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Nathan Goodyear

Effects of androgens on insulin actio... [Diabetes Metab Res Rev. 2008] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...18615851

insulin resistance androgen testosterone DHT DHEA women PCOS hormones hormone

shared by Nathan Goodyear on 17 Oct 12 - No Cached
  • Nathan Goodyear on 17 Oct 12
     
    elevated insulin associated with insulin resistance causes elevated male hormones in women.  Whether it is in PCOS or postmenopausal over-aggressive replacement, Testosterone also turns right around and contributes to insulin resistance.  Vicious cycle.
Nathan Goodyear

Endogenous estrogen, androgen, and progesterone concentrations and breast cancer risk among postmenopausal women. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...15601642

estrogen progesterone cancer breast cancer female hormones hormones women testosterone androgens androstenedione DHEA

shared by Nathan Goodyear on 15 Sep 16 - No Cached
  • Nathan Goodyear on 15 Sep 16
     
    estrogens and androgens found to be directly associated with breast cancer in women.  No association with progesterone and SHBG was found.
Nathan Goodyear

The Diagnostic Applications of Saliva- A Review - 0 views

cro.sagepub.com/...197.long

saliva salivary hormone hormones testing cortisol testosterone estradiol estrone estriol DHEA aldosterone insulin androstendione

shared by Nathan Goodyear on 14 Aug 12 - No Cached
  • Nathan Goodyear on 14 Aug 12
     
    Fantastic article on the review of the clinical use of saliva testing.  Of note, is the extensive documentation of the validation studies of hormone saliva testing.  Clearly, if a physician is against saliva testing, it is because of a lack of knowledge on the subject.
Nathan Goodyear

The Decline of Androgen Levels in Elderly Men and Its Clinical and Therapeutic Implications - 0 views

edrv.endojournals.org/...833.full

androgens testosterone DHEA DHT men male aging low elderly

shared by Nathan Goodyear on 19 Sep 12 - No Cached
  • Nathan Goodyear on 19 Sep 12
     
    discussion of the declining levels of androgens in the aging male.  But the focus of this entire article is wrong.  They are focusing on the blood levels of these androgens.  The biological effects of hormones occur in tissue not blood.  Though this article provides a good discussion of how transport of androgens are effected, it falls far short of providing any useful clinical application, because it fails to discuss peripheral levels of androgens.  
Nathan Goodyear

Intratumoral De Novo Steroid Synthesis Activates Androgen Receptor in Castration Resistant Prostate Cancer and is Upregulated by Treatment with CYP17A1 Inhibitors - 0 views

www.ncbi.nlm.nih.gov/...PMC3209585

prostate cancer DHEA androstenedione

shared by Nathan Goodyear on 27 Jan 14 - No Cached
  • Nathan Goodyear on 27 Jan 14
     
    adrenal androgens contribute to ADT resistant prostate cancer as precursors to T and DHT production.
Nathan Goodyear

An endocrine pathway in the prostate, ERβ, AR, 5α-androstane-3β,17β-diol, and CYP7B1, regulates prostate growth - 0 views

www.pnas.org/...13589.full

3-beta androstanediol DHT metabolite prostate cancer ER-beta ER beta CYP7b1 cytochrome male hormone hormones men

shared by Nathan Goodyear on 27 Jan 14 - No Cached
  • Although the prostate is an androgen-dependent tissue, estrogens influence both normal functions and pathological changes in this gland
  • This dual action may be due to the existence of two estrogen receptors, ERα and ERβ
  • ERα and ERβ have similar affinities for estradiol-17β
  • ...6 more annotations...
  • In this study we have shown that regulation of the levels of 3βAdiol by CYP7B1 is a key factor in regulation of prostatic growth
  • We provide evidence that proliferating cells in the prostate epithelium have elevated levels of AR and that AR protein but not mRNA levels are regulated by ERβ and its ligand 3βAdiol in the prostate epithelium.
  • because inhibition of 5α-reductase causes accumulation of testosterone and removal of ERβ action increases the level of AR in the prostate, the overall effect of Finasteride would be to favor proliferation of the prostate epithelium
  • studies show that ERβ tends to be lost in advanced prostate cancer.
  • DHEA is converted in the body to 5-androstene-3β,17β-diol, which is also a ligand for estrogen receptors (25, 39) and a substrate for CYP7B1
  • At the peak of proliferation, the proliferating epithelial cells in the ventral prostate expressed high levels of CYP7B1 but had no detectable ERβ, whereas in nonproliferating cells the level of ERβ was high and that of CYP7B1 was low.
  • Nathan Goodyear on 27 Jan 14
     
