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Estrogen-Dependent Signaling in a Molecularly Distinct Subclass of Aggressive Prostate ... - 0 views

jnci.oxfordjournals.org/...815.abstract prostate cancer estrogen receptors ER alpha ER-alpha ER beta ER-beta
shared by Nathan Goodyear on 21 Jan 14 - No Cached
  • Nathan Goodyear on 21 Jan 14
     
    Estrogen receptors play a role in prostate cancer.  TMPRSS2-ERG expression is associated with increased aggressive cancer phenotype--ER beta decreases TMPRSS2-ERG expression, whereas ER alpha increases it.
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ERβ Impedes Prostate Cancer EMT by Destabilizing HIF-1α and Inhibiting VEGF-M... - 0 views

www.sciencedirect.com/...S1535610810000826 prostate cancer 3-beta androstanediol male hormone hormones ER HIF-1alpha VEGF estrogen receptor receptors ER beta ER-beta
shared by Nathan Goodyear on 21 Jan 14 - No Cached
  • Loss of ERβ1 expression also resulted in a significant increase in migration and invasion (Figure 2F), functions characteristic of an EMT
  • we hypothesized that ERβ functions as a “gatekeeper” of the epithelial phenotype
  • breast and prostate are different with respect to ER expression and function
  • Nathan Goodyear on 21 Jan 14
     
    The process of androgen deprivation therapy needs to be re-evaluated.  Why?  First, the CVD side effects associated with the androgen depletion.  Second, the depletion of 3 beta androstanediol that has been shown to bind to ER beta and inhibit growth.  As in this study that finds that ER beta activity slows prostate cancer through destabilizing of HIF-1 alpha and by inhibiting VEGF.
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ERα/E2 signaling suppresses the expressi... [Mol Cell Endocrinol. 2012] - Pub... - 0 views

www.ncbi.nlm.nih.gov/...22683664 ER alpha ER-alpha Estradiol Nur77 low T Testosterone
shared by Nathan Goodyear on 15 Feb 14 - No Cached
  • Nathan Goodyear on 15 Feb 14
     
    Another support point for Estrogen as a cause of low Testosterone.  This animal study points to signaling of Estradiol through ER alpha.  This study found high expression of ER alpha and subsequent signaling by E2 decreased cAMP and Nur77 transcription factor.  Nur77 increases steroid synthesis.  This was confirmed with ER alpha knockout mice.
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Estrogen receptor ß genes associated with colorectal cancer mortality - 0 views

www.fhcrc.org/...ith-colorectal-cancer-mor.html colon cancer ER beta ER-beta
shared by Nathan Goodyear on 19 Nov 13 - No Cached
  • Nathan Goodyear on 19 Nov 13
     
    Additional support for ER beta role in protection in colon cancer.  This study found that SNPs in ER beta transcription resulted in reduced ER beta expression and a resultant increase in carcinogenesis.
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Estrogen Receptors in Colorectal Cancer: Goalkeepers, Strikers, or Bystanders? - 0 views

cancerpreventionresearch.aacrjournals.org/...897.full estrogen colon cancer ER beta ER-beta breast
shared by Nathan Goodyear on 19 Nov 13 - No Cached
  • one can conclude that ERβ has an overall antiproliferative effect, thereby inhibiting cancer cell proliferation and antagonizing ERα function in the breast
  • HRT with estrogen alone did not increase the risk of breast cancer in the Women's Health Initiative clinical trials program
  • colorectal normal or cancer epithelium does not coexpress ERα and ERβ
  • ...7 more annotations...
  • ERβ expression resulted in the inhibition of proliferation and G1 phase cell-cycle arrest
  • ERβ expression strongly inhibited cMyc and tumor growth in a xenograft mouse model
  • induced ERβ in CRC cells has an antiproliferative, tumor-suppressive function that is independent of ERα
  • ERs also have the ability to bind many other compounds with an estrogen-like structure, including phytoestrogens and xenoestrogens (or endocrine disruptors)
  • Phytoestrogens are a diverse class of natural compounds with structural similarity to estradiol
  • Barone et al. recently found that two ERβ-selective phytoestrogens effectively counteracted CRC tumorigenesis and surprisingly increased ERβ expression in mice with mutations of the tumor-suppressor gene adenomatous polyposis coli
  • We can conclude that estrogens are important in protecting against CRC initiation and progression, and that the protective effect most likely is mediated by ERβ
  • Nathan Goodyear on 19 Nov 13
     
