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Temporal trends in rates of patient harm result... [N Engl J Med. 2010] - PubMed - NCBI - 0 views

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    alarming statistic:  over 18% of patients are harmed by medical care.
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http://chrisbeatcancer.com/wp-content/uploads/2011/12/contribution-of-chemotherapy-to-5... - 0 views

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    This study from 2004 reveals the marketing-based medicine era that we live in.  This meta-analysis of studies conducted for 5 year survival benefit found the contribution of chemotherapy was 2.3% in Australia and 2.1% in America.  The authors conclusion: "it is clear that cytotoxic chemotherapy only makes a minor contribution to cancer survival".  Compare this to the chemotherapy harm and the balance of benefit versus harm reveals a complete lack of evidence with regards to how therapy is practiced in Cancer
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European Journal of Clinical Nutrition - Effect of maternal n-3 long-chain polyunsatura... - 0 views

  • It is estimated that approximately 30% of children and adolescents in the United States and about 15–30% of those in Europe can be classified as overweight or obese
  • An increasing body of evidence now suggests that the nutritional environment encountered in utero and the early postnatal life may elicit permanent alterations in adipose tissue structure or function and, thereby, programme the individual’s propensity to later obesity
  • The composition of fatty acids in the Western diets has shifted toward an increasing dominance of n-6 relative to n-3 LCPUFAs over the past decades.9,10 This shift is also reflected in the fatty acid composition of breast milk
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  • Evidence from animal studies suggests that the n-6 LCPUFA arachidonic acid promotes adipose tissue deposition, whereas the n-3 LCPUFAs eicosapentaenoic acid and docosahexaenoic acid seem to exert an opposite effect
  • Overall, no effect of supplementation was found on BMI in preschool (<5 years) and school-aged (6–12 years) children
  • increased adiposity, once established in childhood, tends to track into adulthood
  • Many studies have shown that even children <2 years with a high BMI are at increased risk of developing obesity later in life
  • The acquisition of fat cells early in life appears to be an irreversible process
  • Evidence from cell culture and animal studies suggests that early exposure to n-3 LCPUFAs has the potential to limit adipose tissue deposition mainly by attenuating the production of the arachidonic acid metabolite prostacyclin, which has been shown to enhance adipogenesis
  • In conclusion, there is currently no evidence to support that maternal n-3 LCPUFA supplementation during pregnancy and/or lactation exerts a favourable programming effect on adiposity status in childhood
  • our systematic review highlights that most of the trials reviewed were prone to methodological limitations
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    Literature review finds limited data (9 studies, only 6 RCTs) of omega-3 during pregnancy.  No data was found that supported reduced obesity in children by mothers taking n-3 during pregnancy.  No harm was found either.  Data was sparse.   Take home: not enough data, no harm to pregnancy, children, thus if indications are present for mother, then recommend n-3.  At this point not studies have pointed to reduced obesity in children.
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https://www.sightcare-co.com/ - 0 views

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    Sight Care | Official Site sightcare-co.com · by Sight Care Sight Care Only $49/Bottle Limited Time Offer! Sight Care Special Deal + Special 67% Discount Save $600 + 180 Days Money Back Guarantee #1.The Sight Care vision supplement is a dietary supplement for helping you improve your vision and brain health. Sight Care eye supplements are formulated to provide a synergistic blend of vitamins, minerals, antioxidants, and other bioactive compounds that are essential for maintaining healthy vision Regular Price: 147/per bottle Only for: $49/per bottle What Is Sight Care? This powerful vision support supplement is made with a unique blend of natural ingredients and plant extracts that work together synergistically to deliver numerous benefits for your brain and eye health. With Sight Care, you can expect to experience increased energy levels, improved eyesight, and an overall revitalized sense of well-being. Taking care of your vision health is not just about seeing clearly; it's also about maintaining your overall brain health. As we age, our vision deteriorates, and our eyes and brain can experience a decline in function, but there are steps you can take to support your visual and cognitive health. Regular eye exams are crucial for detecting and treating vision problems early on, and making healthy choices such as eating a nutritious diet and exercising regularly can also help. However, with busy schedules, it can be difficult to find the time to devote to a healthy lifestyle. This is where the Sight Care supplement comes in. It's designed to support both vision and brain health with its blend of natural ingredients that have been shown to promote healthy vision and cognitive function You must not compromise your eye health for momentary exhilaration. If you are glued to digital screens day and night, you must take measures to prevent eye diseases like age-related macular degeneration. The SightCare vision supplement has been made using 100% natura
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Frontiers | Primum Non Nocere: An Evolutionary Analysis of Whether Antidepressants Do M... - 0 views

