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Estradiol and Bisphenol A Stimulate Androgen Receptor and Estrogen Receptor Gene Expres... - 0 views

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    Great read on the effects of bisphenol A as an xenoestrogen.  Bisphenol A is a weak estrogen, but it does increase androgen receptor and estrogen receptor alpha transcription.  This is from fetal exposure.
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Low Doses of Bisphenol A Promote Human Seminoma Cell Proliferation by Activating PKA an... - 0 views

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    Bisphenol A: review of the different biochemical effects of bisphenol A.
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Bisphenol A at Low Nanomolar Doses Confers Chemoresistance in Estrogen Recept... - 0 views

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    How do environmental chemicals interfere?  This study shows how Bisphenol A actually interferes at the site of the estrogen receptor alpha.  Bisphenol A decreased the efficacy of chemotherapy in ER +/- breast cancer.  Again, the focus is on the interaction with ER alpha.
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Association between urinary levels of bisp... [Sci Total Environ. 2014] - PubMed - NCBI - 0 views

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    Bisphenol A (BPA) negatively effects estrogen metabolism. Bisphenol A preferentially increases 4OH-estrone which is the most toxic estrogen metabolite.
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Structural and mechanistic insights into bisphenols action provide guidelines for risk ... - 0 views

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    bisphenol A is a estrogen receptor agonist, though partial.
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Urinary Bisphenol A Concentrations in Relation to Serum Thyroid and Reproductive Hormon... - 0 views

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    Granted, these are in men seen in an infertility clinic, but Bisphenol A (BPA) found to disrupt thyroid, increase the E2:T ratio, and a decrease in the free androgen index.  Interestingly, 89% of the men seen in this study tested positive for BPA in the urine.
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Bisphenol A may cause testosterone reduction by adversely affecting both testis and pit... - 0 views

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    Bisphenol-A inhibits testosterone production through direct inhibition of the pituitary and the leydig cells.  This is similar to the way E2 acts on the the pituitary and the leydig cells.  
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Bisphenol A and human health: A review of the... [Reprod Toxicol. 2013] - PubMed - NCBI - 0 views

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    Bisphenol A proving to be an significant endocrine disruptor in humans.
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Bisphenol A Exposure during Adulthood Alters Expression of Aromatase and 5α-R... - 0 views

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    animal model, but Bisphenol A shown to increase aromatase production.  This aids the decreased T:E2 ratio that is commonly found in prostate disease.  So, BPA is a xenoestrogen.  BPA is an androgen receptor antagonist and BPA increases aromatase activity.  
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Bisphenol A enhances kisspeptin neurons in anteroventral periventricular nucleus of fem... - 0 views

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    Mouse model finds that Bisphenol A (BPA) induces LH/FSH and Estradiol production through kisspeptin stimulation.
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Bisphenol A Effects on Estrogen Receptor β Expression: Implications in Prosta... - 0 views

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    Bisphenol A downgregulates ER-beta in male prostate.  This would increase pro-inlfmmatory/growth through ER-alpha theoretically and has implications  in prostate health.
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Exposure to the environmental estrogen bisphenol A ... [Life Sci. 2003] - PubMed - NCBI - 0 views

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    Bisphenol A causes shift in ER-beta to ER-alpha through increase ER alpha transcription in the testis.  This only looked at ER expression in the testis.
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Estradiol and Bisphenol A Stimulate Androgen Receptor and Estrogen Receptor Gene Expres... - 0 views

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    environmental toxin, bisphenol A, shown to increase estrogen receptor and androgen receptor expression in the prostate.  Also, a shift from ER beta to ER alpha occurs, increase the inflammatory and proliferative signal.
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The activity of bisphenol A depends on both the est... [Endocr J. 2002] - PubMed - NCBI - 0 views

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    bisphenol A is shown to be both an ER agonist and an ER antagonist.
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Large Effects from Small Exposures. III. Endocrine Mechanisms Mediating Effects of Bisp... - 0 views

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    bisphenol A increases estrogen signaling.
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Mechanism of Action of Bisphenol A and other Biochemical/Molecular interactions - 0 views

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    Thorough discussion of the scientific knowledge on bisphenol A and its hormonal and receptor effects.
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PLOS ONE: Differential Effects of Bisphenol A and Diethylstilbestrol on Human, Rat and ... - 0 views

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    Bisphenol A decreases testicular testosterone production at the sight of the leydig cells.
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Antiandrogenic effects of bisphenol A and nonylp... [Toxicol Sci. 2003] - PubMed - NCBI - 0 views

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    Bisphenol A acts as androgen receptor antagonist.
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Bisphenol-A acts as a potent estrogen vi... [Mol Cell Endocrinol. 2012] - PubMed - NCBI - 0 views

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    Bisphenol A acts via non-classical genomic signaling and more through weaker non-classical membrane receptors and their secondary messengers.
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Thyroid Hormone Action Is Disrupted by Bisphenol A as an Antagonist - 0 views

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    Bisphenol A (BPA) shown to interfere with the T3 and thyroid hormone receptor interaction.  This study even showed that BPA inhibited thyroid receptor transcription.
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