Group items tagged

low Total Testosterone associated with CAD, particularly aortic.  Obviously, Testosterone, when low, is a marker of poor health in men.  However, low Testosterone can likely play a role in disease development, especially when age is factored in--low Testosterone in younger men likely plays an etiology versus a lesser impact in the elder.

Weak connection, but this study finds that Testosterone in post-menopausal women will reduce cardiovascular disease (CVD) in women.  Their conclusion is based on the rise in CVD in post-menopausal women and the decline in Testosterone levels post-hysterectomy. That is the one instant where Testosterone levels do precipitously decline.  Contrast this with natural menopause where Testosterone does not appear to decline as precipitously.

So many studies point to Testosterone is just an association with CVD and CAD.  This study finds that Testosterone therapy in those with low T and type II diabetes have a reduction in mortality 8.4% versus 19.2% in those untreated.  This study also found an increase in mortality in those with low Testosterone versus those with normal Testosterone.  This was a 6 year f/u of 581 men.

Article highlights the problems with the definition of low T.  This article finds consistent decline in Total Testosterone and FAI with increasing age groups, with a significant portion of men > 60 meeting the required levels for "low T".  This study found a decrease in total T and FAI at a consistent rate independent of variables, such as BMI.    This study did find a decrease in SHBG and total T with obesity; in contrast to other studies.

Long term study finds testosterone therapy associated with reduced mortality in men.

Study of 713 Chinese men finds a correlation between low vitamin D and low total Testosterone.

Study finds that Testosterone therapy reduces LUTS in men with low T.  The definition of low T is a little wide in this study.  Another study that contradicts the belief that Testosterone contributes to LUTS through the prostate.

testosterone therapy does not increase prostate cancer.

Men with CHF and low Testosterone have higher readmission rates within 90 days compared to those men with CHF and normal Testosterone.

low testosterone is risk factor for CVD in men.  Of course, normalization of testosterone should be employed and followed in those men that have low T.

2013 AUA white paper on low Testosterone.

salivary testosterone shown to effective in screening for androgen deficiency in men with ESRD.

androgen deficiency and guidelines for Testosterone therapy.  Nice review of statistics and symptoms.  Many symptoms of low T go unrecognized.

salivary testosterone via immunoassay shown to have sensitivity and specificity to be 100%.  Very reliable method to test for testosterone levels.

Testosterone therapy in men with low T will improve lean body mass, some reduction in abdominal obesity, yet little effect in visceral obesity.

Declining Testosterone, calculated free Testosterone, Estradiol, and Estrone levels appear to be associated with muscle mass/strength decline in elderly men.  This points to a global decrease in HPA function rather than an individual, specific hormone deficiency.

Zinc deficiency associated with low 5-alpha reductase activity and increased aromatase activity.  Additionally, low zinc was associated with decreased LH and testosterone levels in male rats.

Low Testosterone in men with Diabetes predictive of an increase in all-cause mortality.  This fits with other data.  

This study found that lower TT and E1 associated with more "poor health" as defined by questionnaire.  The conclusion might lead one to think that Estrogen therapy is need in men.  Eightly percent of estrogen production in men occurs from Testosterone.  If Testosterone declines, then estrogen production will likewise decline.  A simple fact that the authors did not comment on.  Also, E1 binds with high affinity to ER alpha, which is pro-inflammatory and pro-proliferative: neither of which is a positive health benefit.   This appears to point more to a broad HPA suppression as an association to the "poor health".

Salivary testosterone: a reliable approach to the diagnosis of male hypogonadism.