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Nathan Goodyear

Testosterone Replacement in Hypogonadal Men With Type 2 Diabetes and/or Metabolic Syndr... - 0 views

www.ncbi.nlm.nih.gov/...PMC3064036

low T low Testosterone men male hormone hormones Testosterone diabetes cholesterol insulin resistance insulin sensitivity LDL muscle muscle mass body composition metabolic syndrome

shared by Nathan Goodyear on 05 Mar 15 - No Cached
  • Nathan Goodyear on 05 Mar 15
     
    Testosterone therapy in men with low Testosterone was found to improve insulin sensitivity, total cholesterol levels, LDL, Lpa, and sexual performance in men with low T, type II diabetes and/or metabolic syndrome.  There is suggestion that muscle composition was improved as well.
Nathan Goodyear

Hormonal and lifestyle determinants of appendicular skeletal muscle mass in men: the MI... - 0 views

ajcn.nutrition.org/...496.long

sarcopenia muscle free Testosterone muscle mass low T low Testosterone vitamin D physical activity smoking

shared by Nathan Goodyear on 05 Mar 15 - No Cached
  • Nathan Goodyear on 05 Mar 15
     
    muscle loss, sarcopenia is a significant marker of poor health in men.  This study of 845 men age 45-85 finds that low Testosterone, low vitamin D, low physical activity, smoking, and thin body build are associated with sarcopenia in men.
Nathan Goodyear

Predictors of skeletal muscle mass in elderly men and women - 0 views

www.sciencedirect.com/...S0047637498001304

Testosterone free Testosterone muscle muscle mass men women male female hormone hormones

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  • Nathan Goodyear on 05 Mar 15
     
    Study of men and women finds that low free Testosterone, physical activity, and IGF1 is associated with muscle mass in men; no such relationship between sex hormone and muscle mass in women was found.
Nathan Goodyear

Relationship between Low Free Testosterone Levels and Loss of Muscle Mass : Scientific ... - 0 views

www.nature.com/...srep01818.html

muscle men male hormone Testosterone free Testosterone low T low Testosterone

shared by Nathan Goodyear on 05 Mar 15 - No Cached
  • Our data confirm that a low FT level is a significant predictor of a risk for loss of appendicular muscle
  • Total lean mass is associated with bioavailable T in postmenopausal women
  • Further studies are needed to determine the role of androgens in preserving muscle mass in women
  • ...11 more annotations...
  • Approximately 1% to 2% of T in the blood exists as FT
  • appendicular muscle loss was significantly associated with low levels of FT
  • These results suggest that a threshold level of FT exists for muscle loss, rather than a dose-response relationship
  • In the previous cross-sectional and longitudinal studies of French and American men, no dose-response relationships were reported between T and muscle mass
  • A minimal serum level of FT may be needed to preserve muscle mass in men, regardless of race/ethnicity.
  • Our result is in line with previous studies that reported a relationship between low FT and low muscle mass in men
  • T stimulates protein synthesis and inhibits protein degradation in muscle cells
  • T also increases satellite cell replication and activation in older men
  • In this study, no significant association between TT levels and muscle loss were observed
  • Although a progressive decrease in TT levels with ageing is observed in middle-aged and elderly American men16, 17, the TT levels do not change during ageing in Japanese men
  • FT levels may be a good marker for the loss of muscle mas
  • Nathan Goodyear on 05 Mar 15
     
    study of Japanese men finds that low free Testosterone was a predictor of decrease in muscle mass.
Nathan Goodyear

Nutrition Care for Patients with Weight Regain after Bariatric Surgery - 0 views

www.hindawi.com/...256145

bariatric surgery weight loss surgery obesity obese weight loss nutrition

shared by Nathan Goodyear on 05 Mar 15 - No Cached
  • Nathan Goodyear on 05 Mar 15
     
    Bariatric surgery has a regain of 25-30% of weight loss and a 25% failure to achieve successful weight loss.
Nathan Goodyear

Testosterone and weight loss: the evidence - 0 views

www.ncbi.nlm.nih.gov/...PMC4154787

low T low Testosterone Testosterone men male hormone hormones obesity obese fat adipose tissue visceral fat muscle waist circumference BMI

shared by Nathan Goodyear on 04 Mar 15 - No Cached
    • Nathan Goodyear
      Nathan Goodyear on 04 Mar 15
       
      What a ridiculous statement!
  • Testosterone therapy increases LBM, reduces fat mass and produces sustained and significant weight loss, reduction in waist circumference and BMI
Nathan Goodyear

