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Nathan Goodyear

Perspectives for metabolomics in testosterone replacement therapy - 0 views

joe.endocrinology-journals.org/...3.full

ADS androgen deficiency syndrome low T low Testosterone hormones metabolomics

shared by Nathan Goodyear on 30 Apr 15 - No Cached
  • Nathan Goodyear on 30 Apr 15
     
    androgen deficiency syndrome and metabolomics
Nathan Goodyear

Prevalence of Symptomatic Androgen Deficiency in Men - 0 views

jcem.endojournals.org/...4241.full

low T testosterone androgen deficiency men andropause

shared by Nathan Goodyear on 31 Jan 12 - No Cached
  • Nathan Goodyear on 31 Jan 12
     
    5.6% of men today suffer from symptoms of androgen deficiency.  This problem is expected to amount to 6.5 million men by 2025.
Nathan Goodyear

Waist-to-height ratio as a predictor of serum testosterone in ageing men with symptoms ... - 0 views

www.ncbi.nlm.nih.gov/...PMC3739344

waist to height ratio low T low testosterone aging Testosterone male hormones hormones men

shared by Nathan Goodyear on 19 Sep 16 - No Cached
  • WHt ratio was calculated by dividing waist (cm) by height (cm)
  • nverse relationships of BMI and WC with TT and cFT have been previously documented in unselected cohorts of adult men
  • over the age of 54 years
  • ...5 more annotations...
  • adjusting WC for height (WHt ratio) improves the prediction of TT and cFT compared with either BMI or WC alone
  • there were inverse correlations between cFT, TT and either BMI or WC
  • for each unit increase in BMI, there was a 2% fall in TT and cFT
  • for each 10 cm increment in WC, TT and cFT levels declined by 7%.
  • The magnitude of this relationship between increasing BMI and decreasing TT is similar to that described in the Massachusetts Male Ageing Study
  • Nathan Goodyear on 19 Sep 16
     
    waist to height ratio reliable predictor of low T in men.
Nathan Goodyear

Prevalence and Incidence of Androgen Deficiency in Middle-Aged and Older Men: Estimates... - 0 views

press.endocrine.org/...jc.2003-031719

low T Testosterone hypogonadism age men male hormone hormones aging

shared by Nathan Goodyear on 24 Apr 14 - No Cached
  • Nathan Goodyear on 24 Apr 14
     
    Total prevalence of low Testosterone in this study was 12.3% per 1,000 person years.  With increasing age, comes decreasing Tesosteorne levels in men.
Nathan Goodyear

Sex Steroid Control of Gonadotropin Secretion in the Human Male. II. Effects of Estradi... - 0 views

jcem.endojournals.org/...621

low testosterone estradiol men

shared by Nathan Goodyear on 14 Jan 11 - No Cached
  • Nathan Goodyear on 14 Jan 11
     
    Estrogen reduces testosterone production in men
Nathan Goodyear

Erectile dysfunction and testosterone deficiency. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...19011292

PDE5 PDE5 inhibitors PDE5I low T low Testosterone NO nitric oxide ED men hormones Testosterone

shared by Nathan Goodyear on 18 Nov 15 - No Cached
  • Nathan Goodyear on 18 Nov 15
     
    A high percentage of men that fail PDE5 therapy have low T and the addition of T therapy improves the effects of PDE5 therapy.  T provides a positive impact on NO synthase which increased NO, which PDE5 therapies must have to work.
Nathan Goodyear

Circulating Inflammatory Cytokine Expression in Men With Prostate Cancer Undergoing And... - 0 views

www.andrologyjournal.org/...725

inflammation inflammatory cytokines men androgens deprivation therapy prostate cancer

shared by Nathan Goodyear on 25 Apr 12 - No Cached
  • Nathan Goodyear on 25 Apr 12
     
    this study found no increase in inflammatory cytokines in those men on androgen deprivation therapy for prostate cancer.  The question, is they evaluated testosterone in the serum, so did they really see a decrease in androgens or just a decrease in the transport of androgens.  Saliva would have detected a true androgen deficient state.
Nathan Goodyear

The Dark Side of Testosterone Deficiency: II. Type 2 Diabetes and Insulin Resistance --... - 1 views

www.andrologyjournal.org/...23

testosterone deficiency diabetes insulin resistance type II 2 low T

shared by Nathan Goodyear on 11 Feb 12 - No Cached
  • Nathan Goodyear on 11 Feb 12
     
    here is the full article of a previously posted link.
Nathan Goodyear

The Dark Side of Testosterone Deficiency: III. Cardiovascular Disease - Traish - 2013 -... - 0 views

onlinelibrary.wiley.com/...full

low T Testosterone CVD cardiovascular disease men male hormone hormones

shared by Nathan Goodyear on 30 Jan 14 - No Cached
  • Nathan Goodyear on 30 Jan 14
     
