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Plasma 25-hydroxyvitamin D levels and risk of incident hypertension among young women. Forman JP, Curhan GC, Taylor EN. Hypertension. 2008 Nov;52(5):828-32. Epub 2008 Oct 6. PMID: 18838623 doi: 10.1161/HYPERTENSIONAHA.108.117630 Women in the lowest compared with highest quartile of plasma 25(OH)D had an adjusted odds ratio for incident hypertension of 1.66 (95% CI: 1.11 to 2.48; P for trend=0.01). Compared with women with sufficient levels, those with vitamin D deficiency (<30 ng/mL; 65.7% of the study population) had a multivariable odds ratio of 1.47 (95% CI: 1.10 to 1.97). Plasma 25(OH)D levels are inversely and independently associated with the risk of developing hypertension.

"THURSDAY, Dec. 3 (HealthDay News) -- New research points to the possibility of a genetic link between vitamin D and heart disease. People with high blood pressure who had a gene variant that reduces vitamin D activation in the body were found to be twice as likely as those without the variant to have congestive heart failure, the study found. The finding may lead to a way to identify people at increased risk for heart disease, according to Robert U. Simpson, an assistant professor of pharmacology at the University of Michigan Medical School and his research colleagues. They analyzed the genetic profiles of 617 people. One-third had hypertension, one-third had hypertension and congestive heart failure, and the remaining third served as healthy controls. The researchers found that a variant in the CYP27B1 gene was associated with congestive heart failure in people with hypertension. The study is in the November issue of Pharmacogenomics."

Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials. Rosenfeldt FL, Haas SJ, Krum H, Hadj A, Ng K, Leong JY, Watts GF. J Hum Hypertens. 2007 Apr;21(4):297-306. Epub 2007 Feb 8. PMID: 17287847 We conclude that coenzyme Q10 has the potential in hypertensive patients to lower systolic blood pressure by up to 17 mm Hg and diastolic blood pressure by up to 10 mm Hg without significant side effects.

Nut consumption and risk of hypertension in US male physicians. Djoussé L, Rudich T, Gaziano JM. Clin Nutr. 2009 Feb;28(1):10-4. Epub 2008 Oct 2. PMID: 18834651 doi:10.1016/j.clnu.2008.08.005 CONCLUSION: Our data suggest that nut consumption is associated with a lower risk of hypertension in US male physicians and that such relation may be influenced by adiposity.

Relationship of dietary linoleic acid to blood pressure. The International Study of Macro-Micronutrients and Blood Pressure Study [corrected] Miura K, Stamler J, Nakagawa H, Elliott P, Ueshima H, Chan Q, Brown IJ, Tzoulaki I, Saitoh S, Dyer AR, Daviglus ML, Kesteloot H, Okayama A, Curb JD, Rodriguez BL, Elmer PJ, Steffen LM, Robertson C, Zhao L; International Study of Macro-Micronutrients and Blood Pressure Research Group. Hypertension. 2008 Aug;52(2):408-14. Epub 2008 Jul 7. Erratum in: Hypertension. 2008 Sep;52(3):e29. PMID: 18606902 doi: 10.1161/HYPERTENSIONAHA.108.112383 Dietary linoleic acid intake may contribute to prevention and control of adverse blood pressure levels in general populations

Vitamin D in preventive medicine: are we ignoring the evidence? Zittermann A. Br J Nutr. 2003 May;89(5):552-72. Review. PMID: 12720576 Vitamin D is metabolised by a hepatic 25-hydroxylase into 25-hydroxyvitamin D (25(OH)D) and by a renal 1alpha-hydroxylase into the vitamin D hormone calcitriol. Calcitriol receptors are present in more than thirty different tissues. Apart from the kidney, several tissues also possess the enzyme 1alpha-hydroxylase, which is able to use circulating 25(OH)D as a substrate. Serum levels of 25(OH)D are the best indicator to assess vitamin D deficiency, insufficiency, hypovitaminosis, adequacy, and toxicity. European children and young adults often have circulating 25(OH)D levels in the insufficiency range during wintertime. Elderly subjects have mean 25(OH)D levels in the insufficiency range throughout the year. In institutionalized subjects 25(OH)D levels are often in the deficiency range. There is now general agreement that a low vitamin D status is involved in the pathogenesis of osteoporosis. Moreover, vitamin D insufficiency can lead to a disturbed muscle function. Epidemiological data also indicate a low vitamin D status in tuberculosis, rheumatoid arthritis, multiple sclerosis, inflammatory bowel diseases, hypertension, and specific types of cancer. Some intervention trials have demonstrated that supplementation with vitamin D or its metabolites is able: (i) to reduce blood pressure in hypertensive patients; (ii) to improve blood glucose levels in diabetics; (iii) to improve symptoms of rheumatoid arthritis and multiple sclerosis. The oral dose necessary to achieve adequate serum 25(OH)D levels is probably much higher than the current recommendations of 5-15 microg/d.

