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Nathan Goodyear

Exercise-Associated Muscle Cramps - 0 views

www.ncbi.nlm.nih.gov/...PMC3445088

EAMC exercise associated muscle cramps athletes muscle cramps

shared by Nathan Goodyear on 27 Jan 15 - No Cached
  • athletes who develop EAMC often ingest similar amounts of fluid during exercise as do their noncramping counterparts
  • Oral fluid ingestion may be ineffective, and intravenous fluid may provide a faster delivery for athletes suffering from acute EAMC
  • It is interesting that stretching the affected muscle almost immediately relieves EAMC
  • ...9 more annotations...
  • Stretching, the primary treatment for acute EAMC
  • National Athletic Trainers’ Association recommends that athletes prone to muscle cramping add 0.3 to 0.7 g/L of salt to their drinks to stave off muscle cramps
  • Others have recommended adding higher amounts of sodium (about 3.0 to 6.0 g/L) to sports drinks based on the frequency of EAMC
  • intravenous infusion of fluids removes this delay, and it has been used to aid athletes who develop acute EAMC
  • maintaining hydration and adequate electrolyte levels is a good prevention strategy for individuals susceptible to EAMC
  • Fluid volumes of 1.8 L per hour have been well tolerated by tennis athletes who are susceptible to EAMC
  • Monitoring an athlete’s body weight is an easy method of ensuring adequate fluid replacement and individualizes each athlete’s fluid needs
  • the National Athletic Trainers’ Association and the American College of Sports Medicine recommend a volume of fluid that allows for less than a 2% body weight reduction
  • Endurance training may also serve as an effective means of preventing EAMC by expanding plasma volume and the extracellular fluid compartment15 and delaying neuromuscular fatigue
  • Nathan Goodyear on 27 Jan 15
     
    Exercise associated muscle cramps or EAMC is not worked out.  The theories include dehydration, mineral/electrolyte deficiencies, and neuromuscular activity.
Nathan Goodyear

http://press.endocrine.org/doi/pdf/10.1210/jc.2014-3818 - 0 views

press.endocrine.org/...jc.2014-3818

low T low Testosterone ED Estradiol SHBG erectile dysfunction libido men male hormone hormones

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  • Nathan Goodyear on 27 Jan 15
     
    Study finds that low free T and low Total T were associated with decline in desire, ED and activity versus none with Estradiol and SHBG in older men.  The difficult issue is the threshold of "low T".  The definition of "low T" is not uniform and varies with age.  Thus baseline evaluations and correlation with symptoms, metabolic dysfunction must be done.
Nathan Goodyear

The effects of testosterone treatment on body composition and metab... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...1335979

low T low Testosterone men male hormone hormones visceral fat abdominal fat

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  • Nathan Goodyear on 27 Jan 15
     
    Small study found that Testosterone therapy in men reduced visceral adiposity, but not abdominal adiposity.  This is in contrast to other studies.  IR improved in men with low T levels.
Nathan Goodyear

International Journal of Impotence Research - Obesity, low testosterone levels and erec... - 0 views

www.nature.com/...ijir200842a.html

low T low Testosterone men male hormone hormones ED erectile dysfunction Testosterone diabetes metabolic syndrome obesity

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  • Studies have shown that ED may be an early biomarker of general endothelial dysfunction, atherosclerosis and CVD
  • testosterone treatment of hypogonadal young and older men improves sexual function, increases lean mass and decreases fat mass
  • In men with low serum testosterone (for example, <8 or 230 nmol l−1) with obesity, metabolic syndrome and diabetes mellitus, treatment with testosterone is warranted
  • ...12 more annotations...
  • In obese middle-aged men, testosterone treatment reduced visceral adipocity, insulin resistance, serum cholesterol and glucose levels
  • testosterone replacement has a favorable impact on body mass, insulin secretion and sensitivity, lipid profile and blood pressure in hypogonadal men with the metabolic syndrome as well as type 2 diabetes mellitus
  • Testosterone significantly inhibits lipoprotein lipase activity, which reduces triglycerides uptake into adipocytes in the abdominal adipose tissue
  • testosterone treatment decreased endogenous inflammatory cytokines (tumor necrosis factor-α and IL-1β) and lipids (total cholesterol) and increased IL-10 in hypogonadal men
  • Testosterone treatment reduced leptin and adiponectin levels in hypogonadal type 2 diabetic men after 3 months of testosterone replacement
  • available data clearly show a relationship between obesity, low testosterone levels and ED
  • Obesity adversely affects endothelial function and lowers serum testosterone levels through the development of insulin resistance and metabolic syndrome
  • Metabolic disturbances as well as production of cytokines and adipokines by inflamed fat cells may be causal factors in the development of ED
  • The onset of ED and the associated risk of CVD may be delayed through lifestyle modifications that affect obesity, such as diet and exercise
  • Very low testosterone levels contribute to the development of ED in obesity, metabolic syndrome and type 2 diabetes mellitus
  • Obesity is associated with low total testosterone levels that can be explained at least partially by lower sex hormone-binding globulin (SHBG) in obese men
  • epidemiological studies have shown a negative correlation between BMI and total testosterone and to a lesser extent with free and bioavailable (biologically active) testosterone levels
  • Nathan Goodyear on 27 Jan 15
     