    More recent articles have been published, but this review article reviews the link between low T and cardiovascular disease in men.
Nathan Goodyear

The Dark Side of Testosterone Deficiency: I. Metabolic Syndrome and Erectile Dysfunctio... - 0 views

onlinelibrary.wiley.com/...full

low T Testosterone metabolic syndrome ED metabolic syndrome obesity men male hormone hormones

shared by Nathan Goodyear on 30 Jan 14 - No Cached
  • Nathan Goodyear on 30 Jan 14
     
    Article reviews the link between obesity, low T, metabolic syndrome and ED.  ED has been shown to be predictive of CVD by 3-5 years.  
Nathan Goodyear

Testosterone Deficiency in Young Men: Marked Alterations in Whole Body Protein Kinetics... - 0 views

press.endocrine.org/...jcem.83.6.4892

low T low Testosterone muscle muscle mass strength fat obesity adipose tissue metabolism hormone hormones men male

shared by Nathan Goodyear on 06 Mar 15 - No Cached
  • Nathan Goodyear on 06 Mar 15
     
    low T in men, small study, found to decrease muscle growth, decreased strength as a result, decrease in fat oxidation/breakdown and increase in fat stores.  Low T turns the muscle:fat ratio in men upside down--the result is a metabolic derailment.
Nathan Goodyear

Androgen deficiency and mitochondrial dysfunction: implications for fatigue, muscle dys... - 0 views

www.degruyter.com/...hmbci.2011.132.xml

men male hormone hormones androgens low T low Testosterone low T Testosterone insulin resistance IR diabetes metabolic syndrome obesity mortality disease cardiovascular

shared by Nathan Goodyear on 12 Aug 14 - No Cached
  • Nathan Goodyear on 12 Aug 14
     
    low Androgens, or low T to be specific, associated with insulin resistance, diabetes, metabolic syndrome, obesity, and mortality.
Nathan Goodyear

Characteristics of Secondary, Primary, and Compensated Hypogonadism in Aging Men: Evide... - 0 views

press.endocrine.org/...jc.2009-1796

low T low Testosterone hypogonadism aging obesity men male hormone hormones

shared by Nathan Goodyear on 30 Mar 15 - No Cached
  • Circulating testosterone (T) in men declines progressively by 0.4–2% per year from the third decade onward
  • late-onset hypogonadism (LOH) (6, 7), whereas others have used various terms including andropause, male menopause, and androgen deficiency syndrome of the aging male.
    • Nathan Goodyear
      Nathan Goodyear on 30 Mar 15
       
      all names for Low T--interesting
  • Secondary hypogonadism is associated with obesity (and potentially reversible) independently of age
  • ...2 more annotations...
  • primary hypogonadism (probably the genuine form of LOH) is strongly associated with age
  • Compensated hypogonadism represents a distinct clinical entity that warrants continued monitoring to prevent or preempt further deterioration
  • Nathan Goodyear on 30 Mar 15
     
    Study divides low T into primary (age), secondary (weight), and compensated hypogonadism (elevated LH with normal T)
Nathan Goodyear

Counteracting muscle wasting in HIV-infected individuals - 0 views

trace.tennessee.edu/...viewcontent.cgi

muscle mass low T low testosterone HGH men male

shared by Nathan Goodyear on 12 Nov 12 - No Cached
  • Nathan Goodyear on 12 Nov 12
     
    HIV/AIDS patients are plagues with muscle loss through varying mechanism. This article discusses the various contributors to the muscle mass found in these men. However, this can be applicable to other men with chronic muscle loss, low T, HGH deficiency...
Nathan Goodyear

[Functional states of pituitary-ovary, adrenal and... [Zhonghua Fu Chan Ke Za Zhi. 1998... - 0 views

www.ncbi.nlm.nih.gov/...10682483

PCOS LH insulin hypothyroidism androgens testosterone resistance

shared by Nathan Goodyear on 17 Dec 10 - No Cached
  • CONCLUSION: It appears that ovarian androgen excess in women with PCOS is mainly LH-dependent in Group 1 and insulin-dependent in Group 2. Enhanced adrenal activity may contribute to both hyperandrogenism and insulin resistance in this syndrome, and subclinical hypothyroidism may exist in affected subjects, especially of Group 1.
  • Nathan Goodyear on 17 Dec 10
     
    PCOS is not a birth control pill deficiency, but a complex hormonal imbalance
Nathan Goodyear