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    antidepressants do more harm than good, is the conclusion of this study.
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Guidelines have done more harm than good. [Blood Purif. 2008] - PubMed result - 0 views

  • Guidelines certainly do not encourage clinicians to consider and treat each patient as an individual
  • This all but guarantees many guidelines are obsolete by the time they are published
  • unlikely to stimulate original research
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  • reated by a process that is artificial, laborious and cumbersome
  • uidelines are produced with industry support and recommendations often have a major impact on sales of industry products
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    Medical guidelines likely do more harm than good
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Impact Of Unimaginable Harms Of Chickens Chicken Prevention - Men's Health Clinic - 1 views

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    The harmful effects of chicken papilloma disease not only stop at physical health but also the spirit of patients is seriously affected. Patients may be depressed, mentally in crisis when they know that they can follow them all their lives. Chicken ridge is considered the undeniable obsession of men. Referring to this disease, many boys are bored, because once they get sick, the chicken's neck often hangs and leaves many harms. Dr. Vo Duy Tam said, "The chicken's crest is a sexually transmitted disease caused by HPV (Human Papilloma Virus) - The virus causes human papilloma. Currently there are more than 130 HPV types that have been discovered, among them, the ones that often cause genital warts are types 6, 11, 16, and 18.
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ScienceDirect.com - Toxicology - Estrogen receptor-α mediates the detrimental... - 0 views

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    Study shows that the harmful effects of DES exposure is primarily through ER alpha stimulation.
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Hypnotics' association with mortality or cancer: a matched cohort study -- Kripke et al... - 0 views

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    prescription sleep aids and hypnotics associated with 3 fold increase in death.  Scary thought considering how many use sleep aids today.  First do no harm is suppose to be a physician's moto.
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Estrogen receptor β and the progression of prostate cancer: role of 5α-andros... - 0 views

  • In the prostate, ERβ is highly expressed in the epithelial compartment, where it is the prevailing isoform
  • In the gland, DHT may be either reversibly 3α- or irreversibly 3β-hydroxylated by the different 3α- and 3β-hydroxysteroid dehydrogenases respectively (Steckelbroeck et al. 2004); these transformations generate two metabolites respectively 3α-diol and 3β-Adiol, which are both unable to bind the AR. Instead, 3β-Adiol displays a high affinity for ERβ (Kuiper et al. 1998, Nilsson et al. 2001), and it has been proposed that this metabolite may play a key role in prostate development
  • ERβ signaling, in contrast to ERα, seems to act as a suppressor of prostate growth, and may be positively involved in breast cancer
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  • 3β-Adiol counteracts PC cell proliferation in vitro
  • 3β-Adiol counteracts the biological actions of its androgenic precursors testosterone and DHT
  • functional antagonism of 3β-Adiol appears to be molecularly independent from the activation of the androgenic pathway
  • the action of 3β-Adiol is mediated, at the molecular levels, by the estrogenic pathway.
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    another awesome article dealing with hormone metabolites. Physicians that don't understand metabolites and receptors may be doing more harm than good.   One of the mainstays of the treatment of metastatic prostate disease is androgen deprivation therapy.  This article requires a reassessment of this due to the DHT metabolite 3-beta androstanediol.  This metabolite is produced from DHT production via the enzyme 3beta HSD.  This metabolite binds to ER beta, an estrogen receptor, and inhibits proliferation, migration, promotes adhesion (limits spreading), and stimulates apoptosis.  This is contrast to 3-alpha androstanediol.  Androgen deprivation therapy will decrease 3-beta androstanediol.  This is the likely reason for the increased aggressive prostate cancer found in those men using 5 alpha reductase inhibitors.
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Cognitive effects of estradiol after menopause - 0 views

