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no correlation between Testosterone, estradiol, and DHEAS levels and homocysteine in men >40.

Fascinating article: DHEA found to decrease NF-KappaB activity in the hippocampus region of the brain.  This has implications in protecting the brain.  In this study, the implication was reduction in inflammation in the hippocampus region in diabetic rat model.

DHEA shown to improve diabetes in mice model.

DHEA inhibits NF-kappaB, thus inhibiting inflammation.

Anorexia nervosa associated with elevated cortisol and DHEA diurnal rhythm.

low DHEA associated with increased cardiovascular disease risk.  This was presented at the Endocrine Society 94th Annual meeting.

low cortisol pattern with elevated DHEA found in women with PTSD.  Additionally, elevated levels of TNF-alpha and IL-6 were found. Hormone evaluation was tested through saliva.

DHEA's effect on adipose tissue is through increased adiponectin and increased insulin sensitivity.  This is the mechanism through which DHEA is propose to aid in weight loss.

Interesting animal study finds that the brain can make sex hormones, DHEA and Testosterone in this article, de novo from cholesterol.  This is one mechanism by which the body can adapt to low T.  This also brings to light the effects that low adrenal output can have on T as well.

Saliva and DHEA testing

Conclusion: "the concentration of DHEA in saliva is a reliable index of adrenal DHEA secretion..."

DHEA reduces SLE flares

Low DHEA in postmenopausal women linked to increased risk of mortality, especially Cardiovascular

women with elevated androgens (testosterone, DHT, androstenedione, DHEA...) are shown to have more HTN, insulin resistance, overweight issues, and CVD

Obese rat model finds an improvement in IR with DHEA and exercise.

DHEA proposed to be used to prevent/inhibit colorectal metastasis via inhibition of PRL-3 prenylation.

DHEA supplementation decreased SHBG and an elevation in IGF-1.

saliva used to monitor stress of hypobaric and hypoxic pilots.  Good correlation found to times of hypobaric and hypoxia stress, with pre and post return to normal levels found.  Additionally, DHEA was found to be a component in the stress response of these pilots.

Areas of high exposure of Dioxin in Vietnam found to have associated elevated salivary cortisol, cortisone, and DHEA.  Now, this can only be seen as an association, but they did find these elevations only in the "hot spots" and not in low exposure areas.

salivary cortisol and DHEA correlates well with serum levels before and after exercise.  Testosterone, in this study did not.