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Nathan Goodyear

Effects of gut microbiota on obesity and atherosclerosis via modulation of inflammation... - 0 views

onlinelibrary.wiley.com/...full

gut gut flora gut microbiome gut microbiota inflammation metaboliism

shared by Nathan Goodyear on 05 Jul 15 - No Cached
  • Nathan Goodyear on 05 Jul 15
     
    Gut effects on metabolism are widespread.
Nathan Goodyear

Lipid-Lowering Effects of Curcumin in Patients... [Phytother Res. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25131839

metabolic syndrome curcumin tumeric HDL LDL triglycerides cholesterol natural alternative

shared by Nathan Goodyear on 19 Aug 14 - No Cached
  • Nathan Goodyear on 19 Aug 14
     
    Spice it up for cholesterol.  Study finds small, but significant, improvement in in HDL, LDL, and triglycerides with daily curcumin in those with metabolic syndrome.
Nathan Goodyear

Effect of Levothyroxine Replacement on Lipid Profile and Intima-Media Thickness in Subc... - 0 views

jcem.endojournals.org/...2099.long

levothyroxin subclinical hypothyroidism functional hypothyroidism hypothyroid lipids hypothyroidism cholesterol metabolism thyroid IMT

shared by Nathan Goodyear on 27 Jul 13 - No Cached
  • Nathan Goodyear on 27 Jul 13
     
    synthetic T4, as levothyroxine, in subclinical hypothyroidism is shown to improve cholesterol levels and intima-media thickness.
Nathan Goodyear

The Benefits and Harms of Systemic Dehydroepiandrosterone (DHEA) in Postmenopausal Wome... - 0 views

press.endocrine.org/...jc.2014-2261

DHEA women hormone hormones

shared by Nathan Goodyear on 07 Oct 14 - No Cached
  • Nathan Goodyear on 07 Oct 14
     
    Review of the data points to poor quality of evidence dealing with DHEA in post-menopausal women with normal adrenal function.  Yet if DHEA is low, which is >95% produced by adrenals in women, then how can the adrenal function be "normal".   The meta-analysis found no improvement in libido and/or sexual function, and no improvement in lipids, glucose, weight... was noted.  Essentially not positive or negative effects were noted.  Abstract only available here, so dosage is a question.
Nathan Goodyear

The Effect of Testosterone Replacement on Endogenous Inflammatory Cytokines and Lipid P... - 0 views

jcem.endojournals.org/...3313

testosterone effect lipids cholesterol inflammation

shared by Nathan Goodyear on 02 Mar 11 - No Cached
  • In conclusion, testosterone replacement shifts the cytokine balance to a state of reduced inflammation and lowers total cholesterol.
  • Nathan Goodyear on 02 Mar 11
     
    Testosterone helped to balance inflammation and lower total cholesterol
Nathan Goodyear

Low Testosterone Concentration and Atherosclerotic Disease Markers in Male Patients Wit... - 0 views

press.endocrine.org/...jc.2014-2585

low T low Testosterone low T Testosterone carotid intima-media thickness IMT intima-medial thickness atherosclerosis hsCRP free Testosterone endothelial dysfunction men male hormones hormone cardiovascular disease CVD

shared by Nathan Goodyear on 21 Oct 14 - No Cached
  • Nathan Goodyear on 21 Oct 14
     
    Study of men < 70 finds that low Total Testosterone and Free Testosterone is associated with increased Carotid Intima-media thickness (CIMT), increased endothelial dysfunction.  Atherosclerotic plaque and hsCRP were also found to correlate but were adjusted out when age, DM, HgbA1c, lipids, and BMI were excluded.
Nathan Goodyear

Ozone therapy: A clinical review - 0 views

www.ncbi.nlm.nih.gov/...PMC3312702

cancer Ozone

shared by Nathan Goodyear on 13 Apr 20 - No Cached
  • Its basic function is to protect humans from harmful effects of UV radiation
  • Its effects are proven, consistent and with minimal side effects
  • Medical O3, used to disinfect and treat disease, has been around for over 150 years
  • ...11 more annotations...
  • O3 not only remedied infection, but also had hemodynamic and anti-inflammatory properties
  • Stimulation of oxygen metabolism
  • In fungi, O3 inhibits cell growth at certain stages
  • With viruses, the O3 damages the viral capsid and upsets the reproductive cycle by disrupting the virus-to-cell contact with peroxidation.
  • Inactivation of bacteria, viruses, fungi, yeast and protozoa: Ozone therapy disrupts the integrity of the bacterial cell envelope through oxidation of the phospholipids and lipoproteins
  • Activation of the immune system
  • 30 and 55 μg/cc
  • production of interferon and the greatest output of tumor necrosis factor and interleukin-2
  • Mechanism of action of O3 on the human lung
  • cascade of reactions like peroxidation of lipids leading to changes in membrane permeability,[41] lipid ozonation products (LOP) act as signal transducer molecules
  • Dietary antioxidants or free radical scavengers like vitamin E, C, etc., can prevent aforementioned effects of O3
  • Nathan Goodyear on 13 Apr 20
     
