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neotonics

https://www.fitspresso-co.com/ - 0 views

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    FitSpresso Only $39/Bottle Limited Time Offer! FitSpresso Special Deal + Special 51% Discount Save $660 + 60 Days Money Back Guarantee FitSpresso Herpesyl Five Star FitSpresso is a supplement made to help people lose weight naturally. This supplement comes in the form of veggie capsules, and it is designed to boost metabolism, promote weight loss, burn fat, slow down weight gain, and destroy fat cells. Regular Price: 149/per bottle Only for: $39/per bottle Buy Now What Is FitSpresso? FitSpresso is promoted as a natural supplement that comes in the form of diet pills, and it can aid in rapid and efficient weight loss, similar to many other supplements. The term "natural supplements refers to a nutritional supplement that is made entirely of natural, chemical-free materials. You can utilize these organic ingredients to aid in natural weight loss. It can speed up your body's metabolism and assist with other crucial processes. All parts of our bodies are impacted by weight increase, and not only do we need to deal with the increased weight, but we also need to deal with the numerous problems and illnesses that come along with it. This refers to the risk of developing chronic cardiac conditions, low blood pressure, and, in some circumstances, problems with blood sugar. However, FitSpresso even with its bright and bold claims, can help you efficiently manage your weight and completely avoid these extra uncomfortable problems. FitSpresso is a supplement that comes in the form of a pill, which makes it tasty, simple to swallow, and handy. According to the manufacturer, these diet tablets are GMO-free and toxic-free, making them edible. This is why we have things such as weight loss supplements. Thanks to modern advancements, we can just take a dietary supplement pill to bring about significant weight loss in a completely healthy and natural manner. Not only this, but dietary supplements can also support healthy blood sugar levels and help with insulin re
World Vitamins

Glucosamine and Chondroitin Can Relieve Joint Pain Caused by Osteoarthritis - 4 views

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    If the adage "eat her appointment" is true, it has the opposite effect if you eat food is not hygienic. Finally you will bear all bacteria, fungi, mold Map ... will slowly go into your body. And of course with the naked eye can not see the dirty things in food that contains the seeds and they will cause disease. It's time you need to know what good preservation of food for your family. When shopping - Always look carefully "limited use" (best before) and the time of production date on the box of food. - Never buy the box was open, convex and concave or leak. - Reading in food color, deep, or adhesives that are fresh or not oily. - Open the box to check for eggs is definitely not broken or dirty eggs. - Require vendors to use two or more bags containing meat, fish so they will not dirty water flowing from other foods. - Should go straight home after checkout is completed. Otherwise the food will be damaged (run) and it is an opportunity for bacteria arise. In the kitchen Refrigerator: - Adjust the temperature from 4 º C (39.2 º F) or lower. - Always keep the refrigerator clean. - Arrange the items, but not too tight to open cold air transmission to the proper temperature for food preservation is best. - When you want to melt the ice, you should keep the packaging for meat, fish and placed on disk so they do not leak through other foods. Absolutely not use the microwave oven (microwave) to melt the ice. - Keep raw egg placed in a refrigerator box to warm temperatures is not easy to damage the eggs. - Put food place. Vegetables, fruits and ready-made food is always placed in the last compartment - Do not place or potatoes in the refrigerator. - Do not wash, or marinating food prior to refrigeration. Should only be washed before eating or cooking. - Food for the external balance should not exceed 2 hours or contain no more than 2 days in refrigerator. Freezer co
neotonics

