Dietary acid-base balance, bone resorption, and calcium excretion.
Jajoo R, Song L, Rasmussen H, Harris SS, Dawson-Hughes B.
J Am Coll Nutr. 2006 Jun;25(3):224-30.
PMID: 16766781
Conclusions: Diet changes that increase renal NAE are associated with increases in serum PTH, bone resorption, and calcium excretion over a 60-day period.
Toba Y, Takada Y, Matsuoka Y, Morita Y, Motouri M, Hirai T, Suguri T, Aoe S, Kawakami H, Kumegawa M, Takeuchi A, Itabashi A.
Milk basic protein promotes bone formation and suppresses bone resorption in healthy adult men.
Biosci Biotechnol Biochem. 2001
Krieger NS, Parker WR, Alexander KM, Bushinsky DA.
Prostaglandins regulate acid-induced cell-mediated bone resorption.
Am J Physiol Renal Physiol. 2000 Dec;279(6):F1077-82. Erratum in: Am J Physiol Renal Physiol 2001 Sep;281(3):section F following tabl
Maurer M, Riesen W, Muser J, Hulter HN, Krapf R.
Neutralization of Western diet inhibits bone resorption independently of K intake and reduces cortisol secretion in humans.
Am J Physiol Renal Physiol. 2003 Jan;284(1):F32-40. Epub 2002 Sep 24.
PMID: 12
Zwart SR, Hargens AR, Smith SM.
The ratio of animal protein intake to potassium intake is a predictor of bone resorption in space flight analogues and in ambulatory subjects.
Am J Clin Nutr. 2004 Oct;80(4):1058-65.
PMID: 15447920
Low dietary potassium intakes and high dietary estimates of net endogenous acid production are associated with low bone mineral density in premenopausal women and increased markers of bone resorption in postmenopausal women.
Macdonald HM, New SA, Fraser WD, Campbell MK, Reid DM.
Am J Clin Nutr. 2005 Apr;81(4):923-33.
PMID: 15817873
Various selected vegetables, fruits, mushrooms and red wine residue inhibit bone resorption in rats.
Mühlbauer RC, Lozano A, Reinli A, Wetli H.
J Nutr. 2003 Nov;133(11):3592-7.
PMID: 14608079
Acid-base balance has an effect on bone turnover, especially on the rates of bone resorption and calcium mobilization. Bone mineral participates in the defense against acid-base disturbances, especially against metabolic acidosis (Lemann et al. 1966, Green & Kleeman 1991). The role of the bone mineral is important in the acid-base disorders, as no appreciable change in the intestinal calcium absorption occurs (Bichara et al. 1990).
In the mammalian body, mainly three hormones regulate the calcium metabolism and the bone turnover. 1,25-dihydroxycholecalciferol (vitamin D derivative) increases calcium absorption from the intestine and, indirectly, from bone. Parathyroid hormone mobilizes calcium from the bone and increases the urinary phosphate excretion. Calcitonin inhibits bone resorption (Ganong 1981). Used as drugs, these hormones are also capable of inducing acid-base disorders. Calcitonin administration (Escanero et al. 1991) and vitamin D excess (Bichara et al. 1990) have been reported to cause metabolic alkalosis.
Low vitamin D status, high bone turnover, and bone fractures in centenarians.
Passeri G, Pini G, Troiano L, Vescovini R, Sansoni P, Passeri M, Gueresi P, Delsignore R, Pedrazzoni M, Franceschi C.
J Clin Endocrinol Metab. 2003 Nov;88(11):5109-15.
PMID: 14602735
We conclude that the extreme decades of life are characterized by a pathophysiological sequence of events linking vitamin D deficiency, low serum calcium, and secondary hyperparathyroidism with an increase in bone resorption and severe osteopenia. These data offer a rationale for the possible prevention of elevated bone turnover, bone loss, and consequently the reduction of osteoporotic fractures and fracture-induced disability in the oldest olds through the supplementation with calcium and vitamin D.
A positive dose-response effect of vitamin D supplementation on site-specific bone mineral augmentation in adolescent girls: a double-blinded randomized placebo-controlled 1-year intervention.
Viljakainen HT, Natri AM, Kärkkäinen M, Huttunen MM, Palssa A, Jakobsen J, Cashman KD, Mølgaard C, Lamberg-Allardt C.