    3-beta androstanediola, a product of 3alpha-HSD from DHT binds to ER beta and down regulates AR in prostate cancer.  This study proposes that the mechanism is via CYP7B1.  CYP7B1 inactivates 3-beta androstanediol.  Interesting, because 3-beta androstanediol is considered "inactive" when compared to 3-alpha androstanediol and its interaction with ER alpha.  
Nathan Goodyear

Glucose and lipopolysaccharide regulate pro... [J Reprod Immunol. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24576416

PCOS polycystic ovarian syndrome androgens DHEA Testosterone women hormone hormones atherogenesis CAD obesity obese inflammation

shared by Nathan Goodyear on 03 Mar 14 - No Cached
  • Nathan Goodyear on 03 Mar 14
     
    elevated androgens (male hormones) correlated with low grade inflammation and atherogenesis in women with PCOS.  This was found more in those women that were obese.
Nathan Goodyear

Serum levels of brain-derived ne... [Clin Neuropharmacol. 2011 Jul-Aug] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21617527

l-Theanine BDNF cortisol DHEA

shared by Nathan Goodyear on 04 Nov 13 - No Cached
  • Nathan Goodyear on 04 Nov 13
     
    l-Theanine's positive effects found to occur through BDNF and a decrease in the cortisol:DHEA ratio.  This study looked at schizophrenic patients.
Nathan Goodyear

Inclusion of Endogenous Hormone Levels in Risk ... [J Clin Oncol. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25135988

post-menopause post menopause women female hormones hormone estradiol estrone testosterone DHEA prolactin SHBG dehydroepiandrosterone breast cancer

shared by Nathan Goodyear on 21 Aug 14 - No Cached
  • Nathan Goodyear on 21 Aug 14
     
    study finds hormone evaluations in post menopause women aids in breast cancer risk assessment.
Nathan Goodyear

Association of Mean Platelet Volume With Androgens and Insulin Resistance in Nonobese Patients With Polycystic Ovary Syndrome - 0 views

www.ncbi.nlm.nih.gov/...PMC4338650

MPV mean platelet volume androgens Testosterone DHEA women female hormone hormones PCOS CVD cardiovascular disease

shared by Nathan Goodyear on 10 Mar 15 - No Cached
  • Nathan Goodyear on 10 Mar 15
     
    Mean Platelet Volume (MPV) is associated with increased cardiovascular disease in some studies.  Hyperandrogenism is associated with increased CVD in women with PCOS. This study found that elevated androgen levels in non obese women with/without PCOS was associated with lower MPV values.  This stands in contrast to other studies. 
Nathan Goodyear

Hyperandrogenism sensitizes mononuclear cells to promote glucose-induced inflammation in lean reproductive-age women - 0 views

www.ncbi.nlm.nih.gov/...PMC3287360

inflammation glucose PCOS Testosterone DHEA women female hormone hormones

shared by Nathan Goodyear on 05 Aug 14 - No Cached
  • Nathan Goodyear on 05 Aug 14
     
    Interesting study finds hyperandrogenism stimulates excessive inflammatory response to glucose intake.  This study was done in otherwise healthy women not in women with PCOS.  The inflammatory cytokine production was via NF-KappaB activation.  Again, this has negative implications in women being doped with Testosterone.
Nathan Goodyear

Female pattern hair loss may be triggered by low oestrogen to androgen ratio. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...18333699

hair loss hair hormones estrogen androgens Testosterone DHEA

shared by Nathan Goodyear on 27 Oct 15 - No Cached
  • Nathan Goodyear on 27 Oct 15
     
    Only abstract available here: low estrogen:androgen ratio implicated in female hair loss.
Nathan Goodyear

The Effect of Simvastatin on Plasma Steroid Hormone Levels in Metformin-Treated Women with Non-Classic Congenital Adrenal Hyperplasia. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...26824284

statins statin therapy Testosterone androgens DHEA hormones women CAH

shared by Nathan Goodyear on 02 Feb 16 - No Cached
  • Nathan Goodyear on 02 Feb 16
     
