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Matti Narkia

Artemisinin - Wikipedia, the free encyclopedia - 0 views

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    Artemisinin (pronounced /ɑːtə'misinən/) is a drug used to treat multi-drug resistant strains of falciparum malaria. The compound (a sesquiterpene lactone) is isolated from the plant Artemisia annua. Not all plants of this species contain artemisinin. Apparently it is only produced when the plant is subjected to certain conditions, most likely biotic or abiotic stress. It can be synthesized from artemisinic acid.[1] The drug is derived from a herb used in Chinese traditional medicine, though it is usually chemically modified and combined with other medications.

    Artemisinin is under early research and testing for treatment of cancer, primarily by researchers at the University of Washington.[7][8] Artemisinin has a peroxide lactone group in its structure. It is thought that when the peroxide comes into contact with high iron concentrations (common in cancerous cells), the molecule becomes unstable and releases reactive oxygen species. It has been shown to reduce angiogenesis and the expression of vascular endothelial growth factor in some tissue cultures.
Matti Narkia

Fatty Acid Peroxidation & Free Radicals - 0 views

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    Fatty Acid Peroxidation & Free Radicals
Matti Narkia

Antioxidants prevent health-promoting effects of physical exercise in humans - PNAS - 0 views

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    Antioxidants prevent health-promoting effects of physical exercise in humans.
    Ristow M, Zarse K, Oberbach A, Klöting N, Birringer M, Kiehntopf M, Stumvoll M, Kahn CR, Blüher M.
    Proc Natl Acad Sci U S A. 2009 May 26;106(21):8665-70. Epub 2009 May 11.
    PMID: 19433800
    DOI: 10.1073/pnas.0903485106
Matti Narkia

Fish oil feeding alters liver gene expressions to defend against PPARalpha activation ... - 0 views

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    These data indicate that fish oil feeding downregulated the endogenous PPAR-activation system and increased antioxidant gene expressions to protect against ROS excess

    Fish oil feeding alters liver gene expressions to defend against PPARalpha activation and ROS production.
    Takahashi M, Tsuboyama-Kasaoka N, Nakatani T, Ishii M, Tsutsumi S, Aburatani H, Ezaki O.
    Am J Physiol Gastrointest Liver Physiol. 2002 Feb;282(2):G338-48.
    PMID: 11804856
Matti Narkia

Vitamin-exercise study questioned - 0 views

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    Reports that vitamins C and E may blunt the positive effects of exercise are misleading, according to an antioxidant expert.
    German researchers have reported that antioxidant vitamins C and E may blunt the positive effects of exercise, with respect to insulin sensitivity. Findings were published in the Proceedings of the National Academy of Sciences.

    Reacting to the study , Alexander Schauss, PhD, from AIBMR Life Sciences, a nutraceutical products consultancy, told NutraIngredients.com that the title of the study (Antioxidants prevent health-promoting effects of physical exercise in humans) was misleading.

    "The primary objective of this study was to study the effect of a 4-week intensive 5-days a week exercise program on insulin sensitivity. Yet the title of the paper leads one to believe otherwise," he said.

    "This is a small gender-biased study of 40 male subjects, 25 to 35 years of age. When I read through the study for the first time I had to wonder how could the authors have come up with such a title for their paper?" he asked.
Matti Narkia

Antioxidants may 'block' benefits of exercise: Study - 0 views

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    Supplements of antioxidant vitamins after exercise may decrease the benefits of the workout by blocking the positive effects of reactive oxygen, says a new study.
    Researchers from Germany and the US report in the Proceedings of the National Academy of Sciences that a combination of 1,000 mg per day of vitamin C and 400 IU per day of vitamin E adversely affected insulin sensitivity, and thereby increase the risk of type 2 diabetes.

    Participants, both trained and untrained, underwent 85 minutes of exercise five days per week for four weeks.
Matti Narkia

Oral administration of both tetrahydrobiopterin and L-arginine prevents endothelial dys... - 0 views

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    Oral administration of both tetrahydrobiopterin and L-arginine prevents endothelial dysfunction in rats with chronic renal failure.
    Yamamizu K, Shinozaki K, Ayajiki K, Gemba M, Okamura T.
    J Cardiovasc Pharmacol. 2007 Mar;49(3):131-9.
    PMID: 17414224
    doi: 10.1097/FJC.0b013e31802f9923
Matti Narkia

Antioxidative and anti-inflammatory actions of docosahexaenoic acid and eicosapentaeno... - 0 views

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    Antioxidative and anti-inflammatory actions of docosahexaenoic acid and
    eicosapentaenoic acid in renal epithelial cells and macrophages.
    Kim YJ, Chung HY.
    J Med Food. 2007 Jun;10(2):225-31.
    PMID: 17651056
    doi:10.1089/jmf.2006.092.
Matti Narkia

Aspirin-triggered lipoxin A4 blocks reactive oxygen species generation in end... - 0 views

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    Aspirin-triggered lipoxin A4 blocks reactive oxygen species generation in endothelial cells: a novel antioxidative mechanism.
    Nascimento-Silva V, Arruda MA, Barja-Fidalgo C, Fierro IM.
    Thromb Haemost. 2007 Jan;97(1):88-98.
    PMID: 17200775
    DOI: 10.1160/TH06-06-0315
Matti Narkia

Vitamin C Antagonizes the Cytotoxic Effects of Antineoplastic Drugs - 0 views

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    Vitamin C antagonizes the cytotoxic effects of antineoplastic drugs.\nHeaney ML, Gardner JR, Karasavvas N, Golde DW, Scheinberg DA, Smith EA, O'Connor OA.\nCancer Res. 2008 Oct 1;68(19):8031-8.\nPMID: 18829561
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