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Nutrition & Metabolism | Full text | Over-stimulation of insulin/IGF-1 signaling by Wes... - 0 views

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    Elevated insulin and IGF-1 as a result of the typical western diet results in increased risk of many of the chronic diseases of aging that we see in America--cancer.
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Fifty- two-Week Treatment With Diet and Exercise Plus Transdermal Testosterone Reverses... - 0 views

  • there appears to be a positive correlation between serum testosterone levels and insulin sensitivity in men across the full spectrum of glucose tolerance (Pitteloud et al, 2005), and this relationship is at least partially direct and not fully dependent on (changes in) elements of the MetS
  • supervised D&E alone led to significant improvements in testosterone concentrations, glycemic control, and components of the MetS
  • diet control, exercise, and testosterone supplementation may be beneficial in the management of men with T2D
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  • androgen-deprivation therapy in males with prostatic cancer may be associated with an increased risk for T2D, which may be caused by negative effects on insulin sensitivity
  • insulin sensitivity, measured by HOMA, improved in both groups and with a significantly greater degree when testosterone was added to supervised D&E
  • Fasting insulin concentrations, a good representative of insulin sensitivity, did show a significant correlation with changes in circulating androgen levels, an observation in support of Pitteloud et al (2005), who showed a direct relationship between insulin sensitivity and circulating testosterone concentrations using the hyper-insulinemic euglycemic clamp technique
  • 52 weeks of testosterone treatment also significantly improved circulation levels of adiponectin and hsCRP, key serum markers of insulin sensitivity and hepatic steatosis
  • The changes in both adiponectin and hsCRP were significantly correlated with the therapy-induced changes in bioavailable testosterone
  • a negative correlation was found between hsCRP levels and bioavailable testosterone
  • serum PSA concentrations did not differ between the 2 treatment groups, indicating that short-term testosterone administration appears to be acceptably safe
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    Study of men with metabolic syndrome and type II Diabetes finds that diet and exercise alone improved glucose control and metabolic syndrome components by 31%.  The addition of Testosterone therapy increased this % to 81%.
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JAMA Network | JAMA Internal Medicine | Vegetarian Dietary Patterns and the Risk of Col... - 0 views

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    Vegeterian diet found to reduce colon, colorectal, and rectal cancer when compared to non-vegetarian diets.
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High-fat diet increases thyrotropin and oxygen... [Endocrinology. 2010] - PubMed - NCBI - 0 views

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    Animal study finds that an 8 week course of high fat diet (HF) is associated with an increase serum rT3 levels by 1.5 fold.
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The role of dietary fat in peripheral thyroid hor... [Metabolism. 1980] - PubMed - NCBI - 0 views

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    High fat diet in this small animal study finds an increase in reverse T3 and a decrease in T3.  Higher carbohydrate diet provided no significant change.
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Ketogenic Diet in Neuromuscular and Neurodegenerative Diseases - 0 views

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    I like this review of a ketogenic diet.  This article discusses the use and benefits in neurodegenerative disease.
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Effects of a ketogenic diet on the quality of life in 16 patients with advanced cancer:... - 0 views

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    ketogenic diet aids cancer treatment.
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http://www.eurjmedres.com/content/pdf/s40001-014-0056-6.pdf - 0 views

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    Testosterone therapy in obese men with type II Diabetes and low T improved weight,  lipids, HgbA1c, and blood pressure.  There was more improvement with Leptin than with diet/exercise alone. What is very important is that the control group (diet, exercise, DM meds) had improvement in Testosterone levels, HgbA1c, lipids, BMI, and blood pressure; just not as strong as the treatment arm with Testosterone.
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Effect of the Mediterranean diet with and without weight loss on markers of inflammatio... - 0 views

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    Mediterranean diet plus weight loss results in a greater decrease in inflammation compared to weight loss alone.
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Adherence to the Mediterranean diet attenuates inflammation and coagulation process in ... - 0 views