Fifty- two-Week Treatment With Diet and Exercise Plus Transdermal Testosterone Reverses... - 0 views

onlinelibrary.wiley.com/...full

diet exercise nutrition diabetes metabolic syndrome men male hormone hormones low T low Testosterone

shared by Nathan Goodyear on 04 Mar 15 - No Cached
  • there appears to be a positive correlation between serum testosterone levels and insulin sensitivity in men across the full spectrum of glucose tolerance (Pitteloud et al, 2005), and this relationship is at least partially direct and not fully dependent on (changes in) elements of the MetS
  • supervised D&E alone led to significant improvements in testosterone concentrations, glycemic control, and components of the MetS
  • diet control, exercise, and testosterone supplementation may be beneficial in the management of men with T2D
  • ...7 more annotations...
  • androgen-deprivation therapy in males with prostatic cancer may be associated with an increased risk for T2D, which may be caused by negative effects on insulin sensitivity
  • insulin sensitivity, measured by HOMA, improved in both groups and with a significantly greater degree when testosterone was added to supervised D&E
  • Fasting insulin concentrations, a good representative of insulin sensitivity, did show a significant correlation with changes in circulating androgen levels, an observation in support of Pitteloud et al (2005), who showed a direct relationship between insulin sensitivity and circulating testosterone concentrations using the hyper-insulinemic euglycemic clamp technique
  • 52 weeks of testosterone treatment also significantly improved circulation levels of adiponectin and hsCRP, key serum markers of insulin sensitivity and hepatic steatosis
  • The changes in both adiponectin and hsCRP were significantly correlated with the therapy-induced changes in bioavailable testosterone
  • a negative correlation was found between hsCRP levels and bioavailable testosterone
  • serum PSA concentrations did not differ between the 2 treatment groups, indicating that short-term testosterone administration appears to be acceptably safe
  • Nathan Goodyear on 04 Mar 15
     
    Study of men with metabolic syndrome and type II Diabetes finds that diet and exercise alone improved glucose control and metabolic syndrome components by 31%.  The addition of Testosterone therapy increased this % to 81%.
Nathan Goodyear

Menopause and the Metabolic Syndrome - 0 views

www.ncbi.nlm.nih.gov/...PMC2894539

metabolic syndrome CVD cardiovascular disease Testosterone Menopause women female hormone hormones

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  • Nathan Goodyear on 04 Mar 15
     
    Menopause transition can become a Testosterone dominant phase associated with increased CVD and increased metabolic syndrome.
Nathan Goodyear

Metabolic syndrome, testosterone, and cardiovascular mortality in men. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21676188

low T low Testosterone bioavailable Testosterone cardiovascular disease metabolic syndrome mortality men male hormone hormones

shared by Nathan Goodyear on 04 Mar 15 - No Cached
  • Nathan Goodyear on 04 Mar 15
     
    study of 596 men finds that lower bioavailable Testosterone in those men with Metabolic Syndrome, have an increased cardiovascular mortality in those > 40.
Nathan Goodyear

Associations between Circulating Reproductive Hormones and SHBG and Prevalent and Incid... - 1 views

press.endocrine.org/...jc.2014-2464

metabolic syndrome metabolic syndrome men male hormone hormones health Testosterone DHT SHBG cFT free Testosterone

shared by Nathan Goodyear on 06 Oct 14 - No Cached
  • Nathan Goodyear on 06 Oct 14
     
    The best marker associated with MetS in older men was low SHBG. Low T, DHT, and cFT were found to be more biomarkers of poor health rather than causal.
Nathan Goodyear

Sex Hormone-Binding Globulin, but Not Testosterone, Is Associated Prospectively and Ind... - 0 views

www.ncbi.nlm.nih.gov/...PMC3198304

metabolic syndrome Framingham heart study SHBG Testosterone men male hormone hormones

shared by Nathan Goodyear on 04 Mar 15 - No Cached
  • Nathan Goodyear on 04 Mar 15
     
    Framingham Heart Study finds that low SHBG, not Testosterone was associated with increased risk of metabolic syndrome.
Nathan Goodyear

Estradiol and Metabolic Syndrome in Older Italian Men: the InCHIANTI Study - 0 views

www.ncbi.nlm.nih.gov/...PMC2842460

Men hormone hormones estradiol estrogen metabolic syndrome MetS InCHIANTI study

shared by Nathan Goodyear on 30 Apr 13 - No Cached
  • Nathan Goodyear on 30 Apr 13
     
    Men with metabolic syndrome found to be associated with higher Estradiol levels.  Thus, Estradiol in "older men", >65 in this study, is associated with metabolic syndrome.
Nathan Goodyear

Nuclear TK1 expression is an independent prognostic factor for survival in pre-malignan... - 0 views

