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Matti Narkia

Sloan-Kettering - Integrative Medicine - 0 views

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    The Integrative Medicine Service at Memorial Sloan-Kettering Cancer Center was established in 1999 to complement mainstream medical care and address the emotional, social, and spiritual needs of patients and families. The Service includes:

    patient and outpatient clinical care
    research, and education and training.

    In addition, the Service provides unique access to otherwise unavailable information about over-the-counter products and unproven cancer treatments and their impact in the context of cancer care via our About Herbs database
Matti Narkia

Effect of Fish Oil on Heart Rate in Humans: A Meta-Analysis of Randomized Controlled Tr... - 0 views

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    Effect of fish oil on heart rate in humans: a meta-analysis of randomized controlled trials.
    Mozaffarian D, Geelen A, Brouwer IA, Geleijnse JM, Zock PL, Katan MB.
    Circulation. 2005 Sep 27;112(13):1945-52. Epub 2005 Sep 19.
    PMID: 16172267
    doi: 10.1161/CIRCULATIONAHA.105.556886

    Conclusions- In randomized controlled trials in humans, fish oil reduces HR, particularly in those with higher baseline HR or longer treatment duration. These findings provide firm evidence that fish oil consumption directly or indirectly affects cardiac electrophysiology in humans. Potential mechanisms such as effects on the sinus node, ventricular efficiency, or autonomic function deserve further investigation.
Matti Narkia

Benefit-risk assessment of vitamin D supplementation. - Osteoporos Int. 2009 Dec 3. - S... - 0 views

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    Benefit-risk assessment of vitamin D supplementation.
    Bischoff-Ferrari HA, Shao A, Dawson-Hughes B, Hathcock J, Giovannucci E, Willett WC.
    Osteoporos Int. 2009 Dec 3. [Epub ahead of print]
    PMID: 19957164

    Conclusion Our analysis suggests that mean serum 25(OH)D levels of about 75 to 110 nmol/l provide optimal benefits for all investigated endpoints without increasing health risks. These levels can be best obtained with oral doses in the range of 1,800 to 4,000 IU vitamin D per day; further work is needed, including subject and environment factors, to better define the doses that will achieve optimal blood levels in the large majority of the population.
Matti Narkia

Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials -... - 0 views

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    Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials.
    Rosenfeldt FL, Haas SJ, Krum H, Hadj A, Ng K, Leong JY, Watts GF.
    J Hum Hypertens. 2007 Apr;21(4):297-306. Epub 2007 Feb 8.
    PMID: 17287847

    We conclude that coenzyme Q10 has the potential in hypertensive patients to lower systolic blood pressure by up to 17 mm Hg and diastolic blood pressure by up to 10 mm Hg without significant side effects.
Matti Narkia

JAMA -- Abstract: Cancer Incidence and Mortality After Treatment With Folic Acid and Vi... - 0 views

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    Cancer Incidence and Mortality After Treatment With Folic Acid and Vitamin B12.
    Ebbing M, Bønaa KH, Nygård O, Arnesen E, Ueland PM, Nordrehaug JE, Rasmussen K, Njølstad I, Refsum H, Nilsen DW, Tverdal A, Meyer K, Vollset SE.
    JAMA. 2009 Nov 18;302(19):2119-2126. v
    PMID: 19920236

    Conclusion Treatment with folic acid plus vitamin B12 was associated with increased cancer outcomes and all-cause mortality in patients with ischemic heart disease in Norway, where there is no folic acid fortification of foods.
Matti Narkia

Whole Health Source: paleolithic diet - 0 views

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    Dr. Staffan Lindeberg has published a new study using the "paleolithic diet" to treat type II diabetics (free full text). Type II diabetes, formerly known as late-onset diabetes until it began appearing in children, is typically thought to develop as a result of insulin resistance (a lowered tissue response to the glucose-clearing function of insulin). This is often followed by a decrease in insulin secretion due to degeneration of the insulin-secreting pancreatic beta cells.

