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Nathan Goodyear

Low serum testosterone and increased mortality in men with coronary heart disease -- Ma... - 0 views

heart.bmj.com/...1821.abstract

low testosterone heart disease

shared by Nathan Goodyear on 21 Jan 11 - No Cached
  • n patients with coronary disease testosterone deficiency is common and impacts significantly negatively on survival
  • Nathan Goodyear on 21 Jan 11
     
    Low Testosterone decreases survival in those with heart disease
Nathan Goodyear

Testosterone supplementation in men with type 2 di... [Aging Male. 2003] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...12809074

testosterone supplementation diabetes obesity

shared by Nathan Goodyear on 02 Mar 11 - No Cached
  • the benefit of testosterone supplementation therapy exceeds the correction of symptoms of androgen deficiency and also includes glucose homeostasis and metabolic control.
  • Nathan Goodyear on 02 Mar 11
     
    Testosterone therapy in men with Diabetes
Nathan Goodyear

Testosterone Supplementation in Heart Failure - 0 views

circheartfailure.ahajournals.org/...315.long

heart failure CHF cardiovascular disease low T low Testosterone low T male men hormone hormones congestive heart failure testosterone deficiency

shared by Nathan Goodyear on 15 Nov 13 - No Cached
  • Nathan Goodyear on 15 Nov 13
     
    Review of 4 studies found that Testosterone therapy improved exercise capacity in those patients with heart failure.
Nathan Goodyear

The striking similarities in the metabolic associations of female androgen excess and m... - 0 views

humrep.oxfordjournals.org/...humrep.deu198.short

hormone hormones men women Testosterone androgens female male metabolism fat adipose adiposity

shared by Nathan Goodyear on 13 Aug 14 - No Cached
  • Nathan Goodyear on 13 Aug 14
     
    I love this abstract.  I am going to try and find the full print.  As it relates to metabolic dysfunction, elevated Testosterone provides a similar functional picture in women as low Testosterone does in men.
Nathan Goodyear

Effects of Testosterone Replacement on Metabolic and Inflammatory Markers in Men with O... - 0 views

www.ncbi.nlm.nih.gov/...26928845

low T low Testosterone Testosterone opiates men male hormones inflammation

shared by Nathan Goodyear on 02 Mar 16 - No Cached
  • Nathan Goodyear on 02 Mar 16
     
    Opiates and prescription meds are a common cause of low T in men.  In this study with men with metabolic dysfunction and opiate induced low T, Testosterone therapy did not worsen inflammatory/metabolic markers.  Of note, this study did not find improvement in the metabolic and inflammatory markers as other studies have shown.
Nathan Goodyear

Marked Testosterone Deficiency-Related Symptoms Ma... [J Sex Med. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24975551

low T Testosterone low T low Testosterone CVD cardiovascular disease TDS Testosterone Deficiency Syndrome men male hormone hormones

shared by Nathan Goodyear on 07 Jul 14 - No Cached
  • Nathan Goodyear on 07 Jul 14
     
    The more severe the symptoms, the more the increased risk of CVD in men with low T.
Nathan Goodyear

Access : Testosterone deficiency, insulin resistance and the metabolic syndrome : Natur... - 1 views

www.nature.com/...nrendo.2009.212.html

low T testosterone metabolic syndrome insulin resistance sensitivity diabetes IR men

shared by Nathan Goodyear on 11 Feb 12 - No Cached
  • Nathan Goodyear on 11 Feb 12
     
    testosterone replacement in those with low T shown to improve insulin sensitivity, diabetes control, and metabolic syndrome in men.
Nathan Goodyear

The Dark Side of Testosterone Deficiency: II. Type 2 Diabetes and Insulin Resistance --... - 1 views

www.andrologyjournal.org/...23

low T testosterone insulin resistance IR type II diabetes DM metabolic syndrome fat mortality

shared by Nathan Goodyear on 11 Feb 12 - No Cached
  • Nathan Goodyear on 11 Feb 12
     
    low Testosterone associated with insulin resistance, type II diabetes, metabolic syndrome, and increased fat.  These will all translate to increased mortality.
Nathan Goodyear

Low Sex Hormone-Binding Globulin, Total Testosterone, and Symptomatic Androgen Deficien... - 0 views

press.endocrine.org/...jc.2005-1326

low testosterone T metabolic syndrome SHBG MetS men male hormone hormones

shared by Nathan Goodyear on 04 Feb 14 - No Cached
  • Nathan Goodyear on 04 Feb 14
     