https://www.usneotonics.com/ - 0 views

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    Neotonics Only $49/Bottle Limited Time Offer! Neotonics Special Deal + Special 51% Discount Save $300 + 60 Days Money Back Guarantee Neotonics FDA Five Star Neotonics™ is a dietary supplement specifically designed to provide essential probiotics, which are known to promote youthful, glowing skin while reducing the appearance of wrinkles. Regular Price: $99/per bottle Only for: $49/per bottle Buy Now Support Healthy Eyesight No Matter Your Age 100% NATURAL 100% NATURAL with ingredients sourced from local growers that let plants naturally reach their full maturity and use no chemical treatments 100% EFFECTIVE 100% EFFECTIVE mixing ingredients in the right way and in the right amount to keep their properties intact 100% SAFE 100% SAFE processed under strict sterile standards with regularly disinfected equipment. What Is Neotonics? NeoTonics is an all-natural supplement formulated with strains that promote skin and digestive health. Notably, the combined ingredients are reckoned to foster dermal balance, support digestion, and, thus, ensure a healthy weight. Neotonics Gummies is an all-new supplement created to enhance the health and well-being of your skin. The formula is based on research that suggests gut health plays an important role in maintaining healthy skin. This is why the Neotonics supplement boosts both gut health and skin health by using a combination of amazing nutrients. These transform the gut health and restore its functions effectively. Available as a gummy, Neotonics delivers a blend of crucial probiotics and other complementary ingredients to promote skin health, digestion, weighty loss, and more. Just take one gummy daily to support active effects. The creators of Neotonics developed the gummy based on new scientific discoveries from May 2023. That discovery revealed the root cause of skin cell turnover: an aging gut. Your gut dictates the cellular turnover rate, and gut health can promote skin health. Neotonics is
neotonics

https://www.us-urinoct.com/ - 0 views

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    Urinoct Only $49/Bottle Limited Time Offer! Urinoct Special Deal + Special 51% Discount Save $300 + 60 Days Money Back Guarantee Urinoct urinoct FDA Five Star Urinoct The #1 Solution To Maintain a Prostate and boost your manhood's performance. Prostate health supplements are specifically formulated to support men in maintaining optimal levels of prostate function. These supplements are created with natural ingredients in order to furnish fundamental nutrients for maintaining prostate well-being. Regular Price: $99/per bottle Only for: $49/per bottle Buy Now What Is Urinoct? Urinoct is a nutritional supplement featuring natural ingredients that support prostate health. Developed by a surgeon named Dr. Wesley, Urinoct claims to shrink your prostate, raise testosterone, increase sperm production, boost fertility, enhance lean muscle mass, and reverse balding, among other benefits. The prostate gland is an important part of the male reproductive system, and it plays a crucial role in the production of semen. However, as men age, their risk of developing prostate-related health problems, such as prostate cancer, increases. This is where Urinoct comes in. With Urinoct, you can expect to experience reduced inflammation and increased ability for bladder emptying. Plus, your confidence will get a boost. Every ingredient in Urinoct is sourced from the purest and most potent sources, and the ratios are carefully balanced. Furthermore, each element of the formula is backed by scientific data, ensuring positive results without any risk of side effects. Urinoct is a groundbreaking supplement specifically formulated to address the root causes of Benign Prostatic Hyperplasia (BPH) and urinary issues in men. With its unique combination of natural ingredients, Urinoct not only alleviates the symptoms associated with an enlarged prostate but also promotes overall prostate and urinary health. The creation of the Urinoct supplement undergoes strict manufacturing s
Matti Narkia

Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adipo... - 0 views

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    Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans. Stanhope KL, Schwarz JM, Keim NL, Griffen SC, Bremer AA, Graham JL, Hatcher B, Cox CL, Dyachenko A, Zhang W, McGahan JP, Seibert A, Krauss RM, Chiu S, Schaefer EJ, Ai M, Otokozawa S, Nakajima K, Nakano T, Beysen C, Hellerstein MK, Berglund L, Havel PJ. J Clin Invest. 2009 May;119(5):1322-34. Epub 2009 Apr 20. PMID: 19381015 doi: 10.1172/JCI37385. Studies in animals have documented that, compared with glucose, dietary fructose induces dyslipidemia and insulin resistance. To assess the relative effects of these dietary sugars during sustained consumption in humans, overweight and obese subjects consumed glucose- or fructose-sweetened beverages providing 25% of energy requirements for 10 weeks. Although both groups exhibited similar weight gain during the intervention, visceral adipose volume was significantly increased only in subjects consuming fructose. Fasting plasma triglyceride concentrations increased by approximately 10% during 10 weeks of glucose consumption but not after fructose consumption. In contrast, hepatic de novo lipogenesis (DNL) and the 23-hour postprandial triglyceride AUC were increased specifically during fructose consumption. Similarly, markers of altered lipid metabolism and lipoprotein remodeling, including fasting apoB, LDL, small dense LDL, oxidized LDL, and postprandial concentrations of remnant-like particle-triglyceride and -cholesterol significantly increased during fructose but not glucose consumption. In addition, fasting plasma glucose and insulin levels increased and insulin sensitivity decreased in subjects consuming fructose but not in those consuming glucose. These data suggest that dietary fructose specifically increases DNL, promotes dyslipidemia, decreases insulin sensitivity, and increases visceral adiposity in overweight/obese adults.
Mark Bublitz

