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Matti Narkia

Dr. Joe's E-News - A Diabetes Newsletter: East German Infants Taking Vitamin D - 0 views

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    "From 1955 to 1990, all infants in East Germany received 600,000 IU of Vitamin D every three months for a total of 3,600,000 IU at age 18 months.

    With the 400 IU/day recommendation of the American Pediatric Association in mind, I ran across this amazing paper while surfing Medline for Vitamin D. According to this paper, all infants in the German Democratic Republic (East Germany) received dangerously high doses of Vitamin D every three months in their doctors office. The policy was in place for 35 years. The first 600,000 IU dose was given at three months and then every three months until the child was 18 months of age. This works out to an average of 6,000 IU per day (actually, for several technical reasons it is not equivalent) for 18 months. The authors collected blood before the dose and then 2 weeks after the quarterly dose to obtain 25(OH)D, 1,25(OH)D, and calcium levels on a total of 43 infants.

    Before the first dose, at 3 months of age, the average infant was extremely deficient (median 25(OH)D of 7 ng/ml). Two weeks after the first dose the average 25(OH)D level was 120 ng/ml, the second dose 170 ng/ml, the third dose, 180 ng/ml, the fourth dose, 144 ng/ml, the fifth dose, 110 ng/ml and after the sixth and final dose, 3.6 million total units, at age 18 months, the children had mean levels of 100 ng/ml. That is, by the 15 and 18 month doses, the children were beginning to effectively handle these massive doses.

    The highest level recorded in any of the 43 infants was 408 ng/ml at age 9 months, two weeks after the third 600,000 IU dose. Thirty-four percent of the infants had at least one episode of hypercalcemia but only 3 had an elevated serum 1,25(OH)D. The authors reported that all the infants appeared healthy, even the infant with a level of 408 ng/ml, that is, no clinical toxicity was noted in any of these infants."
Matti Narkia

Benefit-risk assessment of vitamin D supplementation. - Osteoporos Int. 2009 Dec 3. - S... - 0 views

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    Benefit-risk assessment of vitamin D supplementation.
    Bischoff-Ferrari HA, Shao A, Dawson-Hughes B, Hathcock J, Giovannucci E, Willett WC.
    Osteoporos Int. 2009 Dec 3. [Epub ahead of print]
    PMID: 19957164

    Conclusion Our analysis suggests that mean serum 25(OH)D levels of about 75 to 110 nmol/l provide optimal benefits for all investigated endpoints without increasing health risks. These levels can be best obtained with oral doses in the range of 1,800 to 4,000 IU vitamin D per day; further work is needed, including subject and environment factors, to better define the doses that will achieve optimal blood levels in the large majority of the population.
Matti Narkia

[Severe hypercalcemia due to vitamin D intoxication][Arch Pediatr. 2007] - PubMed Result - 0 views

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    [Severe hypercalcemia due to vitamin D intoxication]
    Chambellan-Tison C, Horen B, Plat-Wilson G, Moulin P, Claudet I.
    Arch Pediatr. 2007 Nov;14(11):1328-32. Epub 2007 Oct 10. French.
    PMID: 17931839
Matti Narkia

Hypercalcemia due to Hypervitaminosis D: Report of Seven Patients -- Joshi, 10.1093/tro... - 0 views

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    Hypercalcemia due to Hypervitaminosis D: Report of Seven Patients.
    Joshi R.
    J Trop Pediatr. 2009 Apr 1. [Epub ahead of print]
    PMID: 19339514
Matti Narkia

Vitamin D and Cancer Mini-Symposium: The Risk of Additional Vitamin D - 0 views

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    Evidence from clinical trials shows, with a wide margin of confidence, that a prolonged intake of 10,000IU/d of vitamin D3 poses no risk of adverse effects for adults, even if this is added to a rather high physiologic background level of vitamin D.

    Vitamin D and cancer mini-symposium: the risk of additional vitamin D.
    Vieth R.\nAnn Epidemiol. 2009 Jul;19(7):441-5. Epub 2009 Apr 11.
    PMID: 19364661
    doi:10.1016/j.annepidem.2009.01.009
Matti Narkia

Vitamin D and Cancer Mini-Symposium: The Risk of Additional Vitamin D - ScienceDirect -... - 0 views

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    Vitamin D and Cancer Mini-Symposium: The Risk of Additional Vitamin D.
    Vieth R.
    Ann Epidemiol. 2009 Apr 11. [Epub ahead of print]
    PMID: 19364661
    doi:10.1016/j.annepidem.2009.01.009   
Matti Narkia

Critique of the Considerations for Establishing the Tolerable Upper Intake Level for Vi... - 0 views

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    Vieth R. \nCritique of the considerations for establishing the tolerable upper intake level for vitamin D: critical need for revision upwards.\nJ Nutr. 2006 Apr;136(4):1117-22.\nPMID: 16549491 [PubMed - indexed for MEDLINE]
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