    Low Total Testosterone, low SHBG, and symptoms of low T are associated with an increase risk (relative) of Mets, especially in normal weight men.
Nathan Goodyear

Total and free testosterone concentrations are strongly influenced by age and central o... - 0 views

onlinelibrary.wiley.com/...2B811BB37A876512D30CA68.f04t01

Testosterone low T obesity age aging male men hormone hormones diabetes

shared by Nathan Goodyear on 04 Feb 14 - No Cached
  • Nathan Goodyear on 04 Feb 14
     
    Testosterone levels, measured as total, bioavailable and free, found to be associated with age and central (not visceral) obesity in those men with type I and II Diabetes.  Weakly with symptoms of low T and ED.
Nathan Goodyear

The Dark Side of Testosterone Deficiency: II. Type 2 Diabetes and Insulin Resistance - ... - 0 views

onlinelibrary.wiley.com/...full

low T Testosterone diabetes insulin resistance IR metabolic syndrome metabolic syndrome men male hormone hormones

shared by Nathan Goodyear on 30 Jan 14 - No Cached
  • Nathan Goodyear on 30 Jan 14
     
    low Testosterone linked to insulin resistance, type II Diabetes, and increased  metabolic syndrome.  Low T is linked to increased visceral fat in this study.  
Nathan Goodyear

Testosterone deficiency and severity of erectile d... [Andrology. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24574152

low T Testosterone ED quality of life diabetes men male hormone hormones

shared by Nathan Goodyear on 03 Mar 14 - No Cached
  • Nathan Goodyear on 03 Mar 14
     
    Study finds that low Testosterone (total, free, and bioavailable) associated with reduced quality of life in men with Diabetes.  So was ED.
Nathan Goodyear

PLOS ONE: Prediabetes Is Associated with an Increased Risk of Testosterone Deficiency, ... - 0 views

www.plosone.org/...10.1371%2Fjournal.pone.0074173

hormone hormones Testosterone low T metabolic syndrome obesity overweight MetS insulin resistance pre diabetes

shared by Nathan Goodyear on 20 Dec 13 - No Cached
  • Nathan Goodyear on 20 Dec 13
     
    This study found that low T was clearly associated with "pre diabetes" independent of weight and MetS.  All men that are overweight, obese, with metabolic syndrome, "pre diabetic" need evaluation of hormones, not just Testosterone.
Nathan Goodyear

Hypothalamic-Pituitary-Testicular Axis Disruptions in Older Men Are Differentially Link... - 0 views

press.endocrine.org/...jc.2007-1972

low T low Testosterone low T Testosterone aging LH hormone hormones men male SHBG

shared by Nathan Goodyear on 03 Sep 14 - No Cached
  • 0.4–2% annual decline
  • the age trend in free T was more substantial (−1.3% per annum)
  • The core hormonal pattern with increasing age is suggestive of incipient primary testicular dysfunction with maintained total T and progressively blunted free T associated with higher LH.
  • ...16 more annotations...
  • Obesity was associated with progressively lower total and free T independent of the simultaneous decrease in SHBG.
  • our data highlight the fact that LH was unchanged or even lower in older men in the face of lower T in obesity, suggesting that there may be a failure at the hypothalamic-pituitary level.
  • a change in BMI from nonobese to obese may be equivalent to a 15 yr fall in T.
  • This pattern supports the hypothesis that different underlying mechanisms influence the functions of the HPT axis: age predominantly affects testicular function, whereas obesity impairs hypothalamic/pituitary function.
  • the effects of aging on testicular function can be moderated by increased LH compensation for many decades
  • obesity impairs hypothalamic/pituitary function independent of age, arguably an adaptive response for which there should be no compensatory mechanism.
  • the concurrent but opposite (and separate) effects of obesity and age on SHBG
  • SHBG was negatively associated with increasing strata of obesity
  • Obesity is associated with insulin resistance (28), and the increased circulating insulin inhibits hepatic SHBG synthesis
  • the SHBG increase with age may be related to relative IGF-I deficiency (27), although this has not been directly proven.
  • Obesity is associated with peripheral and central insulin resistance (30) and proinflammatory cytokine production (TNFα and IL-6) from adipocytes (31) and central nervous system endocannibinoid release (32), all of which are potential candidates for abrogating hypothalamic endocrine and downstream reproductive axis functions.
    • Nathan Goodyear
      Nathan Goodyear on 03 Sep 14
       
