular.org/...2007-v22n03-p153.pdf

IV vitamin C vitamin C IV vitamin C antioxidant

shared by Nathan Goodyear on 05 Jun 13 - No Cached
  • Nathan Goodyear on 05 Jun 13
     
    Studies have debated on the proxidant/antioxidant effect of high dose IV vitamin C. This study finds only antioxidant effects from IV vitamin C in vivo. This study also found the antioxidant effect plateaued out at 25 grams.
Nathan Goodyear

Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis - 1 views

www.ncbi.nlm.nih.gov/...PMC3937164

sepsis IV vitamin C vitamin C CRP

shared by Nathan Goodyear on 11 Oct 17 - No Cached
  • Padayatty and colleagues showed that high-level ascorbic acid plasma concentrations could only be achieved by intravenous administration
  • No patient in the low or high dose ascorbic acid treatment arms of this study suffered any identifiable adverse event
  • a pharmacologic ascorbic acid treatment strategy in critically ill patients with severe sepsis appears to be safe
  • ...7 more annotations...
  • subnormal plasma ascorbic acid levels are a predictable feature in patients with severe sepsis
  • Ascorbic acid depletion in sepsis results from ascorbic acid consumption by the reduction of plasma free iron, ascorbic acid consumption by the scavenging of aqueous free radicals (peroxyl radicals), and by the destruction of the oxidized form of ascorbic acid dehydroascorbic acid
  • Sepsis further inhibits intracellular reduction of dehydroascorbic acid, producing acute intracellular ascorbic acid depletion
  • Ascorbic acid treated patients in this study exhibited rapid and sustained increases in plasma ascorbic acid levels using an intermittent every six hours administration protocol
  • Septic ascorbic acid-deficient neutrophils fail to undergo normal apoptosis. Rather, they undergo necrosis thereby releasing hydrolytic enzymes in tissue beds, thus contributing to organ injury
  • We speculate that intravenous ascorbic acid acts to restore neutrophil ascorbic acid levels
  • Repletion of ascorbic acid in this way allows for normal apoptosis, thus, preventing the release of organ damaging hydrolytic enzymes.
  • Nathan Goodyear on 11 Oct 17
     
    Study finds IV vitamin C in patients with sepsis is very safe and blunts the effects (endothelial damage, end organ damage...) of sepsis.  Of note, the IV vitamin C group reached serum levels of ascorbic acid of 1,592 to 5,722 micromol/L.  The IV groups maintained elevated serum C levels for up to 96 hours post infusion.  
Nathan Goodyear

Hypovitaminosis C and vitamin C deficiency in critically ill patients despite recommend... - 0 views

www.ncbi.nlm.nih.gov/...PMC5725835

vitamin C deficiency hypovitaminosis C IV vitamin C septic shock critically ill hypovitaminosis ICU critical illness vitamin C critical care sepsis

shared by Nathan Goodyear on 14 Jul 22 - No Cached
  • Nathan Goodyear on 14 Jul 22
     
    Septic patients have lower vitamin C levels and respond less to typical dosing due to inflammaiton
Nathan Goodyear

Cellular toxicity driven by high-dose vitamin C on normal and cancer stem cells - PubMed - 0 views

pubmed.ncbi.nlm.nih.gov/29432735

IV vitamin C CSC High dose IV vitamin C cancer stem cells vitamin C high dose vitamin C high-dose IV vitamin C cancer

shared by Nathan Goodyear on 03 Sep 22 - No Cached
  • Nathan Goodyear on 03 Sep 22
     
    High dose vitamin C preferentially targets CSC but not differentiated cells.
Nathan Goodyear

Temperature-dependent and time-dependent effects of hyperthermia mediated by dextran-co... - 0 views

www.ncbi.nlm.nih.gov/...PMC4346362

hyperthermia

shared by Nathan Goodyear on 18 Apr 23 - No Cached
  • Nathan Goodyear on 18 Apr 23
     
    effect of time and temperature on the viability of melanoma cell lines and expression of HSP 70 & 90 after brief exposure to hyperthermia. While hyperthermia has multiple mechanisms of action, this paper elucidates two essential benefits of high-dose hyperthermia. First, the study illustrates why high-dose hyperthermia treatments (45°C - 47°C) are so much more effective than the low-dose hyperthermia (39°C - 43°C) produced by commercially available heating devices.
Nathan Goodyear

European Journal of Clinical Nutrition - C-reactive protein concentration and concentra... - 0 views

www.nature.com/...1601667a.html

IV vitamin C intravenous IV vitamin C antioxidants CRP ROS vitamins

shared by Nathan Goodyear on 10 Dec 12 - No Cached
  • Nathan Goodyear on 10 Dec 12
     
    This study shows that inflammation, CRP in this study, was inversely associated with low antioxidants ie. vitamin C.  This makes since as ROS are known to stimulate inflammation.  Vitamin C should be considered as a therapeutic option in those with inflammation.
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