Estradiol increased thyroid papillary and follicular cancer cells via both ER alpha and ER beta in this study. What is also interesting is that estradiol did not increase PR expression.
columnar cell variant of papillary cancer associated with increased estrogen and progesterone nuclear receptor expression. However, when you read this study, the more aggressive tumors were associated with a decrease in progesterone expression.
Though nuclear expression of estrogen and progesterone receptors were increased in papillary cancer, only progesterone receptor expression was decreased in aggressive cancer.
This one size treats all approach that medicine takes in its recommendations to cancer evaluation is BS (forgive my french). Women with Hashimoto's disease are at increased risk of Papillary Thyroid cancer risk (30%) compared to those without.