The Race to Protect Our Most Important Natural Resource | Where to Buy H2O En... - 0 views

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    Written by, Samuel K. Burlum, Investigative Reporter and author of The Green Lane, a syndicated column Published on 4/30/16, a SamBurlum.com Exclusive Source: As we take a look at the poor water quality issues that have hit major metro centers such as Flint, Michigan and Newark, New Jersey, we examine the source of these issues and what some are doing to rush in protecting the most important natural resource vital to the existence of the human race. As our world's population grows and our available sources of clean drinkable freshwater dwindle, the race to find ways to preserve and protect our current water supplies have rapidly increased; while other alternatives on how to clean up used and polluted water supplies are explored. Schools of thought and tech companies are eager to find ways to filter recycled water for reuse; fresh water supplies continue to be maxed out. According to the U.S. Geological Survey; only 2.5% of the Earth's water supply is fresh water. The main sources of available drinkable freshwater supply mainly come from glaciers and ice caps; ground ice and permafrost, and lakes and ground water. It is so surprising that with this natural resource being so scarce, we as a society don't do more to preserve and protect it. And so as a society, we continue to sabotage ourselves by contributing to actions and behaviors that increase pollution of our rivers and lakes. Only about half of the world's population has access to clean drinking water, leaving the other 3 billion people to fight for a source of quality water. In addition to that, according to United Nations Educational, Scientific and Cultural Organization (UNESCO); 783 Million people have no access to any clean water sources. They must rely on "dirty" water or no water at all. This seems like a problem that would only plague impoverished countries, countries without infrastructure and societies without developed economies; however that stereo-typical outlook has been crushed by
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    Written by, Samuel K. Burlum, Investigative Reporter and author of The Green Lane, a syndicated column Published on 4/30/16, a SamBurlum.com Exclusive Source: As we take a look at the poor water quality issues that have hit major metro centers such as Flint, Michigan and Newark, New Jersey, we examine the source of these issues and what some are doing to rush in protecting the most important natural resource vital to the existence of the human race. As our world's population grows and our available sources of clean drinkable freshwater dwindle, the race to find ways to preserve and protect our current water supplies have rapidly increased; while other alternatives on how to clean up used and polluted water supplies are explored. Schools of thought and tech companies are eager to find ways to filter recycled water for reuse; fresh water supplies continue to be maxed out. According to the U.S. Geological Survey; only 2.5% of the Earth's water supply is fresh water. The main sources of available drinkable freshwater supply mainly come from glaciers and ice caps; ground ice and permafrost, and lakes and ground water. It is so surprising that with this natural resource being so scarce, we as a society don't do more to preserve and protect it. And so as a society, we continue to sabotage ourselves by contributing to actions and behaviors that increase pollution of our rivers and lakes. Only about half of the world's population has access to clean drinking water, leaving the other 3 billion people to fight for a source of quality water. In addition to that, according to United Nations Educational, Scientific and Cultural Organization (UNESCO); 783 Million people have no access to any clean water sources. They must rely on "dirty" water or no water at all. This seems like a problem that would only plague impoverished countries, countries without infrastructure and societies without developed economies; however that stereo-typical outlook has been crushed by th
Matti Narkia

Some Diets May Be Better Than Others For Keeping Weight Off And Staying Healthy, Study ... - 0 views

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    ScienceDaily (Mar. 4, 2009) - Any diet will do? Not if you want to lose fat instead of muscle. Not if you want to lower your triglyceride levels so you'll be less likely to develop diabetes and heart disease. Not if you want to avoid cravings that tempt you to cheat on your diet. And not if you want to keep the weight off long-term. "Our latest study shows you have a better chance of achieving all these goals if you follow a diet that is moderately high in protein," said Donald Layman, a University of Illinois professor emeritus of nutrition. The research was published in the March Journal of Nutrition.
Matti Narkia

