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Matti Narkia

SUNARC - Sunlight, Nutrition And Health Research Center - 0 views

    "Cancer mortality rates and multiple sclerosis prevalence rates for U.S. states compared to UVB doses for July"
Matti Narkia - Main - 0 views


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Matti Narkia

Vitamin D, aging, and cancer. Pentti Tuohimaa. 2008; Nutrition Reviews - Wiley InterSci... - 0 views

    Vitamin D, aging, and cancer.
    Tuohimaa P.
    Nutr Rev. 2008 Oct;66(10 Suppl 2):S147-52. Review.
    PMID: 18844842
    DOI: 10.1111/j.1753-4887.2008.00095.x

    Deficiency of the prohormone calcidiol (25OH vitamin D3) seems to be associated with several aging-related chronic diseases including cancer. Our results suggest that calcidiol is mainly responsible for differentiation homeostasis, whereas calcitriol might be more involved in calcium homeostasis. Therefore, an imbalance of calcidiol rather than calcitriol is a risk factor for cancer and chronic diseases. Calcidiol insufficiency, as well as insufficient solar exposure, is associated with increased risk of several solid cancers. Both a vitamin D3 deficiency and a high concentration of calcidiol may increase cancer risk. Similarly, aging phenomena show a U-shaped association with vitamin D bioactivity. Therefore, the chronic diseases and cancers related to aging might be prevented by an optimal concentration of serum calcidiol, which remains to be determined.
Matti Narkia

How this horrible weather could give you heart disease | Mail Online - 1 views

    "We are fond of grumbling about Britain's grey skies, but there may be a good medical reason for doing so. It seems the dreary weather is bad for our hearts - worse, even, than raised cholesterol and an unhealthy diet.

    That's the controversial claim being made by Dr David Grimes, a gastroenterologist from Blackburn. He's been gazing at the sky for 20 years for clues about why his patients get more sick than those in the south of the country.

    And what he's found turns key assumptions about heart disease on their head. 'It's not diet or cholesterol levels that raise your risk of heart disease,' he claims. 'It's where you live. People in the north are more likely to be ill because they get less sunshine

    Basically they are suffering from 'latitude' sickness. The link is vitamin D. While we get some from our diet, the main source is the sun - sunlight converts a compound in the skin into vitamin D, so the amount you make is directly related to the amount of sunshine you get.

    In a new book Dr Grimes argues the higher the level of vitamin D in your blood, the lower your risk of heart disease and a range of other illnesses.

    If he's right, what we need is not diet and lifestyle advice, but food fortified with vitamin D. For years the vitamin was thought to be useful only for preventing rickets.

    So how does he treat them? 'You can do it with diet,' he says 'One Bangladeshi woman eats oily fish every day and now has a vitamin D blood level of 40. 'We give supplements of 1,000 international units (IU) a day or we can give an injection of 300,000 IU that lasts for a year.

    'The patients respond well,' says Grimes 'but what's needed is a proper controlled, long-term trial and who is going to fund that? Not a drug company.'"
Matti Narkia

Maternal vitamin D status during pregnancy and childhood bone mass at age 9 years: a lo... - 0 views

    Maternal vitamin D status during pregnancy and childhood bone mass at age 9 years: a longitudinal study.
    Javaid MK, Crozier SR, Harvey NC, Gale CR, Dennison EM, Boucher BJ, Arden NK, Godfrey KM, Cooper C; Princess Anne Hospital Study Group.
    Lancet. 2006 Jan 7;367(9504):36-43. Erratum in: Lancet. 2006 May 6;367(9521):1486.
    PMID: 16399151

    Maternal vitamin D insufficiency is common during pregnancy and is associated with reduced bone-mineral accrual in the offspring during childhood; this association is mediated partly through the concentration of umbilical venous calcium. Vitamin D supplementation of pregnant women, especially during winter months, could lead to longlasting reductions in the risk of osteoporotic fracture in their offspring.
Matti Narkia