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    No benefit to memory for post menopause women with estradiol therapy.  This study looked at early and late menopause estrogen therapy.  The study also found no harm.  Only abstract available here.  These studies would do more scientific benefit if they would follow hormone levels.  This study did not touch on dementia; other studies have shown benefit from estrogen therapy  in preventing dementia in women.
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How a charity oversells mammography | BMJ - 1 views

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    This article reveals how data is massaged to promote a viewpoint. In this case mammograms.  Don't let your passions get the best of you, objectively review the data.  Scientists are not doing that these days. Mammograms do help and are needed in the screening, however, mammograms do cause harm and help to promote the same disease it seeks to detect early.  This is in some cases. Also, remember, mammograms are early detection, not prevention.
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Caveat Emptor: Does Testosterone Treatment Reduce Mortality in Men? - 0 views

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    Nice editorial response to "does testosterone treatment reduce mortality in men?"  This response points out the flaws with the study.   The point to be taken with all studies, is there will never be a study to end all studies that provides unequivocal results.  We as scientists must view the risks/benefits of all therapies from within the prism that is each person sitting in front of us.  First, and foremost, do no harm.
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Biological functions and clinical implications of oestrogen receptors alfa and beta in ... - 0 views

  • ERα-positive cells respond to E2 with increased proliferation
  • ERβ was artificially introduced into these cells, E2-induced proliferation was inhibited
  • The proliferative response to E2 seems to be determined by the ratio of ERα/ERβ. The functions of ERβ in the breast are probably related to its antiproliferative as well as its prodifferentiative functions
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  • The risk of developing PC seems to be related to the diet
  • In the human prostate, ERβ is expressed in the basal epithelial cells and AR in the luminal epithelium.
  • For many years, DHT was considered to be the main hormone guiding prostate development and function. However, the idea was challenged when in 2001 Mahendroo et al. showed that mice in which both forms of 5α-reductase had been inactivated, have a normal functional prostate [50]. The question was then raised as to what is the real function of DHT in the prostate. In 1989 we hypothesized that DHT is a precursor of an oestrogen, 5α-androstane-3β,17β-diol (3β-Adiol) and that physiological levels of an oestrogen could be produced in the total absence of aromatase [51]. We later demonstrated that 3β-Adiol is abundant in the prostate and is a good natural ligand for ERβ
  • The overall effect of oestrogens in the immune system is determined by a balance between ERα and ERβ signalling
  • The hypothesis of our group is that ERβ plays an important role in regulating the differentiation of pluripotent haematopoietic progenitor cells whereas ERα induces proliferation
  • In tissues and cell lines of mammary epithelium for example, it has been noticed that E2 in the presence of ERα elicits proliferation, but in the presence of ERβ it inhibits proliferation
  • ERα and ERβ have distinctive tissue distributions and to the great surprise of endocrinologists [7] many tissues previously thought to be ‘oestrogen-insensitive tissues’ were found to be ERβ positive and oestrogen sensitive. The most notable of the ERα-negative ERβ-abundant tissues were the epithelium of the rodent ventral prostate [8], the granulosa cells of the ovaries [9] and the parenchyma of the lungs
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    Awesome article discusses the different balance of ER alpha and ER beta and the effects on tissue as it relates to proliferation versus differentiation.  This has clear implications in disease.  Physicians prescribing hormones without a knowledge and understanding of this are only causing potential harm to their clients.
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The Adverse Health Consequences of the Use of Multiple Performance-Enhancing Substances... - 0 views

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    Case study of the harmful effects of Performance enhancing overload.  Physicians are unknownlingly entering this realm in the marketing based medicine approach to the treatment of low T.
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Zeolite Heavy Metal Detoxifier - 0 views