    Statins are known to reduce Testosterone in men; new study finds statins reduce all androgens in women.
Nathan Goodyear

The implication of neuroactive steroids in Tourette syndrome pathogenesis: a role for 5α-reductase? - 0 views

www.ncbi.nlm.nih.gov/...PMC3849218

tourette's syndrome hormones 5-alpha reductase

shared by Nathan Goodyear on 08 Dec 15 - No Cached
  • The typical onset of TS occurs at 6–7 years of age and is characterized by the appearance of simple, recurrent motor tics, followed by the manifestation of phonic tics after several months [12]. In most children, TS symptoms undergo a progressive exacerbation, which reaches its zenith at the beginning of puberty (11–12 years of age), and is then followed by a gradual remission in the majority of patients
  • 30–40% of TS-affected children retain their symptoms in adulthood
  • Multiple neurotransmitters have been implicated in TS, including dopamine (DA), serotonin, norepinephrine, acetylcholine, glutamate and γ-amino-butyric acid (GABA)
  • ...11 more annotations...
  • female gender may predict greater tic severity in adulthood
  • male gender is a major risk factor for TS (with a male:female prevalence ratio estimated at ~4:1)
  • the typical age of onset coincides with adrenarche (6–7 years old); symptoms increase in severity until the beginning of puberty (12 years old) and then undergo a spontaneous amelioration, which becomes apparent with the end of puberty (at 18–19 years of age)
  • TS is diagnosed later in females than males
  • ample evidence supports the involvement of DAergic dysfunctions in TS
  • a number of clinical observations showed that tics in TS patients could be exacerbated by anabolic androgens
  • steroidogenic enzymes and androgen receptors may serve as putative therapeutic targets for this disorder
  • Unlike males, tic severity is typically increased after puberty in females
  • 26% of females were found to experience exacerbation of tics in the estrogenic phase of the menstrual cycle, and this phenomenon was found to be correlated with increased tic severity at menarche
  • biochemical hallmark of adrenarche is the acquisition of 17,20 lyase activity by cytochrome P450 C17 (CYP17A1)
  • increased synthesis of dehydroepiandrosterone (DHEA) and androstenedione, which leads to the growth of axillary and pubic hair as well as enhancement in the oiliness of the skin
  • Nathan Goodyear on 08 Dec 15
     
    interesting read on hormones and tourette's.. Proposed that 5 alpha reductase activity is involved in worsening of tics.  This makes sense as Testosterone in men with low T is known to increase dopamine and dopaminergic dysfunction is known to play a role in tourette's;  the clinical presentation of girls vs boys is very different.  The authors of this article propose that 5 alpha reductase activity controls a back door method where by progesterone is converted to androgens.
Nathan Goodyear

Serum vitamin D and sex hormones levels in men and women: The Multi-Ethnic Study of Atherosclerosis (MESA) - Maturitas - 0 views

www.maturitas.org/...abstract

vitamin D hormones SHBG estradiol Testosterone free Testosterone total Testosterone DHEA

shared by Nathan Goodyear on 13 Mar 17 - No Cached
  • Nathan Goodyear on 13 Mar 17
     
    low vitamin D levels effect sex hormone levels in men and women.
Nathan Goodyear

Sex hormone synthesis, regulation, and function | McMaster Pathophysiology Review - 0 views

www.pathophys.org/sexhormones

hormones HPA Testosterone DHEA estradiol LH FSH Progesterone androgens estrogen

shared by Nathan Goodyear on 02 Oct 17 - No Cached
  • Nathan Goodyear on 02 Oct 17
     
    Good review of the HPA-sex hormone pathways, called the Hypothalamic-Pituitary-Gondal axis, including HP feedback.  This is not a study but has nice diagrams. This is based on 14 referenced articles and 1 book chapter.
vanh14297

Testosteron Booster - Khẳng định đẳng cấp phái mạnh - 1 views

Mạnh mẽ, tự tin, lâu dài,... đó là những gì mà người đàn ông nào cũng mong muốn mình sẽ thể hiện được với người phụ nữ của mình. Đừng lo nếu như bạn chưa có đủ những yếu tố trên vì từ bây giờ, Test...

Testosterone hormone hormones Male men disease low

started by vanh14297 on 23 May 22 no follow-up yet
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