Questions about vitamin D - The Globe and Mail - 0 views

    "This is not one of our usual hour-long live discussions. Rather, this is an online question-and-answer session. Your questions and Dr. Vieth's answers will appear at the bottom of this page after 1 p.m. EDT today."
Matti Narkia

Incident Invasive Breast Cancer, Geographic Location of Residence, and Reported Average... - 0 views

    ncident invasive breast cancer, geographic location of residence, and reported average time spent outside.
    Millen AE, Pettinger M, Freudenheim JL, Langer RD, Rosenberg CA,
    Mossavar-Rahmani Y, Duffy CM, Lane DS, McTiernan A, Kuller LH, Lopez AM, Wactawski-Wende J.
    Cancer Epidemiol Biomarkers Prev. 2009 Feb;18(2):495-507. Epub 2009 Feb 3.
    PMID: 19190147
    doi: 10.1158/1055-9965.EPI-08-0652

    In conclusion, region of residence and geographic solar irradiance are not consistently related to risk of breast cancer and may not be sufficient proxy measures for sunlight/vitamin D exposure. The observed association between time spent outside and breast cancer risk support the hypothesis that vitamin D may protect against breast cancer.
Matti Narkia

Vitamin D and Its Role in Cancer and Immunity: A Prescription for Sunlight -- Mullin an... - 0 views

    Vitamin d and its role in cancer and immunity: a prescription for sunlight.
    Mullin GE, Dobs A.
    Nutr Clin Pract. 2007 Jun;22(3):305-22. Review.
    PMID: 17507731
    DOI: 10.1177/0115426507022003305
Matti Narkia

Vitamin D From Dietary Intake and Sunlight Exposure and the Risk of Hormone-Receptor-De... - 0 views

    Vitamin D from dietary intake and sunlight exposure and the risk of hormone-receptor-defined breast cancer.
    Blackmore KM, Lesosky M, Barnett H, Raboud JM, Vieth R, Knight JA.
    Am J Epidemiol. 2008 Oct 15;168(8):915-24. Epub 2008 Aug 27.
    PMID: 18756015

    This study suggests that vitamin D is associated with a reduced risk of breast cancer regardless of ER/PR status of the tumor. Future studies with a larger number of receptor-negative and mixed tumors are required.
Matti Narkia

Vitamin D and multiple sclerosis. [Proc Soc Exp Biol Med. 1997] - PubMed Result - 0 views

    Vitamin D and multiple sclerosis.
    Hayes CE, Cantorna MT, DeLuca HF.
    Proc Soc Exp Biol Med. 1997 Oct;216(1):21-7. Review.
    PMID: 9316607
Matti Narkia

Vitamin D: a natural inhibitor of multiple sclerosis - 0 views

    Vitamin D: a natural inhibitor of multiple sclerosis.
    Hayes CE.
    Proc Nutr Soc. 2000 Nov;59(4):531-5. Review.
    PMID: 11115787
Matti Narkia

Vitamin D treatment in multiple sclerosis - ScienceDirect - Journal of the Neurological... - 0 views

    Vitamin D treatment in multiple sclerosis.
    Myhr KM.
    J Neurol Sci. 2009 Jun 22. [Epub ahead of print]
    PMID: 19549608

    Epidemiological evidence combined with clinical and laboratory analyses, and experimental animal models, suggest a possible influence of vitamin D on MS susceptibility as well as clinical disease activity.

    Supplement with vitamin D may reduce the risk of developing MS. An intervention may also reduce the risk of conversion from a first clinical event suggestive of MS to clinical definite MS, as well as reduce the relapse rate among patients with relapsing remitting MS. More studies are, however, needed to determine optimal dose and serum level for vitamin D, as well as target populations and optimal timing for intervention.
Matti Narkia

Explaining multiple sclerosis prevalence by ultraviolet exposure: a geospatial analysis... - 0 views

    Explaining multiple sclerosis prevalence by ultraviolet exposure: a geospatial analysis.
    Beretich B, Beretich T.
    Mult Scler. 2009 Aug;15(8):891-8.
    PMID: 19667017
    DOI: 10.1177/1352458509105579


