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Nathan Goodyear

Neonatal exposure to bisphenol A modifies the abundance of estrogen receptor ... - 0 views

joe.endocrinology-journals.org/...201.full

Bisphenol A ER estrogen receptor alpha hormone hormones toxins

shared by Nathan Goodyear on 18 Oct 12 - No Cached
  • Nathan Goodyear on 18 Oct 12
     
    In a rat study, Bisphenol A shown to increase the ER alpha expression in the hypothalamus of the offspring.  So, the effects occur in utero, prior to birth.  The impact is this: the signal interpretation, by the tissue, of the hormone signal is altered prior to birth?
Nathan Goodyear

Bisphenol A Promotes Human Prostate Stem-Progenitor Cell Self-Renewal and Increases In ... - 0 views

www.ncbi.nlm.nih.gov/...PMC3929731

BPA bisphenol A cancer prostate cancer prostate xenoestrogens

shared by Nathan Goodyear on 20 Apr 16 - No Cached
  • these findings show that estrogen stimulates human prostate epithelial stem cell self-renewal and progenitor cell amplification (prostasphere size), with the greatest effects observed at lower E2 doses.
  • Similar to E2, BPA increased prostasphere number and size with significant and maximal effects observed at 10 nM BPA
  • Taken together, these results provide strong evidence that, similar to E2, BPA increases stem cell self-renewal and progenitor amplification in normal human prostate epithelial cells
  • ...13 more annotations...
  • these findings provide further support that E2 and BPA maintain the stem-like state within the normal prostate epithelial cell population
  • Our previous findings demonstrated that normal prostate stem-progenitor cells within the prostaspheres expressed ERα and ERβ, implicating them as direct targets for E2 and BPA action
  • p-Akt and p-Erk, well established downstream targets of membrane-associated ERs
  • BPA and E2 had equimolar capacity for activation of these rapid signaling pathways in human prostaspheres, thus identifying a dynamic and robust signaling pathway initiated by low-dose BPA exposure in prostate stem-progenitor cells.
  • these findings indicate that both rapid membrane-initiated estrogen action and genomic ER signaling pathways are operative in human prostate progenitor cells.
  • these results document the fact that levels of bioactive BPA in the present study are similar to levels found in human umbilical cord blood and newborns in the general population
  • the present findings identify for the first time that in vivo exposure of the human prostate epithelium to low doses of BPA significantly increases the susceptibility of the human prostate epithelium to hormonal carcinogenesis.
  • The current study provides clear evidence that, similar to E2, normal human prostate stem and progenitor cells are direct targets for BPA action
  • Both hormones increased stem-like cell numbers in primary prostate epithelial cultures in a dose-dependent manner and augmented the number and size of 3-D cultured prostaspheres, markers of stem cell self-renewal and progenitor cell proliferation, respectively
  • signaling pathways engaged by estrogens through these separate receptors are multiple and complex, including both membrane-initiated signaling and genomic activation via ER transcriptional activity
  • Estrogen action is mediated by ERα and ERβ
  • the current results indicate that developmental exposure to BPA, at doses routinely found in humans, significantly increases the cancer risk in human prostate epithelium in response to elevated estrogen levels in an androgen-supported milieu. Because relative estrogen levels rise in aging men, we suggest that humans may be susceptible to BPA-driven prostate disease in a manner similar to that in the rodent models.
  • We propose that early-life perturbations in estrogen signaling including inappropriate exposure to BPA have the potential to amplify and modify the stem-progenitor cell populations within the human prostate gland and, in so doing, alter the normal homeostatic mechanisms that maintain a growth neutral state throughout life
  • Nathan Goodyear on 20 Apr 16
     
    Bisphenol A exposure in utero found to increase prostate cancer risk later in life.  This exposure occurred at typical life exposure levels as found in umbilical cord blood sampling,  This occurred through stem cell self-renewal and progenitor amplification
Nathan Goodyear

Bisphenol A and Metabolic Syndrome: Results from NHANES - 0 views

www.hindawi.com/...598180

metabolic syndrome MetS bisphenol A BPA EDC endocrine disruptors

shared by Nathan Goodyear on 04 Sep 13 - No Cached
  • Nathan Goodyear on 04 Sep 13
     