      The HPA axis effect may be the result of inflammation.
  • The relationship between obesity and T can be bidirectional: low T may be the cause rather than consequence of obesity
  • chronic alcohol abuse is known to suppress LH (40), our data showed no significant association among the three hormones or SHBG and alcohol intake.
  • increase in total T in smokers occurs through a primary increase in SHBG with a compensatory rise in LH
  • the effects of obesity (BMI or waist circumference) was by far the most important determinant of variance in total T, whereas age per se was important for SHBG, LH, and free T with comorbidity and smoking being comparatively minor contributors
  • It is noteworthy that these predisposing lifestyle and health factors are modifiable. This implies that the apparent age-related decline in T may constitute a barometer of health and thus be potentially preventable and/or reversible.
  • Nathan Goodyear on 03 Sep 14
     
    Age induced decline in Testosterone is more associated with a decline in leydig cell function and thus elevated LH will be associated.  In contrast, obesity is more of a HPA axis disruption and thus LH may be normal to low.  The pulse amplitude is decrease.  No change in pulse frequency is noted.   With obesity, a decline in TT and fT was independent of SHBG. Aging is associated with a greater decrease in fT versus TT.
Nathan Goodyear

Testosterone deficiency and quality of life in ... [Intern Med J. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25081047

Testosterone quality of life QOL Testicular cancer low T men male hormone hormones

shared by Nathan Goodyear on 04 Aug 14 - No Cached
  • Nathan Goodyear on 04 Aug 14
     
    Small study in men s/p Testicular cancer found no association between Testosterone levels and quality of life measures.
Nathan Goodyear

Testosterone administration to men with testosterone deficiency syndrome after external... - 0 views

www.ncbi.nlm.nih.gov/...18671790

Testosterone low T low Testosterone men male hormones prostate cancer cancer saturation theory prostate

shared by Nathan Goodyear on 10 Oct 16 - No Cached
  • Nathan Goodyear on 10 Oct 16
     
    small study of men post prostate cancer radiotherapy: only 1 of the 5 had a transient rise in PSA, though the level was still below the 1.5 ng/ml threshold.  This fits within the saturation theory concept. F/u in this study was 14.5 months.  Abstract only available here.
Nathan Goodyear

The 20-Year Public Health Impact and Direct Cost of Testosterone Deficiency in U.S. Men... - 0 views

onlinelibrary.wiley.com/...48D8B444401449DB28B6867.d03t01

low T low testosterone cost costs low testosterone deficiency

shared by Nathan Goodyear on 16 Feb 13 - No Cached
  • Nathan Goodyear on 16 Feb 13
     
    This study assumes a 13% low T prevalence.  Probably too low.  This will only grow.  Low T contributes to many disease states in men. This study showed a cost of 190-525$ billion in cost from these disease states over a 20 year time period.
Nathan Goodyear

Sexual dysfunction in males with chronic hepatitis C and antiviral therapy: interferon-... - 0 views

joe.endocrinology-journals.org/...345.long

hepatitis Hepatitis C HCV interferon low T low testosterone deficiency men male hormone hormones depression

shared by Nathan Goodyear on 22 Apr 15 - No Cached
  • Nathan Goodyear on 22 Apr 15
     
    Study of men with hepatitis C and interferon therapy found decrease in free and total Testosterone levels in men.  The study results suggest a non-HPA effect, which suggests more of a peripheral effect at the level of the TEsticles.
Nathan Goodyear

Testosterone deficiency: Practical guidelines for diagnosis and treatment | BC Medical ... - 0 views

www.bcmj.org/...elines-diagnosis-and-treatment

low T low Testosterone hypogonadism men male hormone hormones

shared by Nathan Goodyear on 12 Aug 14 - No Cached
  • Nathan Goodyear on 12 Aug 14
     
    I am not a fan of guideline medicine, but this review of the literature on low T is worth while.
Nathan Goodyear

Androgen insufficiency in women: diagnostic and therapeutic implications - 0 views

humupd.oxfordjournals.org/...421.full

SHBG androgen testosterone androgens DHT women insufficiency deficiency

shared by Nathan Goodyear on 12 Jun 13 - No Cached
  • SHBG has a differing binding affinity for sex steroids in the following order; DHT > testosterone > androstenedione > estradiol > estrone
  • SHBG also weakly binds DHEA, but not DHEAS
  • Nathan Goodyear on 12 Jun 13
     
    Good discuss of androgen deficiency in women.  Also, good discussion of SHBG.  
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