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    Zeolite is a volcanic mineral with a selective molecular trap able to carry harmful toxic substances out of the body via normal excretion processes without interacting with body tissue. This lack of interaction reduces the chance of unwanted side effects.
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Is the use of cholesterol in mortality ris... [J Eval Clin Pract. 2011] - PubMed - NCBI - 0 views

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    cholesterol in women up to 270 is beneficial on CVD, not harmful.  How much does the difference in diet and lifestyle play a role here.  Norwegians have a higher fish intake, but they have a lower sun exposure. Maybe, just maybe, all pub around cholesterol has been overblown.
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Mercury Exposure and Children's Health - 0 views

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    good review of the harmful effects of the different types of Mercurgy
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LeanBiome™ (Official) | Get Save UpTo $540 Today Only! - 0 views

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    LeanBiome™ (Official) | Get Save UpTo $540 Today Only! usleanbiome.com LeanBiome™ Hurry Up! Offer Expires in: 00 HOUR 29 MINUTE 59 SECOND LeanBiome Attention! Get Special 84% Discount Today Faster fat burning and weight loss Healthy cholesterol and sugar levels Higher energy levels Regular price: $129 Only for: 39$ What Is LeanBiome? LeanBiome Lean for Good is a weight loss dietary supplement derived from scientifically researched ingredients and comprehensively developed to help people achieve sustainable weight control. The formula comes in a capsule format that is easy to take and is made with natural ingredients from plants and other sources to achieve its goals. The main ingredient in LeanBiome is piperine, which has been found to affect the body's ability to absorb micronutrients and other compounds more effectively. LeanBiome is a dietary supplement that claims to help weight management. It contains 100% natural ingredients that support healthy weight loss. It does not interfere with any natural process making it safe for use. It ranks among the top weight loss supplements that claim to provide a permanent solution. LeanBiome is made by a company named Lean for Good. It is made with natural and research-backed ingredients that help you lose excess fat without hassles. It is sold in capsule form. The company assures the composition is GMO, gluten, and soy-free. As for manufacturing standards, you need not fret. The company makes the supplement in a facility certified by the FDA. How Does LeanBiome Work? The starting period of the LeanBiome program includes a detoxification process that effectively removes any accumulated ree radicals, toxins, fand oxidative stress. This cleansing enables improved blood circulation, setting the stage for the body to initiate its own fat-burning mechanisms. To enhance metabolic activity, introducing the lean bacteria contained in LeanBiome to your gut microbiome is a beneficial approach. This activation triggers r
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https://www.fitspresso-co.com/ - 0 views

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    FitSpresso™ | Official Site fitspresso-co.com FitSpresso Only $39/Bottle Limited Time Offer! FitSpresso Special Deal + Special 51% Discount Save $660 + 180 Days Money Back Guarantee FitSpresso Herpesyl Five Star A dietary product formulated to assist users in reducing weight can increase other advantages that can support overall health. This product can assist users in getting closer to the desirable body weight. Regular Price: 149/per bottle Only for: $39/per bottle Buy Now What IsFitSpresso? FitSpresso is promoted as a natural supplement that comes in the form of diet pills, and it can aid in rapid and efficient weight loss, similar to many other supplements. The term "natural supplements refers to a nutritional supplement that is made entirely of natural, chemical-free materials. You can utilize these organic ingredients to aid in natural weight loss. It can speed up your body's metabolism and assist with other crucial processes. All parts of our bodies are impacted by weight increase, and not only do we need to deal with the increased weight, but we also need to deal with the numerous problems and illnesses that come along with it. This refers to the risk of developing chronic cardiac conditions, low blood pressure, and, in some circumstances, problems with blood sugar. However, FitSpresso even with its bright and bold claims, can help you efficiently manage your weight and completely avoid these extra uncomfortable problems. FitSpresso is a supplement that comes in the form of a pill, which makes it tasty, simple to swallow, and handy. According to the manufacturer, these diet tablets are GMO-free and toxic-free, making them edible. This is why we have things such as weight loss supplements. Thanks to modern advancements, we can just take a dietary supplement pill to bring about significant weight loss in a completely healthy and natural manner. Not only this, but dietary supplements can also support healthy blood sugar levels and help with
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