Hyperlipid: Kwasniewski paper - 0 views

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    "A friend has emailed me the full text of Pawel Grieb's paper documenting a number of physiological parameters of medium to long term Optimal Diet (OD) eaters in Poland, as pointed out by Flo and Stan. There are a few points worth making. The biggest mistake, BTW, is that the authors claim (correctly) that the OD diet aims for >70% fat with (incorrectly) "no restriction on the type of fat (saturated or unsaturated) or cholesterol level". I think they meant that the OD does not ban saturated fats. This is of course true but the impression given is that the OD allows "healthy" fats, which are, of course, inedible. So the heavy emphasis on saturated fats is missed by the paper. A pity, anyone might be left thinking corn oil is a human food... The first positive aspect is that this is a multi author study, eleven authors from several medical centres/unversities. So it's not a one man band case report. I like that. The second is that it is remarkably positive about the findings throughout. Even the elevated LDL cholesterol levels are not taken as extreme and are not trumpeted from the rooftops as the portent of imminent cardiovascular doom. So refreshing!"
neotonics

Cardio Defend™ (Official) | Pay Just $49/Bottle + Free Bonus - 0 views

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    Cardio Defend™ Only $49/bottle - Limited Time Offer Flat Sale ONLY For Today - Special Offer Save Upto $120 + Special 71% Discount + 180 Day Money Back Guarantee CardioDefend Cardio Defend Rated FDA Approved CardioDefend Rated 5 Star Order TODAY And Save Up To $120! Save Over 71%! Cardio Defend is a dietary supplement that supports a healthy heart naturally. The lifestyle of individuals has evolved drastically, and with this evolution, mankind has seen a rise in individuals suffering from heart-related diseases. It supports healthy blood circulation and reduces blood pressure & the risk of heart disease naturally. Try CardioDefend For Over 71% OFF Today! Regular Price: $147.99/per bottle Only for: $49/per bottle Buy Cardio Defend Proven By Thousands Shannon Curry Mark Angelman Robert S Why Choose Cardio Defend? Made In The USA Made In The USA CardioDefend is manufactured on US soil. Cardio Defend 100% All Natural 100% All Natural All ingredients are pure, natural, and carefully sourced. FDA Approved Facility FDA Approved Facility CardioDefend is manufactured according to the latest standards. CardioDefend Supplement Cardio Defend Facts What is Cardio Defend? Heart disease is one of the top causes of death in the United States, but consumers continue to forgo the nourishment that they need. Even with all of the opportunities to eat better and exercise more, some people still struggle to improve their blood circulation and improve their heart health. Luckily, formulas like Cardio Defend can help a lot. CardioDefend is a dietary supplement that supports a healthy heart naturally. The lifestyle of individuals has evolved drastically, and with this evolution, mankind has seen a rise in individuals suffering from heart-related diseases. Even though exercise and healthy diets may help to reduce the risk of these conditions, they may not be 100% effective. The heart is an extremely important organ and must be taken good care of. CardioDefend naturally supports healt
neotonics