    Bisphenol A clearly associated with increased risk of MetS.
Nathan Goodyear

Low dose of bisphenol A impairs the reprod... [J Physiol Biochem. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24271643

BPA bisphenol A

shared by Nathan Goodyear on 29 Nov 13 - No Cached
  • Nathan Goodyear on 29 Nov 13
     
    BPA shown to effect HPA in rats.  The effects were seen as a result of pre and post natal exposure of low dose bisphenol A.  Testosterone was not found to be negatively impacted.  
Nathan Goodyear

Diverse Influences of Androgen-Disrupting Chemi... [Inflammation. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24287822

Bisphenol-A bisphenol A BPA EDC endocrine disrupting chemicals NO inflammation

shared by Nathan Goodyear on 02 Dec 13 - No Cached
  • Nathan Goodyear on 02 Dec 13
     
    Study proposed immune dysfunction as a result of EDC like BPA. Bisphenol A induced cell apoptosis as well as a reduction of nitric oxide.
Nathan Goodyear

EHP - Bisphenol A Exposure during Adulthood Causes Augmentation of Follicular... - 0 views

ehp.niehs.nih.gov/1205823

Bisphenol A estrogen E2 Estradiol xenoestrogens xenoestrogen hormone hormones BPA

shared by Nathan Goodyear on 19 Jun 13 - No Cached
  • Nathan Goodyear on 19 Jun 13
     
    Bisphenol A shown to disrupt ovarian estrogen production from exposure in adults.  The point of this that is important is that BPA, a xenoestrogen, can infact disrupt physiologic hormone production in adults, and contribute to ovarian failure.  BPA, itself, is 1,000 fold weaker than E2, yet it disrupts ovarian function.
Nathan Goodyear

Environmental Health Perspectives: Relationship between Urinary Phthalate and Bisphenol... - 0 views

ehp03.niehs.nih.gov/...fetchArticle.action

Phthalate Bisphenol A thyroid hormone hypothyroidism

shared by Nathan Goodyear on 08 Sep 11 - No Cached
  • Nathan Goodyear on 08 Sep 11
     
    Phthalate and Bisphenol A interferes with thyroid levels
Nathan Goodyear

Sex differences in the adult HPA axis and affectiv... [Brain Res. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24857958

bisphenol A Bisphenol-A BPA xenoestrogen HPA hypothalamic-pituitary-adrenal EDR endocrine disrupter brain hormone hormones

shared by Nathan Goodyear on 27 May 14 - No Cached
  • Nathan Goodyear on 27 May 14
     
    Animal study finds that Bisphenol A exposure in utero has profound different effects in male offspring versus female offspring.  In the male offspring there appears to be an up regulation of the HPA axis.  The opposite appears true in the female off spring.  Additionally, the receptors are effected differently as well.
Nathan Goodyear

Bisphenol A Promotes Human Prostate Stem-Proge... [Endocrinology. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24424067

BPA bisphenol A Bisphenol-A prostate cancer xenoestrogen xenoestrogens

shared by Nathan Goodyear on 17 Jan 14 - No Cached
  • Nathan Goodyear on 17 Jan 14
     
    Another strike against BPA.  This time, BPA exposure during development increased hormone-dependent cancer risk in the prostate through its interaction with prostate stem-progenitor cells.  Again, we are being altered prior to birth.
Nathan Goodyear

Perinatal exposure to low-dose bisphenol A affects the neuroendocrine stress response i... - 0 views

joe.endocrinology-journals.org/...207.abstract

bisphenol A Bisphenol-A BPA xenoestrogens stress hormone hormones

shared by Nathan Goodyear on 04 Feb 14 - No Cached
  • Nathan Goodyear on 04 Feb 14
     
    intra uterine exposure to BPA disrupts stress response in rat model.
Nathan Goodyear

Association of Serum Bisphenol-A... [Arch Environ Contam Toxicol. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25213476

BPA bisphenol A Bisphenol-A SHBG androstenedione men male hormone hormones

shared by Nathan Goodyear on 15 Sep 14 - No Cached
  • Nathan Goodyear on 15 Sep 14
     
    Increasing BPA levels associated with declining androstenedione levels,but positively associated with SHBG levels in exposed men.
Nathan Goodyear

Disruption of adult expression of s... [Proc Natl Acad Sci U S A. 2011] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21709224