    Ozone therapy review
Nathan Goodyear

Effects of Polyunsaturated Fatty Acids in Growth Medium on Lipid Composition and on Phy... - 0 views

www.ncbi.nlm.nih.gov/...PMC321255

PUFA poly unsaturated fatty acids GI dysbiosis bacteria microbiota

shared by Nathan Goodyear on 01 May 12 - No Cached
  • Nathan Goodyear on 01 May 12
     
    PUFA shown to effect GI bacterial balance.  Altering adhesion of lactobacillus to intestinal surface.  Also, lactobacilli species shown to alter PUFA metabolism in GI.  This article reveals the effect that diet can have on GI bacterial balance.
Nathan Goodyear

Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adipo... - 0 views

www.ncbi.nlm.nih.gov/...PMC2673878

obesity fructose soda weight-gain overweight

shared by Nathan Goodyear on 09 Sep 12 - No Cached
  • Nathan Goodyear on 09 Sep 12
     
    fructose intake, whether in foods or soda, is associated with disrupted metabolism and plays a major role in obesity.
Nathan Goodyear

Fructose, weight gain, and the insulin resistance syndrome - 0 views

www.ajcn.org/...911.abstract

overweight weight gain insulin fructose leptin resistance

shared by Nathan Goodyear on 26 May 11 - No Cached
  • he combined effects of lowered circulating leptin and insulin in individuals who consume diets that are high in dietary fructose could therefore increase the likelihood of weight gain and its associated metabolic sequelae
  • fructose, compared with glucose, is preferentially metabolized to lipid in the liver
  • Fructose consumption induces insulin resistance, impaired glucose tolerance, hyperinsulinemia, hypertriacylglycerolemia, and hypertension in animal models
  • Nathan Goodyear on 26 May 11
     
    Fructose increase in American diets parallels obesity rise in Americans;  Physiologic mechanism of fructose contribution to obesity discussed
Nathan Goodyear

The major green tea polyphenol, (-)-epigallocatech... [J Nutr. 2008] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...18716169

green tea extract weight loss

shared by Nathan Goodyear on 05 May 11 - No Cached
  • Our results indicate that long-term EGCG treatment attenuated the development of obesity, symptoms associated with the metabolic syndrome, and fatty liver. Short-term EGCG treatment appeared to reverse preexisting high-fat-induced metabolic pathologies in obese mice. These effects may be mediated by decreased lipid absorption, decreased inflammation, and other mechanisms.
  • Nathan Goodyear on 05 May 11
     
    Green tea extract results in weight loss, both short-term and long-term
Nathan Goodyear

Curcumin Inhibits Adipogenesis in 3T3-L1 Adipocytes and Angiogenesis and Obesity in C57... - 0 views

jn.nutrition.org/...919.abstract

curcumin adipogenesis obesity weight loss

shared by Nathan Goodyear on 28 Apr 11 - No Cached
  • Dietary polyphenols may suppress growth of adipose tissue through their antiangiogenic activity and by modulating adipocyte metabolism
  • curcumin, the major polyphenol in turmeric spice
  • curcumin suppression of angiogenesis in adipose tissue together with its effect on lipid metabolism in adipocytes may contribute to lower body fat and body weight gain
  • ...1 more annotation...
  • Our findings suggest that dietary curcumin may have a potential benefit in preventing obesity
  • Nathan Goodyear on 28 Apr 11
     
    Curcumin useful in obesity
Nathan Goodyear

The Pharmacokinetics and Interactions of Ivermectin in Humans-A Mini-review - 0 views

www.ncbi.nlm.nih.gov/...PMC2751445

Ivermectin

shared by Nathan Goodyear on 19 Mar 18 - No Cached
  • This drug is extensively metabolized by human liver microsomes by cytochrome P450
  • cytochrome P-4503A4, converting the drug to at least 10 metabolites
  • its elimination half-life is around a day
  • ...12 more annotations...
  • second rise in plasma levels (mostly occurring between 6 and 12&nbsp;h after the dose) suggesting an enterohepatic recycling of the drug
  • Ivermectin is exceptionally potent, with effective dosages levels that are unusually low.
  • the optimal dose of ivermectin is 150&nbsp;μg/kg, but the frequency of administration is still controversial, ranging from 150&nbsp;μg/kg once to three times yearly.
  • high lipid solubility of ivermectin, this compound is widely distributed within the body.
  • To interrupt the transmission of onchocerciasis in humans, the combination of ivermectin and doxycycline is highly effective as, in infested patients, the ingestion of the anthelmintic (200&nbsp;μg/kg, single dose) and the antibacterial (100&nbsp;mg/kg, daily for 6&nbsp;weeks)
  • ivermectin interactions with another concurrently administered drugs can occur.
  • This issue becames important, as combination chemotherapy is being used with increasing frequency as resistance to antiparasitic agents is becoming more widespread.
  • haematomatous swellings
  • prothrombin times were significantly above baseline by one week to one month after drug ingestion, suggesting an antagonist effect against vitamin K
  • bleeding disorders were not found in 15,000 patients treated with ivermectin (150&nbsp;μg/kg)
  • prolonged prothrombin ratios were observed in 148 subjects given ivermectin orally. Although no patients suffered bleeding complications, factor II and VII levels were reduced in most of them, suggesting interference with vitamin K metabolism
  • Ivermectin has a minimal effect on coagulation and concern about mass treatment for this reason appears to be unjustified
  • Nathan Goodyear on 19 Mar 18
     