Urinoct™ (Official) | Support A Healthy Prostate - 0 views

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    Urinoct™ Only $49/bottle - Limited Time Offer Flat Sale ONLY For Today - Special Offer Save Upto $300 + Special 51% Discount + 60 Day Money Back Guarantee Urinoct Urinoct FDA Approved Urinoct 5 Star Order TODAY And Save Up To $300! Save Over 51%! Urinoct is a supplement that helps in combating BPH and prostatic issues. It is made with natural, high-quality ingredients that help vanish urination issues in a few days. Urinoct is a powerful natural supplement that has specific characteristics to reverse BPH and permanently eliminate the urinary problem. It helps to strengthen your muscles, raise sperm production, and encourage the growth of new hair follicles. According to the creator, the urinoct can help completely fix your urinary tract issues. It is claimed to be clinically tested, and the ingredients added are selectively sourced to improve the prostate. The urinoct is a simple & healthy prostate supplement, and reading below in this Urinoct review might help you know all about this excellent formula! Try Urinoct For Over 51% OFF Today! Regular Price: $99/per bottle Only for: $49/per bottle Buy Urinoct Proven By Thousands Sam Perkin Linda Rated 5 Star Verified Purchase "Sam Perkin is enjoying better oral health…!" "I had intense pain in my bladder and rectum for over 5 years, and it got so bad that I would've rather snatch out the prostate myself rather than living one more day like this Fast forward a month later: no more pain, no more standing above the toilet trying to squeeze out a few pee drops, no more sadness! Everything is amazing!" Sam Perkin - Dallas, USA Portia Thompson Debbie Rated 5 Star Verified Purchase "Portia Thompson loves her fresh breath…!" "I'm 67 and I've been suffering from BPH for over 15 years. I've tried everything, from medication to surgical interventions. But this thing is a real game changer. I feel stronger and better than ever, and I didn't have to wake up one more time in the middle of the night t
neotonics

LeanBiome® | OFFICIAL SITE & 100% All Natural Ingredients! - 0 views

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    LeanBiome™ About How it Works? Ingredients Order Now LeanBiome Hurry Up! Offer Expires in: 00 HOUR 23 MINUTE 57 SECOND LeanBiome Attention! Get Special 84% Discount Today Faster fat burning and weight loss Healthy cholesterol and sugar levels Boost energy levels Regular price: $129 Only for: 39$ Buy Now payment_intro What Is LeanBiome? LeanBiome Supplement LeanBiome is a natural dietary supplement available on the market by Lean for Good. This dietary supplement has been designed for women above 18 years of age to support weight loss. The LeanBiome formula is based on the latest Ivy Research and real-world results. It is made using beneficial gut bacteria strains, lean bacteria species, and Phytosome green tea extract. The LeanBiome weight loss formula is helpful in losing weight accumulated in different parts of your body, thus supporting a completely healthy body. The presence of beneficial bacteria in this formula makes it better than other weight loss supplements on the market as these healthy bacteria (good bacteria) help you lose weight, maintain proper gut health, and support healthy digestion through a healthy digestive system. How Does LeanBiome Work? If you're a woman above 18 years old struggling with weight loss, LeanBiome could be the supplement for you. It contains nine beneficial bacteria strains and natural green tea extract. The way LeanBiome operates is by first promoting a healthy stomach. When your stomach is healthy, it contains beneficial bacteria that aid in the digestion and absorption of nutrients from food. The presence of harmful bacteria in your stomach can cause weight gain. LeanBiome promotes the growth of beneficial bacteria and reduces harmful bacteria in your gut, leading to improved digestion and a healthier stomach.Next in the action line is Inulin - a prebiotic fiber that strides hand in hand with these probiotics. It nourishes the friendly bacteria in your gut, promoting better digestion and stable blood sugar levels.
Matti Narkia

Why "Vitamin D" is not a hormone, and not a synonym for 1,25-dihydroxy-vitamin D, its a... - 0 views

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    Why "Vitamin D" is not a hormone, and not a synonym for 1,25-dihydroxy-vitamin D, its analogs or deltanoids. Vieth R. J Steroid Biochem Mol Biol. 2004 May;89-90(1-5):571-3. PMID: 15225841 doi:10.1016/j.jsbmb.2004.03.037
Matti Narkia

Long-term consumption of a carbohydrate-restricted diet does not induce deleterious met... - 0 views

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    Long-term consumption of a carbohydrate-restricted diet does not induce deleterious metabolic effects. Grieb P, K?apcin'ska B, Smol E, Pilis T, Pilis W, Sadowska-Krepa E, Sobczak A, Bartoszewicz Z, Nauman J, Stan'czak K, Langfort J. Nutr Res. 2008 Dec;28(12):825-33. PMID: 19083495 doi:10.1016/j.nutres.2008.09.011 These results indicate that long-term (>1 year) compliance with a low-CHO high-fat "optimal diet" does not induce deleterious metabolic effects and does not increase the risk for cardiovascular disease, as evidenced by maintenance of adequate glycemic control and relatively low values for conventional cardiovascular risk factors.
Theo Walcot