Harauma A, Moriguchi T. Aged garlic extract improves blood pressure in spontaneously hypertensive rats more safely than raw garlic. J Nutr. 2006 Mar;136(3 Suppl):769S-773S. PMID: 16484560 [PubMed - indexed for MEDLINE]

Essential fatty acids and their metabolites could function as endogenous HMG-CoA reductase and ACE enzyme inhibitors, anti-arrhythmic, anti-hypertensive, anti-atherosclerotic, anti-inflammatory, cytoprotective, and cardioprotective molecules.\nDas UN.\nLipids Health Dis. 2008 Oct 15;7:37. Review.\nPMID: 18922179 \ndoi:10.1186/1476-511X-7-37

Hypertension, endothelial dysfunction and cardiovascular risk] Nitenberg A. Arch Mal Coeur Vaiss. 2006 Oct;99(10):915-21. Review. French. PMID: 17100143

Litchi for Heart Disease Litchi is loaded with the good amount of minerals (potassium and copper) which helps in maintaining the body fluid balance, heart beat control as well as blood pressure control. It provides protection against various heart diseases like stroke, hypertension and coronary heart diseases. It helps in normalizing the blood pressure and heart rate under control to prevent from further development of coronary heart diseases. Its highest amount of polyphenols helps in promoting the heart health and reduces the occurrence of cardiovascular diseases. Its availability with high amount of dietary fibers makes it able to promote the cardiovascular health by regularizing the functioning. Eating lychee regularly helps in reducing the level of bad cholesterol as well as increasing the level of good cholesterol in the blood. Litchi improves the flow of blood containing nourishing nutrients to the heart thus reduces the risk of heart disorders such as stroke, heart attack, hypertension, atherosclerosis and etc. It helps in the better development of some important agents inside the body such as antiplatelet, anticoagulant, thrombolytic agents and etc thus prevents from cardiovascular problems. Other Health Benefits of Litchi It contains high level of polyphenol called oligonol which has antioxidant and anti-influenza property and prevents from various infections. Litchi contains high level of vitamin C which enhances body resistance against various infections and prevents from harmful effects of free radicals. It is the richest source of B-complex vitamins which act as co-factors in the metabolic reactions to metabolize the food elements such as carbohydrates, protein, and fats. Oligonol polyphenol found in it helps in improving the blood circulation, reducing weight and protecting skin from the ultraviolet sun rays. It helps in removing out the extra body fat, enhances body stamina, reduces weakness and other problems. Its high level of vita

Optimal vitamin D status attenuates the age-associated increase in systolic blood pressure in white Americans: results from the third National Health and Nutrition Examination Survey. Judd SE, Nanes MS, Ziegler TR, Wilson PW, Tangpricha V. Am J Clin Nutr. 2008 Jan;87(1):136-41. PMID: 18175747 Conclusions: SBP is inversely associated with serum vitamin D concentrations in nonhypertensive white persons in the United States. This observation provides a rationale for studies on the potential effects of vitamin D supplementation as a method to reduce SBP in persons at risk of hypertension.

Derived from the bulb or clove of the plant. Garlic is used as a spice and to treat hyperlipidemia, hypertension, atherosclerosis, cancer, and infections. Processing can have a substantial effect on the chemical content in garlic; the volatile oil components are sensitive to heat and certain enzymes are acid-labile. Several oral garlic formulations are available, and clinical studies have addressed a variety of the proposed claims. Placebo-controlled trials on the cholesterol lowering effect of garlic yielded mixed results (16) (17) (18) (21) (22) (26). Studies evaluating the antithrombotic effects repeatedly have shown modest reduction in platelet aggregation, but varying levels of fibrinolytic activity. Research shows mixed effects with regard to reductions in blood glucose, blood pressure, or risk of cardiovascular disease (23). Frequently reported adverse events include bad breath, headache, fatigue, GI upset, diarrhea, sweating, and possible hypoglycemia (9). Because garlic is known to decrease platelet aggregation and potentially elevate the INR, it should not be used with anticoagulants or in patients with platelet dysfunction (15). Garlic appears to induce cytochrome p450 3A4 and may enhance metabolism of many medications (e.g. cyclosporin and saquinavir) (12). An analysis of several case-control studies in Europe suggests an inverse association between garlic consumption and risk of common cancers (25).