www.ncbi.nlm.nih.gov/...PMC3665464

TK-1 TK-1 cancer thymidine kinase 1 cancer biomarker

shared by Nathan Goodyear on 04 Mar 15 - No Cached
  • Thymidine kinase 1 (TK1) is a proliferation biomarker
  • Nuclear TK1 expression in early grade CIN predicts risk for progression to malignancy
  • Nuclear TK1 expression is also a prognostic factor for treatment outcome
  • ...9 more annotations...
  • TK1 LI was found to be a more reliable prognostic marker for 5-year survival than pathological stages, FIGO stages and Ki-67,
  • nuclear TK1 expression is a reliable prognostic factor in CIN patients, a group of cervical lesion patients that respond positively to treatment
  • nuclear TK1 expression is correlated with advanced stage of invasive cervical carcinomas
  • a low TK1 LI can help to identify with a better survival
  • low TK1 expression in the tumors in these patients might indicate that these tumors have a lower proliferation rate
  • TK1 is a key kinase in the one-step salvage pathway by which thymidine is introduced into DNA via the salvage pathway
  • TK1 participates in DNA synthesis and is therefore closely related to the S-phase of the cell cycle, and is correlated with proliferation
  • TK1 intensity (TK1 synthesis rate) increases from CIN grade I to CIN grade III, but does not further increase in invasive cervical carcinomas.
  • TK1 intensity seems to be a prognostic factor particularly when pre-malignant cervical lesions progress to malignancy
  • Nathan Goodyear on 04 Mar 15
     
    TK-1 is a proliferation biomarker of DNA repair. TK-1 is a nuclear biomarker of cancer prognosis, survival, recurrence and predicts risk of progression of pre-malignant disease.
Nathan Goodyear

Thymidine Kinase 1 Upregulation Is an Early Event in Breast Tumor Formation - 0 views

www.hindawi.com/...575647

thymidine kinase 1 TK-1 cancer breast cancer

shared by Nathan Goodyear on 19 Feb 15 - No Cached
  • Thymidine kinase 1 (TK1), a proliferation marker involved in DNA repair
  • prognostic potential
  • TK1 upregulation is an early event in tumor tissue formation
  • Nathan Goodyear on 19 Feb 15
     
    Upregulation of TK-1 found to be an early event in breast tumor development. This has implications in precancerous tissue and elevations correlate to stage of cancer. TK-1 has also been found to correlate with Cancer recurrence.
Nathan Goodyear

PLOS ONE: Testosterone, Sex Hormone-Binding Globulin and the Metabolic Syndrome in Men:... - 0 views

journals.plos.org/...article

Testosterone metabolic syndrome total Testosterone free Testosterone SHBG men male hormone hormones

shared by Nathan Goodyear on 03 Mar 15 - No Cached
  • Nathan Goodyear on 03 Mar 15
     
    Meta-analysis finds that men with low total Testosterone, free Testosterone, and SHBG are more at risk for MetS than those with elevated levels.
Nathan Goodyear

Testosterone and metabolic syndrome: a meta-analysis study. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...20807333

Testosterone metabolic syndrome glucose HOMA triglycerides waist circumference HDL men male hormone hormones

shared by Nathan Goodyear on 03 Mar 15 - No Cached
  • Nathan Goodyear on 03 Mar 15
     
    Men with metabolic syndrome have lower Testosterone levels when compared to "healthy" individuals.  All men with MetS should have a full androgen analysis performed.  This meta-analysis of 20 studies found Testosterone therapy reduced fasting glucose, HOMA, triglycerides, waist circumference by Testosterone in men with MetS.  This study found that Testosterone therapy increased HDL as well.
Nathan Goodyear

Testosterone, cardiovas... [Best Pract Res Clin Endocrinol Metab. 2011] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21397202

low T low testosterone T CV cardiovascular disease CVD MetS metabolic syndrome

shared by Nathan Goodyear on 10 Nov 12 - No Cached
  • Nathan Goodyear on 10 Nov 12
     
    low T is associated with increased risk of CV death.  Additionally, Testosterone therapy shown to improve MetS.
Nathan Goodyear

Aging, androgens, and the metabolic syndrome in a longitudinal stud... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...17595254

metabolic syndrome SHBG Testosterone total Testosterone men male hormone hormones

shared by Nathan Goodyear on 03 Mar 15 - No Cached
  • Nathan Goodyear on 03 Mar 15
     
    In men, 20-94, lower Total Testosterone and SHBG was found to be associated with a higher incidence of metabolic syndrome.  Abstract only.  The greatest association was found with SHBG.
Nathan Goodyear

Cytokines and steroidogenesis. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...15026186

inflammation cytokines hormone hormones IL-1 LH

shared by Nathan Goodyear on 03 Mar 15 - No Cached
  • Nathan Goodyear on 03 Mar 15
     
    Inflammatory cytokines appear to inhibit hormone production at the levels of the adrenal glands, testes, and ovaries.  This is in addition to suppression at the level of the hypothalamus and pituitary.  One proposed mechanism is via a reduction of sensitivity of the testes to LH.
Nathan Goodyear

LPS-Induced Inflammation Potentiates the IL-1-Mediated Reduction of LH Secretion from t... - 0 views

www.hindawi.com/...926937

inflammation luteinizing hormone LH hypothalamus pituitary Testosterone LPS IL-1beta

shared by Nathan Goodyear on 03 Mar 15 - No Cached
  • Nathan Goodyear on 03 Mar 15
     
    IL-1beta reduced GNRH and LH production at the level of the Hypothalamus and the Pituitary respectively. What is interesting in this animal model is that greater LH suppression at the pituitary was found to occur in those animals with prior LPS exposure--priming??
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