    After Dr. Lindeberg's wild success treating patients with type II diabetes or glucose intolerance, in which he normalized the glucose tolerance of all 14 of his volunteers in 12 weeks, he set out to replicate the experiment. This time, he began with 13 men and women who had been diagnosed with type II diabetes for an average of 9 years.
Matti Narkia

Effects of n-3 long-chain polyunsaturated fatty acids on depressed mood: systematic rev... - 0 views

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    Effects of n-3 long-chain polyunsaturated fatty acids on depressed mood: systematic review of published trials.
    Appleton KM, Hayward RC, Gunnell D, Peters TJ, Rogers PJ, Kessler D, Ness AR.
    Am J Clin Nutr. 2006 Dec;84(6):1308-16. Review.
    PMID: 17158410

    Conclusions: Trial evidence that examines the effects of n-3 PUFAs on depressed mood is limited and is difficult to summarize and evaluate because of considerable heterogeneity. The evidence available provides little support for the use of n-3 PUFAs to improve depressed mood. Larger trials with adequate power to detect clinically important benefits are required.
Matti Narkia

Defining Adequate Vitamin D Intake : Cross-sectional and Intervention Studies - 0 views

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    Defining Adequate Vitamin D Intake : Cross-sectional and Intervention Studies
    Viljakainen, Heli Tuulikki
    University of Helsinki
    2008-05-23
    Doctoral dissertation (article-based)

    Vitamin D is required for normal bone growth and maintenance of the skeleton throughout life. In Finland, like in many other Western countries, the population suffers from inadequate or deficient vitamin D status, especially during winter, which is thought to increase the risk of osteoporosis. New strategies to prevent osteoporosis are actively being sought. The main objective of this thesis was to determine whether vitamin D is feasible in the primary prevention of osteoporosis; does it affect bone mineral accrual during the growth period? A second goal was to ascertain whether seasonal variation in calcitropic hormones affects bone remodelling, and to elucidate the vitamin D intake needed to overcome this variation in different age groups.

    In summary, vitamin D intake remains inadequate among the target groups of this thesis, as reflected by seasonal variation in calcitropic hormones and bone metabolism. Dietary intake of vitamin D should be increased to achieve at least an adequate vitamin D status (S-25-OHD>50 nmol/l) and possibly an optimal vitamin D status (S-25-OHD>80 nmol/l) throughout the year. This could be accomplished by introducing new vitamin D-fortified foods to the market."
Matti Narkia

Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of ran... - 0 views

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    Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of randomised controlled trials.
    Bischoff-Ferrari HA, Dawson-Hughes B, Staehelin HB, Orav JE, Stuck AE, Theiler R, Wong JB, Egli A, Kiel DP, Henschkowski J.
    BMJ. 2009 Oct 1;339:b3692. doi: 10.1136/bmj.b3692.
    PMID: 19797342
    doi: 10.1136/bmj.b3692

    Conclusions Supplemental vitamin D in a dose of 700-1000 IU a day reduced the risk of falling among older individuals by 19% and to a similar degree as active forms of vitamin D. Doses of supplemental vitamin D of less than 700 IU or serum 25-hydroxyvitamin D concentrations of less than 60 nmol/l may not reduce the risk of falling among older individuals.
Matti Narkia

Vitamin K and the Prevention of Fractures: Systematic Review and Meta-analysis of Rando... - 0 views

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    Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials.
    Cockayne S, Adamson J, Lanham-New S, Shearer MJ, Gilbody S, Torgerson DJ.
    Arch Intern Med. 2006 Jun 26;166(12):1256-61. Review.
    PMID: 16801507

    Conclusions This systematic review suggests that supplementation with phytonadione and menaquinone-4 reduces bone loss. In the case of the latter, there is a strong effect on incident fractures among Japanese patients.
Matti Narkia

Evidence-based decision making on micronutrients and chronic disease: long-term randomi... - 0 views