Hormonal Modulation in Aging Patients with Erectile Dysfunction and Metabolic Syndrome - 0 views

www.ncbi.nlm.nih.gov/...PMC3888699

low T Testosterone hypogonadism MetS metabolic syndrome men male hormone hormones

shared by Nathan Goodyear on 05 Feb 14 - No Cached
  • Hypogonadism and MetS are strongly associated [12, 13, 16], having even been demonstrated that with the increasing number of MetS parameters there is a proportional raise in the incidence of hypogonadism
  • increasing number of MetS components is inversely associated with T levels
  • the presence of MetS did not prove to be a significant determinant of hypogonadism, as it did not lead to a decline in T levels, in MetS patients with already established hypogonadism, the increasing number of MetS features was associated with further decline in T
  • ...15 more annotations...
  • In the setting of MetS, hypertriglyceridemia and increased WC have been reported as the most important determinants of hypogonadism
  • recent literature consistently associates obesity not only with higher risk of hypogonadism [4, 6, 27] but also with lower T levels
  • Visceral adiposity has been particularly related with reduction of T and SHBG levels (independent of other metabolic disorders)
  • WC was one of the MetS parameters with the greatest influence in T levels decrease, presenting itself as a strong risk factor for hypogonadism development
  • MetS-related T decline was not accompanied by an increase in pituitary LH levels, suggesting impairment in gonadotropin secretion
  • The molecules behind this smoothing compensatory effect of GnRH/LH are still unknown, but estrogens and insulin, as well as leptin, TNF-α, and other adipokines, were proposed candidates
  • fat stores undertake an increase aromatization of androgens, therefore raising estrogen levels [9, 15], which in turn decrease LH secretion
  • our data contradicts the concept that estradiol exerts a negative feedback on hypothalamic GnRH secretion
  • taking into account that high estradiol levels have already been described as the only abnormality in a subset of patients with ED, the hypothesis that the later might not only be caused by androgen deficiency is becoming increasingly evident
  • it has been reported that the chronic exposure to phosphodiesterase type 5 inhibitors (PDE5i), widely used for the treatment of ED, may influence serum estradiol levels
  • thyroid disorders (specially hyperthyroidism) have been related to ED and hypogonadism, and so must be considered in a sexual-dysfunction setting
  • It is clear from the current literature that collecting a more thorough hormonal panel might be a wise approach to further uncover hormonal relations
    • Nathan Goodyear
      Nathan Goodyear on 05 Feb 14
       
      outstanding point.  This hits to the point that Low T is the effect not the cause.
  • We concluded that in ED patients with hypogonadism and MetS, the attenuated response of HPG axis (normal or low LH levels) might not always be due to an underlying adiposity-dependent estrogen-raising effect.
  • our findings indicate that ED, aging, and estradiol might have a stronger connection than what is currently described in the literature.
  • this study underlines the importance of the collection of a full hormonal panel in ED men
  • Nathan Goodyear on 05 Feb 14
     
    low T strongly associated with metabolic syndrome in men.
Nathan Goodyear

Prevalence and Incidence of Androgen Deficiency in Middle-Aged and Older Men: Estimates... - 0 views

jcem.endojournals.org/...5920.full

lot T testosterone Massachusetts male aging study MMAS hypogonadism

shared by Nathan Goodyear on 20 Nov 13 - No Cached
  • Nathan Goodyear on 20 Nov 13
     
    The Massachusetts male aging study found 2.4 million men with hypogonadism.  They estimated 481,000 new cases annually in the age group of 40-69.  This was in very stringent definition of "hypogonadism".
Nathan Goodyear

Therapy in the Early Stage: Incretins - 0 views

care.diabetesjournals.org/...S264.full

incretins glucose diabetes

shared by Nathan Goodyear on 11 Dec 13 - No Cached
  • Increased resistance to insulin action in the skeletal muscle and liver associated with enhanced hepatic glucose output and impaired insulin secretion due to a progressive decline of β-cell function are long-recognized core defects
  • in addition, other mechanisms/organs are involved, augmenting the pathological pathways: adipocytes (altered fat metabolism due to insulin resistance), gastrointestinal tract (incretin deficiency and/or resistance), pancreatic α-cells (hyperglucagonemia and increased hepatic sensitivity to glucagon), kidneys (enhanced glucose reabsorption), and central nervous system (insulin resistance)
  • β-cell failure
    • Nathan Goodyear
      Nathan Goodyear on 11 Dec 13
       
      and studies have shown that a reduction in insulin function will decrease LH production and thus lead to a decrease in Testosterone production in men.
  • ...2 more annotations...
  • Incretins are gut-derived hormones, members of the glucagon superfamily, released in response to nutrient ingestion (mainly glucose and fat)
  • They exert a wide range of effects, including stimulation of pancreatic insulin secretion in a glucose-dependent manner and play an important role in the local gastrointestinal and whole-body physiology
  • Nathan Goodyear on 11 Dec 13
     
    good discussion on incretins and their role in glucose homeostasis. 
Nathan Goodyear

Prevalence of Symptomatic Androgen Deficiency in Men: The Journal of Clinical Endocrino... - 0 views

press.endocrine.org/...jc.2007-1245

low T Testosterone male men hormone hormones hypogonadism

shared by Nathan Goodyear on 24 Apr 14 - No Cached
  • Nathan Goodyear on 24 Apr 14
     
    Prevalence of low T is 5-10% based on this study from 2007.
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