Bisphenol A hormone disruptors envornmental toxins

shared by Nathan Goodyear on 08 Sep 11 - No Cached
  • Nathan Goodyear on 08 Sep 11
     
    Female deer mice want nothing to do with Bisphenol A toxic male deer mice
Nathan Goodyear

PRECLINICAL STUDY: Changes in central dopaminergic systems and morphine reward by prena... - 0 views

onlinelibrary.wiley.com/...full

bisphenol-A bisphenol A BPA dopamine mesolimbic lactation organogenesis prenatal exposure

shared by Nathan Goodyear on 10 Oct 11 - No Cached
  • Nathan Goodyear on 10 Oct 11
     
    great study that shows how BPA exposure has its largest impact on the mesolimbic/dopamine system during organogenesis and lactation periods.
Nathan Goodyear

Sex-specific effects of long-term exposure to bi... [Chemosphere. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25112706

bisphenol A BPA xenoestrogens ER beta ER-beta hormone hormones anxiety depression

shared by Nathan Goodyear on 13 Aug 14 - No Cached
  • Nathan Goodyear on 13 Aug 14
     
    really interesting abstract.  Bisphenol A (BPA)  is a xenoestrogen.  This animal study finds that BPA down regulated ER-beta in the brains of male rats.  It also blocked the production of GABA(A)alpha 2 receptor.  These long term effects were evident in anxiety and depression in adult mice. Pregnancy exposure would set up an ER-alpha dominance in the male brain increasing risk of continuous ER alpha stim.
Nathan Goodyear

Large Effects from Small Exposures. III. Endocrine Mechanisms Mediating Effects of Bisp... - 0 views

endo.endojournals.org/...s56.full

BPA bisphenol A pregnant children hormone receptors environment environmental toxins

shared by Nathan Goodyear on 15 Dec 12 - No Cached
  • Nathan Goodyear on 15 Dec 12
     
    Very low levels of BPA shown to be present in pregnant and unborn children.  These levels exceed the levels at which documented receptor change occurs as the result of BPA.
Nathan Goodyear

Serum bisphenol-A concentration and sex hormone levels in men - 0 views

www.fertstert.org/...abstract

BPA hormone hormones xenoestrogen Bisphenol-A low testosterone low T testosterone male man SHBG

shared by Nathan Goodyear on 09 May 13 - No Cached
  • Nathan Goodyear on 09 May 13
     
    Study finds that men exposed to BPA have lower androstenedione and free testosterone compared to those not exposed.  Also of note, SHBG is increased, which is what one would expect with xenoestrogen exposure.
Nathan Goodyear

Delayed Neuroendocrine Sexual Maturation in Female Rats After a Very Low Dose of Bisphe... - 0 views

press.endocrine.org/...en.2015-1937

BPA toxins environmental toxins xenoextrogens bisphenol A hormones

shared by Nathan Goodyear on 18 May 16 - No Cached
  • Nathan Goodyear on 18 May 16
     
    low dose of BPA in rat model finds delayed sexual maturation.
Nathan Goodyear

BPA, BPA glucuronide, and BPA sulfate in... [Environ Sci Technol. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23941471

BPA Bisphenol A Bisphenol-A endocrine disruptor EDC

shared by Nathan Goodyear on 04 Sep 13 - No Cached
  • Nathan Goodyear on 04 Sep 13
     
    Startling finding: 100% of all pregnancies in this study were found to have detectable BPA levels.  BPA is a known endocrine disruptor.
Nathan Goodyear

Similarity of Bisphenol A Pharmacokinetics in Rhesus Monkeys and Mice: Relevance for Hu... - 0 views

www.ncbi.nlm.nih.gov/...PMC3080921

BPA Bisphenol A environmental Toxin

shared by Nathan Goodyear on 10 Oct 11 - No Cached
  • Nathan Goodyear on 10 Oct 11
     
    BPA levels in people is much higher than previously suspected.   Additionally, how the BPA works in women is similar to that in monkeys and mice.  Remember, most of the studies have been done on mice and monkeys.
Nathan Goodyear

Bisphenol A (BPA) Information for Parents - 0 views

www.hhs.gov/bpa

BPA bisphenol A children

shared by Nathan Goodyear on 10 Oct 11 - Cached
  • Nathan Goodyear on 10 Oct 11
     
    great review of BPA for parents.
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