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    Evidence-based decision making on micronutrients and chronic disease: long-term randomized controlled trials are not enough.
    Ames BN, McCann JC, Stampfer MJ, Willett WC.
    Am J Clin Nutr. 2007 Aug;86(2):522-3; author reply 523-4.
    PMID: 17684228
Matti Narkia

JAMA -- Fracture Prevention With Vitamin D Supplementation: A Meta-analysis of Randomiz... - 0 views

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    Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials.
    Bischoff-Ferrari HA, Willett WC, Wong JB, Giovannucci E, Dietrich T, Dawson-Hughes B.
    JAMA. 2005 May 11;293(18):2257-64. Review.
    PMID: 15886381

    Conclusions Oral vitamin D supplementation between 700 to 800 IU/d appears to reduce the risk of hip and any nonvertebral fractures in ambulatory or institutionalized elderly persons. An oral vitamin D dose of 400 IU/d is not sufficient for fracture prevention.
Matti Narkia

Vitamin D Supplementation and Total Mortality: A Meta-analysis of Randomized Controlled... - 0 views

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    Vitamin D supplementation and total mortality: a meta-analysis of randomized controlled trials.
    Autier P, Gandini S.
    Arch Intern Med. 2007 Sep 10;167(16):1730-7. Review.
    PMID: 17846391

    Conclusions Intake of ordinary doses of vitamin D supplements seems to be associated with decreases in total mortality rates. The relationship between baseline vitamin D status, dose of vitamin D supplements, and total mortality rates remains to be investigated. Population-based, placebo-controlled randomized trials with total mortality as the main end point should be organized for confirming these findings.
Matti Narkia

Vitamin D and Cancer Mini-Symposium: The Risk of Additional Vitamin D - 0 views

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    Evidence from clinical trials shows, with a wide margin of confidence, that a prolonged intake of 10,000IU/d of vitamin D3 poses no risk of adverse effects for adults, even if this is added to a rather high physiologic background level of vitamin D.

    Vitamin D and cancer mini-symposium: the risk of additional vitamin D.
    Vieth R.\nAnn Epidemiol. 2009 Jul;19(7):441-5. Epub 2009 Apr 11.
    PMID: 19364661
    doi:10.1016/j.annepidem.2009.01.009
Matti Narkia

Coffee consumption and serum lipids: a meta-analysis of randomized controlled clinical ... - 0 views

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    Coffee consumption and serum lipids: a meta-analysis of randomized controlled clinical trials.
    Jee SH, He J, Appel LJ, Whelton PK, Suh I, Klag MJ.
    Am J Epidemiol. 2001 Feb 15;153(4):353-62.
    PMID: 11207153 [
Matti Narkia

Prevention of Nonvertebral Fractures With Oral Vitamin D and Dose Dependency: A Meta-an... - 0 views

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    Prevention of nonvertebral fractures with oral vitamin D and dose dependency: a meta-analysis of randomized controlled trials.
    Bischoff-Ferrari HA, Willett WC, Wong JB, Stuck AE, Staehelin HB, Orav EJ, Thoma A, Kiel DP, Henschkowski J.
    Arch Intern Med. 2009 Mar 23;169(6):551-61.
    PMID: 19307517

    Conclusion Nonvertebral fracture prevention with vitamin D is dose dependent, and a higher dose should reduce fractures by at least 20% for individuals aged 65 years or older.
Matti Narkia

A meta-analytic review of double-blind, placebo-controlled trials of antidepressant eff... - 0 views

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    Lin PY, Su KP.
    A meta-analytic review of double-blind, placebo-controlled trials of antidepressant efficacy of omega-3 fatty acids.
    J Clin Psychiatry. 2007 Jul;68(7):1056-61.
    PMID: 17685742 [PubMed - in process]
Matti Narkia

Herbal medicines for treatment of bacterial infections: a review of controlled clinical... - 0 views

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    Martin KW, Ernst E. \nHerbal medicines for treatment of bacterial infections: a review of controlled clinical trials.\nJ Antimicrob Chemother. 2003 Feb;51(2):241-6. Review.\nPMID: 12562687 [PubMed - indexed for MEDLINE]
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