J Bone Miner Res. 2006 Jun;21(6):836-44.
PMID: 16753014
doi: 10.1359/jbmr.060302
We conclude that the current vitamin D recommendation for adolescent girls, at least in the northern latitudes, is too low to ensure sufficient vitamin D status during winter. Intake of vitamin D at rates of 10-15 μg/day aids to maintain stable S-25(OH)D concentrations during winter. Vitamin D induced BMC augmentation by decreasing bone resorption, but not affecting bone formation, which was reflected by the biochemical markers of bone turnover. Optimizing bone mineral gain in adolescence is crucial to the prevention of osteoporosis later in life. Increasing vitamin D intake to 10-15 μg/day aids in attaining this goal.
Fatigue fractures in military conscripts : A study on risk factors, diagnostics and long-term consequences
Ruohola, Juha-Petri
University of Helsinki, Faculty of Medicine, Institute of Clinical Medicine, Orthopaedics and Traumatology, Helsinki University Central Hospital
Centre of Military Medicine, Helsinki
2007-03-09
Doctoral dissertation (article-based)
It seems likely that low vitamin D levels are related to fatigue fractures, and that an increasing trend exists between TRACP-5b bone resorption marker elevation and fatigue fracture incidence. Though seldom detected by plain radiography, fatigue fractures often underlie unclear lower leg stress-related pain occurring in the distal parts of the tibia. Femoral neck fatigue fractures, when displaced, lead to long-term morbidity in a high percentage of patients, whereas, when non-displaced, they do not predispose patients to subsequent adverse complications. Importantly, an educational intervention can diminish the incidence of fracture displacement by enhancing awareness and providing instructions for earlier diagnosis of fatigue fractures
Association of low 25-hydroxyvitamin D concentrations with elevated parathyroid hormone concentrations and low cortical bone density in early pubertal and prepubertal Finnish girls.
Cheng S, Tylavsky F, Kröger H, Kärkkäinen M, Lyytikäinen A, Koistinen A, Mahonen A, Alen M, Halleen J, Väänänen K, Lamberg-Allardt C.
Am J Clin Nutr. 2003 Sep;78(3):485-92. Erratum in: Am J Clin Nutr. 2006 Jan;83(1):174.
PMID: 12936933
CONCLUSIONS: Vitamin D-deficient girls have low cortical BMD and high iPTH concentrations, which are consistent with secondary hyperparathyroidism. A low vitamin D concentration accompanied by high bone resorption (TRAP 5b) may limit the accretion of bone mass in young girls.
Dietary influences on bone mass and bone metabolism: further evidence of a positive link between fruit and vegetable consumption and bone health?
New SA, Robins SP, Campbell MK, Martin JC, Garton MJ, Bolton-Smith C, Grubb DA, Lee SJ, Reid DM.
Am J Clin Nutr. 2000 Jan;71(1):142-51.
PMID: 10617959
Conclusion: The BMD results confirm our previous work (but at peripheral bone mass sites), and our findings associating bone resorption with dietary factors provide further evidence of a positive link between fruit and vegetable consumption and bone health.
Uenishi K, Ishida H, Toba Y, Aoe S, Itabashi A, Takada Y.
Milk basic protein increases bone mineral density and improves bone metabolism in healthy young women.
Osteoporos Int. 2007 Mar;18(3):385-90. Epub 2006 Oct 18.
PMID: 17048062 [PubMed - in proce
In humans, the bones are completely regenerated over a period of about three years.
Osteoclast cells destroy old bones, and osteoblast cells create new ones. This way, bones are regenerated little by little every day. MBP® is a useful part in this remod
Frick KK, LaPlante K, Bushinsky DA.
RANK ligand and TNF-alpha mediate acid-induced bone calcium efflux in vitro.
Am J Physiol Renal Physiol. 2005 Nov;289(5):F1005-11. Epub 2005 Jun 21.
PMID: 15972386 [PubMed - indexed for MEDLINE
Putnam SE, Scutt AM, Bicknell K, Priestley CM, Williamson EM.
Natural products as alternative treatments for metabolic bone disorders and for maintenance of bone health.
Phytother Res. 2006 Nov 14; [Epub ahead of print]
PMID: 17106868 [PubMed - as supp