    ER beta is a new potential mode of therapy in colon cancer.  ER beta stimulation has been shown to inhibit colon cancer cell growth.
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Tumor Repressive Functions of Estrogen Receptor β in SW480 Colon Cancer Cells - 0 views

cancerres.aacrjournals.org/...6100.long colon colon cancer cancer estrogen ER beta ER-beta
shared by Nathan Goodyear on 19 Nov 13 - No Cached
  • Nathan Goodyear on 19 Nov 13
     
    Stimulation of ER-beta provides inhibition of colon cancer cell proliferation.  ER-beta is the prominent ER in the colon.
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Expression of estrogen receptor beta in colon cancer progression. - Abstract - Europe P... - 0 views

europepmc.org/...sionid=ltxxinSJWIC7B5g4GZdb.38 ER beta ER-beta colon colorectal cancer estrogen
shared by Nathan Goodyear on 19 Nov 13 - No Cached
  • Nathan Goodyear on 19 Nov 13
     
    ER beta expression is dominant in healthy colon epithelium.  This study found that as colon disease progressed, ER beta expression declined.  So that, early disease was associated with the highest level of ER beta expression.
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Estradiol-induced proliferation of papillary and follicular thyroid cancer ce... - 0 views

www.spandidos-publications.com/...1067 thyroid papillary follicular cancer estrogen estradiol hormone hormones ER alpha ER-alpha ER beta ER-beta PR receptors progesterone
shared by Nathan Goodyear on 25 Nov 13 - No Cached
  • Nathan Goodyear on 25 Nov 13
     
    Estradiol increased thyroid papillary and follicular cancer cells via both ER alpha and ER beta in this study.  What is also interesting is that estradiol did not increase PR expression.
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Loss of expression of oestrogen receptor beta in c... [Oncol Rep. 2005] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...15944762 ER beta ER-beta colon cancer estrogen receptor estrogen receptors estrogen receptor beta colorectal
shared by Nathan Goodyear on 19 Nov 13 - No Cached
  • Nathan Goodyear on 19 Nov 13
     
    Loss of ER beta associated with higher risk of colon cancer.  ER beta has been shown to be highly expressed in health colons.  It has been proposed that loss of this ER beta expression is associated with carcinogenesis.
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Loss of ERbeta expression as a common step in estrogen-dependent tumor progression - 0 views

erc.endocrinology-journals.org/...537.full.pdf ER-beta ER beta estrogen cancer hormone hormones ER estrogen receptors receptor breast colon colorectal alpha ER-alpha
shared by Nathan Goodyear on 19 Nov 13 - No Cached
  • Nathan Goodyear on 19 Nov 13
     
    ER beta loss has been shown to contribute to tumor progression
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Estrogens and epithelial ovarian cancer - 0 views

www.sciencedirect.com/...S0090825804001994 cancer ovarian cancer ER alpha ER beta ER-alpha ER-beta estrogen hormones
shared by Nathan Goodyear on 11 Sep 15 - No Cached
  • Nathan Goodyear on 11 Sep 15
     