Vitamin D and calcium insufficiency-related chronic diseases: molecular and cellular pathophysiology. Peterlik M, Cross HS. Eur J Clin Nutr. 2009 Dec;63(12):1377-86. Epub 2009 Sep 2. PMID: 19724293 doi:10.1038/ejcn.2009.105 A compromised vitamin D status, characterized by low 25-hydroxyvitamin D (25-(OH)D) serum levels, and a nutritional calcium deficit are widely encountered in European and North American countries, independent of age or gender. Both conditions are linked to the pathogenesis of many degenerative, malignant, inflammatory and metabolic diseases. Studies on tissue-specific expression and activity of vitamin D metabolizing enzymes, 25-(OH)D-1alpha-hydroxylase and 25-(OH)D-24-hydroxylase, and of the extracellular calcium-sensing receptor (CaR) have led to the understanding of how, in non-renal tissues and cellular systems, locally produced 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) and extracellular Ca2+ act jointly as key regulators of cellular proliferation, differentiation and function. Impairment of cooperative signalling from the 1,25-(OH)2D3-activated vitamin D receptor (VDR) and from the CaR in vitamin D and calcium insufficiency causes cellular dysfunction in many organs and biological systems, and, therefore, increases the risk of diseases, particularly of osteoporosis, colorectal and breast cancer, inflammatory bowel disease, insulin-dependent diabetes mellitus type I, metabolic syndrome, diabetes mellitus type II, hypertension and cardiovascular disease. Understanding the underlying molecular and cellular processes provides a rationale for advocating adequate intake of vitamin D and calcium in all populations, thereby preventing many chronic diseases worldwide.

"March 18, 2009 | Marlene Busko Palm Harbor, FL - In a large study of adolescents, low serum levels of 25-dihydroxyvitamin D (25[OH]D) strongly predicted prevalence of hypertension, hyperglycemia, and metabolic syndrome [1]. The findings were reported at the AHA 49th Annual Conference on Cardiovascular Disease Epidemiology and Prevention. Adolescents with vitamin-D levels in the lowest quartile were almost four times more likely to have metabolic syndrome than those with vitamin-D levels in the highest quartile. "I think that is quite alarming," lead author Dr Jared P Reis (Johns Hopkins Medical Institutions, Baltimore, MD) said in an AHA podcast issued to the media."

Hundreds of miraculous health benefits are associated with the consumption of lemon juice. In this article, I have elaborated on the top ten amongst all the lemon juice benefits. Lemon enjoys a global eminence, thanks to its incredible health benefits. Several advantages are also associated with the consumption of this tangy juice. Scroll down and enjoy the read. Lemon Juice: Prevents Cancer Lemon is well-known for its richness in multipurpose flavonoid compounds which defend your body against different types of cancer. Thus, regular consumption of lemon juice ensures the prevention of cancerous cells. Lemon Juice: Treat the Upset Stomach Lemon juice is a marvellous drink for people who are suffering from an upset stomach. Digestive problems like diarrhoea or constipation make you feel uncomfortable in addition to botching up your daily routine. To deal with such problems, intake one glass lemon water at the start of the new day. You can maximize the benefits by adding one teaspoon of honey to this solution. Lemon Juice: Good for Liver One of the main advantages of lemon juice is its assistance in improving the liver function and flushing out the toxins from the body. This zesty fruit increase the production of bile in the body that is required for breaking down the fats and lipids. Lemon Juice: Assists in dealing with infections Lemons contain a high amount of Vitamin C, which is essential for strengthening the immune system. So, consuming it in any form is a natural way to prevent viral infections like cold and flu. Lemon water also aids in treating urinary tract infections. Lemon Juice: Best for Hypertension Patients People, who don't consume sufficient amount of potassium, are at higher risks of getting affected by cardiological disorders. Lemon juice contains a satisfactory amount of potassium, so it can help in reducing the risks of such problems. Lemon Juice: Acts as Natural Cleanser for Skin The cleansing properties of lemon juice

Bob Roskamp hoped his drug discovery institute would be thriving without his help by now. The developer and philanthropist imagined 200 scientists and a steady cash flow from the discovery that a hypertension drug could also treat Alzheimer's disease.

From health to cosmetics. The other dragon fruit health benefits are to improve vision health, avoid hypertension and also able to lose weight.

AUGUSTA, Ga. - Too little vitamin D could be bad for more than your bones; it may also lead to fatter adolescents, researchers say.\n\nA Medical College of Georgia study of more than 650 teens age 14-19 has found that those who reported higher vitamin D intakes had lower overall body fat and lower amounts of the fat in the abdomen, a type of fat known as visceral fat, which has been associated with health risks such as heart disease, stroke, diabetes and hypertension

An estimated 50% to 60% of older people have suboptimal vitamin D levels, which is a problem that could affect more than bone health. Recent cross-sectional studies have also shown an association between low vitamin D levels and cardiovascular disease, hypertension, and metabolic syndrome. In a long-term prospective study from Germany, researchers assessed whether 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels were associated with all-cause and cardiovascular mortality among more than 3000 consecutive patients (mean age, 62) referred for coronary angiography.

Dark Chocolate, Other Cocoa-Rich Foods May Lower Blood Pressure Better Than Tea April 9, 2007 -- A chocolate treat may be better than green or black tea at keeping high blood pressure in check. A new study suggests that dark chocolate and other coco