Top 10 Foods That Will Boost Your Mood - 12 views

The US communications agency has taken the first step toward lifting a ban on mobile phone calls during flights.The Federal Communications Commission (FCC) voted on Thursday to launch a public revi...

nutrition

teman bloggercuy

Tips To Help You Get Started On Your Own Bodyweight Loss Journey - 0 views

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    Drinking anything at all other than water could spell significant trouble for the weight loss efforts. Not diet soda, not concentrated fruit drinks, and not even black coffee or tea. Water is the best beverage it has no fat, calories, cholesterol, or sodium. It also aids to flush toxins from the system and maintain your skin browsing excellent.
Matti Narkia

DCA and vanadium combination - The DCA Site - Updating You on DCA and Cancer - Dichloro... - 0 views

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    Simultaneously Blocking Glycolysis and Fat Metabolism Can the use of DCA and a fatty acid metabolism blocker together force more cancer cells into using aerobic metabolism? Tim McGough used green tea extract, which contains EGCG, in his fantastic response. DCA works by reactivating mitochondria and shifts metabolism from glycolysis to glucose oxidation. Hopefully the cancer cell will then undergo apoptosis. However, cancer cells have an alternate energy source: fat metabolism. This page explores to possibility of blocking fat metabolism to help force the cell into apoptosis. Oral squamous cell carcinoma is a cancer that does not respond well to DCA. This study, Head and Neck Cancer Cell Lines Are Resistant to Mitochondrial-Depolarization-Induced Apoptosis states: "Results: ΔΨm in head and neck cell lines started to show slight loss of ΔΨm, while HL-60 showed significant loss of ΔΨm after 30 min of treatment. All cell lines demonstrated complete mitochondrial depolarization within 24 h, however, only the control cell line HL-60 underwent apoptosis. In addition, HNSCC cell lines did not demonstrate cytoplasmic cytochrome c release despite significant mitochondrial membrane depolarization, while HL-60 cell initiated apoptosis and cytochcrome c release after 24 h of treatment. Conclusions: Head and neck cancer cell lines exhibit defects in mitochondrial-membrane-depolarization-induced apoptosis as well as impaired release of cytochrome c despite significant mitochondrial membrane depolarization. Proximal defects in the mitochondrial apoptosis pathway are a feature of HNSCC.(head and neck squamous cell carcinoma)" Note that although the cell lines were depolarized, apoptosis did not occur. So I checked to see if fatty acid metabolism is used by squamous cell carcinoma.
Matti Narkia

Vitamin D deficiency and bone health in healthy adults in Finland: could this be a conc... - 0 views

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    Vitamin D deficiency and bone health in healthy adults in Finland: could this be a concern in other parts of Europe? Lamberg-Allardt CJ, Outila TA, Kärkkainen MU, Rita HJ, Valsta LM. J Bone Miner Res. 2001 Nov;16(11):2066-73. PMID: 11697803 Low vitamin D status was prevalent in these young adults in northern Europe in winter, although the vitamin D intake met the recommendation. This probably is not a local problem for northern Europe, because the natural sources of vitamin D are scarce and fortification is not very common in Europe, and with the exception of the southern part of Europe, sunshine is not very abundant in this part of the world. Thus, the results of this study indicate that more attention should be focused on vitamin D status and the sources of vitamin D in these countries.
Matti Narkia

Effectiveness and Safety of Vitamin D in Relation to Bone Health (full text) - 0 views

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    Effectiveness and safety of vitamin D in relation to bone health. Cranney A, Horsley T, O'Donnell S, Weiler H, Puil L, Ooi D, Atkinson S, Ward L, Moher D, Hanley D, Fang M, Yazdi F, Garritty C, Sampson M, Barrowman N, Tsertsvadze A, Mamaladze V. Evid Rep Technol Assess (Full Rep). 2007 Aug;(158):1-235. Review. PMID: 18088161 CONCLUSIONS: The results highlight the need for additional high quality studies in infants, children, premenopausal women, and diverse racial or ethnic groups. There was fair evidence from studies of an association between circulating 25(OH)D concentrations with some bone health outcomes (established rickets, PTH, falls, BMD). However, the evidence for an association was inconsistent for other outcomes (e.g., BMC in infants and fractures in adults). It was difficult to define specific thresholds of circulating 25(OH)D for optimal bone health due to the imprecision of different 25(OH)D assays. Standard reference preparations are needed so that serum 25(OH)D can be accurately and reliably measured, and validated. In most trials, the effects of vitamin D and calcium could not be separated. Vitamin D(3) (>700 IU/day) with calcium supplementation compared to placebo has a small beneficial effect on BMD, and reduces the risk of fractures and falls although benefit may be confined to specific subgroups. Vitamin D intake above current dietary reference intakes was not reported to be associated with an increased risk of adverse events. However, most trials of higher doses of vitamin D were not adequately designed to assess long-term harms.
Matti Narkia