    Obesity is associated with low Testosterone and ED in men.
Nathan Goodyear

Erectile dysfunction is associated with low total serum testosteron... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25562576

ED erectile dysfunction low Testosterone low T Testosterone men male hormone hormones

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  • Nathan Goodyear on 27 Jan 15
     
    low Testosterone correlated with moderate to severe ED, but not mild ED in men 40-80.
Nathan Goodyear

Effect of bipolar androgen therapy for asymptomatic men with castra... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25568070

prostate cancer BAT bipolar androgen therapy PSA AR androgen receptor ADT androgen deprivation therapy men male hormone hormones

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  • Nathan Goodyear on 27 Jan 15
     
    bipolar androgen therapy proposed as a mechanism to restore AR sensitivity in those men with castration resistant prostate cancer.  This was a very small pilot study.  The effects on PSA were limited in effect as all men eventually developed PSA increase
Nathan Goodyear

Testosterone Deficiency, Cardiac Health, and Older Men - 0 views

www.ncbi.nlm.nih.gov/...PMC4000629

low T low Testosterone hypogonadism men male hormone hormones Testosterone therapy disease diabetes metabolic syndrome osteoporosis HIV infertility opiates

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  • 2.1 standard deviations in total testosterone was associated with a 25% increase in mortality
  • Erectile dysfunction is an established marker for future cardiovascular risk and the major presenting symptom leading to a diagnosis of low testosterone
  • There is a considerable body of evidence that low testosterone is associated with increased cardiovascular and cancer mortality
  • ...1 more annotation...
  • There is considerable evidence of modest cardiac and metabolic benefits that are shown to reduce cardiovascular risk plus sexual, mood, and quality of life changes associated with restoring testosterone levels
  • Nathan Goodyear on 27 Jan 15
     
    low Testosterone is associated with increased mortality in men and Testosterone therapy in men with low T is associated with a reduction in mortality in men.
Nathan Goodyear

Low Testosterone Has a Similar Prevalence among Men with Sexual Dys... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25580982

low Testosterone low T ED Peyronie's disease Testosterone men male hormone hormones

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  • Nathan Goodyear on 27 Jan 15
     
    low Testosterone prevalence found to be no different between men with ED or Peyronie's disease.
Nathan Goodyear

Low serum testosterone levels are associated with increased risk of mortality in a popu... - 0 views

eurheartj.oxfordjournals.org/...1494.long

low T low testosterone mortality men male hormone hormones testosterone CVD

shared by Nathan Goodyear on 17 Jul 12 - No Cached
  • Nathan Goodyear on 17 Jul 12
     
    low testosterone associated with increased mortality.  This is an increased risk of all-cause mortality in men.  The mortality rate due to CVD was found to be inversely associated with Testosterone levels.
Nathan Goodyear

Low testosterone and non-alcoholic fatty liver disease: Evidence for their independent ... - 0 views

www.maneyonline.com/...2045772314Y.0000000288

NAFLD non-alcoholic fatty liver disease low T low Testosterone Testosterone men male hormone hormones fatty liver

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  • Nathan Goodyear on 27 Jan 15
     
    Low Testosterone increased nonalcoholic fatty liver disease in men. The prevalence of NAFLD reached 85% with Total Testosterone was < 300 ng/dl.  Free Testosterone required a greater drop to increase the NAFLD, but it to still was found to be associated.
Nathan Goodyear