    ER-alpha >ER-beta expression appears to play role in ovarian carcinogenesis.
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Loss of ERβ expression as a common step in estrogen-dependent tumor progression - 0 views

www.ncbi.nlm.nih.gov/...PMC2072930 ER beta hormones ER-beta estrogen receptor estrogen receptor beta ER alpha ER-alpha estrogen cancer tumor carcinogenesis
shared by Nathan Goodyear on 11 Sep 15 - No Cached
  • Nathan Goodyear on 11 Sep 15
     
    loss of ER-beta expression is associated with increased carcinogenesis, suggesting a protective role for ER-beta against tumor proliferation.
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Urinary Estrogens and Estrogen Metabolites and Subsequent Risk of Breast Cancer among P... - 0 views

cancerres.aacrjournals.org/...696.full estrogen metabolites estrogen metabolism ER estrogen receptors ROS hormones cancer breast cancer
shared by Nathan Goodyear on 07 Oct 15 - No Cached
  • both 2- and 4-catechol estrogen metabolites bind to the ER with affinities comparable with estradiol, 4-catechol estrogen metabolites have lower dissociation rates than estradiol and an enhanced ability to upregulate ER-dependent processes
  • 2-catechol estrogen metabolites act as either weak mitogens (39) or weak inhibitors of cell proliferation
  • While 16α-hydroxyestrone binds to the ER with lower affinity than estradiol, it binds covalently (41) and leads to a constitutively activated ER
  • ...15 more annotations...
  • 4-hydroxyestradiol and 16α-hydroxyestrone increasing proliferation and decreasing apoptosis in a manner similar to estradiol; however, these effects were achieved only at concentrations 10-fold higher than estradiol (39). In contrast, 2-hydroxyestradiol did not have substantial proliferative or antiapoptotic effects
  • In our study, the associations with both 2-hydroxyestrone and 16α-hydroxyestrone were nonsignificantly inverse and we did not observe a consistent trend or significant associations between the 2-hydroxyestrone:16α-hydroxyestrone ratio and breast cancer risk
  • Ratios of the 3 hydroxylation pathways were not significantly associated with risk although the 2:16-pathway and 4:16-pathway ratios were suggestively inversely associated
  • a significant inverse association with the ratio of parent estrogens to estrogen metabolites
  • several potentially estrogenic and genotoxic mechanisms
  • Estrogen metabolites also can be genotoxic
  • Catechol estrogens can be oxidized into quinones and induce DNA damage directly through the formation of DNA adducts, or indirectly via redox cycling and generation of reactive oxygen species
  • the oxidized forms of the catechol estrogens differ in their ability to damage DNA through adducts, with oxidized 2-catechols forming stable and reversible DNA adducts and oxidized 4-catechols forming unstable adducts, which lead to depurination and mutations
  • 2- and 4-catechols have been shown to produce reactive oxygen species and induce oxidative DNA damage
  • act independently from the ER
  • 16α-Hydroxyestrone also may be genotoxic
  • While the catechol estrogens have estrogenic and genotoxic potential, the methylated catechol estrogens, which are catechol estrogens with one hydroxyl group methylated, have been hypothesized to lower the risk of breast cancer
  • The suggested mechanisms are indirect, by decreasing circulating levels of catechol estrogens and thereby the opportunity for catechols to exert genotoxic or proliferative effects, or direct, by inhibiting tumor growth and inducing apoptosis
  • the balance between phase I (oxidation) and phase II (methylation) metabolism of estrogen may be important in hormonally related cancer development.
  • Despite the estrogenic and genotoxic potential of many of the estrogen metabolites, we only observed a significantly increased breast cancer risk with one estrogen metabolite, 17-epiestriol, which has particularly strong estrogenic activity and binds to both ERα and ERβ with an affinity comparable with estradiol
  • Nathan Goodyear on 07 Oct 15
     
    review of estrogen metabolites and breast cancer risk in premenopausal women.
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Expression of androgen and oestrogen receptors and its prognostic significance in uroth... - 0 views

onlinelibrary.wiley.com/...abstract AR androgen receptor androgen receptors androgen receptor ER alpha ER-alpha bladder cancer bladder cancer ER-beta ER beta hormone hormones
shared by Nathan Goodyear on 05 Jan 15 - No Cached
  • Nathan Goodyear on 05 Jan 15
     