Effectiveness and safety of vitamin D in relation to bone health. - [Evid Rep Technol A... - 0 views

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    Effectiveness and safety of vitamin D in relation to bone health. Cranney A, Horsley T, O'Donnell S, Weiler H, Puil L, Ooi D, Atkinson S, Ward L, Moher D, Hanley D, Fang M, Yazdi F, Garritty C, Sampson M, Barrowman N, Tsertsvadze A, Mamaladze V. Evid Rep Technol Assess (Full Rep). 2007 Aug;(158):1-235. Review. PMID: 18088161 CONCLUSIONS: The results highlight the need for additional high quality studies in infants, children, premenopausal women, and diverse racial or ethnic groups. There was fair evidence from studies of an association between circulating 25(OH)D concentrations with some bone health outcomes (established rickets, PTH, falls, BMD). However, the evidence for an association was inconsistent for other outcomes (e.g., BMC in infants and fractures in adults). It was difficult to define specific thresholds of circulating 25(OH)D for optimal bone health due to the imprecision of different 25(OH)D assays. Standard reference preparations are needed so that serum 25(OH)D can be accurately and reliably measured, and validated. In most trials, the effects of vitamin D and calcium could not be separated. Vitamin D(3) (>700 IU/day) with calcium supplementation compared to placebo has a small beneficial effect on BMD, and reduces the risk of fractures and falls although benefit may be confined to specific subgroups. Vitamin D intake above current dietary reference intakes was not reported to be associated with an increased risk of adverse events. However, most trials of higher doses of vitamin D were not adequately designed to assess long-term harms.
Matti Narkia

Diagnosis and treatment of vitamin D deficiency; Expert Opinion on Pharmacotherapy - 9(... - 0 views

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    Diagnosis and treatment of vitamin D deficiency. Cannell JJ, Hollis BW, Zasloff M, Heaney RP. Expert Opin Pharmacother. 2008 Jan;9(1):107-18. PMID: 18076342 The recent discovery - in a randomised, controlled trial - that daily ingestion of 1100 IU of colecalciferol (vitamin D) over a 4-year period dramatically reduced the incidence of non-skin cancers makes it difficult to overstate the potential medical, social and economic implications of treating vitamin D deficiency. Not only are such deficiencies common, probably the rule, vitamin D deficiency stands implicated in a host of diseases other than cancer. The metabolic product of vitamin D is a potent, pleiotropic, repair and maintenance, secosteroid hormone that targets > 200 human genes in a wide variety of tissues, meaning it has as many mechanisms of action as genes it targets. A common misconception is that government agencies designed present intake recommendations to prevent or treat vitamin D deficiency. They did not. Instead, they are guidelines to prevent particular metabolic bone diseases. Official recommendations were never designed and are not effective in preventing or treating vitamin D deficiency and in no way limit the freedom of the physician - or responsibility - to do so. At this time, assessing serum 25-hydroxy-vitamin D is the only way to make the diagnosis and to assure that treatment is adequate and safe. The authors believe that treatment should be sufficient to maintain levels found in humans living naturally in a sun-rich environment, that is, > 40 ng/ml, year around. Three treatment modalities exist: sunlight, artificial ultraviolet B radiation or supplementation. All treatment modalities have their potential risks and benefits. Benefits of all treatment modalities outweigh potential risks and greatly outweigh the risk of no treatment. As a prolonged 'vitamin D winter', centred on the winter solstice, occurs at many temperate latitudes, ≤ 5000 IU (125 μg) of vitamin D/d
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