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    Mediterranean diet reduced IL-6, homocysteine and CRP; as well as WBCs and fibrinogen.
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Neuroprotective and disease-modifying effects of the ketogenic diet - 0 views

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    great review of the ketogenic diet in neuroprotective and treatment of excitotoxic disease.
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Lipid-Based Diets Improve Muscarinic Neurotransmission in the Hippocampus of Transgenic... - 0 views

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    Proof of concept study in Alzheimer's model finds high fat diet improves brain cholinergic synapses, targeting directly the neurotransmission deficits in Alzheimer's disease
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Ketogenic diets as an adjuvant cancer therapy: History and potential mechanism - 1 views

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    review of science and mechanisms of ketogenic diet and cancer.
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Ketogenic diets as an adjuvant cancer therapy: History and potential mechanism - 0 views

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    Very good review on the ketogenic diet in cancer.
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The Effect of a Vegetarian vs Conventional Hypocaloric Diabetic Diet on Thigh Adipose T... - 0 views

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    Vegetarian diet out performs low calorie diet by reducing more muscle fat.
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Mediterranean diet, cognitive function, and dementia: a systematic review. - PubMed - NCBI - 0 views

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    review finds Mediterranean diet may slow cognitive decline and decrease risk of Alzheimer's disease.
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Mediterranean Diet, Cognitive Function, and Dementia: A Systematic Review of the Evidence - 0 views

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    review finds Mediterranean diet associated with improved cognitive function and possible delay in cognitive decline.
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Chronic exposure to Low dose bacterial lipopolysaccharide inhibits leptin signaling in ... - 0 views

  • Obesity and models of obesity induced by ingestion of HF-diet in rodents are associated with chronically elevated circulating levels of LPS
  • chronic low-dose administration of LPS induces leptin-resistance in vagal afferent neurons and abolition of CCK-induced inhibition of food intake
  • HF fat feeding has been shown to enhance gastrointestinal permeability promoting the translocation of LPS to the circulation
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  • LPS leads to an increase in SOCS3 expression [20]. SOCS3 is a negative regulator of leptin signaling
  • We observed a significant increase in energy intake in the LPS-treated rats
  • the data provides a mechanism linking changes in gut microbiota induced by ingestion of HF diets to dysregulation of food intake and body weight
  • Chronic low-dose LPS treatment induced TLR4 activation and MyD88 signaling in vagal afferent neurons, associated with increased SOCS3 expression and reduced leptin-signaling, characterized by the absence of leptin-induced pSTAT3.
  • SOCS3 is an important mechanism by which leptin resistance develops in vagal afferent neurons and coincides with the onset of hyperphagia
  • We demonstrate that this chronic low dose LPS is sufficient to induce leptin–resistance in vagal afferent neurons, reduced sensitivity to the satiating effects of CCK, and loss of vagal afferent plasticity
  • it suggests that the increase in food intake and body weight we observed at week 6 in the LPS treated rats may be caused by LPS-induced leptin resistance.
  • chronic LPS treatment of mice for four weeks increased body weight
  • chronic LPS treatment of mice for four weeks increased subcutaneous fat
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    Very interesting study.  High fat diet in rats induced gut flora change that resulted in LPS which induced appetite through leptin resistance and reduced cholecystokinin signaling.
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Postnatal diet remodels hepatic DNA methylation in metabolic pathways established by a ... - 0 views

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    Only abstract available here.  Maternal nutrition, high fat diet in this study, altered genetic expression of offspring to increase future disease risk.  This study would have been better served if they had differentiated fats i.e. PUFA, MUFA, SF, TF....
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Mediterranean Diet and SARS-COV-2 Infection: Is There Any Association? A Proof-of-Conce... - 0 views

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    Direct inverse correlation between decrease in Mediterranean diet and increase in hospitalization and severity of SARS-CoV-2 infection.
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