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Nathan Goodyear

Estrogen receptor related beta is expressed in human endometrium throughout the normal ... - 0 views

humrep.oxfordjournals.org/...2782.full.pdf

ER-alpha ER-beta estrogen receptor receptors menstrual cycle menstruation endometriumestrogen receptors estrogen receptor estrogen receptor alpha estrogen receptor beta

shared by Nathan Goodyear on 07 Dec 12 - No Cached
  • Nathan Goodyear on 07 Dec 12
     
    ER beta appears to be expressed through the menstruation cycle with predominance follicular and early secretory phases. Contrast with ER alpha predominance in late follicular and early secretory phases.
Nathan Goodyear

Endogenous Steroid Hormone Concentrations and Risk of Breast Cancer Among Premenopausal... - 0 views

jnci.oxfordjournals.org/...1406.long

hormone hormones Testosterone free total estradiol breast cancer women female

shared by Nathan Goodyear on 21 Mar 14 - No Cached
  • Nathan Goodyear on 21 Mar 14
     
    Prospective study finds that elevated total and free Estradiol levels in the follicular phase and elevated total and free Testosterone levels in both the follicular and luteal phase are associated with increased breast cancer in women.  The risk is for pre menopause in this study.  This and several other studies point to serious questions about the massive dosing of Testosterone via pellets, injections, and topicals for libido.  We appear to be following the same patter as seen with premarin, provera, now Testosterone in men and this may be the next ball to drop.  Is the Testosterone therapy merely producing an environment that feeds breast cancer?
Nathan Goodyear

Estradiol-induced proliferation of papillary and follicular thyroid cancer ce... - 0 views

www.spandidos-publications.com/...1067

thyroid papillary follicular cancer estrogen estradiol hormone hormones ER alpha ER-alpha ER beta ER-beta PR receptors progesterone

shared by Nathan Goodyear on 25 Nov 13 - No Cached
  • Nathan Goodyear on 25 Nov 13
     
    Estradiol increased thyroid papillary and follicular cancer cells via both ER alpha and ER beta in this study.  What is also interesting is that estradiol did not increase PR expression.
Nathan Goodyear

Follicular and luteal phase salivary progesterone ... [Gynecol Endocrinol. 1994] - PubM... - 0 views

www.ncbi.nlm.nih.gov/...8059613

salivary saliva luteal testing progesterone hormone hormones

shared by Nathan Goodyear on 22 Nov 10 - No Cached
  • Nathan Goodyear on 22 Nov 10
     
    Follicular and luteal phase salivary progesterone profiles in women with endometriosis and infertility.
Nathan Goodyear

Menstrual and hormonal alterations in juvenile systemi... [Lupus. 2009] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...19074167

progesterone low Lupus SLE juvenile hormone hormones

shared by Nathan Goodyear on 30 Oct 13 - No Cached
  • Nathan Goodyear on 30 Oct 13
     
    low Progesterone and progesterone "disturbances" found to be common in juvenile Lupus.  The authors in this study proposed it was due to low follicular reserves.  The point is that low progesterone increases inflammatory cytokines.
Nathan Goodyear

Association between Lead and Cadmium and Reproductive Hormones in Peripubertal U.S. Girls - 0 views

www.ncbi.nlm.nih.gov/...PMC3002200

heavy metals hormones girls puberty

shared by Nathan Goodyear on 20 Jul 14 - No Cached
  • Nathan Goodyear on 20 Jul 14
     
    Study finds higher Pb levels in young girls is associated with delayed puberty onset.  This occurs through an inverse relationship with inhibin B and follicular development.  This relationship was also found with Cadmium.  Both of these heavy metals are toxic to the ovaries.
Nathan Goodyear

EHP - Bisphenol A Exposure during Adulthood Causes Augmentation of Follicular... - 0 views

ehp.niehs.nih.gov/1205823

Bisphenol A estrogen E2 Estradiol xenoestrogens xenoestrogen hormone hormones BPA

shared by Nathan Goodyear on 19 Jun 13 - No Cached
  • Nathan Goodyear on 19 Jun 13
     
    Bisphenol A shown to disrupt ovarian estrogen production from exposure in adults.  The point of this that is important is that BPA, a xenoestrogen, can infact disrupt physiologic hormone production in adults, and contribute to ovarian failure.  BPA, itself, is 1,000 fold weaker than E2, yet it disrupts ovarian function.
Nathan Goodyear

Salivary estradiol and progesterone during the normal ovulatory menstrual cycle in Chin... - 0 views

www.journals.elsevierhealth.com/...abstract

salivary estradiol

shared by Nathan Goodyear on 20 Jan 11 - No Cached
  • Measurements of these salivary steroids may be used to assess follicular dynamics. Moreover, salivary sampling is simple, convenient and stress free.
  • Nathan Goodyear on 20 Jan 11
     
    salivary sampling is simple, convenient and stress free.
Nathan Goodyear

Diagnosing Growth Hormone Deficiency in Adults - 0 views

www.hindawi.com/...972617

HGH GH human growth hormone growth hormone IGF-1

shared by Nathan Goodyear on 04 Nov 14 - No Cached
  • it is clear that serum IGF-1 and or IGFBP-3 can be normal in patients with undisputed GHD
  • Various investigators have reported normal IGF-1 values in 37–70% of GH deficient adults
  • The co-administration of arginine and GHRH (the combined test) is a powerful stimulus for GH production and has gained increasing acceptance as a useful method of diagnosing GHD [34]. This test has been advocated as a suitable alternative to ITT
  • ...12 more annotations...
  • The glucagon stimulation test (GST) is a reliable, safe alternative to the ITT in the diagnosis of GHD
  • An intravenous infusion of arginine (0.5 g/kg body weight) together with an intravenous bolus of GHRH (1 mcg/kg body weight) is administered [30]. Serum samples for GH are then obtained every 15–30 minutes for two hours.
  • Obesity, particularly marked obesity, is associated with blunted GH secretion in response to provocative stimuli
  • It has also been suggested that that even mildly increased BMI (25–30 kg/m2) can result in diminished stimulated GH production in 13% of healthy subjects
  • Corneli et al. have defined BMI-specific cut-off points for diagnosing adult-onset GHD using GHRH + arginine—11.5 ng/mL for those with BMI < 25 kg/m2, 8.0 ng/mL for BMI 25–30 kg/m2, 4.2 ng/mL for those with BMI > 30 kg/m2
  • GH levels are higher during the luteal phase in comparison with the follicular phase of the cycle
  • Oral, in contrast to transdermal oestrogen, lowers IGF-1 levels and is associated with increased GH levels
  • Adequate pituitary replacement with thyroxine and hydrocortisone are needed for optimal GH production
  • one cannot rely on a low IGF-1 to diagnose GHD in women taking oral oestrogen preparations.
  • Numerous GH secretagogues are available with the insulin tolerance test being the gold standard and the glucagon stimulation test or the GHRH + arginine as acceptable alternatives
  • ain et al. found the GST to be at least as good as the ITT in provoking GH secretion
  • the GST is safe, with almost no contraindications, it causes nausea and sometimes vomiting in 15–20% of subjects
  • Nathan Goodyear on 04 Nov 14
     
    Nice, more recent analysis, of HGH testing.
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