    Review of Ivermectin as an anti-parasitic.
Nathan Goodyear

Effects of Cortisol on Carbohydrate, Lipid, and Protein Metabolism: Studies of Acute Co... - 0 views

jcem.endojournals.org/...3553.full

cortisol glucose glucose homeostasis insulin resistance T3

shared by Nathan Goodyear on 01 Apr 13 - No Cached
  • Nathan Goodyear on 01 Apr 13
     
    This study they looked at the withdrawal of cortisol on glucose homeostasis.  The point is that cortisol has profound effects on glucose homeostasis.  Elevated cortisol or exogenous intake reduces T3 and increases insulin resistance.
Nathan Goodyear

Effects of testosterone on body composition, bone metabolism and serum lipid profile in... - 0 views

www.ncbi.nlm.nih.gov/...16117815

Testosterone low t low testosterone Testosterone therapy body composition fat muscle male hormones hormones

shared by Nathan Goodyear on 09 Jan 17 - No Cached
  • Nathan Goodyear on 09 Jan 17
     
    Meta-analysis finds that Testosterone therapy in men 40+ reduced total body fat with an increase in fat free mass. 
Nathan Goodyear

Ovarian estradiol production and lipid metabolism ... [Menopause. 2014] - PubMed - NCBI - 1 views

www.ncbi.nlm.nih.gov/...24569620

menopause post-menopause estradiol E2 women hormone hormones estrogen

shared by Nathan Goodyear on 03 Mar 14 - No Cached
  • Nathan Goodyear on 03 Mar 14
     
    contrary to popular thought, the ovaries dont' shrivel up and die post menopause.  This study finds Estradiol production on going post menopause.
Nathan Goodyear

Metabolic Effects of Dietary Fiber Consumption and Prevention of Diabetes - 0 views

jn.nutrition.org/...439.long

soluble insoluble fiber dietary diet nutrition diabetes

shared by Nathan Goodyear on 22 Oct 13 - No Cached
  • DF are highly complex substances that can be described as any nondigestible carbohydrates and lignins not degraded in the upper gut
  • Commonly, DF are classified according to their solubility in water, even though grading according to viscosity, gel-forming capabilities, or fermentation rate by the gut microbiota might be physiologically more relevant
  • Main sources of soluble DF are fruits and vegetables
  • ...8 more annotations...
  • n increased intake of total DF was inversely associated with markers of insulin resistance in several studies
  • consumption of insoluble DF increased whole body glucose disposal independent of changes in body weight in both short-term and more prolonged studies
  • Short-chain fatty acids (SCFA) such as acetate, propionate, and butyrate are produced by bacterial fermentation of indigestible DF polysaccharides in the colon
  • increased production of SCFA is assumed to be beneficial by reducing hepatic glucose output and improving lipid homeostasis
  • a high DF diet (oligofructose) reduced gram-negative bacterial content and body weight, whereas a high fat diet increased the proportion of a gram-negative bacterial lipopolysaccharides (LPS) containing microbiota in humans
  • Prospective cohort studies indicate that diets high in insoluble cereal DF and whole grains might reduce diabetes risk
  • soluble DF (i.e., pectin, inulin, and β-glucans)
  • cereal DF (i.e., cellulose and hemicelluloses)
  • Nathan Goodyear on 22 Oct 13
     
    Good discussion of dietary fiber intake and Diabetes.  
Nathan Goodyear

Interplay between lipids and branched-chain amino acids in development of insulin resis... - 0 views

www.ncbi.nlm.nih.gov/...PMC3695706

protein high diet insulin resistance metabolism obesity diabetes fatty acids essential

shared by Nathan Goodyear on 21 Oct 13 - No Cached
  • Nathan Goodyear on 21 Oct 13
     
    High branch chain amino acids can promote insulin resistance.  This study points out that long-term high protein dietary intake can actually have significant deleterious effects and lead to disease.  A high fat diet appears to be required for this effect.
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