    Study finds that loss of AR and ER-alpha is associated with high grade bladder cancer and ER-beta was positively associated. This has been contradicted by other studies.
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Sex-specific effects of long-term exposure to bi... [Chemosphere. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25112706 bisphenol A BPA xenoestrogens ER beta ER-beta hormone hormones anxiety depression
shared by Nathan Goodyear on 13 Aug 14 - No Cached
  • Nathan Goodyear on 13 Aug 14
     
    really interesting abstract.  Bisphenol A (BPA)  is a xenoestrogen.  This animal study finds that BPA down regulated ER-beta in the brains of male rats.  It also blocked the production of GABA(A)alpha 2 receptor.  These long term effects were evident in anxiety and depression in adult mice. Pregnancy exposure would set up an ER-alpha dominance in the male brain increasing risk of continuous ER alpha stim.
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Estrogen receptor transcription and transactivation: Estrogen receptor alpha and estrog... - 1 views

www.ncbi.nlm.nih.gov/...PMC138655 ER alpha ER beta estrogen receptors estrogen receptor alpha estrogen receptor beta estrogen cancer
shared by Nathan Goodyear on 06 Oct 18 - No Cached
  • Nathan Goodyear on 06 Oct 18
     
    estrogen receptors are not created equally.  ER-alpha is the predominant pro-stimulatory signal receptor, whereas the ER-beta is the inhibitory receptor signaling pathway.  SERMS are not created equally as well dependent on how they bind the respective ER receptors.
  • walterbradford on 12 Oct 18
     
    Thank you for sharing
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Adaptive changes result in activation of alternate signaling pathways and acquisition o... - 0 views

www.ncbi.nlm.nih.gov/...PMC3131492 ER alpha cancer aromatase inhibitor breast ER-alpha HER-2
shared by Nathan Goodyear on 14 Sep 20 - No Cached
  • Nathan Goodyear on 14 Sep 20
     
    Interesting cross-talk between EGF and ER. Inhibition of EGFR increases ER-alpha. Herceptin is a negative signal on ER expression.
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Diagnostic Pathology | Full text | Estrogen receptor beta expression in prostate adenoc... - 0 views

www.diagnosticpathology.org/...61 prostate cancer estrogen receptor estrogen receptor beta ER-beta hormone hormones receptor receptors estrogen
shared by Nathan Goodyear on 09 Jan 13 - No Cached
  • Nathan Goodyear on 09 Jan 13
     
    ER beta and prostate cancer.  More aggressive prostate cancer is found to be associated with lower ER beta expression in the prostate.  this makes sense, as other studies have shown that ER beta in the prostate can induce apoptosis (cell death), which is a powerful mechanism to regulate uncontrolled growth as found in cancer.
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Frequent Loss of Estrogen Receptor-β Expression in Prostate Cancer - 0 views

cancerres.aacrjournals.org/...5331.long ER beta prostate cancer prostate cancer estrogen receptor estrogen receptor receptors hormone hormones
shared by Nathan Goodyear on 05 Feb 13 - No Cached
  • Nathan Goodyear on 05 Feb 13
     
    Loss of ER-beta expression in the prostate associated with increased progression from a normal prostate to prostate cancer.
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Estrogen receptor-alpha expression in human meningiomas - 0 views

igitur-archive.library.uu.nl/...c8.pdf meningioma hormone receptors hormone receptor hormones estrogen receptor ER alpha PR progesterone receptor
shared by Nathan Goodyear on 05 Feb 13 - No Cached
  • Nathan Goodyear on 05 Feb 13
     
    This is a dissertation, but they found ER alpha expression in all meningioma samplings. This is in contrast to previous studies. As further research has come with meningiomas, more ER presence is found, likely due to improved testing techniques. What is interesting here is that Low/no PR status was associated with Increased ER alpha status. This has been shown to be a more pro-inflammatory/pro-growth picture in disease states, such as breast and prostate CA.
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