Great read on the effects of bisphenol A as an xenoestrogen. Bisphenol A is a weak estrogen, but it does increase androgen receptor and estrogen receptor alpha transcription. This is from fetal exposure.
How do environmental chemicals interfere? This study shows how Bisphenol A actually interferes at the site of the estrogen receptor alpha. Bisphenol A decreased the efficacy of chemotherapy in ER +/- breast cancer. Again, the focus is on the interaction with ER alpha.
Bisphenol A (BPA) negatively effects estrogen metabolism. Bisphenol A preferentially increases 4OH-estrone which is the most toxic estrogen metabolite.
Granted, these are in men seen in an infertility clinic, but Bisphenol A (BPA) found to disrupt thyroid, increase the E2:T ratio, and a decrease in the free androgen index. Interestingly, 89% of the men seen in this study tested positive for BPA in the urine.
Bisphenol-A inhibits testosterone production through direct inhibition of the pituitary and the leydig cells. This is similar to the way E2 acts on the the pituitary and the leydig cells.
animal model, but Bisphenol A shown to increase aromatase production. This aids the decreased T:E2 ratio that is commonly found in prostate disease. So, BPA is a xenoestrogen. BPA is an androgen receptor antagonist and BPA increases aromatase activity.
Bisphenol A downgregulates ER-beta in male prostate. This would increase pro-inlfmmatory/growth through ER-alpha theoretically and has implications in prostate health.
Bisphenol A causes shift in ER-beta to ER-alpha through increase ER alpha transcription in the testis. This only looked at ER expression in the testis.
environmental toxin, bisphenol A, shown to increase estrogen receptor and androgen receptor expression in the prostate. Also, a shift from ER beta to ER alpha occurs, increase the inflammatory and proliferative signal.
Bisphenol A (BPA) shown to interfere with the T3 and thyroid hormone receptor interaction. This study even showed that BPA inhibited thyroid receptor transcription.