Exertional Dysnatremia in Collapsed Marathon Runners - 0 views

ajcp.ascpjournals.org/...336.long

marathon runners hypernatremia hyponatremia endurance athletes endurance exercise endurance sports

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  • Nathan Goodyear on 27 Jan 15
     
    Nice review of the treatment of hyper/hyponatremia with marathon runners.
Nathan Goodyear

Dysnatremia predicts a delayed recovery in collapsed ultramarathon ... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...17620783

hyponatremia hypernatremia ultramarathon runners endurance athletes endurance exercise IV fluids athletes

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  • Nathan Goodyear on 27 Jan 15
     
    The majority of ultra marathon runners deal with hypernatremia versus hyponatremia.  The majority were normonatremic.  Intravenous fluids can more rapidly resolve hypernatremia versus oral liquids and serves as useful means to reduce hypernatremia when oral liquids proves intolerable.
Nathan Goodyear

Diagnosis and prevention of hyponatremia at an ultradistance triath... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...10695851

hyponatremia triathlon endurance athletes endurance exercise endurance athletes weight

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  • Nathan Goodyear on 27 Jan 15
     
    over hydration increases risk of hyponatremia.  Body weight is inversely associated with Na levels.  Weight evaluations are an appropriate means to evaluate.  Endurance triathlon athletes can lose up to 5% without any negative physiologic impact.
Nathan Goodyear

Exercise-associated hyponatremia: role of cytokines. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...16843089

EAH exercise induced hyponatremia SIADH rhabdomyolysis hyponatremia endurance exercise endurance athletes endurance sports endurance athletes

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  • Nathan Goodyear on 27 Jan 15
     
    study links rhabdomyolysis to exercise induced hyponatremia.  This article links the depletion of glycogen to muscle release of IL-6 leading to increase in ECW and thus hyponatremia. The abstract discusses fluid restriction vs hypertonic 3% NaCL to reverse the more severe cases.  The first signs are of weight gain and thus weight should be monitored.  Decreased renal output is also associated with EAH.  Altered mental status is an early sign.
Nathan Goodyear

Exercise-associated hyponatremia. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...19523574

exercise induced hyponatremia hyponatremia endurance athletes endurance sports endurance athletes

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  • Nathan Goodyear on 27 Jan 15
     
    hyponatremia due to exercise, or exercise induced hyponatremia, is multifactorial: over-hydration, poor renal clearance, SIADH thus inhibition of renal fluid clearance, and excessive Na loss through sweat.
Nathan Goodyear

Hypertonic (3%) sodium chloride for emergent treatment of exercise-... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...17465635

endurance athletes exercise induced hyponatremia hyponatremia marathon runners athletes SIADH

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  • Nathan Goodyear on 27 Jan 15
     
    event over hydration with under renal excretion can lead to hyponatremia.  SIADH and resultant increased ECW is involved.  Weight is an adequate means to evaluate--no weight loss and/or weight gain may suggest fluid overload and potential hyponatremia.
Nathan Goodyear

Weight changes, sodium levels, and performance in the South African... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...12466696

endurance athletes Ironman triathlon sodium body weight

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  • Nathan Goodyear on 27 Jan 15
     
    Body weight post race was inversely associated with serum sodium i.e.  less weight loss was associated with lower serum sodium.  Body weight loss was unrelated to marathon time.
Nathan Goodyear

Study of hematological and biochemical parameters in runners comple... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...15523206

hyponatremia marathon runners endurance athletes

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  • Nathan Goodyear on 27 Jan 15
     
    No cases of hyponatremia noted in marathon runners.   Of note, over hydration was prevented through limited stations enroute.  NSAIDS negatively altered renal function
Nathan Goodyear

Serum biochemistry and morbidity among runners presenting for medic... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...17620786

ultra-marathons endurance athletes IV fluids hyponatremia

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  • Nathan Goodyear on 27 Jan 15
     
    Study looked at 9 athletes that were treated with IV fluids and found no significant morbidity with exercise associated hyponatremia.
Nathan Goodyear

Fluid Balance During and After an Ironman Triathlon - ResearchGate - 0 views

www.researchgate.net/...and_After_an_Ironman_Triathlon

ironman triathlon endurance athletes athletes athlete endurance IV fluids

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  • Nathan Goodyear on 27 Jan 15
     
    ultra distance triathlon athletes lost 2.5 kg weight during event.  Athletes that developed hyponatremia appeared to be fluid overloaded during event.
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