    This analysis suggests a strong association between UV radiation and MS distribution, and an increase in risk for MS in those areas with a low UVI.
Matti Narkia

The Association of Solar Ultraviolet B (UVB) with Reducing Risk of Cancer: Multifactori... - 0 views

    The association of solar ultraviolet B (UVB) with reducing risk of cancer: multifactorial ecologic analysis of geographic variation in age-adjusted cancer mortality rates.
    Grant WB, Garland CF.
    Anticancer Res. 2006 Jul-Aug;26(4A):2687-99.
    PMID: 16886679

    CONCLUSION: These results provide additional support for the hypothesis that solar UVB, through photosynthesis of vitamin D, is inversely-associated with cancer mortality rates, and that various other cancer risk-modifying factors do not detract from this link. It is thought that sun avoidance practices after 1980, along with improved cancer treatment, led to reduced associations in the latter period. The results regarding solar UVB should be studied further with additional observational and intervention studies of vitamin D indices and cancer incidence, mortality and survival rates.
Matti Narkia

Are sunlight deprivation and influenza epidemics associated with the onset of acute leu... - 0 views

    Are sunlight deprivation and influenza epidemics associated with the onset of acute leukemia?
    Timonen T, Näyhä S, Koskela T, Pukkala E.
    Haematologica. 2007 Nov;92(11):1553-6.
    PMID: 18024404

    Month of diagnosis of 7,423 cases of acute leukemia (AL) in Finland during 1964-2003 were linked with data on influenza and solar radiation. Acute myeloblastic leukemia (AML) showed the highest risk in the dark season. During the light season, the incidence decreased by 58% (95% confidence interval, 16-79%) per 1,000 kJ/m2/d increase of solar radiation. Independent of solar radiation, AML increased by 9% (95% confidence interval, 0-19%) during influenza epidemics. Reoccurring at the same time annually, darkness-related vitamin D deficiency and influenza could cause successive and co-operative mutations leading to AL with a short latency.
Matti Narkia

Sunlight, vitamin D, sexual performance and fertility, Vitamin D Deficiency - 0 views

    In 1939, Dr. Abraham Myerson measured initial levels of circulating testosterone in men and exposed their various body parts to UVB light.

    After five days of chest exposure sufficient to cause reddening, circulating testosterone increased by 120%. After eight days without additional UV exposure, testosterone returned to initial levels. When the genital area was exposed, testosterone levels increased by 200%!
Matti Narkia

Sunlight, vitamin D and the prevention of cancer: a systematic review of epidemiologica... - 0 views

    Sunlight, vitamin D and the prevention of cancer: a systematic review of epidemiological studies.
    Rhee HV, Coebergh JW, Vries ED.
    Eur J Cancer Prev. 2009 Aug 26. [Epub ahead of print]
    PMID: 19730382

    We, therefore, conclude that there is accumulating evidence for sunlight as a protective factor for several types of cancer. The same conclusion can be made concerning high vitamin D levels and the risk of colorectal cancer. This evidence, however, is not conclusive, because the number of (good quality) studies is still limited and publication biases cannot be excluded. The discrepancies between the epidemiological evidence for a possible preventive effect of sunlight and vitamin D and the question of how to apply the findings on the beneficial effects of sunlight to (public) health recommendations are discussed.
Matti Narkia

Towards an adequate intake of vitamin D. An advisory report of the Health Council of th... - 0 views

    Towards an adequate intake of vitamin D. An advisory report of the Health Council of the Netherlands
    R M Weggemans, G Schaafsma and D Kromhout
    Eur J Clin Nutr advance online publication, July 22, 2009; doi:10.1038/ejcn.2009.67
Matti Narkia

Investigating the links between muscle strength, sun exposure, dietary vitamin D intake... - 0 views

    Investigating the links between muscle strength, sun exposure, dietary vitamin D intake and the vitamin D status of ambulatory older adults in South East Queensland
    Borradale, David (2008)
    QUT Thesis]
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